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J. T. Van Dissel - One of the best experts on this subject based on the ideXlab platform.
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Polymorphisms in proinflammatory genes and susceptibility to typhoid Fever and Paratyphoid Fever.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2007Co-Authors: Soegianto Ali, A. M. Vollaard, Suwandhi Widjaja, Charles Surjadi, E. Van De Vosse, Dennis Kremer, Adriëtte W. De Visser, Cerithsa A.e. Martina, Eline Slagboom, J. T. Van DisselAbstract:Host genetic factors are thought to contribute to susceptibility and outcome in infectious diseases. A polymorphism in a proinflammatory gene, tumor necrosis factor-alpha (TNFA - 308), was recently found to be associated with susceptibility to typhoid Fever. As the observation was made in hospitalized patients, a potential confounder could be that the TNFA polymorphism is associated with the severity of established illness resulting in hospital admission rather than susceptibility to disease. We tested whether the association with TNFA - 308 is present also in typhoid Fever patients enrolled in a community-based case-control study in an endemic area in Indonesia. Common polymorphisms in other proinflammatory genes were assayed as well. Samples of patients with blood culture-confirmed typhoid Fever (n = 90) and Paratyphoid Fever (n = 26) and Fever controls (n = 337) were compared with those of community controls (n = 322). In these groups, we analyzed polymorphisms in TNFA by PCR and RFLP, polymorphisms of IFNG, IL1A, IL1B, IL1R1, TNFRSF1A, CASP1, and CRP by Sequenom MassArray (San Diego, CA), and polymorphisms in IL12B and IFNGR1 by fragment length analysis. The IL1R1 polymorphisms were nearly absent in the Indonesian population. The TNFA - 308 polymorphism was not associated with typhoid Fever (OR 0.35, 95% CI 0.1-1.0) in this population. The polymorphisms at TNFA - 238 or in IFNG, IL1A, IL1B, IL12B, TNFRSF1A, IFNGR1, CASP1, and CRP were also not associated with typhoid or Paratyphoid Fever. We conclude that polymorphisms in proinflammatory genes do not contribute to susceptibility to typhoid Fever and, in view of earlier findings, suggest that the TNFA - 308 polymorphism is likely related to severity of established disease rather than to susceptibility per se.
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park2 pacrg polymorphisms and susceptibility to typhoid and Paratyphoid Fever
Clinical and Experimental Immunology, 2006Co-Authors: Soegianto Ali, A. M. Vollaard, Suwandhi Widjaja, Charles Surjadi, E. Van De Vosse, J. T. Van DisselAbstract:Summary Host genetic factors may contribute to susceptibility to and outcome in infec- tious diseases. Recently polymorphisms in PARK2/PACRG , a gene cluster linked to ubiquitination and proteasome-mediated protein degradation, were found to be associated with manifest infection by M. leprae . Here, we address whether these polymorphisms are associated with susceptibility to infection with Salmonella typhi and S. paratyphi A, intracellular pathogens that upon infection of humans share with mycobacteria aspects of the hosts' immune response. The polymorphisms of PARK_e01( − 697) , PARK2_e01( − − − 2599) , rs1333955 and rs1040079 were analysed by polymerase chain reaction and restriction fragment length polymorphism in a case-control study of typhoid and Paratyphoid Fever patients in an endemic area in Jakarta, Indonesia. For this study, samples were obtained from patients with blood culture-confirmed typhoid Fever ( n = 90), Paratyphoid Fever ( n = 26) and Fever controls ( n = 337) in a passive, community-based surveillance and compared to those of ran- domly selected community controls ( n = 322) from the same city area. The PARK2_e01( − 2599) allele T was significantly associated with typhoid and Paratyphoid Fever (OR: 1·51, 95%CI: 1·02-2·23) but the other polymor- phisms, PARK2_e01( − 697) , rs1333955 and rs1040079 , were not associated. Although within the PARK2/PACRG gene cluster the PARK2_e01( − 2599) allele T was most strongly associated with leprosy (OR ∼ ∼ ∼ 3-5), the association with typhoid is much less strong. Our findings suggest that this polymor- phism in PARK2/PACRG plays a small but significant role in susceptibility to the intracellular pathogens S. typhi and S. paratyphi .
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park2 pacrg polymorphisms and susceptibility to typhoid and Paratyphoid Fever
Clinical and Experimental Immunology, 2006Co-Authors: Soegianto Ali, A. M. Vollaard, Suwandhi Widjaja, Charles Surjadi, E. Van De Vosse, J. T. Van DisselAbstract:Host genetic factors may contribute to susceptibility to and outcome in infectious diseases. Recently polymorphisms in PARK2/PACRG, a gene cluster linked to ubiquitination and proteasome-mediated protein degradation, were found to be associated with manifest infection by M. leprae. Here, we address whether these polymorphisms are associated with susceptibility to infection with Salmonella typhi and S. paratyphi A, intracellular pathogens that upon infection of humans share with mycobacteria aspects of the hosts' immune response. The polymorphisms of PARK_e01(-697), PARK2_e01(-2599), rs1333955 and rs1040079 were analysed by polymerase chain reaction and restriction fragment length polymorphism in a case-control study of typhoid and Paratyphoid Fever patients in an endemic area in Jakarta, Indonesia. For this study, samples were obtained from patients with blood culture-confirmed typhoid Fever (n=90), Paratyphoid Fever (n=26) and Fever controls (n=337) in a passive, community-based surveillance and compared to those of randomly selected community controls (n=322) from the same city area. The PARK2_e01(-2599) allele T was significantly associated with typhoid and Paratyphoid Fever (OR: 1.51, 95%CI: 1.02-2.23) but the other polymorphisms, PARK2_e01(-697), rs1333955 and rs1040079, were not associated. Although within the PARK2/PACRG gene cluster the PARK2_e01(-2599) allele T was most strongly associated with leprosy (OR approximately 3-5), the association with typhoid is much less strong. Our findings suggest that this polymorphism in PARK2/PACRG plays a small but significant role in susceptibility to the intracellular pathogens S. typhi and S. paratyphi.
