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Gustavo Garcia - One of the best experts on this subject based on the ideXlab platform.
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modeling secondary Particle Tracks generated by intermediate and low energy protons in water with the low energy Particle Track simulation code
Radiation Physics and Chemistry, 2017Co-Authors: Alexey Verkhovtsev, Francisco J Blanco, Ali Traore, Antonio Munoz, Gustavo GarciaAbstract:Abstract Using a recent extension of the Low-Energy Particle Track Simulation (LEPTS) Monte Carlo code, we model the slowing-down of heavy charged Particles propagating in water, combined with an explicit molecular-level description of radiation effects due to the formation of secondary electrons, their propagation through the medium, and electron-induced molecular dissociations. As a case study, we consider the transport of protons with the initial energy of 1 MeV until their thermalization, so that we cover the energy range that contributes mainly to the energy deposition in the Bragg peak region. In order to include protons into the simulation procedure, a comprehensive dataset of integral and differential cross sections of elastic and inelastic scattering of intermediate- and low-energy protons from water molecules is created. Experimental and theoretical cross sections available in the literature are carefully examined, compared and verified. The ionization cross section by protons includes recent experimental measurements of the production of different charged fragments.
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monte carlo based modeling of secondary Particle Tracks generated by intermediate and low energy protons in water
nain, 2017Co-Authors: Alexey Verkhovtsev, Francisco J Blanco, Gustavo Garcia, Pedro Arce, Antonio MunozAbstract:This chapter gives an overview of recent developments in the Monte Carlo-based modeling of the interaction of ionizing radiation with biologically relevant systems. Several Track structure codes, such as Geant4 (GEometry ANd Tracking 4), Geant4-DNA, and LEPTS (Low-Energy Particle Track Simulation), are described. Main features, areas of application and current limitations of each tool are discussed. A special attention is focused on the energy range covered by primary and secondary charged Particles and on the type of interactions included in the simulation. A recent development of LEPTS is presented, aimed at the simulation of full slowing-down of protons in water together with all molecular processes involving secondary Particles. The utilized approach allows one to study radiation effects on the nanoscale in terms of the number and the type of induced molecular processes. Development of new tools for the simulation of biologically relevant materials opens the way for a more realistic, physically meaningful description of radiation damage in living tissue.
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integration of the low energy Particle Track simulation code in geant4
European Physical Journal D, 2015Co-Authors: Pedro Arce, Gustavo Garcia, Antonio Munoz, M Moraleda, Jose Maria Gomez Ros, Fernando Blanco, Jose Manuel PerezAbstract:The Low-Energy Particle Track Simulation code (LEPTS) is a Monte Carlo code developed to simulate the damage caused by radiation at molecular level. The code is based on experimental data of scattering cross sections, both differential and integral, and energy loss data, complemented with theoretical calculations. It covers the interactions of electrons and positrons from energies of 10 keV down to 0.1 eV in different biologically relevant materials. In this article we briefly mention the main characteristics of this code and we present its integration within the Geant4 Monte Carlo toolkit.
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differential and integral electron scattering cross sections from tetrahydrofuran thf over a wide energy range 1 10 000 ev
European Physical Journal D, 2014Co-Authors: Martina Fuss, Francisco J Blanco, P Limaovieira, A G Sanz, M J Brunger, Gustavo GarciaAbstract:Total, integral inelastic and integral and differential elastic cross sections have been calculated with the screening-corrected additivity rule (SCAR) method based on the independent atom model (IAM) for electron scattering from tetrahydrofuran (THF). Since the permanent dipole moment of THF enhances rotational excitation particularly at low energies and for small angles, an estimate of the rotational excitation cross section was also computed by assuming the interaction with a free electric dipole as an independent, additional process. Our theoretical results compare very favourably to the existing experimental data. Finally, a self-consistent set of integral and differential interaction CSs for the incident energy range 1 eV–10 keV is established for use in our low energy Particle Track simulation (LEPTS). All cross section data are supplied numerically in tabulated form.
