The Experts below are selected from a list of 300 Experts worldwide ranked by ideXlab platform
D. A. Jarvis - One of the best experts on this subject based on the ideXlab platform.
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norpethidine toxicity and Patient Controlled Analgesia
BJA: British Journal of Anaesthesia, 1993Co-Authors: P. A. Stone, P. E. Macintyre, D. A. JarvisAbstract:Patient-Controlled Analgesia (PCA) with i.v. opioids is prescribed increasingly. We report three cases of norpethidine toxicity in Patients receiving pethidine by PCA. (Br. J. Anaesth. 1993; 71: 738–740)
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NORPETHIDINE TOXICITY AND Patient Controlled Analgesia
British journal of anaesthesia, 1993Co-Authors: P. A. Stone, P. E. Macintyre, D. A. JarvisAbstract:Patient-Controlled Analgesia (PCA) with i.v. opioids is prescribed increasingly. We report three cases of norpethidine toxicity in Patients receiving pethidine by PCA.
Joseph Chuan Shih Yang - One of the best experts on this subject based on the ideXlab platform.
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comparison of tramadol and tramadol droperidol mixture for Patient Controlled Analgesia
Canadian Journal of Anaesthesia-journal Canadien D Anesthesie, 1997Co-Authors: Siu Lun Tsui, Joseph Chuan Shih YangAbstract:Purpose To compare the analgesic efficacy and side effects of tramadolvs tramadol and dropendol for post-operative Patient-Controlled Analgesia (PCA).
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Comparison of tramadol and tramadol/droperidol mixture for Patient-Controlled Analgesia
Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1997Co-Authors: Siu Lun Tsui, Joseph Chuan Shih YangAbstract:Purpose To compare the analgesic efficacy and side effects of tramadolvs tramadol and dropendol for post-operative Patient-Controlled Analgesia (PCA).
P. A. Stone - One of the best experts on this subject based on the ideXlab platform.
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norpethidine toxicity and Patient Controlled Analgesia
BJA: British Journal of Anaesthesia, 1993Co-Authors: P. A. Stone, P. E. Macintyre, D. A. JarvisAbstract:Patient-Controlled Analgesia (PCA) with i.v. opioids is prescribed increasingly. We report three cases of norpethidine toxicity in Patients receiving pethidine by PCA. (Br. J. Anaesth. 1993; 71: 738–740)
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NORPETHIDINE TOXICITY AND Patient Controlled Analgesia
British journal of anaesthesia, 1993Co-Authors: P. A. Stone, P. E. Macintyre, D. A. JarvisAbstract:Patient-Controlled Analgesia (PCA) with i.v. opioids is prescribed increasingly. We report three cases of norpethidine toxicity in Patients receiving pethidine by PCA.
Harry Owen - One of the best experts on this subject based on the ideXlab platform.
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Variable-dose Patient-Controlled Analgesia. A preliminary report.
Anaesthesia, 1995Co-Authors: Harry Owen, John L. Plummer, Anthony H. Ilsley, Russell Hawkins, Z. Arfeen, K. TordoffAbstract:Summary One size of Patient-Controlled Analgesia demand dose does not suit all Patients after surgery. We have constructed a new Patient-Controlled Analgesia system (variable-dose Patient-Controlled Analgesia) in which Patients have a choice of demand dose sizes. In an initial trial, Patients could choose between 0.5, 1.0 or 1.5mg morphine. Patients readily understood the system and were all ‘satisfied’ (n = 1) or ‘very satisfied’ (n = 9) with the system. Only two Patients sought ‘complete relief’ from pain, most reported seeking ‘moderate relief’. AN Patients obtained ‘a lot of relief’ or ‘complete relief’ with this Patient-Controlled Analgesia system. This preliminary experience suggests that variable dose Patient-Controlled Analgesia warrants further investigation and comparison with conventional Patient-Controlled Analgesia.
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Patient-Controlled Analgesia
Current Anaesthesia & Critical Care, 1995Co-Authors: Z. Arfeen, Harry OwenAbstract:Patient-Controlled Analgesia (PCA) is now one of the preferred methods of postoperative pain control after surgery. Many routes have been used to administer PCA, but intravenous drug delivery is most commonly used. This article discusses advantages and limitations of PCA and how some of the limitations can be addressed.
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Laboratory evaluation of the Baxter Patient-Controlled Analgesia Infusor System: a disposable Patient-Controlled Analgesia device.
Anesthesia and analgesia, 1993Co-Authors: N. A. Mackey, Harry Owen, Anthony H. Ilsley, John L. PlummerAbstract:The purpose of this study was to determine the accuracy of bolus-demand volumes obtained from the Baxter Patient-Controlled Analgesia Infusor System, a disposable Patient-Controlled Analgesia device. An automated system was used to make demands in a pattern designed to simulate those made by a Patient in the first 24 postoperative hours. Following this, a pattern of varying short interdemand intervals was used to evaluate performance of the device when demands were made near the nominal lockout interval of 6 min. Finally, a prolonged array of short interdemand intervals was used to evaluate performance as the reservoir of the devices became exhausted. Ten devices were tested. One device failed; after 70 min of testing the reservoir burst. The mean delivery of the remaining nine devices for the first 24 h of testing was 92.6% of nominal (SD = 3.9%). Evaluation near the nominal lockout interval revealed a departure of delivered volume from nominal (worst = 73.9% at an interdemand interval of 6 min). As the reservoir became exhausted, delivery increased to a maximum value, ranging from 118% to 137% of nominal, before falling to zero. In general, the devices performed consistently and the departures from nominal delivery were not considered to be of clinical significance.
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An automated system for testing the accuracy of Patient-Controlled Analgesia devices.