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PARK2/PACRG polymorphisms and susceptibility to typhoid and Paratyphoid Fever
Clinical and Experimental Immunology, 2006Co-Authors: Soegianto Ali, A. M. Vollaard, Suwandhi Widjaja, Charles Surjadi, E. Van De Vosse, J. T. Van DisselAbstract:Summary Host genetic factors may contribute to susceptibility to and outcome in infec- tious diseases. Recently polymorphisms in PARK2/PACRG , a gene cluster linked to ubiquitination and proteasome-mediated protein degradation, were found to be associated with manifest infection by M. leprae . Here, we address whether these polymorphisms are associated with susceptibility to infection with Salmonella typhi and S. paratyphi A, intracellular pathogens that upon infection of humans share with mycobacteria aspects of the hosts' immune response. The polymorphisms of PARK_e01( − 697) , PARK2_e01( − − − 2599) , rs1333955 and rs1040079 were analysed by polymerase chain reaction and restriction fragment length polymorphism in a case-control study of typhoid and Paratyphoid Fever patients in an endemic area in Jakarta, Indonesia. For this study, samples were obtained from patients with blood culture-confirmed typhoid Fever ( n = 90), Paratyphoid Fever ( n = 26) and Fever controls ( n = 337) in a passive, community-based surveillance and compared to those of ran- domly selected community controls ( n = 322) from the same city area. The PARK2_e01( − 2599) allele T was significantly associated with typhoid and Paratyphoid Fever (OR: 1·51, 95%CI: 1·02-2·23) but the other polymor- phisms, PARK2_e01( − 697) , rs1333955 and rs1040079 , were not associated. Although within the PARK2/PACRG gene cluster the PARK2_e01( − 2599) allele T was most strongly associated with leprosy (OR ∼ ∼ ∼ 3-5), the association with typhoid is much less strong. Our findings suggest that this polymor- phism in PARK2/PACRG plays a small but significant role in susceptibility to the intracellular pathogens S. typhi and S. paratyphi .
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PARK2/PACRG polymorphisms and susceptibility to typhoid and Paratyphoid Fever
Clinical and experimental immunology, 2006Co-Authors: Soegianto Ali, A. M. Vollaard, Suwandhi Widjaja, Charles Surjadi, E. Van De Vosse, J. T. Van DisselAbstract:Host genetic factors may contribute to susceptibility to and outcome in infectious diseases. Recently polymorphisms in PARK2/PACRG, a gene cluster linked to ubiquitination and proteasome-mediated protein degradation, were found to be associated with manifest infection by M. leprae. Here, we address whether these polymorphisms are associated with susceptibility to infection with Salmonella typhi and S. paratyphi A, intracellular pathogens that upon infection of humans share with mycobacteria aspects of the hosts' immune response. The polymorphisms of PARK_e01(-697), PARK2_e01(-2599), rs1333955 and rs1040079 were analysed by polymerase chain reaction and restriction fragment length polymorphism in a case-control study of typhoid and Paratyphoid Fever patients in an endemic area in Jakarta, Indonesia. For this study, samples were obtained from patients with blood culture-confirmed typhoid Fever (n=90), Paratyphoid Fever (n=26) and Fever controls (n=337) in a passive, community-based surveillance and compared to those of randomly selected community controls (n=322) from the same city area. The PARK2_e01(-2599) allele T was significantly associated with typhoid and Paratyphoid Fever (OR: 1.51, 95%CI: 1.02-2.23) but the other polymorphisms, PARK2_e01(-697), rs1333955 and rs1040079, were not associated. Although within the PARK2/PACRG gene cluster the PARK2_e01(-2599) allele T was most strongly associated with leprosy (OR approximately 3-5), the association with typhoid is much less strong. Our findings suggest that this polymorphism in PARK2/PACRG plays a small but significant role in susceptibility to the intracellular pathogens S. typhi and S. paratyphi.
Soegianto Ali - One of the best experts on this subject based on the ideXlab platform.
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Polymorphisms in proinflammatory genes and susceptibility to typhoid Fever and Paratyphoid Fever.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2007Co-Authors: Soegianto Ali, A. M. Vollaard, Suwandhi Widjaja, Charles Surjadi, E. Van De Vosse, Dennis Kremer, Adriëtte W. De Visser, Cerithsa A.e. Martina, Eline Slagboom, J. T. Van DisselAbstract:Host genetic factors are thought to contribute to susceptibility and outcome in infectious diseases. A polymorphism in a proinflammatory gene, tumor necrosis factor-alpha (TNFA - 308), was recently found to be associated with susceptibility to typhoid Fever. As the observation was made in hospitalized patients, a potential confounder could be that the TNFA polymorphism is associated with the severity of established illness resulting in hospital admission rather than susceptibility to disease. We tested whether the association with TNFA - 308 is present also in typhoid Fever patients enrolled in a community-based case-control study in an endemic area in Indonesia. Common polymorphisms in other proinflammatory genes were assayed as well. Samples of patients with blood culture-confirmed typhoid Fever (n = 90) and Paratyphoid Fever (n = 26) and Fever controls (n = 337) were compared with those of community controls (n = 322). In these groups, we analyzed polymorphisms in TNFA by PCR and RFLP, polymorphisms of IFNG, IL1A, IL1B, IL1R1, TNFRSF1A, CASP1, and CRP by Sequenom MassArray (San Diego, CA), and polymorphisms in IL12B and IFNGR1 by fragment length analysis. The IL1R1 polymorphisms were nearly absent in the Indonesian population. The TNFA - 308 polymorphism was not associated with typhoid Fever (OR 0.35, 95% CI 0.1-1.0) in this population. The polymorphisms at TNFA - 238 or in IFNG, IL1A, IL1B, IL12B, TNFRSF1A, IFNGR1, CASP1, and CRP were also not associated with typhoid or Paratyphoid Fever. We conclude that polymorphisms in proinflammatory genes do not contribute to susceptibility to typhoid Fever and, in view of earlier findings, suggest that the TNFA - 308 polymorphism is likely related to severity of established disease rather than to susceptibility per se.
