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Krishna R Murthy - One of the best experts on this subject based on the ideXlab platform.

  • associations of fuchs heterochromic iridocyclitis in a south indian Patient Population
    Journal of Ophthalmic Inflammation and Infection, 2013
    Co-Authors: Kalpana Babu, Madhura Adiga, Sunil R Govekar, B Ravi V Kumar, Krishna R Murthy
    Abstract:

    Background The purpose of this study is to look for any possible associations in 58 consecutive cases of Fuchs heterochromic iridocyclitis (FHI) in a South Indian Patient Population. Fifty-eight consecutive cases (59 eyes) of FHI underwent a detailed ocular and systemic evaluation. Routine laboratory investigations for uveitis including serum angiotensin-converting enzyme and enzyme-linked immunosorbent assay (ELISA) for toxoplasmosis (IgG and IgM) were done in all the cases. Syndrome Evaluation System comprising of multiplex nucleic acid amplification and signature specific hybridization on the aqueous fluid was done in all 59 eyes for herpes simplex virus (HSV), varicella zoster virus, cytomegalovirus (CMV), rubella virus, chikungunya virus, Toxoplasma, and Mycobacterium tuberculosis. The results were statistically assessed using the SPSS (version 15) package.

  • Utility of QuantiFERON TB gold test in a south Indian Patient Population of ocular inflammation
    Indian Journal of Ophthalmology, 2009
    Co-Authors: Kalpana Babu, Vidya Satish, Sheo Satish, D.k. Subbakrishna, Mariamma Philips Abraham, Krishna R Murthy
    Abstract:

    Aim : To study the utility of interferon-g release assays (QuantiFERON TB gold test) in a south Indian Patient Population of intraocular inflammation. Design : Evaluation of a diagnostic test- a pilot study from January 2007 to October 2008. Materials and Methods : QuantiFERON TB gold test was performed on the following groups of Patients following an informed consent. Group A included healthy volunteers without any exposure to tuberculosis (TB) or past history of TB (n=22). Group B included Patients with active systemic TB diagnosed by the demonstration of acid-fast bacilli or by the histopathology finding of caseation with granuloma formation from the sputum, lymph node, skin or intestinal biopsies (n=26). Group C included Patients with uveitis of known etiologies other than intraocular TB without any history of exposure to active TB (n=21). Group D included Patients with a diagnosis of presumed intraocular TB, who responded to antitubercular therapy by decreased or no recurrences following treatment and with a minimum of nine months follow-up following initiation of antitubercular therapy (n=39). Results : The sensitivity and specificity of the QuantiFERON TB gold test to pick up active systemic TB was 58% and 77% respectively. The sensitivity and specificity of the QuantiFERON TB gold test to pickup intraocular TB was 82% and 76% respectively. Conclusions : QuantiFERON TB gold test alone may not be specific for intraocular TB. The significance of this test in a case scenario needs to be interpreted with clinical presentation and other evidences for intraocular TB.

Thomas S Roukis - One of the best experts on this subject based on the ideXlab platform.

Kalpana Babu - One of the best experts on this subject based on the ideXlab platform.

  • associations of fuchs heterochromic iridocyclitis in a south indian Patient Population
    Journal of Ophthalmic Inflammation and Infection, 2013
    Co-Authors: Kalpana Babu, Madhura Adiga, Sunil R Govekar, B Ravi V Kumar, Krishna R Murthy
    Abstract:

    Background The purpose of this study is to look for any possible associations in 58 consecutive cases of Fuchs heterochromic iridocyclitis (FHI) in a South Indian Patient Population. Fifty-eight consecutive cases (59 eyes) of FHI underwent a detailed ocular and systemic evaluation. Routine laboratory investigations for uveitis including serum angiotensin-converting enzyme and enzyme-linked immunosorbent assay (ELISA) for toxoplasmosis (IgG and IgM) were done in all the cases. Syndrome Evaluation System comprising of multiplex nucleic acid amplification and signature specific hybridization on the aqueous fluid was done in all 59 eyes for herpes simplex virus (HSV), varicella zoster virus, cytomegalovirus (CMV), rubella virus, chikungunya virus, Toxoplasma, and Mycobacterium tuberculosis. The results were statistically assessed using the SPSS (version 15) package.