Anaesthesia, 1992Co-Authors: D. J. Hawkins, Anthony H. Ilsley, John L. Plummer, D. R. D. Roberts, Harry OwenAbstract:Summary A system was developed to test the accuracy of Patient-Controlled Analgesia devices in situations simulating clinical use. Bolus requests are made automatically at predetermined intervals, and the infusate delivered is measured and recorded without the need for operator presence. To ensure clinical relevance, the bolus request times used in this study corresponded to a pattern typical of those requested by Patients on the ward. Graseby, Abbott Provider 5500 and IVAC Patient-Controlled Analgesia devices were tested and found to deliver reasonably accurately over a 24 h period. However, when an infusion was started in an unprimed system or after a period of no bolus requests in a bolus-only mode the Graseby and IVAC machines under-delivered. This system provides a means of testing Patient-Controlled Analgesia devices operating in any delivery mode.
Laurence E. Mather - One of the best experts on this subject based on the ideXlab platform.
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Nausea and vomiting in the postoperative Patient‐Controlled Analgesia environment
Anaesthesia, 1997Co-Authors: A. Woodhouse, Laurence E. MatherAbstract:Despite common clinical opinion that Patient-Controlled Analgesia should be renamed 'Patient-Controlled nausea', there is little evidence in support of the notion that postoperative nausea and vomiting are exacerbated by the method. Indeed, data indicate that opioid-sparing techniques are not associated with less postoperative nausea and vomiting. Although some evidence suggests that certain opioids are less emetogenic than others, this too does not stand scrutiny when compared across Patients, although research is still required to find whether individual Patients are better treated with a particular opioid. Similarly, the emerging practice of combining anti-emetics with Patient-Controlled Analgesia needs wider study before it can be supported.
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The influence of age upon opioid analgesic use in the Patient-Controlled Analgesia (PCA) environment.
Anaesthesia, 1997Co-Authors: A. Woodhouse, Laurence E. MatherAbstract:It is often asserted that older Patients are more sensitive to opioid analgesics than younger Patients but experimental evidence for this assertion remains sparse. Two studies were conducted investigating the relationship between age and opioid analgesic use in the Patient-Controlled Analgesia environment. In study I, the relationship was analysed subsequent to our publication of a study investigating Patients' responses to opioid use with Patient-Controlled Analgesia. Fifty-five postoperative Patients, stratified into 'older' and 'younger' Patients by median age, received morphine or pethidine or fentanyl Patient-Controlled Analgesia. A strong inverse relationship was found between age and fentanyl and morphine use but not between age and pethidine use. Study II was a retrospective study of the medical records of 199 Patient-Controlled Analgesia Patients who had received morphine or pethidine Patient-Controlled Analgesia; there were insufficient Patients who had used fentanyl for a reasonable sample. There was a difference in morphine use with the younger Patients using significantly more morphine than the older Patients (< 60 years). Findings were less clear for Patients receiving pethidine but there was an inverse correlation between age and pethidine use as well. Overall, the findings of these two studies supported the common clinical belief that older Patients require less opioids than younger Patients.
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Patient-Controlled Analgesia
Clinical Pharmacokinetics, 1993Co-Authors: Harlan F. Hill, Laurence E. MatherAbstract:The opioid analgesic agents exhibit relatively large pharmacokinetic differences between drugs, and there is substantial pharmacokinetic and pharmacodynamic variability across subjects or Patients with each agent. The advent of Patient-Controlled analgesic administration techniques and their widespread use in contemporary pain management, especially in postsurgical and cancer Patients, has decreased the unfortunate impact of interPatient variability on achieving the optimal balance between pain relief and opioid adverse effect intensity. The improvements in pain management provided by Patient-Controlled Analgesia do not, however, decrease the importance of knowledge of opioid pharmacokinetics towards enlightened use of these drugs and attainment of maximal benefits from them in any Patient. Future improvements in Patient-Controlled Analgesia technology will probably be based on the pharmacokinetic behaviour of different opioid analgesic agents in specific receptor-containing regions. Finally, physicochemical and pharmacokinetic characteristics of these agents are important determinants of the speed of onset of effects, duration of action and spinal selectivity of epidurally and intrathecally administered analgesics. Thus, effective Patient-Controlled Analgesia depends on an understanding of the differential pharmacokinetics of opioids self-administered by a variety of possible modes.
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Patient-Controlled Analgesia. Pharmacokinetic and therapeutic considerations.
Clinical pharmacokinetics, 1993Co-Authors: Harlan F. Hill, Laurence E. MatherAbstract:The opioid analgesic agents exhibit relatively large pharmacokinetic differences between drugs, and there is substantial pharmacokinetic and pharmacodynamic variability across subjects or Patients with each agent. The advent of Patient-Controlled analgesic administration techniques and their widespread use in contemporary pain management, especially in postsurgical and cancer Patients, has decreased the unfortunate impact of interPatient variability on achieving the optimal balance between pain relief and opioid adverse effect intensity. The improvements in pain management provided by Patient-Controlled Analgesia do not, however, decrease the importance of knowledge of opioid pharmacokinetics towards enlightened use of these drugs and attainment of maximal benefits from them in any Patient. Future improvements in Patient-Controlled Analgesia technology will probably be based on the pharmacokinetic behaviour of different opioid analgesic agents in specific receptor-containing regions. Finally, physicochemical and pharmacokinetic characteristics of these agents are important determinants of the speed of onset of effects, duration of action and spinal selectivity of epidurally and intrathecally administered analgesics. Thus, effective Patient-Controlled Analgesia depends on an understanding of the differential pharmacokinetics of opioids self-administered by a variety of possible modes.