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park2 pacrg polymorphisms and susceptibility to typhoid and Paratyphoid Fever
Clinical and Experimental Immunology, 2006Co-Authors: Soegianto Ali, A. M. Vollaard, Suwandhi Widjaja, Charles Surjadi, E. Van De Vosse, J. T. Van DisselAbstract:Summary Host genetic factors may contribute to susceptibility to and outcome in infec- tious diseases. Recently polymorphisms in PARK2/PACRG , a gene cluster linked to ubiquitination and proteasome-mediated protein degradation, were found to be associated with manifest infection by M. leprae . Here, we address whether these polymorphisms are associated with susceptibility to infection with Salmonella typhi and S. paratyphi A, intracellular pathogens that upon infection of humans share with mycobacteria aspects of the hosts' immune response. The polymorphisms of PARK_e01( − 697) , PARK2_e01( − − − 2599) , rs1333955 and rs1040079 were analysed by polymerase chain reaction and restriction fragment length polymorphism in a case-control study of typhoid and Paratyphoid Fever patients in an endemic area in Jakarta, Indonesia. For this study, samples were obtained from patients with blood culture-confirmed typhoid Fever ( n = 90), Paratyphoid Fever ( n = 26) and Fever controls ( n = 337) in a passive, community-based surveillance and compared to those of ran- domly selected community controls ( n = 322) from the same city area. The PARK2_e01( − 2599) allele T was significantly associated with typhoid and Paratyphoid Fever (OR: 1·51, 95%CI: 1·02-2·23) but the other polymor- phisms, PARK2_e01( − 697) , rs1333955 and rs1040079 , were not associated. Although within the PARK2/PACRG gene cluster the PARK2_e01( − 2599) allele T was most strongly associated with leprosy (OR ∼ ∼ ∼ 3-5), the association with typhoid is much less strong. Our findings suggest that this polymor- phism in PARK2/PACRG plays a small but significant role in susceptibility to the intracellular pathogens S. typhi and S. paratyphi .
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park2 pacrg polymorphisms and susceptibility to typhoid and Paratyphoid Fever
Clinical and Experimental Immunology, 2006Co-Authors: Soegianto Ali, A. M. Vollaard, Suwandhi Widjaja, Charles Surjadi, E. Van De Vosse, J. T. Van DisselAbstract:Host genetic factors may contribute to susceptibility to and outcome in infectious diseases. Recently polymorphisms in PARK2/PACRG, a gene cluster linked to ubiquitination and proteasome-mediated protein degradation, were found to be associated with manifest infection by M. leprae. Here, we address whether these polymorphisms are associated with susceptibility to infection with Salmonella typhi and S. paratyphi A, intracellular pathogens that upon infection of humans share with mycobacteria aspects of the hosts' immune response. The polymorphisms of PARK_e01(-697), PARK2_e01(-2599), rs1333955 and rs1040079 were analysed by polymerase chain reaction and restriction fragment length polymorphism in a case-control study of typhoid and Paratyphoid Fever patients in an endemic area in Jakarta, Indonesia. For this study, samples were obtained from patients with blood culture-confirmed typhoid Fever (n=90), Paratyphoid Fever (n=26) and Fever controls (n=337) in a passive, community-based surveillance and compared to those of randomly selected community controls (n=322) from the same city area. The PARK2_e01(-2599) allele T was significantly associated with typhoid and Paratyphoid Fever (OR: 1.51, 95%CI: 1.02-2.23) but the other polymorphisms, PARK2_e01(-697), rs1333955 and rs1040079, were not associated. Although within the PARK2/PACRG gene cluster the PARK2_e01(-2599) allele T was most strongly associated with leprosy (OR approximately 3-5), the association with typhoid is much less strong. Our findings suggest that this polymorphism in PARK2/PACRG plays a small but significant role in susceptibility to the intracellular pathogens S. typhi and S. paratyphi.
