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Valery Krasnov - One of the best experts on this subject based on the ideXlab platform.
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FRI0097 Factors Associated with Major Depressive Disorder in Rheumatoid Arthritis Patients
Annals of the Rheumatic Diseases, 2014Co-Authors: T. A. Lisitsyna, D. Veltishchev, A. N. Gerasimov, O. Seravina, O. Kovalevskaya, A. Zeltyn, Valery KrasnovAbstract:Background Psychiatric disorders occur in rheumatoid arthritis (RA) patients very often. It is considered that major depressive disorder (MDD) in RA is stress-related and associated with disease activity and chronic pain. Objectives to determine the factors associated with MDD in RA pts by linear regression analysis. Methods 125 RA pts were enrolled in this study. 86% RA pts were women with a mean age of 47.4±11.3 (M±m). The disease activity was assessed by DAS28 score. 52% of RA pts had a high activity of disease (DAS28>5,1). 67% RA pts were taking prednisone in mean dose 5±2.7 mg/day (M±m). 80% RA pts were taking DMARDs: most of them - methotrexate (45%) and leflunomide (21%). All patients were taking NSADs. MDD was diagnosed by psychiatrist in accordance with the DSM-IV after structured interview. Psychiatric scales used: Hospital Anxiety and Depression Scale, Perceived Stress Scale (PSS-10) and projective psychological methods for affectivity (anxious, melancholic or apathetic) type detection. We studied also the history of stressful life events before and during RA and adverse childhood experiences (ACEs) that included childhood (up to 11 years age) physical, emotional or sexual abuse; witnessing domestic violence; growing up with household substance abuse, mental illness, Parental death or divorce (Parental Deprivation) and/or an incarcerated household member. Fatigue was evaluated using Fatigue Severity Scale (FSS). The Brief Pain Inventory (BPI) was used for pain assessment. Results Stressful life events preceded the RA onset in 97 (77,6%) pts and the RA exacerbations in 76 (60,8%) pts. ACEs, the Parental Deprivation most often, were reported by 97 (77,6%) RA pts. MDD was diagnosed in 43 (34.4%) RA pts. All RA pts with MDD had stressful life events history and ACEs. The factors associated with MDD were found during Pearson correlations. Then linear regression analysis was done and obtaining prognostic model showed that MDD was associated with ACEs (β=0,096), stressful life events before RA onset (β=0,303), apathetic or melancholic affects (β=0,179), such inflammatory factors as blood platelets number (β=0,338), swollen joints count (β=0,143), RA exacerbations number (β=0,123), the most intensive pain (BPI-max) (β=0,075) and fatigue (FSS≥4) (β=0,215) (area under the ROC curve =0,912). Conclusions MDD in RA pts connected first of all with stressful life events and associated with more intensive inflammatory signs, pain and fatigue. The results have confirmed studies on the impact of early and subsequent life stress on inflammatory responses which is biological basis of RA and MDD. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.2151
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EPA-0163 – The adverse children experience in sjogren's syndrome adult patients suffering mental disorders
European Psychiatry, 2014Co-Authors: O. Shelomkova, T. A. Lisitsyna, D. Veltishchev, O. Seravina, O. Kovalevskaya, V. Vasiliev, Valery KrasnovAbstract:Introduction The adverse experience in childhood (Parental Deprivation mostly) (AEC) has an important role in predisposing to mood and immuno-inflammatory rheumatic disorders in adults via chronic stress mechanisms. The primary Sjogren's Syndrome (SS) - a chronic, systemic autoimmune disease, which has some common pathogenic links with stress-related mental disorders. Objectives/Aims To evaluate the AEC and MD presentation in SS patients. Methods 80 inpatients (mean age 46,2+12,3 yrs) suffering SS were enrolled in the study. MD were diagnosed in accordance with ICD-10 criteria. The severity of depression, anxiety, stress were measured with HADS, MADRS, HAM-A, PSS-10. Results The AEC had 78,7% of SS patients (recurrent events – 32,5%). Patients with AEC had an increased risk of developing dysthymia (OR=1,34; 95% CI=0,26–6,83) and depressive episode (OR=1,75 (0,35–8,65)) in adults. Recurrent depression was not revealed in patients with ACE. However, patients with AEC had no reliable differences in the MADRS, HAM-A, HADS, PSS-10 compared to patients without AEC. Patients with AEC had an increased risk of suicide attempts (OR=2,15; (0,25–37,2)) and suicidal thoughts (OR=4,58; (0,25–18,5)). The reliable correlations of the severity of SS symptoms (dry eyes/mouth, lymphoma) and AEC have not been confirmed. Patients with AEC had early onset SS (33,6±13,0 vs 38,1±14,2) and MD (28,4±12,6 vs 34,1±13,5) than patients without AEC. Conclusion AE? is a significant risk factor for depression and suicidal thoughts and attempts in patients suffering SS.
