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Jaegook Shin - One of the best experts on this subject based on the ideXlab platform.

  • genetic variants of the organic cation transporter 2 influence the disposition of metformin
    Clinical Pharmacology & Therapeutics, 2008
    Co-Authors: Imsook Song, E J Shim, I S Jung, Jihong Shon, H.j. Shin, Jaegook Shin
    Abstract:

    Genetic variants of the organic cation transporter 2 (protein, OCT2; gene, SLC22A2) were evaluated for their contribution to the variations in the pharmacokinetics of metformin, especially to its renal elimination. Genetic variants of SLC22A2 (c.596C>T, c.602C>T, and c.808G>T) showed significant differences in metformin pharmacokinetics when compared with the reference genotype, with higher Peak Plasma Concentration (Cmax) and area under the curve (AUC) and lower renal clearance (Clrenal), thereby suggesting that a decrease in transport function associated with the SLC22A2 variants results in reduced Clrenal of metformin and consequently leads to increased Plasma Concentrations. Clinical Pharmacology & Therapeutics (2008); 84, 5, 559–562 doi:10.1038/clpt.2008.61

  • genetic variants of the organic cation transporter 2 influence the disposition of metformin
    Clinical Pharmacology & Therapeutics, 2008
    Co-Authors: Imsook Song, E J Shim, I S Jung, Jihong Shon, H.j. Shin, W Y Kim, Jaegook Shin
    Abstract:

    Genetic variants of the organic cation transporter 2 (protein, OCT2; gene, SLC22A2) were evaluated for their contribution to the variations in the pharmacokinetics of metformin, especially to its renal elimination. Genetic variants of SLC22A2 (c.596C>T, c.602C>T, and c.808G>T) showed significant differences in metformin pharmacokinetics when compared with the reference genotype, with higher Peak Plasma Concentration (C(max)) and area under the curve (AUC) and lower renal clearance (Cl(renal)), thereby suggesting that a decrease in transport function associated with the SLC22A2 variants results in reduced Cl(renal) of metformin and consequently leads to increased Plasma Concentrations.

Imsook Song - One of the best experts on this subject based on the ideXlab platform.

  • genetic variants of the organic cation transporter 2 influence the disposition of metformin
    Clinical Pharmacology & Therapeutics, 2008
    Co-Authors: Imsook Song, E J Shim, I S Jung, Jihong Shon, H.j. Shin, Jaegook Shin
    Abstract:

    Genetic variants of the organic cation transporter 2 (protein, OCT2; gene, SLC22A2) were evaluated for their contribution to the variations in the pharmacokinetics of metformin, especially to its renal elimination. Genetic variants of SLC22A2 (c.596C>T, c.602C>T, and c.808G>T) showed significant differences in metformin pharmacokinetics when compared with the reference genotype, with higher Peak Plasma Concentration (Cmax) and area under the curve (AUC) and lower renal clearance (Clrenal), thereby suggesting that a decrease in transport function associated with the SLC22A2 variants results in reduced Clrenal of metformin and consequently leads to increased Plasma Concentrations. Clinical Pharmacology & Therapeutics (2008); 84, 5, 559–562 doi:10.1038/clpt.2008.61

  • genetic variants of the organic cation transporter 2 influence the disposition of metformin
    Clinical Pharmacology & Therapeutics, 2008
    Co-Authors: Imsook Song, E J Shim, I S Jung, Jihong Shon, H.j. Shin, W Y Kim, Jaegook Shin
    Abstract:

    Genetic variants of the organic cation transporter 2 (protein, OCT2; gene, SLC22A2) were evaluated for their contribution to the variations in the pharmacokinetics of metformin, especially to its renal elimination. Genetic variants of SLC22A2 (c.596C>T, c.602C>T, and c.808G>T) showed significant differences in metformin pharmacokinetics when compared with the reference genotype, with higher Peak Plasma Concentration (C(max)) and area under the curve (AUC) and lower renal clearance (Cl(renal)), thereby suggesting that a decrease in transport function associated with the SLC22A2 variants results in reduced Cl(renal) of metformin and consequently leads to increased Plasma Concentrations.

Tero Alakokko - One of the best experts on this subject based on the ideXlab platform.