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PARK2/PACRG polymorphisms and susceptibility to typhoid and Paratyphoid Fever
Clinical and Experimental Immunology, 2006Co-Authors: Soegianto Ali, A. M. Vollaard, Suwandhi Widjaja, Charles Surjadi, E. Van De Vosse, J. T. Van DisselAbstract:Summary Host genetic factors may contribute to susceptibility to and outcome in infec- tious diseases. Recently polymorphisms in PARK2/PACRG , a gene cluster linked to ubiquitination and proteasome-mediated protein degradation, were found to be associated with manifest infection by M. leprae . Here, we address whether these polymorphisms are associated with susceptibility to infection with Salmonella typhi and S. paratyphi A, intracellular pathogens that upon infection of humans share with mycobacteria aspects of the hosts' immune response. The polymorphisms of PARK_e01( − 697) , PARK2_e01( − − − 2599) , rs1333955 and rs1040079 were analysed by polymerase chain reaction and restriction fragment length polymorphism in a case-control study of typhoid and Paratyphoid Fever patients in an endemic area in Jakarta, Indonesia. For this study, samples were obtained from patients with blood culture-confirmed typhoid Fever ( n = 90), Paratyphoid Fever ( n = 26) and Fever controls ( n = 337) in a passive, community-based surveillance and compared to those of ran- domly selected community controls ( n = 322) from the same city area. The PARK2_e01( − 2599) allele T was significantly associated with typhoid and Paratyphoid Fever (OR: 1·51, 95%CI: 1·02-2·23) but the other polymor- phisms, PARK2_e01( − 697) , rs1333955 and rs1040079 , were not associated. Although within the PARK2/PACRG gene cluster the PARK2_e01( − 2599) allele T was most strongly associated with leprosy (OR ∼ ∼ ∼ 3-5), the association with typhoid is much less strong. Our findings suggest that this polymor- phism in PARK2/PACRG plays a small but significant role in susceptibility to the intracellular pathogens S. typhi and S. paratyphi .
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PARK2/PACRG polymorphisms and susceptibility to typhoid and Paratyphoid Fever
Clinical and experimental immunology, 2006Co-Authors: Soegianto Ali, A. M. Vollaard, Suwandhi Widjaja, Charles Surjadi, E. Van De Vosse, J. T. Van DisselAbstract:Host genetic factors may contribute to susceptibility to and outcome in infectious diseases. Recently polymorphisms in PARK2/PACRG, a gene cluster linked to ubiquitination and proteasome-mediated protein degradation, were found to be associated with manifest infection by M. leprae. Here, we address whether these polymorphisms are associated with susceptibility to infection with Salmonella typhi and S. paratyphi A, intracellular pathogens that upon infection of humans share with mycobacteria aspects of the hosts' immune response. The polymorphisms of PARK_e01(-697), PARK2_e01(-2599), rs1333955 and rs1040079 were analysed by polymerase chain reaction and restriction fragment length polymorphism in a case-control study of typhoid and Paratyphoid Fever patients in an endemic area in Jakarta, Indonesia. For this study, samples were obtained from patients with blood culture-confirmed typhoid Fever (n=90), Paratyphoid Fever (n=26) and Fever controls (n=337) in a passive, community-based surveillance and compared to those of randomly selected community controls (n=322) from the same city area. The PARK2_e01(-2599) allele T was significantly associated with typhoid and Paratyphoid Fever (OR: 1.51, 95%CI: 1.02-2.23) but the other polymorphisms, PARK2_e01(-697), rs1333955 and rs1040079, were not associated. Although within the PARK2/PACRG gene cluster the PARK2_e01(-2599) allele T was most strongly associated with leprosy (OR approximately 3-5), the association with typhoid is much less strong. Our findings suggest that this polymorphism in PARK2/PACRG plays a small but significant role in susceptibility to the intracellular pathogens S. typhi and S. paratyphi.
Hasifa Bukirwa - One of the best experts on this subject based on the ideXlab platform.
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azithromycin for treating uncomplicated typhoid and Paratyphoid Fever enteric Fever
Cochrane Database of Systematic Reviews, 2011Co-Authors: Emmanuel E Effa, Hasifa BukirwaAbstract:Reason for withdrawal from publication 2011, Issue 10: Review status: Current question – no update intended. Azithromycin treatments are included in the review: Fluoroquinolones for treating typhoid and Paratyphoid Fever (enteric Fever). (Thaver D, Zaidi AKM, Critchley JA, Azmatullah A, Madni SA, Bhutta ZA. Fluoroquinolones for treating typhoid and Paratyphoid Fever (enteric Fever). Cochrane Database of Systematic Reviews 2008, Issue 4. Art. No.: CD004530. DOI: 10.1002/14651858.CD004530.pub3.) This latter review is being updated, and will be published in late 2011. The azithrocycin review is therefore withdrawn. The review status reports aims to help the reader understand whether the review concerns a current question, and whether it is up to date. It is a pilot project by the Cochrane Infectious Diseases Group editors to help readers and we welcome feedback. It has three components: 1. Whether the review is currently relevant. For this, we classify reviews into: Historical question, where the intervention or policy has been superseded by new medical developments (such as a new drug); Current question, which is still relevant to current policy or practice. 2. Whether the review is up to date: for this, we classify reviews into: Up to date; Update pending; or No update intended. 3. An explanation of the review status. This narrative text provides a little more additional information to explain the categories selected. To view the published versions of this article, please click the 'Other versions' tab.