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P.2.h.011 Mental disorders and adverse experience in childhood in primary Sjögren's syndrome
European Neuropsychopharmacology, 2014Co-Authors: O. Shelomkova, T. A. Lisitsyna, D. Veltishchev, O. Seravina, O. Kovalevskaya, V. Vasiliev, Valery KrasnovAbstract:Introduction: The physical and mental well-being of patients with primary Sjogren’s syndrome (SS) are significantly reduced [1]. Patients with SS have significantly higher scores for anxiety, depression, paranoid ideation and somatization than healthy controls. Adverse experience in childhood (AEC − mostly Parental Deprivation) has an important role in predisposing to mood and immuno-inflammatory rheumatic disorders in adults via chronic stress mechanisms [2]. Primary SS is a chronic, systemic autoimmune disease, characterized by lymphocytic infiltration of endocrine glands and functional impairment of the salivary and lacrimal glands; it has some pathogenic traits in common with stress-related mental disorders (MD). Objectives/Aims: To evaluate AEC and MD presentation in SS patients. Methods: Eighty inpatients (mean age 46.2±12.3 yrs) with SS were enrolled in the study. MD were diagnosed in accordance with ICD-10 criteria. Mean age of patients at first MD and SS manifestation were 31.18±14.6 and 34.6±13.3 yrs, respectively. The severity of depression, anxiety and stress was measured with HADS, MADRS, HAM-A and PSS-10. Results: Stress factors and reactions were diagnoses preceding the SS symptoms in all cases. In most cases ‘loss’, ‘frustration’, ‘disaster’ were related to acute (p< 0.02), and ‘danger’ to chronic reactions. AEC were present in 78.7% of SS patients (recurrent events − 32.5%). Chronic stress factors preceded MD in most cases (55; 68.7%). MD were diagnosed in 78 SS patients (97.5%): depressive episode (mild/moderate; single/recurrent, n = 27; 33.7%); dysthymia (n = 12; 15%); generalized anxiety disorder (n = 9; 11.3%); adjustment disorder (n = 11; 13.7%); schizotypal disorder (SD) (n = 19; 23.75%). Patients with AEC had an increased risk of developing dysthymia (OR= 1.34; 95%CI = 0.26–6.83) and depressive episode (OR= 1.75; 0.35–8.65) in adults. Recurrent depression was not found in patients with AEC. Patients with AEC had no significant differences in the MADRS, HAM-A, HADS, PSS-10 compared to patients without AEC. Nearly one-third of SS patients had visited psychiatrists in the past. Suicide attempts and suicidal thoughts had occurred in 9 (11.2%) and 9 (11.2%) patients before and during the disease, respectively. Patients with AEC had an increased risk of suicide attempts (OR= 2.15; 0.25–37.2) and suicidal thoughts (OR= 4.58; 0.25–18.5). No significant correlation was found between the severity of SS symptoms (dry eyes/mouth, lymphoma) and AEC. Patients with AEC had earlier onset of SS (33.6±13.0 vs 38.1±14.2) and MD (28.4±12.6 vs 34.1±13.5) than patients without AEC. Acute stress factors and reactions preceded the SS symptoms in all cases. Patients with AEC had higher OR for loss and other stress factors. Conclusion: AEC is a significant risk factor for depression and suicidal thoughts and attempts in patients suffering SS. MD are more pronounced in the presence of AEC. Patients with AEC are more sensitive to loss in the future repeated. Among patients suffering SS, mood disorders prevailed.
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979 – Stress factors and structure of mental disorders in sjögren's syndrome
European Psychiatry, 2013Co-Authors: O. Shelomkova, T. A. Lisitsyna, D. Veltishchev, O. Seravina, O. Kovalevskaya, V. Vasiliev, Valery KrasnovAbstract:Introduction The primary Sjogren's Syndrome (SS) - a chronic, systemic autoimmune disease, characterized by lymphocytic infiltration of endocrine glands, functional impairment of the salivary and lachrymal glands, which has some common pathogenic links with stress-related mental disorders (MD). Objectives To evaluate the occurrence rate/severity of MD and the influence of stress factors in SS patients. Methods 50 inpatient women (mean age 46+13.16 yrs) suffering SS were enrolled in the study. MD were diagnosed in accordance with ICD-10 criteria. The severity of depression, anxiety and stress load were measured with MADRS, HAM-A and PSS. Results MD were diagnosed in 42 (84%) of SS patients: depressive episode (mild/moderate; single/recurrent, n=9;18%); dysthymia (n=9;18%); generalized anxiety disorder (n=7;14%); adjustment disorder (n=8;16%); schizotypal disorder (n=9;18%). Mean severity levels of anxiety, depression and stress were 16.5+6.5; 17.2+7.9 and 16.9+6.0 accordingly. The acute stress factors and reactions were preceded the SS symptoms in most cases (n= 27, 54%). MD had the significant precipitating chronic stress factors in 36 (72%) patients. The adverse experience in childhood (Parental Deprivation mostly) had 32 (64%) of SS patients (recurrent events - 48%). Conclusion The study revealed high occurrence rate of MD, precipitating stress factors and childhood adverse experience in SS patients. The results support the stress-diathesis model of mental disorders in patients suffering rheumatic disease.