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current prospects on low energy Particle Track simulation for biomedical applications
Applied Radiation and Isotopes, 2014Co-Authors: Martina Fuss, Francisco J Blanco, A Munoz, P Limaovieira, A G Sanz, M J Brunger, Stephen Buckman, Gustavo GarciaAbstract:The Low Energy Particle Track Simulation code is a radiation interaction simulation tool specifically designed to describe electron and positron interactions below 10 keV at a molecular level. Relying on carefully selected, preferentially experimental input parameters that account for all expected scattering processes, it provides detailed results about all collisional events undergone by an incident radiation Particle during its slowdown until thermalisation. Here, we give an up-to-date description of its input data sources and selection procedure and summarise the current contents of the resulting database.
M J Brunger - One of the best experts on this subject based on the ideXlab platform.
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differential and integral electron scattering cross sections from tetrahydrofuran thf over a wide energy range 1 10 000 ev
European Physical Journal D, 2014Co-Authors: Martina Fuss, Francisco J Blanco, P Limaovieira, A G Sanz, M J Brunger, Gustavo GarciaAbstract:Total, integral inelastic and integral and differential elastic cross sections have been calculated with the screening-corrected additivity rule (SCAR) method based on the independent atom model (IAM) for electron scattering from tetrahydrofuran (THF). Since the permanent dipole moment of THF enhances rotational excitation particularly at low energies and for small angles, an estimate of the rotational excitation cross section was also computed by assuming the interaction with a free electric dipole as an independent, additional process. Our theoretical results compare very favourably to the existing experimental data. Finally, a self-consistent set of integral and differential interaction CSs for the incident energy range 1 eV–10 keV is established for use in our low energy Particle Track simulation (LEPTS). All cross section data are supplied numerically in tabulated form.
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current prospects on low energy Particle Track simulation for biomedical applications
Applied Radiation and Isotopes, 2014Co-Authors: Martina Fuss, Francisco J Blanco, A Munoz, P Limaovieira, A G Sanz, M J Brunger, Stephen Buckman, Gustavo GarciaAbstract:The Low Energy Particle Track Simulation code is a radiation interaction simulation tool specifically designed to describe electron and positron interactions below 10 keV at a molecular level. Relying on carefully selected, preferentially experimental input parameters that account for all expected scattering processes, it provides detailed results about all collisional events undergone by an incident radiation Particle during its slowdown until thermalisation. Here, we give an up-to-date description of its input data sources and selection procedure and summarise the current contents of the resulting database.
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interaction model for electron scattering from ethylene in the energy range 1 10 000 ev
Chemical Physics Letters, 2013Co-Authors: Martina Fuss, A Munoz, A G Sanz, M J Brunger, F Blanco, J C Oller, Kate Nixon, M J Hubinfranskin, Gustavo GarciaAbstract:We present new experimental electron energy loss distribution functions for ethylene (C2H4) measured with two different apparatus (Liege and Madrid) in different incident electron energy ranges. Theoretical cross sections for electron scattering from C2H4 were calculated using the screening-corrected additivity rule (IAM-SCAR) method. Through a critical comparison of our new data and existing results from other groups, we obtain a self-consistent set of recommended interaction cross section values and energy loss spectra. Finally, electron Tracks in C2H4 are simulated with our Low Energy Particle Track Simulation (LEPTS) in order to demonstrate the efficacy of our recommended data.
Martina Fuss - One of the best experts on this subject based on the ideXlab platform.
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differential and integral electron scattering cross sections from tetrahydrofuran thf over a wide energy range 1 10 000 ev
European Physical Journal D, 2014Co-Authors: Martina Fuss, Francisco J Blanco, P Limaovieira, A G Sanz, M J Brunger, Gustavo GarciaAbstract:Total, integral inelastic and integral and differential elastic cross sections have been calculated with the screening-corrected additivity rule (SCAR) method based on the independent atom model (IAM) for electron scattering from tetrahydrofuran (THF). Since the permanent dipole moment of THF enhances rotational excitation particularly at low energies and for small angles, an estimate of the rotational excitation cross section was also computed by assuming the interaction with a free electric dipole as an independent, additional process. Our theoretical results compare very favourably to the existing experimental data. Finally, a self-consistent set of integral and differential interaction CSs for the incident energy range 1 eV–10 keV is established for use in our low energy Particle Track simulation (LEPTS). All cross section data are supplied numerically in tabulated form.