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withdrawn azithromycin for treating uncomplicated typhoid and Paratyphoid Fever enteric Fever
Cochrane Database of Systematic Reviews, 2011Co-Authors: Emmanuel E Effa, Hasifa BukirwaAbstract:Background Review status: Current question - no update intended. Azithromycin treatments are included in the review: Fluoroquinolones for treating typhoid and Paratyphoid Fever (enteric Fever). (Thaver D, Zaidi AKM, Critchley JA, Azmatullah A, Madni SA, Bhutta ZA. Fluoroquinolones for treating typhoid and Paratyphoid Fever (enteric Fever). Cochrane Database of Systematic Reviews 2008, Issue 4. Art. No.: CD004530. DOI: 10.1002/14651858.CD004530.pub3.) This latter review is being updated, and will be published in late 2011.Enteric Fever (typhoid and Paratyphoid Fever) is potentially fatal. Infection with drug-resistant strains of the causative organism Salmonella enterica serovar Typhi or Paratyphi increases morbidity and mortality. Azithromycin may have better outcomes in people with uncomplicated forms of the disease. Objectives To compare azithromycin with other antibiotics for treating uncomplicated enteric Fever. Search strategy In August 2008, we searched the Cochrane Infectious Diseases Group Specialized Register, CENTRAL (The Cochrane Library 2008, Issue 3), MEDLINE, EMBASE, LILACS, and mRCT. We also searched conference proceedings, reference lists, and contacted researchers and a pharmaceutical company. Selection criteria Randomized controlled trials comparing azithromycin with other antibiotics for treating children and adults with uncomplicated enteric Fever confirmed by cultures of S. Typhi or Paratyphi in blood and/or stool. Data collection and analysis Both authors independently extracted data and assessed the risk of bias. Dichotomous data were presented and compared using the odds ratio, and continuous data were reported as arithmetic means with standard deviations and were combined using the mean difference (MD). Both were presented with 95% confidence intervals (CI). Main results Seven trials involving 773 participants met the inclusion criteria. The trials used adequate methods to generate the allocation sequence and conceal allocation, and were open label. Three trials exclusively included adults, two included children, and two included both adults and children; all were hospital inpatients. One trial evaluated azithromycin against chloramphenicol and did not demonstrate a difference for any outcome (77 participants, 1 trial). When compared with fluoroquinolones in four trials, azithromycin significantly reduced clinical failure (OR 0.48, 95% CI 0.26 to 0.89; 564 participants, 4 trials) and duration of hospital stay (MD -1.04 days, 95% CI -1.73 to -0.34 days; 213 participants, 2 trials); all four trials included people with multiple-drug-resistant or nalidixic acid-resistant strains of S. Typhi or S. Paratyphi. We detected no statistically significant difference in the other outcomes. Compared with ceftriaxone, azithromycin significantly reduced relapse (OR 0.09, 95% CI 0.01 to 0.70; 132 participants, 2 trials) and not other outcome measures. Few adverse events were reported, and most were mild and self limiting. Authors' conclusions Azithromycin appears better than fluoroquinolone drugs in populations that included participants with drug-resistant strains. Azithromycin may perform better than ceftriaxone.
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The Cochrane Library - Azithromycin for treating uncomplicated typhoid and Paratyphoid Fever (enteric Fever).
The Cochrane database of systematic reviews, 2008Co-Authors: Emmanuel E Effa, Hasifa BukirwaAbstract:Reason for withdrawal from publication 2011, Issue 10: Review status: Current question – no update intended. Azithromycin treatments are included in the review: Fluoroquinolones for treating typhoid and Paratyphoid Fever (enteric Fever). (Thaver D, Zaidi AKM, Critchley JA, Azmatullah A, Madni SA, Bhutta ZA. Fluoroquinolones for treating typhoid and Paratyphoid Fever (enteric Fever). Cochrane Database of Systematic Reviews 2008, Issue 4. Art. No.: CD004530. DOI: 10.1002/14651858.CD004530.pub3.) This latter review is being updated, and will be published in late 2011. The azithrocycin review is therefore withdrawn. The review status reports aims to help the reader understand whether the review concerns a current question, and whether it is up to date. It is a pilot project by the Cochrane Infectious Diseases Group editors to help readers and we welcome feedback. It has three components: 1. Whether the review is currently relevant. For this, we classify reviews into: Historical question, where the intervention or policy has been superseded by new medical developments (such as a new drug); Current question, which is still relevant to current policy or practice. 2. Whether the review is up to date: for this, we classify reviews into: Up to date; Update pending; or No update intended. 3. An explanation of the review status. This narrative text provides a little more additional information to explain the categories selected. To view the published versions of this article, please click the 'Other versions' tab.
Meiying Yan - One of the best experts on this subject based on the ideXlab platform.
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spatial and temporal clustering characteristics of typhoid and Paratyphoid Fever and its change pattern in 3 provinces in southwestern china 2001 2012
Chinese journal of epidemiology, 2017Co-Authors: L Wang, Meiying Yan, Bo Yang, Yaqing Tang, Zhongcheng Liu, Ruiqin Wang, Biao KanAbstract:Objective: To analyze the spatial and temporal clustering characteristics of typhoid and Paratyphoid Fever and its change pattern in Yunnan, Guizhou and Guangxi provinces in southwestern China in recent years. Methods: The incidence data of typhoid and Paratyphoid Fever cases at county level in 3 provinces during 2001-2012 were collected from China Information System for Diseases Control and Prevention and analyzed by the methods of descriptive epidemiology and geographic informatics. And the map showing the spatial and temporal clustering characters of typhoid and Paratyphoid Fever cases in three provinces was drawn. SaTScan statistics was used to identify the typhoid and Paratyphoid Fever clustering areas of three provinces in each year from 2001 to 2012. Results: During the study period, the reported cases of typhoid and Paratyphoid Fever declined with year. The reported incidence decreased from 30.15 per 100 000 in 2001 to 10.83 per 100 000 in 2006(annual incidence 21.12 per 100 000); while during 2007-2012, the incidence became stable, ranging from 4.75 per 100 000 to 6.83 per 100 000 (annual incidence 5.73 per 100 000). The seasonal variation of the incidence was consistent in three provinces, with majority of cases occurred in summer and autumn. The spatial and temporal clustering of typhoid and Paratyphoid Fever was demonstrated by the incidence map. Most high-incidence counties were located in a zonal area extending from Yuxi of Yunnan to Guiyang of Guizhou, but were concentrated in Guilin in Guangxi. Temporal and spatial scan statistics identified the positional shifting of class Ⅰ clustering area from Guizhou to Yunnan. Class Ⅰ clustering area was located around the central and western areas (Zunyi and Anshun) of Guizhou during 2001-2003, and moved to the central area of Yunnan during 2004-2012. Conclusion: Spatial and temporal clustering of typhoid and Paratyphoid Fever existed in the endemic areas of southwestern China, and the clustering area covered a zone connecting the central areas of Guizhou and Yunnan. From 2004 to 2012, the most important clustering area shifted from Guizhou to Yunnan. Findings from this study provided evidence for the identifying key areas for typhoid and Paratyphoid Fever control and prevention and allocate health resources.