T. A. Lisitsyna - One of the best experts on this subject based on the ideXlab platform.
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Chronic stress and mental disorders in patients with systemic scleroderma: Results of an interdisciplinary study
Terapevticheskii arkhiv, 2017Co-Authors: O. Seravina, T. A. Lisitsyna, O. Kovalevskaya, M N Starovoytova, O V Desinova, D Yu VeltishchevAbstract:Aim To analyze of the prevalence of stressful factors and mental disorders (MDs), as well as their clinical psychopathological and clinical psychological characteristics to improve the comprehensive diagnosis and treatment of systemic scleroderma (SSD). Subjects and methods Examinations were performed in 110 patients (predominantly women (n=97 (88.2%); mean age, 49.9±2.47 years) with a documented diagnosis of SSD (its mean duration, 7.25±0.42 years). 62 (56.4%) patients had limited SSD, 36 (32.7%) had diffuse SSD, and 12 (10.9%) had overlap syndrome. The disease was rapidly and slowly progressive in 33 (30%) and 77 (70%) patients, respectively. Oral glucocorticosteroids were used in 99 (90%) patients included in the study, cytotoxic drugs in 66 (60%), plaquenil in 33 (30%); 8 (7%) patients were treated with the biological agent rituximab. All the patients were examined by a psychologist and a psychiatrist. The psychopathological diagnosis of MD was made during a semistructured interview in accordance with the ICD-10 criteria. The Montgomery-Asberg depression and Hamilton anxiety rating scales were used to evaluate the severity of depression and anxiety, respectively. All patients underwent a clinical and psychological examination, including tests assessing memory, attention, and logical thinking, as well as projective techniques. Results MDs were detected in 91 (83%) patients with SSD. There was a preponderance of depressive disorders in 74 (67.3%) patients: chronic (dysthymia in 33 (30%) patients)) and recurrent (recurrent depressive disorder in 34 (31%)) depressions. Cognitive impairment (CI) of varying severities was diagnosed in 100% of the patients. Schizotypal personality disorder was stated in 44 (40%) patients. 90% of patients were found to have chronic psychic traumas mainly as Parental Deprivation in childhood (in children less than 11 years of age). 76.7% of the SSD cases developed recurrent episodes of depression in the presence of long-term MD or had a history of the episodes. There was no relationship of MD to gender, age, duration of SSD and its individual clinical manifestations. The nature of SSD treatment did not affect the frequency and spectrum of MD. Conclusion MDs, predominantly chronic and recurrent depression, and CI are characteristic of most SSD patients. Multiple chronic stressful factors, both previous SSD and those over time, have commonly an impact on the mental health of patients with SSD.
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Stress factors and mental disorders in systemic sclerosis
European Psychiatry, 2016Co-Authors: D. Veltishchev, O. Seravina, O. Kovalevskaya, M.n. Starovoitova, T. A. LisitsynaAbstract:Introduction Systemic sclerosis (SSc) is a chronic, multisystem disease of unknown etiology characterized by autoimmune inflammation, abnormalities in small blood vessels, and progressive fibrosis of the skin and visceral organs. Mental disorders (MD), especially depression, occur quite often with SSc. The influence of childhood experience, relations’ traumatic events with SSc and MD, and MD's clinical specific have not investigated carefully still. The investigation has been realized in accordance with the interdisciplinary program “stress factors and mental disorders in auto-immune inflammatory rheumatic diseases”. Methods Sixty SSc patients (4 male and 56 female mean age 49.9 ± 13.5) were included. ICD-10 criteria were used for MD semi-structured interview. The stress factors were analyzed with the specially elaborated scale. The cognitive disorders and their severity were diagnosed by neuropsychology tests. Results Early traumatic childhood experiences (Parental Deprivation mainly) observed in 90% cases. The significant stress factors were preceded SSc symptoms in 80% and MD in 70% cases. Most patients self-reported connection between stressful life events and exacerbation of SSc. MD preceded SSc in 76.6% cases. MD were diagnosed in 48 (80%) SSc patients: depressive episode (mild, moderate) − 26.6%, recurrent depressive disorder − 16.6%, dysthymia – 23.3%, adjustment disorder − 6.6% and schizotypal disorder – 40%. The mild or moderate cognitive impairments were diagnosed in all MD cases. Conclusion Individual history of stressful life events is important factor for the predisposition and provocation of the rheumatic disease and MD in SSc patients. Depressive, schizotypal and cognitive disorders are the common MD in SSc patients.
