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Halis Suleyman - One of the best experts on this subject based on the ideXlab platform.

  • amiodarone has anti inflammatory and anti oxidative properties an experimental study in rats with carrageenan induced Paw Edema
    European Journal of Pharmacology, 2007
    Co-Authors: Zekai Halici, Halis Suleyman, Gunnur Ozbakis Dengiz, Fehmi Odabasoglu, Elif Cadirci, Mesut Halici
    Abstract:

    Abstract Amiodarone is a widely used anti-arrhythmic agent. We have investigated alterations in the glutathione (GSH) level and the activities of anti-oxidative enzymes (superoxide dismutase, catalase, glutathione s-transferase and glutathione reductase) and myeloperoxidase, as marker of acute inflammation, following oral administration of amiodarone and diclofenac in rats with carrageenan-induced Paw Edema. In the present study, we found that 1) Amiodarone reduced the development of carrageenan-induced Paw Edema, to a greater degree than diclofenac; 2) Amiodarone and diclofenac alleviated increases in the activities of catalase and glutathione s-transferase enzymes resulting from Edema; 3) Amiodarone and diclofenac ameliorated depressions in the GSH level and the activities of superoxide dismutase and glutathione reductase enzymes caused by carrageenan injection; and 4) All doses of amiodarone and diclofenac caused an amplification in myeloperoxidase activity resulting from induced Paw Edema. These results suggest that the anti-inflammatory effect of amiodarone on carrageenan-induced acute inflammation can be attributed to its ameliorating effect on the oxidative damage.

  • The effects of newly synthesized pyrazole derivatives on formaldehyde-, carrageenan-, and dextran-induced acute Paw Edema in rats.
    Biological & Pharmaceutical Bulletin, 2001
    Co-Authors: Halis Suleyman, Mehmet Emin Buyukokuroglu
    Abstract:

    The antiinflammatory effects of 10 newly synthesized pyrazole derivatives on formaldehyde-induced rat Paw Edema were investigated. The most effective of them (K-3) was investigated again in dextran- and carrageenan-induced Paw Edema. In formaldehyde-induced Paw Edema, K-3 50, 100, and 200 mg/kg p.o. inhibited the Edema by 48.9% (p

  • the effects of newly synthesized pyrazole derivatives on formaldehyde carrageenan and dextran induced acute Paw Edema in rats
    Biological & Pharmaceutical Bulletin, 2001
    Co-Authors: Halis Suleyman, Mehmet Emin Buyukokuroglu
    Abstract:

    The antiinflammatory effects of 10 newly synthesized pyrazole derivatives on formaldehyde-induced rat Paw Edema were investigated. The most effective of them (K-3) was investigated again in dextran- and carrageenan-induced Paw Edema. In formaldehyde-induced Paw Edema, K-3 50, 100, and 200 mg/kg p.o. inhibited the Edema by 48.9% (p<0.002), 68.7% (p<0.001), and 79.1% (p<0.001), respectively, 3 h after administration. In dextran-induced Paw Edema, the same dose of K-3 produced 27.1% (p<0.05), 46.8% (p<0.01), and 63.8% (p<0.002) inhibition, respectively. In the carrageenan-induced Paw Edema test, K-3 100 mg/kg decreased the inflammatory response by 52.0% after 4 h. Acute toxicity studies revealed that K-3 was nontoxic up to an oral dose of 2500 mg/kg.

Benildo Sousa Cavada - One of the best experts on this subject based on the ideXlab platform.

  • neutrophil infiltrated Paw Edema induced by mannose binding dioclea violacea lectin
    Pharmacological Reports, 2013
    Co-Authors: Nylane M N Alencar, Ana Maria Sampaio Assreuy, Mario Rogerio Lima Mota, Natalia V F C Rodrigues, J L Martins, Kyria S Nascimento, Benildo Sousa Cavada
    Abstract:

    Abstract Background The potential Edematogenic effect and the pharmacological characterization of a glucose-mannose-binding lectin from Dioclea violacea (DvL) were investigated. Methods Paw Edema was induced with DvL in control animals, and in animals pretreated with glucocorticoid or with blockers of histamine, nitric oxide synthase, cyclooxygenase, platelet activating factor (PAF), bradykinin and lipoxygenase. Results DvL-induced Paw Edema paralleled with an increase in vascular permeability and myeloperoxidase (MPO) activity. DvL-induced Edema could be prevented by pre-treatment with the lectin-binding sugar α-D-methyl mannoside. Dexamethasone, meclizine and N ω -nitro-L-arginine methyl ester hydrochloride (L-NAME) inhibited this effect. Conclusions DvL induces Edema, increase in vascular permeability and neutrophil infiltration. The Edematogenic activity involves the lectin mannose-binding sites and is associated with histamine, cytokines and nitric oxide, since it could be treated with meclizine, dexamethasone and L-NAME.

