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M. B. Jackson - One of the best experts on this subject based on the ideXlab platform.

  • anoxia tolerance in the aquatic monocot potamogeton pectinatus absence of oxygen stimulates elongation in association with an unusually large Pasteur Effect
    Journal of Experimental Botany, 2000
    Co-Authors: Jacky E. Summers, R. G. Ratcliffe, M. B. Jackson
    Abstract:

    Elongation by stems of overwintered tubers of Potamogeton pectinatus (L.) is strongly promoted over several days by oxygen-free conditions. Characteristics of the respiration underpinning this unusual response were examined. Anaerobic plants produced ethanol and CO(2) in approximately equimolar amounts, indicating that glycolysis coupled to alcoholic fermentation was the principal CO(2)-producing respiratory pathway. Rates of CO(2) evolution by aerobic and anaerobic whole plants (shoot and tuber) were similar, suggesting a rate of glycolysis three times that of aerobic plants, i.e. a strong Pasteur Effect. In the shoot alone, anaerobic CO(2) production was twice the aerobic rate indicating a 6-fold increase in the rate of glycolysis in this tissue. Anoxic stems contained more sucrose at a stronger concentration than slower-growing aerobic stems or anaerobic leaves, demonstrating that sugar supply to the site of most rapid growth exceeded demand in the absence of oxygen. Concentrations of potentially toxic acetaldehyde in the external medium were small (approximately 0.2 mol m(-3)) during anoxia and on return to aerated conditions. Lactic acid was undetectable under anaerobic conditions and in vivo (31)P-NMR analysis of shoots revealed a cytoplasmic acidification of only

  • Anoxia tolerance in the aquatic monocot Potamogeton pectinatus: absence of oxygen stimulates elongation in association with an unusually large Pasteur Effect
    Journal of Experimental Botany, 2000
    Co-Authors: Jacky E. Summers, R. G. Ratcliffe, M. B. Jackson
    Abstract:

    Elongation by stems of overwintered tubers of Potamogeton pectinatus (L.) is strongly promoted over several days by oxygen-free conditions. Characteristics of the respiration underpinning this unusual response were examined. Anaerobic plants produced ethanol and CO(2) in approximately equimolar amounts, indicating that glycolysis coupled to alcoholic fermentation was the principal CO(2)-producing respiratory pathway. Rates of CO(2) evolution by aerobic and anaerobic whole plants (shoot and tuber) were similar, suggesting a rate of glycolysis three times that of aerobic plants, i.e. a strong Pasteur Effect. In the shoot alone, anaerobic CO(2) production was twice the aerobic rate indicating a 6-fold increase in the rate of glycolysis in this tissue. Anoxic stems contained more sucrose at a stronger concentration than slower-growing aerobic stems or anaerobic leaves, demonstrating that sugar supply to the site of most rapid growth exceeded demand in the absence of oxygen. Concentrations of potentially toxic acetaldehyde in the external medium were small (approximately 0.2 mol m(-3)) during anoxia and on return to aerated conditions. Lactic acid was undetectable under anaerobic conditions and in vivo (31)P-NMR analysis of shoots revealed a cytoplasmic acidification of only

Jacky E. Summers - One of the best experts on this subject based on the ideXlab platform.

  • anoxia tolerance in the aquatic monocot potamogeton pectinatus absence of oxygen stimulates elongation in association with an unusually large Pasteur Effect
    Journal of Experimental Botany, 2000
    Co-Authors: Jacky E. Summers, R. G. Ratcliffe, M. B. Jackson
    Abstract:

    Elongation by stems of overwintered tubers of Potamogeton pectinatus (L.) is strongly promoted over several days by oxygen-free conditions. Characteristics of the respiration underpinning this unusual response were examined. Anaerobic plants produced ethanol and CO(2) in approximately equimolar amounts, indicating that glycolysis coupled to alcoholic fermentation was the principal CO(2)-producing respiratory pathway. Rates of CO(2) evolution by aerobic and anaerobic whole plants (shoot and tuber) were similar, suggesting a rate of glycolysis three times that of aerobic plants, i.e. a strong Pasteur Effect. In the shoot alone, anaerobic CO(2) production was twice the aerobic rate indicating a 6-fold increase in the rate of glycolysis in this tissue. Anoxic stems contained more sucrose at a stronger concentration than slower-growing aerobic stems or anaerobic leaves, demonstrating that sugar supply to the site of most rapid growth exceeded demand in the absence of oxygen. Concentrations of potentially toxic acetaldehyde in the external medium were small (approximately 0.2 mol m(-3)) during anoxia and on return to aerated conditions. Lactic acid was undetectable under anaerobic conditions and in vivo (31)P-NMR analysis of shoots revealed a cytoplasmic acidification of only