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FRI0097 Factors Associated with Major Depressive Disorder in Rheumatoid Arthritis Patients
Annals of the Rheumatic Diseases, 2014Co-Authors: T. A. Lisitsyna, D. Veltishchev, A. N. Gerasimov, O. Seravina, O. Kovalevskaya, A. Zeltyn, Valery KrasnovAbstract:Background Psychiatric disorders occur in rheumatoid arthritis (RA) patients very often. It is considered that major depressive disorder (MDD) in RA is stress-related and associated with disease activity and chronic pain. Objectives to determine the factors associated with MDD in RA pts by linear regression analysis. Methods 125 RA pts were enrolled in this study. 86% RA pts were women with a mean age of 47.4±11.3 (M±m). The disease activity was assessed by DAS28 score. 52% of RA pts had a high activity of disease (DAS28>5,1). 67% RA pts were taking prednisone in mean dose 5±2.7 mg/day (M±m). 80% RA pts were taking DMARDs: most of them - methotrexate (45%) and leflunomide (21%). All patients were taking NSADs. MDD was diagnosed by psychiatrist in accordance with the DSM-IV after structured interview. Psychiatric scales used: Hospital Anxiety and Depression Scale, Perceived Stress Scale (PSS-10) and projective psychological methods for affectivity (anxious, melancholic or apathetic) type detection. We studied also the history of stressful life events before and during RA and adverse childhood experiences (ACEs) that included childhood (up to 11 years age) physical, emotional or sexual abuse; witnessing domestic violence; growing up with household substance abuse, mental illness, Parental death or divorce (Parental Deprivation) and/or an incarcerated household member. Fatigue was evaluated using Fatigue Severity Scale (FSS). The Brief Pain Inventory (BPI) was used for pain assessment. Results Stressful life events preceded the RA onset in 97 (77,6%) pts and the RA exacerbations in 76 (60,8%) pts. ACEs, the Parental Deprivation most often, were reported by 97 (77,6%) RA pts. MDD was diagnosed in 43 (34.4%) RA pts. All RA pts with MDD had stressful life events history and ACEs. The factors associated with MDD were found during Pearson correlations. Then linear regression analysis was done and obtaining prognostic model showed that MDD was associated with ACEs (β=0,096), stressful life events before RA onset (β=0,303), apathetic or melancholic affects (β=0,179), such inflammatory factors as blood platelets number (β=0,338), swollen joints count (β=0,143), RA exacerbations number (β=0,123), the most intensive pain (BPI-max) (β=0,075) and fatigue (FSS≥4) (β=0,215) (area under the ROC curve =0,912). Conclusions MDD in RA pts connected first of all with stressful life events and associated with more intensive inflammatory signs, pain and fatigue. The results have confirmed studies on the impact of early and subsequent life stress on inflammatory responses which is biological basis of RA and MDD. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.2151
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EPA-0163 – The adverse children experience in sjogren's syndrome adult patients suffering mental disorders
European Psychiatry, 2014Co-Authors: O. Shelomkova, T. A. Lisitsyna, D. Veltishchev, O. Seravina, O. Kovalevskaya, V. Vasiliev, Valery KrasnovAbstract:Introduction The adverse experience in childhood (Parental Deprivation mostly) (AEC) has an important role in predisposing to mood and immuno-inflammatory rheumatic disorders in adults via chronic stress mechanisms. The primary Sjogren's Syndrome (SS) - a chronic, systemic autoimmune disease, which has some common pathogenic links with stress-related mental disorders. Objectives/Aims To evaluate the AEC and MD presentation in SS patients. Methods 80 inpatients (mean age 46,2+12,3 yrs) suffering SS were enrolled in the study. MD were diagnosed in accordance with ICD-10 criteria. The severity of depression, anxiety, stress were measured with HADS, MADRS, HAM-A, PSS-10. Results The AEC had 78,7% of SS patients (recurrent events – 32,5%). Patients with AEC had an increased risk of developing dysthymia (OR=1,34; 95% CI=0,26–6,83) and depressive episode (OR=1,75 (0,35–8,65)) in adults. Recurrent depression was not revealed in patients with ACE. However, patients with AEC had no reliable differences in the MADRS, HAM-A, HADS, PSS-10 compared to patients without AEC. Patients with AEC had an increased risk of suicide attempts (OR=2,15; (0,25–37,2)) and suicidal thoughts (OR=4,58; (0,25–18,5)). The reliable correlations of the severity of SS symptoms (dry eyes/mouth, lymphoma) and AEC have not been confirmed. Patients with AEC had early onset SS (33,6±13,0 vs 38,1±14,2) and MD (28,4±12,6 vs 34,1±13,5) than patients without AEC. Conclusion AE? is a significant risk factor for depression and suicidal thoughts and attempts in patients suffering SS.
