The Experts below are selected from a list of 327 Experts worldwide ranked by ideXlab platform
David A Woolfson - One of the best experts on this subject based on the ideXlab platform.
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hydrogel forming microneedle arrays can be effectively inserted in skin by self application a pilot study centred on pharmacist intervention and a Patient Information Leaflet
Pharmaceutical Research, 2014Co-Authors: Ryan F Donnelly, Kurtis Moffatt, Ahlam Zaid Alkilani, Eva M Vicenteperez, Johanne Barry, Maeliosa T C Mccrudden, David A WoolfsonAbstract:Purpose To investigate, for the first time, the influence of pharmacist intervention and the use of a Patient Information Leaflet on self-application of hydrogel-forming microneedle arrays by human volunteers without the aid of an applicator device.
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hydrogel forming microneedle arrays can be effectively inserted in skin by self application a pilot study centred on pharmacist intervention and a Patient Information Leaflet
Pharmaceutical Research, 2014Co-Authors: Ryan F Donnelly, Kurtis Moffatt, Ahlam Zaid Alkilani, Eva M Vicenteperez, Johanne Barry, Maeliosa T C Mccrudden, David A WoolfsonAbstract:To investigate, for the first time, the influence of pharmacist intervention and the use of a Patient Information Leaflet on self-application of hydrogel-forming microneedle arrays by human volunteers without the aid of an applicator device. A Patient Information Leaflet was drafted and pharmacist counselling strategy devised. Twenty human volunteers applied 11 × 11 arrays of 400 μm hydrogel-forming microneedle arrays to their own skin following the instructions provided. Skin barrier function disruption was assessed using transepidermal water loss measurements and optical coherence tomography and results compared to those obtained when more experienced researchers applied the microneedles to the volunteers or themselves. Volunteer self-application of the 400 μm microneedle design resulted in an approximately 30% increase in skin transepidermal water loss, which was not significantly different from that seen with self-application by the more experienced researchers or application to the volunteers. Use of optical coherence tomography showed that self-application of microneedles of the same density (400 μm, 600 μm and 900 μm) led to percentage penetration depths of approximately 75%, 70% and 60%, respectively, though the diameter of the micropores created remained quite constant at approximately 200 μm. Transepidermal water loss progressively increased with increasing height of the applied microneedles and this data, like that for penetration depth, was consistent, regardless of applicant. We have shown that hydrogel-forming microneedle arrays can be successfully and reproducibly applied by human volunteers given appropriate instruction. If these outcomes were able to be extrapolated to the general Patient population, then use of bespoke MN applicator devices may not be necessary, thus possibly enhancing Patient compliance.
Ross E G Upshur - One of the best experts on this subject based on the ideXlab platform.
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a randomised comparison of the effect of three Patient Information Leaflet models on older Patients treatment intentions
British Journal of General Practice, 2002Co-Authors: S Whatley, Muhammad Mamdani, Ross E G UpshurAbstract:One hundred and ninety-six Patients over the age of 65 years suffering from joint pain were randomised to receive one of three Patient Information Leaflets describing a hypothetical pain medication, a standard textual Patient Information Leaflet (PIL) given out by a pharmaceutical chain, and two alternate-forms depicting Information with icons and graphs. The results showed that Patients randomised to the traditional PIL were less likely to consider taking the hypothetical medication.
Ahlam Zaid Alkilani - One of the best experts on this subject based on the ideXlab platform.
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hydrogel forming microneedle arrays can be effectively inserted in skin by self application a pilot study centred on pharmacist intervention and a Patient Information Leaflet
Pharmaceutical Research, 2014Co-Authors: Ryan F Donnelly, Kurtis Moffatt, Ahlam Zaid Alkilani, Eva M Vicenteperez, Johanne Barry, Maeliosa T C Mccrudden, David A WoolfsonAbstract:Purpose To investigate, for the first time, the influence of pharmacist intervention and the use of a Patient Information Leaflet on self-application of hydrogel-forming microneedle arrays by human volunteers without the aid of an applicator device.
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hydrogel forming microneedle arrays can be effectively inserted in skin by self application a pilot study centred on pharmacist intervention and a Patient Information Leaflet
Pharmaceutical Research, 2014Co-Authors: Ryan F Donnelly, Kurtis Moffatt, Ahlam Zaid Alkilani, Eva M Vicenteperez, Johanne Barry, Maeliosa T C Mccrudden, David A WoolfsonAbstract:To investigate, for the first time, the influence of pharmacist intervention and the use of a Patient Information Leaflet on self-application of hydrogel-forming microneedle arrays by human volunteers without the aid of an applicator device. A Patient Information Leaflet was drafted and pharmacist counselling strategy devised. Twenty human volunteers applied 11 × 11 arrays of 400 μm hydrogel-forming microneedle arrays to their own skin following the instructions provided. Skin barrier function disruption was assessed using transepidermal water loss measurements and optical coherence tomography and results compared to those obtained when more experienced researchers applied the microneedles to the volunteers or themselves. Volunteer self-application of the 400 μm microneedle design resulted in an approximately 30% increase in skin transepidermal water loss, which was not significantly different from that seen with self-application by the more experienced researchers or application to the volunteers. Use of optical coherence tomography showed that self-application of microneedles of the same density (400 μm, 600 μm and 900 μm) led to percentage penetration depths of approximately 75%, 70% and 60%, respectively, though the diameter of the micropores created remained quite constant at approximately 200 μm. Transepidermal water loss progressively increased with increasing height of the applied microneedles and this data, like that for penetration depth, was consistent, regardless of applicant. We have shown that hydrogel-forming microneedle arrays can be successfully and reproducibly applied by human volunteers given appropriate instruction. If these outcomes were able to be extrapolated to the general Patient population, then use of bespoke MN applicator devices may not be necessary, thus possibly enhancing Patient compliance.