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current prospects on low energy Particle Track simulation for biomedical applications
Applied Radiation and Isotopes, 2014Co-Authors: Martina Fuss, Francisco J Blanco, A Munoz, P Limaovieira, A G Sanz, M J Brunger, Stephen Buckman, Gustavo GarciaAbstract:The Low Energy Particle Track Simulation code is a radiation interaction simulation tool specifically designed to describe electron and positron interactions below 10 keV at a molecular level. Relying on carefully selected, preferentially experimental input parameters that account for all expected scattering processes, it provides detailed results about all collisional events undergone by an incident radiation Particle during its slowdown until thermalisation. Here, we give an up-to-date description of its input data sources and selection procedure and summarise the current contents of the resulting database.
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interaction model for electron scattering from ethylene in the energy range 1 10 000 ev
Chemical Physics Letters, 2013Co-Authors: Martina Fuss, A Munoz, A G Sanz, M J Brunger, F Blanco, J C Oller, Kate Nixon, M J Hubinfranskin, Gustavo GarciaAbstract:We present new experimental electron energy loss distribution functions for ethylene (C2H4) measured with two different apparatus (Liege and Madrid) in different incident electron energy ranges. Theoretical cross sections for electron scattering from C2H4 were calculated using the screening-corrected additivity rule (IAM-SCAR) method. Through a critical comparison of our new data and existing results from other groups, we obtain a self-consistent set of recommended interaction cross section values and energy loss spectra. Finally, electron Tracks in C2H4 are simulated with our Low Energy Particle Track Simulation (LEPTS) in order to demonstrate the efficacy of our recommended data.
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energy deposition by a 106ru 106rh eye applicator simulated using lepts a low energy Particle Track simulation
Applied Radiation and Isotopes, 2011Co-Authors: Martina Fuss, A Munoz, P Limaovieira, Fernando Blanco, J C Oller, A Williart, Maria Jose Garcia Borge, O Tengblad, C Huerga, M TellezAbstract:Abstract The present study introduces LEPTS, an event-by-event Monte Carlo programme, for simulating an ophthalmic 106Ru/106Rh applicator relevant in brachytherapy of ocular tumours. The distinctive characteristics of this code are the underlying radiation–matter interaction models that distinguish elastic and several kinds of inelastic collisions, as well as the use of mostly experimental input data. Special emphasis is placed on the treatment of low-energy electrons for generally being responsible for the deposition of a large portion of the total energy imparted to matter.
A Munoz - One of the best experts on this subject based on the ideXlab platform.
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modeling secondary Particle Tracks generated by high energy protons in water
XXIX International Conference on Photonic Electronic and Atomic Collisions (ICPEAC 2015), 2015Co-Authors: Francisco J Blanco, A Munoz, Diogo Almeida, Ferreira F Da Silva, P Limaovieira, Alexey Verkhovtsev, L Ellisgibbings, K Krupa, Ali Traore, Garcia GarciaAbstract:We present interaction probability data of low-energy secondary electrons and positrons produced due to the proton impact. The probability distribution functions serve as input data for the Low Energy Particle Track Simulation (LEPTS) approach which allows one to include the effect of low-energy species in medical applications of radiation and in ion-beam cancer therapy, in particular.
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induced molecular dissociations as a radiation damage descriptor nanodosimetry
Journal of Physics: Conference Series, 2015Co-Authors: Ali Traore, A Munoz, Alexey Verkhovtsev, L Ellisgibbings, K Krupa, F Blanco, G GarciaAbstract:We present a nanodosimeter software based on Monte Carlo, termed: Low Energy Particle Track Simulation. For medical applications purposes, we propose bond breakings to describe the energy deposited taking water as an example. This tool aims to improve current treatment planning approach based on absorbed dose.
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current prospects on low energy Particle Track simulation for biomedical applications
Applied Radiation and Isotopes, 2014Co-Authors: Martina Fuss, Francisco J Blanco, A Munoz, P Limaovieira, A G Sanz, M J Brunger, Stephen Buckman, Gustavo GarciaAbstract:The Low Energy Particle Track Simulation code is a radiation interaction simulation tool specifically designed to describe electron and positron interactions below 10 keV at a molecular level. Relying on carefully selected, preferentially experimental input parameters that account for all expected scattering processes, it provides detailed results about all collisional events undergone by an incident radiation Particle during its slowdown until thermalisation. Here, we give an up-to-date description of its input data sources and selection procedure and summarise the current contents of the resulting database.