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P.2.h.011 Mental disorders and adverse experience in childhood in primary Sjögren's syndrome
European Neuropsychopharmacology, 2014Co-Authors: O. Shelomkova, T. A. Lisitsyna, D. Veltishchev, O. Seravina, O. Kovalevskaya, V. Vasiliev, Valery KrasnovAbstract:Introduction: The physical and mental well-being of patients with primary Sjogren’s syndrome (SS) are significantly reduced [1]. Patients with SS have significantly higher scores for anxiety, depression, paranoid ideation and somatization than healthy controls. Adverse experience in childhood (AEC − mostly Parental Deprivation) has an important role in predisposing to mood and immuno-inflammatory rheumatic disorders in adults via chronic stress mechanisms [2]. Primary SS is a chronic, systemic autoimmune disease, characterized by lymphocytic infiltration of endocrine glands and functional impairment of the salivary and lacrimal glands; it has some pathogenic traits in common with stress-related mental disorders (MD). Objectives/Aims: To evaluate AEC and MD presentation in SS patients. Methods: Eighty inpatients (mean age 46.2±12.3 yrs) with SS were enrolled in the study. MD were diagnosed in accordance with ICD-10 criteria. Mean age of patients at first MD and SS manifestation were 31.18±14.6 and 34.6±13.3 yrs, respectively. The severity of depression, anxiety and stress was measured with HADS, MADRS, HAM-A and PSS-10. Results: Stress factors and reactions were diagnoses preceding the SS symptoms in all cases. In most cases ‘loss’, ‘frustration’, ‘disaster’ were related to acute (p< 0.02), and ‘danger’ to chronic reactions. AEC were present in 78.7% of SS patients (recurrent events − 32.5%). Chronic stress factors preceded MD in most cases (55; 68.7%). MD were diagnosed in 78 SS patients (97.5%): depressive episode (mild/moderate; single/recurrent, n = 27; 33.7%); dysthymia (n = 12; 15%); generalized anxiety disorder (n = 9; 11.3%); adjustment disorder (n = 11; 13.7%); schizotypal disorder (SD) (n = 19; 23.75%). Patients with AEC had an increased risk of developing dysthymia (OR= 1.34; 95%CI = 0.26–6.83) and depressive episode (OR= 1.75; 0.35–8.65) in adults. Recurrent depression was not found in patients with AEC. Patients with AEC had no significant differences in the MADRS, HAM-A, HADS, PSS-10 compared to patients without AEC. Nearly one-third of SS patients had visited psychiatrists in the past. Suicide attempts and suicidal thoughts had occurred in 9 (11.2%) and 9 (11.2%) patients before and during the disease, respectively. Patients with AEC had an increased risk of suicide attempts (OR= 2.15; 0.25–37.2) and suicidal thoughts (OR= 4.58; 0.25–18.5). No significant correlation was found between the severity of SS symptoms (dry eyes/mouth, lymphoma) and AEC. Patients with AEC had earlier onset of SS (33.6±13.0 vs 38.1±14.2) and MD (28.4±12.6 vs 34.1±13.5) than patients without AEC. Acute stress factors and reactions preceded the SS symptoms in all cases. Patients with AEC had higher OR for loss and other stress factors. Conclusion: AEC is a significant risk factor for depression and suicidal thoughts and attempts in patients suffering SS. MD are more pronounced in the presence of AEC. Patients with AEC are more sensitive to loss in the future repeated. Among patients suffering SS, mood disorders prevailed.
Ps Bhat - One of the best experts on this subject based on the ideXlab platform.
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Parental Deprivation due to death in male soldiers with psychiatric disorders
Indian Journal of Psychiatry, 2005Co-Authors: M.s.v Kama Raju, Kalpana Srivastava, Manoj Diwakar, Ps BhatAbstract:Background: The importance of early relationship with parents has been stressed by most personality theorists. Deprivation of the nurturing influence can lead to an adverse impact. Aim: To study the effect of early Parental loss in the development of adult psychiatric disorder. Methods: A total of 289 soldiers suffering from assorted ICD-10 identified psychiatric disorders were studied to ascertain Parental losses during their developmental period. The findings were compared with those of 127 patients drawn from general medical wards. Results: A higher percentage of psychiatric patients had lost their parents before the age of 18 years compared with medical patients (21.5% vs. 8.7%). The difference, which was highly significant, was due to bipolar disorder to some extent and alcohol dependence syndrome to a larger extent. Loss of the father appears to be more significant than loss of the mother. Parental loss is found to be not a significant factor in depression and neurotic disorders. There is no excess of maternal loss in cases of depression. Conclusion: This study indicates that Parental loss is a significant factor in the future development of psychiatric disorders. It does not appear to be an important factor in the development of neurotic disorders. The aspect requires comprehensive evaluation.
Paul J. Harrison - One of the best experts on this subject based on the ideXlab platform.