  • pharmacokinetics of 0 5 levobupivacaine following ilioinguinal iliohypogastric nerve blockade in children
    Acta Anaesthesiologica Scandinavica, 2005
    Co-Authors: Tero Alakokko, E Raiha, J Karinen, Kai Kiviluoma, S Alahuhta
    Abstract:

    Background:  Bupivacaine (2 mg kg−1) has been recommended for blockade of the ilioinguinal and iliohypogastric nerves in paediatric patients undergoing inguinal surgery. We determined the Plasma Concentrations of levobupivacaine following ilioinguinal-iliohypogastric block. Methods:  Twenty children scheduled for elective surgery for inguinal surgery received 2 mg kg−1 of 0.5% levobupivacaine. Surgical anaesthesia was maintained with mask inhalation of oxygen, nitrous oxide and sevoflurane. Venous blood samples were drawn at regular intervals up to 2 h and Plasma was separated. Total venous Plasma Concentrations were determined by gas chromatography. Bupivacaine Concentrations from a study with a similar protocol were used as historical controls for comparison. Results:  The groups were similar with respect to age, weight and dosage of local anaesthetic. The initial distribution half-time (Talpha), the Peak Plasma Concentration (Cmax) achieved, the time to the Peak Plasma Concentration were similar (Tmax), and the mean areas under the Concentration time curve (AUC) were similar between the two local anaesthetics. Conclusions:  Levobupivacaine and bupivacaine are equally absorbed to similar maximum Concentrations.

  • pharmacokinetics of 0 75 ropivacaine and 0 5 bupivacaine after ilioinguinal iliohypogastric nerve block in children
    BJA: British Journal of Anaesthesia, 2002
    Co-Authors: Tero Alakokko, E Raiha, J Karinen, Kai Kiviluoma, S Alahuhta
    Abstract:

    Background. Blockade of the ilioinguinal and iliohypogastric nerves is a useful procedure in paediatric patients undergoing inguinal surgery. Bupivacaine 2 mg kg~ has been recommended for this block. We compared the Plasma Concentrations of ropivacaine and bupivacaine following an ilioinguinal—iliohypogastric block. Methods. Forty children scheduled for elective inguinal surgery were randomized to receive 2 mg kg" 1 of either 0.75% ropivacaine or 0.5% bupivacaine. Surgical anaesthesia was maintained with mask inhalation of oxygen, nitrous oxide and sevoflurane. Venous blood samples were drawn at regular intervals for up to 2 h and Plasma was separated. Total venous Plasma Concentrations were determined by gas chromatography. Results. The groups were similar with respect to age, weight and dose of local anaesthetic. The Peak Plasma Concentration achieved was significantly higher in the bupivacaine group compared with the ropivacaine group (2.2 vs 1.2 jug ml" 1 , P=0.025). The time to Peak Plasma Concentration was significantly shorter in the bupivacaine group (24 vs 35 min, P=0.024). The initial distribution half time of bupivacaine was significantly shorter (3.6 vs 6.5 min, P=0.020) compared with that of ropivacaine. Conclusions. Bupivacaine is more rapidly absorbed from the injection site and leads to higher Plasma Concentrations than ropivacaine. Brj'Anaesth 2002; 89: 438-41

S Alahuhta - One of the best experts on this subject based on the ideXlab platform.

  • pharmacokinetics of 0 5 levobupivacaine following ilioinguinal iliohypogastric nerve blockade in children
    Acta Anaesthesiologica Scandinavica, 2005
    Co-Authors: Tero Alakokko, E Raiha, J Karinen, Kai Kiviluoma, S Alahuhta
    Abstract:

    Background:  Bupivacaine (2 mg kg−1) has been recommended for blockade of the ilioinguinal and iliohypogastric nerves in paediatric patients undergoing inguinal surgery. We determined the Plasma Concentrations of levobupivacaine following ilioinguinal-iliohypogastric block. Methods:  Twenty children scheduled for elective surgery for inguinal surgery received 2 mg kg−1 of 0.5% levobupivacaine. Surgical anaesthesia was maintained with mask inhalation of oxygen, nitrous oxide and sevoflurane. Venous blood samples were drawn at regular intervals up to 2 h and Plasma was separated. Total venous Plasma Concentrations were determined by gas chromatography. Bupivacaine Concentrations from a study with a similar protocol were used as historical controls for comparison. Results:  The groups were similar with respect to age, weight and dosage of local anaesthetic. The initial distribution half-time (Talpha), the Peak Plasma Concentration (Cmax) achieved, the time to the Peak Plasma Concentration were similar (Tmax), and the mean areas under the Concentration time curve (AUC) were similar between the two local anaesthetics. Conclusions:  Levobupivacaine and bupivacaine are equally absorbed to similar maximum Concentrations.