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interaction model for electron scattering from ethylene in the energy range 1 10 000 ev
Chemical Physics Letters, 2013Co-Authors: Martina Fuss, A Munoz, A G Sanz, M J Brunger, F Blanco, J C Oller, Kate Nixon, M J Hubinfranskin, Gustavo GarciaAbstract:We present new experimental electron energy loss distribution functions for ethylene (C2H4) measured with two different apparatus (Liege and Madrid) in different incident electron energy ranges. Theoretical cross sections for electron scattering from C2H4 were calculated using the screening-corrected additivity rule (IAM-SCAR) method. Through a critical comparison of our new data and existing results from other groups, we obtain a self-consistent set of recommended interaction cross section values and energy loss spectra. Finally, electron Tracks in C2H4 are simulated with our Low Energy Particle Track Simulation (LEPTS) in order to demonstrate the efficacy of our recommended data.
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energy deposition by a 106ru 106rh eye applicator simulated using lepts a low energy Particle Track simulation
Applied Radiation and Isotopes, 2011Co-Authors: Martina Fuss, A Munoz, P Limaovieira, Fernando Blanco, J C Oller, A Williart, Maria Jose Garcia Borge, O Tengblad, C Huerga, M TellezAbstract:Abstract The present study introduces LEPTS, an event-by-event Monte Carlo programme, for simulating an ophthalmic 106Ru/106Rh applicator relevant in brachytherapy of ocular tumours. The distinctive characteristics of this code are the underlying radiation–matter interaction models that distinguish elastic and several kinds of inelastic collisions, as well as the use of mostly experimental input data. Special emphasis is placed on the treatment of low-energy electrons for generally being responsible for the deposition of a large portion of the total energy imparted to matter.
Francis A Cucinotta - One of the best experts on this subject based on the ideXlab platform.
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Non-Targeted Effects Models Predict Significantly Higher Mars Mission Cancer Risk than Targeted Effects Models
Scientific Reports, 2017Co-Authors: Francis A Cucinotta, Eliedonna CacaoAbstract:Cancer risk is an important concern for galactic cosmic ray (GCR) exposures, which consist of a wide-energy range of protons, heavy ions and secondary radiation produced in shielding and tissues. Relative biological effectiveness (RBE) factors for surrogate cancer endpoints in cell culture models and tumor induction in mice vary considerable, including significant variations for different tissues and mouse strains. Many studies suggest non-targeted effects (NTE) occur for low doses of high linear energy transfer (LET) radiation, leading to deviation from the linear dose response model used in radiation protection. Using the mouse Harderian gland tumor experiment, the only extensive data-set for dose response modelling with a variety of Particle types (>4), for the first-time a Particle Track structure model of tumor prevalence is used to investigate the effects of NTEs in predictions of chronic GCR exposure risk. The NTE model led to a predicted risk 2-fold higher compared to a targeted effects model. The scarcity of data with animal models for tissues that dominate human radiation cancer risk, including lung, colon, breast, liver, and stomach, suggest that studies of NTEs in other tissues are urgently needed prior to long-term space missions outside the protection of the Earth’s geomagnetic sphere.
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the effects of delta rays on the number of Particle Track traversals per cell in laboratory and space exposures
Radiation Research, 1998Co-Authors: Francis A Cucinotta, Hooshang Nikjoo, D T GoodheadAbstract:It is a common practice to estimate the number of Particle-Track traversals per cell or cell nucleus as the product of the ion's linear energy transfer (LET) and cell area. This practice ignores the effects of Track width due to the lateral extension of delta rays. We make estimates of the number of Particle-Track traversals per cell, which includes the effects of delta rays using radial cutoffs in the ionization density about an ion's Track of 1 mGy and 1 cGy. Calculations for laboratory and space radiation exposures are discussed, and show that the LET approximation provides a large underestimate of the actual number of Particle-Track traversals per cell from high-charge and energy (HZE) ions. In light of the current interest in the mechanisms of radiation action, including signal transduction and cytoplasmic damage, these results should be of interest for radiobiology studies with HZE ions.