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Early Parental Deprivation in the Marmoset Monkey Produces Long-term Changes in Hippocampal Expression of Genes Involved in Synaptic Plasticity and Implicated in Mood Disorder
2015Co-Authors: A J. Law, Qi Pei, Mary Walker, Helen Gordon-andrews, Cyndi Shannon, Joram Feldon, Christopher R. Pryce, Paul J. HarrisonAbstract:In mood disorder, early stressors including Parental separation are vulnerability factors, and hippocampal involvement is prominent. In common marmoset monkeys, daily Parental Deprivation during infancy produces a pro-depressive state of increased basal activity and reactivity in stress systems and mild anhedonia that persists at least to adolescence. Here we examined the expression of eight genes, each implicated in neural plasticity and in the pathophysiology of mood disorder, in the hippocampus of these same adolescent marmosets, relative to their normally-reared sibling controls. We also measured hippocampal volume. Early Deprivation led to decreases in hippocampal GAP-43 mRNA, 5-HT1A receptor mRNA and 5-HT1AR binding ([3H]WAY100,635), and to increased VGAT mRNA. BDNF, synaptophysin, VGluT1, MAP2, and spinophilin transcripts were unchanged. There were some correlations with in vivo biochemical and behavioural indices, including VGluT1 mRNA with reward-seeking behaviour, and 5-HT1AR mRNA with CSF cortisol. Early Deprivation did not affect hippocampal volume. We conclude that early Deprivation in a non-human primate, in the absence of subsequent stressors, has a long-term effect on the hippocampal expression of genes implicated in synapti
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Early Parental Deprivation in the Marmoset Monkey Produces Long-Term Changes in Hippocampal Expression of Genes Involved in Synaptic Plasticity and Implicated in Mood Disorder
Neuropsychopharmacology, 2009Co-Authors: A J. Law, Qi Pei, Mary Walker, Helen Gordon-andrews, Joram Feldon, Christopher R. Pryce, Cyndi Shannon Weickert, Paul J. HarrisonAbstract:In mood disorder, early stressors including Parental separation are vulnerability factors, and hippocampal involvement is prominent. In common marmoset monkeys, daily Parental Deprivation during infancy produces a prodepressive state of increased basal activity and reactivity in stress systems and mild anhedonia that persists at least to adolescence. Here we examined the expression of eight genes, each implicated in neural plasticity and in the pathophysiology of mood disorder, in the hippocampus of these same adolescent marmosets, relative to their normally reared sibling controls. We also measured hippocampal volume. Early Deprivation led to decreases in hippocampal growth-associated protein-43 (GAP-43) mRNA, serotonin 1A receptor (5-HT_1AR) mRNA and binding ([^3H]WAY100635), and to increased vesicular GABA transporter mRNA. Brain-derived neurotrophic factor (BDNF), synaptophysin, vesicular glutamate transporter 1 (VGluT1), microtubule-associated protein-2, and spinophilin transcripts were unchanged. There were some correlations with in vivo biochemical and behavioral indices, including VGluT1 mRNA with reward-seeking behavior, and serotonin 1A receptor mRNA with CSF cortisol. Early Deprivation did not affect hippocampal volume. We conclude that early Deprivation in a nonhuman primate, in the absence of subsequent stressors, has a long-term effect on the hippocampal expression of genes implicated in synaptic function and plasticity. The reductions in GAP-43 and serotonin 1A receptor expressions are comparable with findings in mood disorder, supporting the possibility that the latter reflect an early developmental contribution to disease vulnerability. Equally, the negative results suggest that other features of mood disorder, such as decreased hippocampal volume and BDNF expression, are related to different aspects of the pathophysiological process.
D. Veltishchev - One of the best experts on this subject based on the ideXlab platform.
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Stress factors and mental disorders in systemic sclerosis
European Psychiatry, 2016Co-Authors: D. Veltishchev, O. Seravina, O. Kovalevskaya, M.n. Starovoitova, T. A. LisitsynaAbstract:Introduction Systemic sclerosis (SSc) is a chronic, multisystem disease of unknown etiology characterized by autoimmune inflammation, abnormalities in small blood vessels, and progressive fibrosis of the skin and visceral organs. Mental disorders (MD), especially depression, occur quite often with SSc. The influence of childhood experience, relations’ traumatic events with SSc and MD, and MD's clinical specific have not investigated carefully still. The investigation has been realized in accordance with the interdisciplinary program “stress factors and mental disorders in auto-immune inflammatory rheumatic diseases”. Methods Sixty SSc patients (4 male and 56 female mean age 49.9 ± 13.5) were included. ICD-10 criteria were used for MD semi-structured interview. The stress factors were analyzed with the specially elaborated scale. The cognitive disorders and their severity were diagnosed by neuropsychology tests. Results Early traumatic childhood experiences (Parental Deprivation mainly) observed in 90% cases. The significant stress factors were preceded SSc symptoms in 80% and MD in 70% cases. Most patients self-reported connection between stressful life events and exacerbation of SSc. MD preceded SSc in 76.6% cases. MD were diagnosed in 48 (80%) SSc patients: depressive episode (mild, moderate) − 26.6%, recurrent depressive disorder − 16.6%, dysthymia – 23.3%, adjustment disorder − 6.6% and schizotypal disorder – 40%. The mild or moderate cognitive impairments were diagnosed in all MD cases. Conclusion Individual history of stressful life events is important factor for the predisposition and provocation of the rheumatic disease and MD in SSc patients. Depressive, schizotypal and cognitive disorders are the common MD in SSc patients.
