The Experts below are selected from a list of 213 Experts worldwide ranked by ideXlab platform

Feng Shen - One of the best experts on this subject based on the ideXlab platform.

  • a nomogram predicting pulmonary metastasis of hepatocellular carcinoma following Partial Hepatectomy
    British Journal of Cancer, 2014
    Co-Authors: Jun Li, Mengchao Wu, Kang Wang, Feng Shen
    Abstract:

    A nomogram predicting pulmonary metastasis of hepatocellular carcinoma following Partial Hepatectomy

  • Partial Hepatectomy for ruptured hepatocellular carcinoma
    British Journal of Surgery, 2013
    Co-Authors: Tian Yang, Jin Zhang, Junhua Lu, Feng Shen, Mengchao Wu
    Abstract:

    Background Improvements in surgical technique and perioperative care have made Partial Hepatectomy a safe and effective treatment for hepatocellular carcinoma (HCC), even in the event of spontaneous HCC rupture. Methods A consecutive cohort of patients who underwent Partial Hepatectomy for HCC between 2000 and 2009 was divided into a ruptured group and a non-ruptured group. Patients with ruptured HCC were further divided into emergency and staged Hepatectomy subgroups. Mortality and morbidity, overall survival and recurrence-free survival (RFS) were compared. Prognostic factors for overall survival and RFS were identified by univariable and multivariable analyses. Results A total of 1233 patients underwent Partial Hepatectomy for HCC, of whom 143 had a ruptured tumour. The morbidity and mortality rates were similar in the ruptured and non-ruptured groups, as well as in the emergency and staged subgroups. In univariable analyses, overall survival and RFS were lower in the ruptured group than in the non-ruptured group (both P < 0·001), and also in the emergency subgroup compared with the staged subgroup (P = 0·016 and P = 0·025 respectively). In multivariable analysis, spontaneous rupture independently predicted poor overall survival after Hepatectomy (hazard ratio 1·54, 95 per cent confidence interval 1·24 to 1·93) and RFS (HR 1·75, 1·39 to 2·22). Overall survival and RFS after Hepatectomy for ruptured HCC in the emergency and staged subgroups were not significantly different in multivariable analyses. Conclusion Spontaneous rupture predicted poor long-term survival after Hepatectomy for HCC, but surgical treatment seems possible, safe and appropriate in selected patients.

  • prognostic nomogram for intrahepatic cholangiocarcinoma after Partial Hepatectomy
    Journal of Clinical Oncology, 2013
    Co-Authors: Yizhou Wang, Mengchao Wu, Jun Li, Renyan Gong, Kui Wang, Dong Wu, Feng Shen
    Abstract:

    Purpose This study aimed to establish an effective prognostic nomogram for intrahepatic cholangiocarcinoma (ICC) after Partial Hepatectomy. Patients and Methods The nomogram was based on a retrospectively study on 367 patients who underwent Partial Hepatectomy for ICC at the Eastern Hepatobiliary Surgery Hospital from 2002 to 2007. The predictive accuracy and discriminative ability of the nomogram were determined by concordance index (C-index) and calibration curve and compared with five currently used staging systems on ICC. The results were validated using bootstrap resampling and a prospective study on 82 patients operated on from 2007 to 2008 at the same institution. Results On multivariate analysis of the primary cohort, independent factors for survival were serum carcinoembryonic antigen, CA 19-9, tumor diameter and number, vascular invasion, lymph node metastasis, direct invasion, and local extrahepatic metastasis, which were all selected into the nomogram. The calibration curve for probability of ...

Mengchao Wu - One of the best experts on this subject based on the ideXlab platform.