  • vatairea macrocarpa lectin induces Paw Edema with leukocyte infiltration
    Protein and Peptide Letters, 2004
    Co-Authors: Nylane M N Alencar, Ana Maria Sampaio Assreuy, David N Criddle, Emmanuel P Souza, Pedro Marcos Gomes Soares, Alexandre Havt, Karoline S Aragao, Daniel P Bezerra, R A Ribeiro, Benildo Sousa Cavada
    Abstract:

    A lectin from Vatairea macrocarpa (Vmac) seeds was investigated in a model of Paw Edema in rats and the possible involvement of leukocytes. Vmac (200 and 400μg / Paw, s.c.) induced a significant time- and dose-dependent Paw Edema, with leukocyte infiltration, which was drastically reduced in leukopaenic animals. These data suggest a pro-inflammatory effect for this lectin that is dependent on the presence of leukocytes.

  • rat Paw Edema and leukocyte immigration induced by plant lectins
    Inflammation Research, 1993
    Co-Authors: C A M Bento, Benildo Sousa Cavada, Jose T A Oliveira, R A Moreira, C Barjafidalgo
    Abstract:

    Lectins fromDioclea grandiflora (DG) andCanavalia brasiliensis (CB) were compared with Concanavalin A (ConA) for their ability to induce Paw Edema and peritoneal cell immigration in rats. ConA caused a slight Edema with a peak at 1 h after injection, while DG or CB induced a pronounced and long-lasting Edema that reached a maximum at about 6 h. Different antiinflammatory drugs partially inhibited the Edema. α-d-glucose (GLU) partially blocked the Edema caused by ConA and markedly inhibited that due to CB, but had no effect on the Edema induced by DG. α-Methyl mannoside (α-MM) blocked the Edema caused by DG and ConA, but did not affect that caused by CB. At doses much lower than those used to induce Paw Edema, the lectins promoted an intense accumulation of neutrophil and mononuclear cells in the rat peritoneal cavity. CB and DG were more potent than ConA, which also presented a different profile of cell immigration. GLU significantly inhibited leukocyte accumulation caused by all lectins. α-MM impaired ConA- and DG-induced cell immigration, but only partially inhibited CB. Thus, despite their physicochemical similarities with ConA, DG and CB have more powerful pro-inflammatory effects. This difference seems to be related to their sugar-binding properties. However, while ConA- and DG-induced effects were inhibited more by α-MM than by GLU, CB-induced effects were inhibited more by glucose.

Rodrigo Alvaro Brandao Lopesmartins - One of the best experts on this subject based on the ideXlab platform.

  • the effect of inhaled nitric oxide on the carrageenan induced Paw Edema
    Histology and Histopathology, 2015
    Co-Authors: Carly Faria Coelho, Rodolfo De Paula Vieira, Patricia Sardinha Leonardo Lopesmartins, Simone A Teixeira, Alexandre U Borbely, Irene Maria Gouvea, Lucio Frigo, Rodrigo Alvaro Brandao Lopesmartins
    Abstract:

    Inhaled nitric oxide therapy reaches not only pulmonary vessels, but also other vasculatures, presenting anti-inflammatory effects. Therefore, this study investigated the effects of inhaled nitric oxide on a mice model of carrageenan-induced Paw Edema. Paw Edema was induced in male Swiss mice (20-30 g) by subplantar injection of carrageenan (0.05 ml of a 1% suspension in 0.9% saline). The evaluation of timecourse Edema (mililiter) was measured by plethysmometry until 12 h following carrageenan administration. Thirty minutes after carrageenan injection, some groups received inhaled nitric oxide (300 ppm at variable doses and times) or Indometacin (INDO 5 mg/Kg, v.o), while others received sildenafil (1 mg/Kg, i.p) or rolipram (3 mg/Kg, i.p.) with or without inhaled nitric oxide. Paws were assessed for Edema levels by plethysmometry, mieloperoxidase activity and histological analysis. Inhaled nitric oxide significantly reduced carrageenan-induced Paw Edema, mieloperoxidase activity and inflammatory infiltrate, although similar results were also observed in sildenafil and rolipram treated groups. In addition, significant effects between inhaled nitric oxide with pharmacological therapy was observed. Inhaled nitric oxide presents anti-inflammatory effects on carrageenaninduce Paw Edema, as observed through reduced Edema, mieloperoxidase activity and neutrophil infiltration, indicating that inhaled nitric oxide therapy goes beyond lung vascular effects.