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An outbreak of Paratyphoid Fever in a county of Yunnan province, 2010-2011
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi, 2017Co-Authors: Shukun Wang, Bo Yang, Zhigang Wang, Xiaohe Zhang, Yanhua Zhou, Rusong Yang, Biao Kan, Meiying YanAbstract:Objective: To identify the source and to comment on control program regarding an outbreak of Paratyphoid A Fever in a county, through field studies. Methods: Descriptive epidemiological methods were adopted to describe the epidemiological characteristics of the outbreak, which occurred in Yuanjiang county, Yunan province between 2010-2011, China. Case-control study with environmental investigation was performed to identify related risk factors and pathogens while isolation and susceptibility on the suspected pathogens were conducted. Subsequently, intervention and preventive measures were taken for the control of the outbreak. Results: A total of 600 cases were diagnosed and reported as Paratyphoid Fever A which spread over the whole Yuanjiang county, including 10 townships with different incidence rates. The disease was spatially clustered and the prevalence rates in these townships decreased with increasing distances from the polluted fields. Data from the case-control study discovered that consumption of raw vegetables was the main risk factor associated with this outbreak of Paratyphoid Fever (OR=65.3, P
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an outbreak of Paratyphoid Fever in a county of yunnan province 2010 2011
Chinese journal of epidemiology, 2017Co-Authors: Shukun Wang, Bo Yang, Zhigang Wang, Xiaohe Zhang, Yanhua Zhou, Rusong Yang, Biao Kan, Meiying YanAbstract:Objective: To identify the source and to comment on control program regarding an outbreak of Paratyphoid A Fever in a county, through field studies. Methods: Descriptive epidemiological methods were adopted to describe the epidemiological characteristics of the outbreak, which occurred in Yuanjiang county, Yunan province between 2010-2011, China. Case-control study with environmental investigation was performed to identify related risk factors and pathogens while isolation and susceptibility on the suspected pathogens were conducted. Subsequently, intervention and preventive measures were taken for the control of the outbreak. Results: A total of 600 cases were diagnosed and reported as Paratyphoid Fever A which spread over the whole Yuanjiang county, including 10 townships with different incidence rates. The disease was spatially clustered and the prevalence rates in these townships decreased with increasing distances from the polluted fields. Data from the case-control study discovered that consumption of raw vegetables was the main risk factor associated with this outbreak of Paratyphoid Fever (OR=65.3, P<0.001). Management of patients did not meet the requirements while feces and urine of the outpatients polluted the wastewater system in the city. Salmonella paratyphi A isolates were identified from the improperly disinfected wastewaters in hospitals and city systems, respectively. After the measures as prohibiting the planting of vegetables in contaminated fields and disinfection of hospital wastewater were taken, the outbreak subsided. Conclusions: Urban and hospital wastewater used for vegetables irrigation together with the tradition of eating uncooked vegetables seemed responsible for the outbreak of this Paratyphoid Fever. Intervention programs carried by the local government played a key role in controlling this large outbreak.
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A Large-Scale Community-Based Outbreak of Paratyphoid Fever Caused by Hospital-Derived Transmission in Southern China.
PLoS neglected tropical diseases, 2015Co-Authors: Meiying Yan, Bo Yang, Zhigang Wang, Shukun Wang, Xiaohe Zhang, Yanhua Zhou, Bo Pang, Baowei Diao, Rusong YangAbstract:Background Since the 1990s, Paratyphoid Fever caused by Salmonella Paratyphi A has emerged in Southeast Asia and China. In 2010, a large-scale outbreak involving 601 cases of Paratyphoid Fever occurred in the whole of Yuanjiang county in China. Epidemiological and laboratory investigations were conducted to determine the etiology, source and transmission factors of the outbreak.