  • a nomogram predicting pulmonary metastasis of hepatocellular carcinoma following Partial Hepatectomy
    British Journal of Cancer, 2014
    Co-Authors: Jun Li, Mengchao Wu, Kang Wang, Feng Shen
    Abstract:

    A nomogram predicting pulmonary metastasis of hepatocellular carcinoma following Partial Hepatectomy

  • Partial Hepatectomy for ruptured hepatocellular carcinoma
    British Journal of Surgery, 2013
    Co-Authors: Tian Yang, Jin Zhang, Junhua Lu, Feng Shen, Mengchao Wu
    Abstract:

    Background Improvements in surgical technique and perioperative care have made Partial Hepatectomy a safe and effective treatment for hepatocellular carcinoma (HCC), even in the event of spontaneous HCC rupture. Methods A consecutive cohort of patients who underwent Partial Hepatectomy for HCC between 2000 and 2009 was divided into a ruptured group and a non-ruptured group. Patients with ruptured HCC were further divided into emergency and staged Hepatectomy subgroups. Mortality and morbidity, overall survival and recurrence-free survival (RFS) were compared. Prognostic factors for overall survival and RFS were identified by univariable and multivariable analyses. Results A total of 1233 patients underwent Partial Hepatectomy for HCC, of whom 143 had a ruptured tumour. The morbidity and mortality rates were similar in the ruptured and non-ruptured groups, as well as in the emergency and staged subgroups. In univariable analyses, overall survival and RFS were lower in the ruptured group than in the non-ruptured group (both P < 0·001), and also in the emergency subgroup compared with the staged subgroup (P = 0·016 and P = 0·025 respectively). In multivariable analysis, spontaneous rupture independently predicted poor overall survival after Hepatectomy (hazard ratio 1·54, 95 per cent confidence interval 1·24 to 1·93) and RFS (HR 1·75, 1·39 to 2·22). Overall survival and RFS after Hepatectomy for ruptured HCC in the emergency and staged subgroups were not significantly different in multivariable analyses. Conclusion Spontaneous rupture predicted poor long-term survival after Hepatectomy for HCC, but surgical treatment seems possible, safe and appropriate in selected patients.

  • prognostic nomogram for intrahepatic cholangiocarcinoma after Partial Hepatectomy
    Journal of Clinical Oncology, 2013
    Co-Authors: Yizhou Wang, Mengchao Wu, Jun Li, Renyan Gong, Kui Wang, Dong Wu, Feng Shen
    Abstract:

    Purpose This study aimed to establish an effective prognostic nomogram for intrahepatic cholangiocarcinoma (ICC) after Partial Hepatectomy. Patients and Methods The nomogram was based on a retrospectively study on 367 patients who underwent Partial Hepatectomy for ICC at the Eastern Hepatobiliary Surgery Hospital from 2002 to 2007. The predictive accuracy and discriminative ability of the nomogram were determined by concordance index (C-index) and calibration curve and compared with five currently used staging systems on ICC. The results were validated using bootstrap resampling and a prospective study on 82 patients operated on from 2007 to 2008 at the same institution. Results On multivariate analysis of the primary cohort, independent factors for survival were serum carcinoembryonic antigen, CA 19-9, tumor diameter and number, vascular invasion, lymph node metastasis, direct invasion, and local extrahepatic metastasis, which were all selected into the nomogram. The calibration curve for probability of ...

Jun Li - One of the best experts on this subject based on the ideXlab platform.

  • a nomogram predicting pulmonary metastasis of hepatocellular carcinoma following Partial Hepatectomy
    British Journal of Cancer, 2014
    Co-Authors: Jun Li, Mengchao Wu, Kang Wang, Feng Shen
    Abstract:

    A nomogram predicting pulmonary metastasis of hepatocellular carcinoma following Partial Hepatectomy

  • prognostic nomogram for intrahepatic cholangiocarcinoma after Partial Hepatectomy
    Journal of Clinical Oncology, 2013
    Co-Authors: Yizhou Wang, Mengchao Wu, Jun Li, Renyan Gong, Kui Wang, Dong Wu, Feng Shen
    Abstract:

    Purpose This study aimed to establish an effective prognostic nomogram for intrahepatic cholangiocarcinoma (ICC) after Partial Hepatectomy. Patients and Methods The nomogram was based on a retrospectively study on 367 patients who underwent Partial Hepatectomy for ICC at the Eastern Hepatobiliary Surgery Hospital from 2002 to 2007. The predictive accuracy and discriminative ability of the nomogram were determined by concordance index (C-index) and calibration curve and compared with five currently used staging systems on ICC. The results were validated using bootstrap resampling and a prospective study on 82 patients operated on from 2007 to 2008 at the same institution. Results On multivariate analysis of the primary cohort, independent factors for survival were serum carcinoembryonic antigen, CA 19-9, tumor diameter and number, vascular invasion, lymph node metastasis, direct invasion, and local extrahepatic metastasis, which were all selected into the nomogram. The calibration curve for probability of ...