Javed Iqbal - One of the best experts on this subject based on the ideXlab platform.

  • ziziphora clinopodioides ameliorated rheumatoid arthritis and inflammatory Paw Edema in different models of acute and chronic inflammation
    Biomedicine & Pharmacotherapy, 2018
    Co-Authors: Arham Shabbir, Syeda Amina Batool, Muhammad Irfan Basheer, Muhammad Shahzad, Kishwar Sultana, Rasool Baksh Tareen, Javed Iqbal
    Abstract:

    Abstract Ziziphora clinopodioides has been used in traditional medicine for its anti-inflammatory properties. Current study is believed to first time report the potential of Z. clinopodioides extracts to ameliorate joint inflammation using model of chronic joint inflammation (FCA-induced rheumatoid arthritis). The study further investigates the effects on joint inflammation using acute inflammatory Paw Edema models. The anti-inflammatory effects were also supported by using xylene-induced ear Edema model. Results showed that Z. clinopodioides significantly ameliorated rheumatoid arthritis as indicated by the inhibition of arthritic development and Paw Edema. Histopathological examination showed significant attenuation in pannus formation, bone erosion, and joint inflammation. Treatment with the plant extracts also nearly normalized counts of RBCs, platelets, and total leukocytes along with hemoglobin (Hb) content. Biochemical analysis (AST, ALT, urea, and creatinine) showed that plant extracts did not possess hepatotoxic or nephrotoxic effects. Water displacement plethysmometric analysis showed that Z. clinopodioides significantly attenuated carrageenan-induced Paw Edema. To evaluate the mechanism, anti-inflammatory effects were further evaluated using histamine- and serotonin-induced inflammatory Paw Edema models. Z. clinopodioides significantly suppressed Paw Edema induced by both histamine and serotonin, and also caused the inhibition of xylene-induced ear Edema. This suggested the inhibition of autacoids as one of the mechanisms of anti-inflammatory effects of plant. GC–MS analysis showed that the plant is rich in essential oils, including terpenoids, esters, alcohols, furans, cyclic ketones, epoxides, oxanes, and acyclic hydrocarbons. In conclusion, current study demonstrated that Z. clinopodioides possessed significant anti-arthritic and anti-inflammatory properties which might be attributed to the inhibition of autacoids.

Mohammad Miraj - One of the best experts on this subject based on the ideXlab platform.

  • efficacy of curcumin with iontophoretic application on Paw Edema and hematological responses in collagen induced arthritis rat models
    Evidence-based Complementary and Alternative Medicine, 2020
    Co-Authors: Ahmad H Alghadir, Mohammad Miraj
    Abstract:

    Background. According to previous studies, oral administration of curcumin elucidates anti-inflammatory effect irrespective of its poor bioavailability. This study aims to measure the efficacy of lyophilized curcumin extracts with iontophoresis in arthritic rat models. Methods. Lyophilization and characterization of curcumin using the standard HPTLC method was carried out followed by induction of inflammatory arthritis in male albino rats. The animals were then treated with curcumin in three different forms, i.e., oral curcumin (OCU), oral curcumin with topical application (OCU + TOCU), and oral curcumin along with iontophoretically applied curcumin (OCU + IOCU). Various objective variables including body weight, Paw Edema, arthritic scores, and hematological and biochemical parameters, as well as histopathological examinations were conducted. Results. All the curcumin-treated groups showed significant alleviation of arthritic condition ( ) when compared with arthritic controls. Group V (OCU + IOCU) demonstrated maximum therapeutic effect by restoring the body weight, decreasing the Paw Edema, and normalizing the Erythrocyte sedimentation rate and leukocyte count, when compared with other experimental rat groups ( ). Conclusions. Iontophoretic administration of curcumin may ameliorate arthritic symptoms significantly, and the effect is assumed to be due to better penetration and enhanced bioavailability. Geriatrics patients are supposed to be benefited fairly by this technique.