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FRI0097 Factors Associated with Major Depressive Disorder in Rheumatoid Arthritis Patients
Annals of the Rheumatic Diseases, 2014Co-Authors: T. A. Lisitsyna, D. Veltishchev, A. N. Gerasimov, O. Seravina, O. Kovalevskaya, A. Zeltyn, Valery KrasnovAbstract:Background Psychiatric disorders occur in rheumatoid arthritis (RA) patients very often. It is considered that major depressive disorder (MDD) in RA is stress-related and associated with disease activity and chronic pain. Objectives to determine the factors associated with MDD in RA pts by linear regression analysis. Methods 125 RA pts were enrolled in this study. 86% RA pts were women with a mean age of 47.4±11.3 (M±m). The disease activity was assessed by DAS28 score. 52% of RA pts had a high activity of disease (DAS28>5,1). 67% RA pts were taking prednisone in mean dose 5±2.7 mg/day (M±m). 80% RA pts were taking DMARDs: most of them - methotrexate (45%) and leflunomide (21%). All patients were taking NSADs. MDD was diagnosed by psychiatrist in accordance with the DSM-IV after structured interview. Psychiatric scales used: Hospital Anxiety and Depression Scale, Perceived Stress Scale (PSS-10) and projective psychological methods for affectivity (anxious, melancholic or apathetic) type detection. We studied also the history of stressful life events before and during RA and adverse childhood experiences (ACEs) that included childhood (up to 11 years age) physical, emotional or sexual abuse; witnessing domestic violence; growing up with household substance abuse, mental illness, Parental death or divorce (Parental Deprivation) and/or an incarcerated household member. Fatigue was evaluated using Fatigue Severity Scale (FSS). The Brief Pain Inventory (BPI) was used for pain assessment. Results Stressful life events preceded the RA onset in 97 (77,6%) pts and the RA exacerbations in 76 (60,8%) pts. ACEs, the Parental Deprivation most often, were reported by 97 (77,6%) RA pts. MDD was diagnosed in 43 (34.4%) RA pts. All RA pts with MDD had stressful life events history and ACEs. The factors associated with MDD were found during Pearson correlations. Then linear regression analysis was done and obtaining prognostic model showed that MDD was associated with ACEs (β=0,096), stressful life events before RA onset (β=0,303), apathetic or melancholic affects (β=0,179), such inflammatory factors as blood platelets number (β=0,338), swollen joints count (β=0,143), RA exacerbations number (β=0,123), the most intensive pain (BPI-max) (β=0,075) and fatigue (FSS≥4) (β=0,215) (area under the ROC curve =0,912). Conclusions MDD in RA pts connected first of all with stressful life events and associated with more intensive inflammatory signs, pain and fatigue. The results have confirmed studies on the impact of early and subsequent life stress on inflammatory responses which is biological basis of RA and MDD. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.2151
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EPA-0163 – The adverse children experience in sjogren's syndrome adult patients suffering mental disorders
European Psychiatry, 2014Co-Authors: O. Shelomkova, T. A. Lisitsyna, D. Veltishchev, O. Seravina, O. Kovalevskaya, V. Vasiliev, Valery KrasnovAbstract:Introduction The adverse experience in childhood (Parental Deprivation mostly) (AEC) has an important role in predisposing to mood and immuno-inflammatory rheumatic disorders in adults via chronic stress mechanisms. The primary Sjogren's Syndrome (SS) - a chronic, systemic autoimmune disease, which has some common pathogenic links with stress-related mental disorders. Objectives/Aims To evaluate the AEC and MD presentation in SS patients. Methods 80 inpatients (mean age 46,2+12,3 yrs) suffering SS were enrolled in the study. MD were diagnosed in accordance with ICD-10 criteria. The severity of depression, anxiety, stress were measured with HADS, MADRS, HAM-A, PSS-10. Results The AEC had 78,7% of SS patients (recurrent events – 32,5%). Patients with AEC had an increased risk of developing dysthymia (OR=1,34; 95% CI=0,26–6,83) and depressive episode (OR=1,75 (0,35–8,65)) in adults. Recurrent depression was not revealed in patients with ACE. However, patients with AEC had no reliable differences in the MADRS, HAM-A, HADS, PSS-10 compared to patients without AEC. Patients with AEC had an increased risk of suicide attempts (OR=2,15; (0,25–37,2)) and suicidal thoughts (OR=4,58; (0,25–18,5)). The reliable correlations of the severity of SS symptoms (dry eyes/mouth, lymphoma) and AEC have not been confirmed. Patients with AEC had early onset SS (33,6±13,0 vs 38,1±14,2) and MD (28,4±12,6 vs 34,1±13,5) than patients without AEC. Conclusion AE? is a significant risk factor for depression and suicidal thoughts and attempts in patients suffering SS.