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typhoid and Paratyphoid Fever in yunnan province distributional patterns and the related meteorological factors
Chinese journal of epidemiology, 2011Co-Authors: L Wang, Jing Zhang, Junling Sun, Meiying Yan, Liqun Fang, Duochun Wang, Wuchun Cao, Biao KanAbstract:Objective To characterize the spatial distribution of typhoid and Paratyphoid Fever(TPF)in Yunnan province, China and to determine the effectiveness of meteorological factors on the epidemics of TPE Methods Data of reported TPF cases in Yunnan province(2001 -2007)from the China Information System for Diseases Control and Prevention was applied to GIS-based spatial analyses to detect their spatial distribution and clustering of TPF incidence at the county level.Panel data analysis was used to identify the relationships between the TPF incidence and meteorological factors including monthly average temperature, monthly cumulative precipitation and monthly average relative humidity. Results During the study period, the average incidence of TPF in Yunnan province was 23.11/100 000, with majority of the TPF cases emerged in summer and autumn. Although widely distributed, two TPF clusters were detected in Yunnan province based on the spatial analysis:one area around Yuxi city with the average annual incidence as 207.45/100 000 and another at the junctions of Yunnan province with Burma and Laos. Based on results from panel data analysis, the incidence of TFP was shown to be associated with meteorological factors such as temperature,precipitation, relative humidity and one month lag of temperature increase [10 ℃ increase in the monthly average temperature:IRR=1.30(95%CI: 1.24-1.36);10% increase in monthly average relative humidity:IRR= 1.07(95%CI: 1.05-1.09); 100 mm rise in monthly cumulative precipitation:IRR=1.02(95%CI: 1.00-1.03); and 10 ℃ average temperature increase, the last month: IRR=1.73(95%CI: 1.64-1.82)]. Conclusion Areas with high TPF incidence were detected in this study,which indicated the key areas for TPF control in Yunnan province. Meteorological factors such as temperature, precipitation and humidity played a role in the incidence of TPF. Key words: Typhoid and Paratyphoid Fever; Spatial analysis; Panel data analysis; Meteorological factors
A. M. Vollaard - One of the best experts on this subject based on the ideXlab platform.
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Polymorphisms in proinflammatory genes and susceptibility to typhoid Fever and Paratyphoid Fever.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2007Co-Authors: Soegianto Ali, A. M. Vollaard, Suwandhi Widjaja, Charles Surjadi, E. Van De Vosse, Dennis Kremer, Adriëtte W. De Visser, Cerithsa A.e. Martina, Eline Slagboom, J. T. Van DisselAbstract:Host genetic factors are thought to contribute to susceptibility and outcome in infectious diseases. A polymorphism in a proinflammatory gene, tumor necrosis factor-alpha (TNFA - 308), was recently found to be associated with susceptibility to typhoid Fever. As the observation was made in hospitalized patients, a potential confounder could be that the TNFA polymorphism is associated with the severity of established illness resulting in hospital admission rather than susceptibility to disease. We tested whether the association with TNFA - 308 is present also in typhoid Fever patients enrolled in a community-based case-control study in an endemic area in Indonesia. Common polymorphisms in other proinflammatory genes were assayed as well. Samples of patients with blood culture-confirmed typhoid Fever (n = 90) and Paratyphoid Fever (n = 26) and Fever controls (n = 337) were compared with those of community controls (n = 322). In these groups, we analyzed polymorphisms in TNFA by PCR and RFLP, polymorphisms of IFNG, IL1A, IL1B, IL1R1, TNFRSF1A, CASP1, and CRP by Sequenom MassArray (San Diego, CA), and polymorphisms in IL12B and IFNGR1 by fragment length analysis. The IL1R1 polymorphisms were nearly absent in the Indonesian population. The TNFA - 308 polymorphism was not associated with typhoid Fever (OR 0.35, 95% CI 0.1-1.0) in this population. The polymorphisms at TNFA - 238 or in IFNG, IL1A, IL1B, IL12B, TNFRSF1A, IFNGR1, CASP1, and CRP were also not associated with typhoid or Paratyphoid Fever. We conclude that polymorphisms in proinflammatory genes do not contribute to susceptibility to typhoid Fever and, in view of earlier findings, suggest that the TNFA - 308 polymorphism is likely related to severity of established disease rather than to susceptibility per se.
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park2 pacrg polymorphisms and susceptibility to typhoid and Paratyphoid Fever
Clinical and Experimental Immunology, 2006Co-Authors: Soegianto Ali, A. M. Vollaard, Suwandhi Widjaja, Charles Surjadi, E. Van De Vosse, J. T. Van DisselAbstract:Summary Host genetic factors may contribute to susceptibility to and outcome in infec- tious diseases. Recently polymorphisms in PARK2/PACRG , a gene cluster linked to ubiquitination and proteasome-mediated protein degradation, were found to be associated with manifest infection by M. leprae . Here, we address whether these polymorphisms are associated with susceptibility to infection with Salmonella typhi and S. paratyphi A, intracellular pathogens that upon infection of humans share with mycobacteria aspects of the hosts' immune response. The polymorphisms of PARK_e01( − 697) , PARK2_e01( − − − 2599) , rs1333955 and rs1040079 were analysed by polymerase chain reaction and restriction fragment length polymorphism in a case-control study of typhoid and Paratyphoid Fever patients in an endemic area in Jakarta, Indonesia. For this study, samples were obtained from patients with blood culture-confirmed typhoid Fever ( n = 90), Paratyphoid Fever ( n = 26) and Fever controls ( n = 337) in a passive, community-based surveillance and compared to those of ran- domly selected community controls ( n = 322) from the same city area. The PARK2_e01( − 2599) allele T was significantly associated with typhoid and Paratyphoid Fever (OR: 1·51, 95%CI: 1·02-2·23) but the other polymor- phisms, PARK2_e01( − 697) , rs1333955 and rs1040079 , were not associated. Although within the PARK2/PACRG gene cluster the PARK2_e01( − 2599) allele T was most strongly associated with leprosy (OR ∼ ∼ ∼ 3-5), the association with typhoid is much less strong. Our findings suggest that this polymor- phism in PARK2/PACRG plays a small but significant role in susceptibility to the intracellular pathogens S. typhi and S. paratyphi .