Tim Chadborn - One of the best experts on this subject based on the ideXlab platform.
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Applying behavioural science to increase uptake of the NHS Health Check: a randomised controlled trial of gain- and loss-framed messaging in the national Patient Information Leaflet
BMC public health, 2019Co-Authors: Natalie Gold, Caroline Durlik, Jet Gabrielle Gabrielle Sanders, Katherine Thompson, Tim ChadbornAbstract:The NHS Health Check (NHSHC) is a national programme for the prevention of non-communicable diseases. Patients aged 40–74 without an existing cardiovascular-related condition should be invited quinquennially. Uptake is lower than anticipated. We assessed the impact on uptake of two new behaviourally-enhanced Leaflets (with the current national Leaflet as a control), enclosed with the invitation letter: the first trial on the Leaflet. A double-blind three-armed randomized controlled trial was conducted. The new Leaflets were shorter (two pages, instead of four); one was loss-framed (‘don’t miss out’) and the other was gain-framed (‘make the most of life’). The participants were Patients from 39 practices in Lewisham and 17 practices in NE Lincolnshire, who were allocated to interventions using a random-number generator and received one of the Leaflets with their invitation letter from April–September 2018. The outcome measure was uptake of an NHSHC by November 2018. The trial was powered to detect a 2% effect. Uptake was 17.6% in the control condition (n = 3677), 17.4% in the loss-framed condition (n = 3664), and 18.2% in the gain-framed condition (n = 3697). Leaflet type was not a significant predictor of NHSHC uptake in a logistic regression that controlled for demographic variables, with GP practice as a random effect. Statistically significant predictors of uptake included location (higher uptake in Lewisham), age (increased age was associated with increased attendance) and sex (higher uptake in females). The Bayes Factor comparing the null to a hypothesis of differences between conditions was 416, which is extreme evidence in favour of the null hypothesis. There was no evidence for a meaningful effect of either a loss-framed or gain-framed behaviourally-informed Leaflet type on uptake, which is surprising, given that behaviourally informed letters have improved uptake of NHSHCs. It is possible that people do not pay attention to Leaflets that are enclosed with letters, or that the Leaflet continues to support informed decision-making but this does not affect uptake. Clinicaltrials.gov, NCT03524131. Registered May 14, 2018. Retrospectively registered.
Ros Dowse - One of the best experts on this subject based on the ideXlab platform.
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comprehension and acceptability of a Patient Information Leaflet pil for antiretroviral therapy
Health Sa Gesondheid, 2006Co-Authors: Betty Mwingira, Ros DowseAbstract:The Patient Information Leaflet (PIL) is recognised as playing a key role in informing Patients about their medicines. The objectives of this research were to evaluate the readability and understanding of a PIL for the first-line ARV (antiretroviral) regimen available in the South African public health sector, and investigate its acceptability in the target Xhosa population. The study took place between August 2003 and July 2004. A PIL was designed for the antiretroviral regimen of stavudine, lamivudine and efavirenz, using established usability guidelines. South African legal requirements concerning PILs were incorporated and the PILs were available in both English and isiXhosa. Sixty Xhosa participants between the ages of 18 and 61 years old, with varied levels of education, ranging from no schooling to tertiary level education, were interviewed and demographic data were collected. All participants had stated that they could read. They were asked to read the PIL and a series of questions was asked to assess its comprehension and acceptability. The overall average rate of understanding was 80%. Six of the 20 questions were located and understood by all participants, and only two questions resulted in less than an 85% correct response. The PIL was rated as difficult to read by only three participants. Physical appearance and quantity of Information were highly rated and all participants were enthusiastic about the inclusion of pictograms.
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effect of pictograms on readability of Patient Information materials
Annals of Pharmacotherapy, 2003Co-Authors: Leila E Mansoor, Ros DowseAbstract:OBJECTIVE:To design, develop, and evaluate a simple, understandable medicine label and Patient Information Leaflet (PIL) for nystatin suspension, and to assess the effect of incorporating pictograms on understanding in low-literate participants.METHODS:Patient Information materials were designed and pretested in a pilot study (n = 20), and were subjected to the Fry's readability test. The final evaluation was conducted with 60 low-literate participants who had a maximum of 7 years of formal schooling and for whom English was their second language. Demographic data were collected. Participants were randomly allocated to a control (text-only Information) or experimental (text + pictogram Information) group, shown the medicine label and PIL, and asked to read them. A series of questions was asked about the instructions and an understanding level was calculated in each case. A second series of questions assessed Patient acceptability of the materials. Differences in understanding were determined by χ2 tests.R...