Michio Sata - One of the best experts on this subject based on the ideXlab platform.

  • expression and role of vascular endothelial growth factor in liver regeneration after Partial Hepatectomy in rats
    Journal of Histochemistry and Cytochemistry, 2001
    Co-Authors: Eitaro Taniguchi, Shotaro Sakisaka, Katsuhiko Matsuo, Kyuichi Tanikawa, Michio Sata
    Abstract:

    SUMMARY Vascular endothelial growth factor (VEGF) plays a major role in angiogenesis, which is essential for both healing of injured tissue and proliferation of carcinoma cells. In this study we elucidated the expression and role of VEGF in rat liver regeneration after Partial Hepatectomy. VEGF expression was mainly detected in periportal hepatocytes and reached a maximal level 48‐72 hr after Partial Hepatectomy by both immunohistochemistry and in situ hybridization. Similarly, immunohistochemistry for Ki-67 showed that the proliferative activity of sinusoidal endothelial cells was highest in the periportal area and reached a maximal level 72 hr after Partial Hepatectomy. Moreover, neutralization of VEGF significantly inhibited proliferative activity of hepatocytes ( p , 0.0001), as well as sinusoidal endothelial cells ( p , 0.001), at 48 and 96 hr after Partial Hepatectomy. Conversely, injection of VEGF significantly promoted proliferative activity of hepatocytes ( p , 0.0001) as well as sinusoidal endothelial cells ( p , 0.0005) at 48 hr after Partial Hepatectomy. These results suggest that VEGF promotes proliferation of hepatocytes through reconstruction of liver sinusoids by proliferation of sinusoidal endothelial cells. Furthermore, these data point to a new therapeutic strategy, the use of VEGF and other hepatocyte growth factors in fulminant or severe acute hepatitis. (J Histochem Cytochem 49:121‐129, 2001)

Tian Yang - One of the best experts on this subject based on the ideXlab platform.

  • Partial Hepatectomy for ruptured hepatocellular carcinoma
    British Journal of Surgery, 2013
    Co-Authors: Tian Yang, Jin Zhang, Junhua Lu, Feng Shen, Mengchao Wu
    Abstract:

    Background Improvements in surgical technique and perioperative care have made Partial Hepatectomy a safe and effective treatment for hepatocellular carcinoma (HCC), even in the event of spontaneous HCC rupture. Methods A consecutive cohort of patients who underwent Partial Hepatectomy for HCC between 2000 and 2009 was divided into a ruptured group and a non-ruptured group. Patients with ruptured HCC were further divided into emergency and staged Hepatectomy subgroups. Mortality and morbidity, overall survival and recurrence-free survival (RFS) were compared. Prognostic factors for overall survival and RFS were identified by univariable and multivariable analyses. Results A total of 1233 patients underwent Partial Hepatectomy for HCC, of whom 143 had a ruptured tumour. The morbidity and mortality rates were similar in the ruptured and non-ruptured groups, as well as in the emergency and staged subgroups. In univariable analyses, overall survival and RFS were lower in the ruptured group than in the non-ruptured group (both P < 0·001), and also in the emergency subgroup compared with the staged subgroup (P = 0·016 and P = 0·025 respectively). In multivariable analysis, spontaneous rupture independently predicted poor overall survival after Hepatectomy (hazard ratio 1·54, 95 per cent confidence interval 1·24 to 1·93) and RFS (HR 1·75, 1·39 to 2·22). Overall survival and RFS after Hepatectomy for ruptured HCC in the emergency and staged subgroups were not significantly different in multivariable analyses. Conclusion Spontaneous rupture predicted poor long-term survival after Hepatectomy for HCC, but surgical treatment seems possible, safe and appropriate in selected patients.