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park2 pacrg polymorphisms and susceptibility to typhoid and Paratyphoid Fever
Clinical and Experimental Immunology, 2006Co-Authors: Soegianto Ali, A. M. Vollaard, Suwandhi Widjaja, Charles Surjadi, E. Van De Vosse, J. T. Van DisselAbstract:Host genetic factors may contribute to susceptibility to and outcome in infectious diseases. Recently polymorphisms in PARK2/PACRG, a gene cluster linked to ubiquitination and proteasome-mediated protein degradation, were found to be associated with manifest infection by M. leprae. Here, we address whether these polymorphisms are associated with susceptibility to infection with Salmonella typhi and S. paratyphi A, intracellular pathogens that upon infection of humans share with mycobacteria aspects of the hosts' immune response. The polymorphisms of PARK_e01(-697), PARK2_e01(-2599), rs1333955 and rs1040079 were analysed by polymerase chain reaction and restriction fragment length polymorphism in a case-control study of typhoid and Paratyphoid Fever patients in an endemic area in Jakarta, Indonesia. For this study, samples were obtained from patients with blood culture-confirmed typhoid Fever (n=90), Paratyphoid Fever (n=26) and Fever controls (n=337) in a passive, community-based surveillance and compared to those of randomly selected community controls (n=322) from the same city area. The PARK2_e01(-2599) allele T was significantly associated with typhoid and Paratyphoid Fever (OR: 1.51, 95%CI: 1.02-2.23) but the other polymorphisms, PARK2_e01(-697), rs1333955 and rs1040079, were not associated. Although within the PARK2/PACRG gene cluster the PARK2_e01(-2599) allele T was most strongly associated with leprosy (OR approximately 3-5), the association with typhoid is much less strong. Our findings suggest that this polymorphism in PARK2/PACRG plays a small but significant role in susceptibility to the intracellular pathogens S. typhi and S. paratyphi.
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PARK2/PACRG polymorphisms and susceptibility to typhoid and Paratyphoid Fever
Clinical and Experimental Immunology, 2006Co-Authors: Soegianto Ali, A. M. Vollaard, Suwandhi Widjaja, Charles Surjadi, E. Van De Vosse, J. T. Van DisselAbstract:Summary Host genetic factors may contribute to susceptibility to and outcome in infec- tious diseases. Recently polymorphisms in PARK2/PACRG , a gene cluster linked to ubiquitination and proteasome-mediated protein degradation, were found to be associated with manifest infection by M. leprae . Here, we address whether these polymorphisms are associated with susceptibility to infection with Salmonella typhi and S. paratyphi A, intracellular pathogens that upon infection of humans share with mycobacteria aspects of the hosts' immune response. The polymorphisms of PARK_e01( − 697) , PARK2_e01( − − − 2599) , rs1333955 and rs1040079 were analysed by polymerase chain reaction and restriction fragment length polymorphism in a case-control study of typhoid and Paratyphoid Fever patients in an endemic area in Jakarta, Indonesia. For this study, samples were obtained from patients with blood culture-confirmed typhoid Fever ( n = 90), Paratyphoid Fever ( n = 26) and Fever controls ( n = 337) in a passive, community-based surveillance and compared to those of ran- domly selected community controls ( n = 322) from the same city area. The PARK2_e01( − 2599) allele T was significantly associated with typhoid and Paratyphoid Fever (OR: 1·51, 95%CI: 1·02-2·23) but the other polymor- phisms, PARK2_e01( − 697) , rs1333955 and rs1040079 , were not associated. Although within the PARK2/PACRG gene cluster the PARK2_e01( − 2599) allele T was most strongly associated with leprosy (OR ∼ ∼ ∼ 3-5), the association with typhoid is much less strong. Our findings suggest that this polymor- phism in PARK2/PACRG plays a small but significant role in susceptibility to the intracellular pathogens S. typhi and S. paratyphi .
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PARK2/PACRG polymorphisms and susceptibility to typhoid and Paratyphoid Fever
Clinical and experimental immunology, 2006Co-Authors: Soegianto Ali, A. M. Vollaard, Suwandhi Widjaja, Charles Surjadi, E. Van De Vosse, J. T. Van DisselAbstract:Host genetic factors may contribute to susceptibility to and outcome in infectious diseases. Recently polymorphisms in PARK2/PACRG, a gene cluster linked to ubiquitination and proteasome-mediated protein degradation, were found to be associated with manifest infection by M. leprae. Here, we address whether these polymorphisms are associated with susceptibility to infection with Salmonella typhi and S. paratyphi A, intracellular pathogens that upon infection of humans share with mycobacteria aspects of the hosts' immune response. The polymorphisms of PARK_e01(-697), PARK2_e01(-2599), rs1333955 and rs1040079 were analysed by polymerase chain reaction and restriction fragment length polymorphism in a case-control study of typhoid and Paratyphoid Fever patients in an endemic area in Jakarta, Indonesia. For this study, samples were obtained from patients with blood culture-confirmed typhoid Fever (n=90), Paratyphoid Fever (n=26) and Fever controls (n=337) in a passive, community-based surveillance and compared to those of randomly selected community controls (n=322) from the same city area. The PARK2_e01(-2599) allele T was significantly associated with typhoid and Paratyphoid Fever (OR: 1.51, 95%CI: 1.02-2.23) but the other polymorphisms, PARK2_e01(-697), rs1333955 and rs1040079, were not associated. Although within the PARK2/PACRG gene cluster the PARK2_e01(-2599) allele T was most strongly associated with leprosy (OR approximately 3-5), the association with typhoid is much less strong. Our findings suggest that this polymorphism in PARK2/PACRG plays a small but significant role in susceptibility to the intracellular pathogens S. typhi and S. paratyphi.