  • Anoxia tolerance in the aquatic monocot Potamogeton pectinatus: absence of oxygen stimulates elongation in association with an unusually large Pasteur Effect
    Journal of Experimental Botany, 2000
    Co-Authors: Jacky E. Summers, R. G. Ratcliffe, M. B. Jackson
    Abstract:

    Elongation by stems of overwintered tubers of Potamogeton pectinatus (L.) is strongly promoted over several days by oxygen-free conditions. Characteristics of the respiration underpinning this unusual response were examined. Anaerobic plants produced ethanol and CO(2) in approximately equimolar amounts, indicating that glycolysis coupled to alcoholic fermentation was the principal CO(2)-producing respiratory pathway. Rates of CO(2) evolution by aerobic and anaerobic whole plants (shoot and tuber) were similar, suggesting a rate of glycolysis three times that of aerobic plants, i.e. a strong Pasteur Effect. In the shoot alone, anaerobic CO(2) production was twice the aerobic rate indicating a 6-fold increase in the rate of glycolysis in this tissue. Anoxic stems contained more sucrose at a stronger concentration than slower-growing aerobic stems or anaerobic leaves, demonstrating that sugar supply to the site of most rapid growth exceeded demand in the absence of oxygen. Concentrations of potentially toxic acetaldehyde in the external medium were small (approximately 0.2 mol m(-3)) during anoxia and on return to aerated conditions. Lactic acid was undetectable under anaerobic conditions and in vivo (31)P-NMR analysis of shoots revealed a cytoplasmic acidification of only

R. G. Ratcliffe - One of the best experts on this subject based on the ideXlab platform.

  • anoxia tolerance in the aquatic monocot potamogeton pectinatus absence of oxygen stimulates elongation in association with an unusually large Pasteur Effect
    Journal of Experimental Botany, 2000
    Co-Authors: Jacky E. Summers, R. G. Ratcliffe, M. B. Jackson
    Abstract:

    Elongation by stems of overwintered tubers of Potamogeton pectinatus (L.) is strongly promoted over several days by oxygen-free conditions. Characteristics of the respiration underpinning this unusual response were examined. Anaerobic plants produced ethanol and CO(2) in approximately equimolar amounts, indicating that glycolysis coupled to alcoholic fermentation was the principal CO(2)-producing respiratory pathway. Rates of CO(2) evolution by aerobic and anaerobic whole plants (shoot and tuber) were similar, suggesting a rate of glycolysis three times that of aerobic plants, i.e. a strong Pasteur Effect. In the shoot alone, anaerobic CO(2) production was twice the aerobic rate indicating a 6-fold increase in the rate of glycolysis in this tissue. Anoxic stems contained more sucrose at a stronger concentration than slower-growing aerobic stems or anaerobic leaves, demonstrating that sugar supply to the site of most rapid growth exceeded demand in the absence of oxygen. Concentrations of potentially toxic acetaldehyde in the external medium were small (approximately 0.2 mol m(-3)) during anoxia and on return to aerated conditions. Lactic acid was undetectable under anaerobic conditions and in vivo (31)P-NMR analysis of shoots revealed a cytoplasmic acidification of only

  • Anoxia tolerance in the aquatic monocot Potamogeton pectinatus: absence of oxygen stimulates elongation in association with an unusually large Pasteur Effect
    Journal of Experimental Botany, 2000
    Co-Authors: Jacky E. Summers, R. G. Ratcliffe, M. B. Jackson
    Abstract:

    Elongation by stems of overwintered tubers of Potamogeton pectinatus (L.) is strongly promoted over several days by oxygen-free conditions. Characteristics of the respiration underpinning this unusual response were examined. Anaerobic plants produced ethanol and CO(2) in approximately equimolar amounts, indicating that glycolysis coupled to alcoholic fermentation was the principal CO(2)-producing respiratory pathway. Rates of CO(2) evolution by aerobic and anaerobic whole plants (shoot and tuber) were similar, suggesting a rate of glycolysis three times that of aerobic plants, i.e. a strong Pasteur Effect. In the shoot alone, anaerobic CO(2) production was twice the aerobic rate indicating a 6-fold increase in the rate of glycolysis in this tissue. Anoxic stems contained more sucrose at a stronger concentration than slower-growing aerobic stems or anaerobic leaves, demonstrating that sugar supply to the site of most rapid growth exceeded demand in the absence of oxygen. Concentrations of potentially toxic acetaldehyde in the external medium were small (approximately 0.2 mol m(-3)) during anoxia and on return to aerated conditions. Lactic acid was undetectable under anaerobic conditions and in vivo (31)P-NMR analysis of shoots revealed a cytoplasmic acidification of only

Sevil Acar - One of the best experts on this subject based on the ideXlab platform.

  • the environmental kuznets curve and the Pasteur Effect environmental costs in sweden 1850 2000
    European Review of Economic History, 2014
    Co-Authors: Magnus Lindmark, Sevil Acar
    Abstract:

    The dynamics of environmental problems is among other things affected by knowledge and economic growth and the perception of welfare. In this article, we present a method for aggregating historically relevant environmental pressure indicators, thereby acknowledging that the complexity of environmental problems calls for multi-indicator approaches. Secondly, we use the aggregate for exploring the long-run dynamics between the environment and economic growth, using a methodology used in the study of the so-called environmental Kuznets curve. We find evidence for a right tilted-S form dynamic relationship. The dynamics is analyzed in a framework stressing that new knowledge of environmental problems is an important driver for the changing relationship, here called "the Pasteur Effect".

  • The environmental Kuznets curve and the Pasteur Effect : Environmental costs in Sweden 1850–2000
    European Review of Economic History, 2014
    Co-Authors: Magnus Lindmark, Sevil Acar
    Abstract:

    The dynamics of environmental problems is among other things affected by knowledge and economic growth and the perception of welfare. In this article, we present a method for aggregating historically relevant environmental pressure indicators, thereby acknowledging that the complexity of environmental problems calls for multi-indicator approaches. Secondly, we use the aggregate for exploring the long-run dynamics between the environment and economic growth, using a methodology used in the study of the so-called environmental Kuznets curve. We find evidence for a right tilted-S form dynamic relationship. The dynamics is analyzed in a framework stressing that new knowledge of environmental problems is an important driver for the changing relationship, here called "the Pasteur Effect".

David Carling - One of the best experts on this subject based on the ideXlab platform.

  • phosphorylation and activation of heart pfk 2 by ampk has a role in the stimulation of glycolysis during ischaemia
    Current Biology, 2000
    Co-Authors: Annesophie Marsin, Luc Bertrand, Mark H Rider, Johan Deprez, Christophe Beauloye, Mariefrancoise Vincent, G Van Den Berghe, David Carling
    Abstract:

    BACKGROUND: The role of protein phosphorylation in the Pasteur Effect--the phenomenon whereby anaerobic conditions stimulate glycolysis--has not been addressed. The AMP-activated protein kinase (AMPK) is activated when the oxygen supply is restricted. AMPK acts as an energy-state sensor and inhibits key biosynthetic pathways, thus conserving ATP. Here, we studied whether AMPK is involved in the Pasteur Effect in the heart by phosphorylating and activating 6-phosphofructo-2-kinase (PFK-2), the enzyme responsible for the synthesis of fructose 2,6-bisphosphate, a potent stimulator of glycolysis. RESULTS: Heart PFK-2 was phosphorylated on Ser466 and activated by AMPK in vitro. In perfused rat hearts, anaerobic conditions or inhibitors of oxidative phosphorylation (oligomycin and antimycin) induced AMPK activation, which correlated with PFK-2 activation and with an increase in fructose 2,6-bisphosphate concentration. Moreover, in cultured cells transfected with heart PFK-2, oligomycin treatment resulted in a parallel activation of endogenous AMPK and PFK-2. In these cells, the activation of PFK-2 was due to the phosphorylation of Ser466. A dominant-negative construct of AMPK abolished the activation of endogenous and cotransfected AMPK, and prevented both the activation and phosphorylation of transfected PFK-2 by oligomycin. CONCLUSIONS: AMPK phosphorylates and activates heart PFK-2 in vitro and in intact cells. AMPK-mediated PFK-2 activation is likely to be involved in the stimulation of heart glycolysis during ischaemia.