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P.2.h.011 Mental disorders and adverse experience in childhood in primary Sjögren's syndrome
European Neuropsychopharmacology, 2014Co-Authors: O. Shelomkova, T. A. Lisitsyna, D. Veltishchev, O. Seravina, O. Kovalevskaya, V. Vasiliev, Valery KrasnovAbstract:Introduction: The physical and mental well-being of patients with primary Sjogren’s syndrome (SS) are significantly reduced [1]. Patients with SS have significantly higher scores for anxiety, depression, paranoid ideation and somatization than healthy controls. Adverse experience in childhood (AEC − mostly Parental Deprivation) has an important role in predisposing to mood and immuno-inflammatory rheumatic disorders in adults via chronic stress mechanisms [2]. Primary SS is a chronic, systemic autoimmune disease, characterized by lymphocytic infiltration of endocrine glands and functional impairment of the salivary and lacrimal glands; it has some pathogenic traits in common with stress-related mental disorders (MD). Objectives/Aims: To evaluate AEC and MD presentation in SS patients. Methods: Eighty inpatients (mean age 46.2±12.3 yrs) with SS were enrolled in the study. MD were diagnosed in accordance with ICD-10 criteria. Mean age of patients at first MD and SS manifestation were 31.18±14.6 and 34.6±13.3 yrs, respectively. The severity of depression, anxiety and stress was measured with HADS, MADRS, HAM-A and PSS-10. Results: Stress factors and reactions were diagnoses preceding the SS symptoms in all cases. In most cases ‘loss’, ‘frustration’, ‘disaster’ were related to acute (p< 0.02), and ‘danger’ to chronic reactions. AEC were present in 78.7% of SS patients (recurrent events − 32.5%). Chronic stress factors preceded MD in most cases (55; 68.7%). MD were diagnosed in 78 SS patients (97.5%): depressive episode (mild/moderate; single/recurrent, n = 27; 33.7%); dysthymia (n = 12; 15%); generalized anxiety disorder (n = 9; 11.3%); adjustment disorder (n = 11; 13.7%); schizotypal disorder (SD) (n = 19; 23.75%). Patients with AEC had an increased risk of developing dysthymia (OR= 1.34; 95%CI = 0.26–6.83) and depressive episode (OR= 1.75; 0.35–8.65) in adults. Recurrent depression was not found in patients with AEC. Patients with AEC had no significant differences in the MADRS, HAM-A, HADS, PSS-10 compared to patients without AEC. Nearly one-third of SS patients had visited psychiatrists in the past. Suicide attempts and suicidal thoughts had occurred in 9 (11.2%) and 9 (11.2%) patients before and during the disease, respectively. Patients with AEC had an increased risk of suicide attempts (OR= 2.15; 0.25–37.2) and suicidal thoughts (OR= 4.58; 0.25–18.5). No significant correlation was found between the severity of SS symptoms (dry eyes/mouth, lymphoma) and AEC. Patients with AEC had earlier onset of SS (33.6±13.0 vs 38.1±14.2) and MD (28.4±12.6 vs 34.1±13.5) than patients without AEC. Acute stress factors and reactions preceded the SS symptoms in all cases. Patients with AEC had higher OR for loss and other stress factors. Conclusion: AEC is a significant risk factor for depression and suicidal thoughts and attempts in patients suffering SS. MD are more pronounced in the presence of AEC. Patients with AEC are more sensitive to loss in the future repeated. Among patients suffering SS, mood disorders prevailed.
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979 – Stress factors and structure of mental disorders in sjögren's syndrome
European Psychiatry, 2013Co-Authors: O. Shelomkova, T. A. Lisitsyna, D. Veltishchev, O. Seravina, O. Kovalevskaya, V. Vasiliev, Valery KrasnovAbstract:Introduction The primary Sjogren's Syndrome (SS) - a chronic, systemic autoimmune disease, characterized by lymphocytic infiltration of endocrine glands, functional impairment of the salivary and lachrymal glands, which has some common pathogenic links with stress-related mental disorders (MD). Objectives To evaluate the occurrence rate/severity of MD and the influence of stress factors in SS patients. Methods 50 inpatient women (mean age 46+13.16 yrs) suffering SS were enrolled in the study. MD were diagnosed in accordance with ICD-10 criteria. The severity of depression, anxiety and stress load were measured with MADRS, HAM-A and PSS. Results MD were diagnosed in 42 (84%) of SS patients: depressive episode (mild/moderate; single/recurrent, n=9;18%); dysthymia (n=9;18%); generalized anxiety disorder (n=7;14%); adjustment disorder (n=8;16%); schizotypal disorder (n=9;18%). Mean severity levels of anxiety, depression and stress were 16.5+6.5; 17.2+7.9 and 16.9+6.0 accordingly. The acute stress factors and reactions were preceded the SS symptoms in most cases (n= 27, 54%). MD had the significant precipitating chronic stress factors in 36 (72%) patients. The adverse experience in childhood (Parental Deprivation mostly) had 32 (64%) of SS patients (recurrent events - 48%). Conclusion The study revealed high occurrence rate of MD, precipitating stress factors and childhood adverse experience in SS patients. The results support the stress-diathesis model of mental disorders in patients suffering rheumatic disease.