  • Utility of QuantiFERON TB gold test in a south Indian Patient Population of ocular inflammation
    Indian Journal of Ophthalmology, 2009
    Co-Authors: Kalpana Babu, Vidya Satish, Sheo Satish, D.k. Subbakrishna, Mariamma Philips Abraham, Krishna R Murthy
    Abstract:

    Aim : To study the utility of interferon-g release assays (QuantiFERON TB gold test) in a south Indian Patient Population of intraocular inflammation. Design : Evaluation of a diagnostic test- a pilot study from January 2007 to October 2008. Materials and Methods : QuantiFERON TB gold test was performed on the following groups of Patients following an informed consent. Group A included healthy volunteers without any exposure to tuberculosis (TB) or past history of TB (n=22). Group B included Patients with active systemic TB diagnosed by the demonstration of acid-fast bacilli or by the histopathology finding of caseation with granuloma formation from the sputum, lymph node, skin or intestinal biopsies (n=26). Group C included Patients with uveitis of known etiologies other than intraocular TB without any history of exposure to active TB (n=21). Group D included Patients with a diagnosis of presumed intraocular TB, who responded to antitubercular therapy by decreased or no recurrences following treatment and with a minimum of nine months follow-up following initiation of antitubercular therapy (n=39). Results : The sensitivity and specificity of the QuantiFERON TB gold test to pick up active systemic TB was 58% and 77% respectively. The sensitivity and specificity of the QuantiFERON TB gold test to pickup intraocular TB was 82% and 76% respectively. Conclusions : QuantiFERON TB gold test alone may not be specific for intraocular TB. The significance of this test in a case scenario needs to be interpreted with clinical presentation and other evidences for intraocular TB.

Steven Rosenzweig - One of the best experts on this subject based on the ideXlab platform.

  • mindfulness based stress reduction and health related quality of life in a heterogeneous Patient Population
    General Hospital Psychiatry, 2001
    Co-Authors: Diane K Reibel, Jeffrey M Greeson, George C Brainard, Steven Rosenzweig
    Abstract:

    This study examined the effects of mindfulness-based stress reduction (MBSR) on health-related quality of life and physical and psychological symptomatology in a heterogeneous Patient Population. Patients (n=136) participated in an 8-week MBSR program and were required to practice 20 min of meditation daily. Pre- and post-intervention data were collected by using the Short-Form Health Survey (SF-36), Medical Symptom Checklist (MSCL) and Symptom Checklist-90 Revised (SCL-90-R). Health-related quality of life was enhanced as demonstrated by improvement on all indices of the SF-36, including vitality, bodily pain, role limitations caused by physical health, and social functioning (all P<.01). Alleviation of physical symptoms was revealed by a 28% reduction on the MSCL (P<.0001). Decreased psychological distress was indicated on the SCL-90-R by a 38% reduction on the Global Severity Index, a 44% reduction on the anxiety subscale, and a 34% reduction on the depression subscale (all P<.0001). One-year follow-up revealed maintenance of initial improvements on several outcome parameters. We conclude that a group mindfulness meditation training program can enhance functional status and well-being and reduce physical symptoms and psychological distress in a heterogeneous Patient Population and that the intervention may have long-term beneficial effects.

  • mindfulness based stress reduction and health related quality of life in a heterogeneous Patient Population
    General Hospital Psychiatry, 2001
    Co-Authors: Diane K Reibel, Jeffrey M Greeson, George C Brainard, Steven Rosenzweig
    Abstract:

    This study examined the effects of mindfulness-based stress reduction (MBSR) on health-related quality of life and physical and psychological symptomatology in a heterogeneous Patient Population. Patients ( n5136) participated in an 8-week MBSR program and were required to practice 20 min of meditation daily. Pre- and post-intervention data were collected by using the Short-Form Health Survey (SF-36), Medical Symptom Checklist (MSCL) and Symptom Checklist-90 Revised (SCL-90-R). Health-related quality of life was enhanced as demonstrated by improvement on all indices of the SF-36, including vitality, bodily pain, role limitations caused by physical health, and social functioning (all P,.01). Alleviation of physical symptoms was revealed by a 28% reduction on the MSCL (P,.0001). Decreased psychological distress was indicated on the SCL-90-R by a 38% reduction on the Global Severity Index, a 44% reduction on the anxiety subscale, and a 34% reduction on the depression subscale (all P,.0001). One-year follow-up revealed maintenance of initial improvements on several outcome parameters. We conclude that a group mindfulness meditation training program can enhance functional status and well-being and reduce physical symptoms and psychological distress in a heterogeneous Patient Population and that the intervention may have long-term beneficial effects. © 2001 Elsevier Science Inc. All rights reserved.

Monica H Schweinberger - One of the best experts on this subject based on the ideXlab platform.