  • pharmacokinetics of 0 75 ropivacaine and 0 5 bupivacaine after ilioinguinal iliohypogastric nerve block in children
    BJA: British Journal of Anaesthesia, 2002
    Co-Authors: Tero Alakokko, E Raiha, J Karinen, Kai Kiviluoma, S Alahuhta
    Abstract:

    Background. Blockade of the ilioinguinal and iliohypogastric nerves is a useful procedure in paediatric patients undergoing inguinal surgery. Bupivacaine 2 mg kg~ has been recommended for this block. We compared the Plasma Concentrations of ropivacaine and bupivacaine following an ilioinguinal—iliohypogastric block. Methods. Forty children scheduled for elective inguinal surgery were randomized to receive 2 mg kg" 1 of either 0.75% ropivacaine or 0.5% bupivacaine. Surgical anaesthesia was maintained with mask inhalation of oxygen, nitrous oxide and sevoflurane. Venous blood samples were drawn at regular intervals for up to 2 h and Plasma was separated. Total venous Plasma Concentrations were determined by gas chromatography. Results. The groups were similar with respect to age, weight and dose of local anaesthetic. The Peak Plasma Concentration achieved was significantly higher in the bupivacaine group compared with the ropivacaine group (2.2 vs 1.2 jug ml" 1 , P=0.025). The time to Peak Plasma Concentration was significantly shorter in the bupivacaine group (24 vs 35 min, P=0.024). The initial distribution half time of bupivacaine was significantly shorter (3.6 vs 6.5 min, P=0.020) compared with that of ropivacaine. Conclusions. Bupivacaine is more rapidly absorbed from the injection site and leads to higher Plasma Concentrations than ropivacaine. Brj'Anaesth 2002; 89: 438-41

Jihong Shon - One of the best experts on this subject based on the ideXlab platform.

  • genetic variants of the organic cation transporter 2 influence the disposition of metformin
    Clinical Pharmacology & Therapeutics, 2008
    Co-Authors: Imsook Song, E J Shim, I S Jung, Jihong Shon, H.j. Shin, Jaegook Shin
    Abstract:

    Genetic variants of the organic cation transporter 2 (protein, OCT2; gene, SLC22A2) were evaluated for their contribution to the variations in the pharmacokinetics of metformin, especially to its renal elimination. Genetic variants of SLC22A2 (c.596C>T, c.602C>T, and c.808G>T) showed significant differences in metformin pharmacokinetics when compared with the reference genotype, with higher Peak Plasma Concentration (Cmax) and area under the curve (AUC) and lower renal clearance (Clrenal), thereby suggesting that a decrease in transport function associated with the SLC22A2 variants results in reduced Clrenal of metformin and consequently leads to increased Plasma Concentrations. Clinical Pharmacology & Therapeutics (2008); 84, 5, 559–562 doi:10.1038/clpt.2008.61

  • genetic variants of the organic cation transporter 2 influence the disposition of metformin
    Clinical Pharmacology & Therapeutics, 2008
    Co-Authors: Imsook Song, E J Shim, I S Jung, Jihong Shon, H.j. Shin, W Y Kim, Jaegook Shin
    Abstract:

    Genetic variants of the organic cation transporter 2 (protein, OCT2; gene, SLC22A2) were evaluated for their contribution to the variations in the pharmacokinetics of metformin, especially to its renal elimination. Genetic variants of SLC22A2 (c.596C>T, c.602C>T, and c.808G>T) showed significant differences in metformin pharmacokinetics when compared with the reference genotype, with higher Peak Plasma Concentration (C(max)) and area under the curve (AUC) and lower renal clearance (Cl(renal)), thereby suggesting that a decrease in transport function associated with the SLC22A2 variants results in reduced Cl(renal) of metformin and consequently leads to increased Plasma Concentrations.