The Experts below are selected from a list of 21 Experts worldwide ranked by ideXlab platform
Raffaele Ferri - One of the best experts on this subject based on the ideXlab platform.
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comparison between oral ferrous sulfate and intravenous ferric carboxymaltose in children with restless Sleep Disorder
Sleep, 2021Co-Authors: Lourdes M. Delrosso, Daniel L. Picchietti, Raffaele FerriAbstract:STUDY OBJECTIVES Recent work has identified clinical and polysomnographic features of a newly defined Pediatric Sleep Disorder, restless Sleep Disorder (RSD). One of these features is low serum ferritin. In this retrospective, pilot study, we assess the response to iron supplementation. Children were given oral ferrous sulfate (FS) or intravenous ferric carboxymaltose (IV FCM). METHODS Children 5-18 years old with a diagnosis of RSD were evaluated clinically. Serum ferritin, iron profile, and video-polysomnography were obtained at baseline. Oral or IV iron supplementation was offered as part of routine care. Oral FS was one 325 mg tablet daily or 3 mg/kg/day liquid for 3 months. IV FCM was 15 mg/kg, up to 750 mg as a single infusion. Adverse effects were assessed. Ferritin and iron profile were checked after 2-3 months. Eight weeks after FCM, the phosphorus level was checked. Clinical Global Impression (CGI) scale was obtained pre- and posttreatment. RESULTS A total of 15 children received oral FS and 15 IV FCM. Baseline RSD severity, age, gender, or pretreatment lab values did not differ significantly between groups. CGI-improvement median score was "minimally improved" after oral FS and "much improved" after IV FCM (effect size 1.008, p < 0.023). All iron parameters were found to be significantly higher after intravenous iron treatment than oral iron, especially ferritin (effect size 3.743, p < 0.00003). Adverse effects: constipation, three with FS; noncompliance, one with FS; syncope, one with FCM infusion; and hypophosphatemia, zero post-FCM. CONCLUSIONS In this retrospective, clinical case series, RSD responded to iron supplementation with improvement in both clinical and laboratory parameters. The response was greater with IV FCM than oral FS.
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Restless Sleep Disorder, restless legs syndrome, and periodic limb movement Disorder-Sleep in motion!
Pediatric pulmonology, 2021Co-Authors: Lourdes M. Delrosso, Maria Paola Mogavero, Raffaele FerriAbstract:Sleep-related movement Disorders (SRMDs) represent an important part of Pediatric Sleep Disorders. The most common complaint in SRMD is restless Sleep at night. Restless Sleep is reported in up to 80% of children with restless legs syndrome (RLS) and children with periodic limb movements of Sleep (PLMS) Disorder (PLMD). However, restless Sleep causing daytime behavioral consequences can be seen in children without another apparent condition and has recently been identified as a new independent primary Pediatric Sleep Disorder, called restless Sleep Disorder (RSD). This study describes these three main SRMDs (RSD, RLS, and PLMD), explains the new consensus criteria for RSD, emphasizes the rapidly evolving areas of research in this field, and proposes recommendations for future research. In particular, the published data constitute convincing evidence that Sleep-related movements are disruptors of Sleep quality and continuity. However, while important advancements have recently been reported in adults, a detailed analysis of the phenomenology and consequences of Sleep-related movements has just started in children. New approaches, standardized diagnostic methods, and specific guidelines are needed in the field of Pediatric SRMD.
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Consensus diagnostic criteria for a newly defined Pediatric Sleep Disorder: restless Sleep Disorder (RSD).
Sleep medicine, 2020Co-Authors: Lourdes M. Delrosso, Raffaele Ferri, Richard P. Allen, Oliviero Bruni, Diego Garcia-borreguero, Suresh Kotagal, Judith A. Owens, Patricio Peirano, Narong Simakajornboon, Daniel L. PicchiettiAbstract:Abstract Background Restless Sleep is a frequent complaint in clinical practice and has been reported in the medical literature since the 1970s. Most often, it has been described in association with specific Sleep or medical conditions. However, more recently, publications have emerged that describe a Disorder characterized by restless Sleep as the core feature. To assess this further, the International Restless Legs Syndrome Study Group (IRLSSG) appointed a task force composed of international Sleep experts. Methods A committee of 10 Sleep clinicians developed a set of 16 consensus questions to review, conducted a comprehensive literature search, and extensively discussed potential diagnostic criteria. The committee recommendations were reviewed and endorsed by the IRLSSG Executive Committee. Results Based on the medical literature and expert clinical experience, the task force found sufficient evidence to formulate diagnostic criteria for a clinical entity designated “restless Sleep Disorder” (RSD). Eight essential criteria were agreed upon, which include a complaint of restless Sleep, observed large body movements during Sleep, video-polysomnographic documentation of 5 or more large body movements/hour, occurrence at least three times a week for at least three months, clinically significant impairment, and differentiation from other conditions that might secondarily cause restless Sleep. However, the current evidence limits application to ages 6-18 years. Diagnostic coding, addition to existing diagnostic nosologies, and name selection are discussed. Conclusions Consensus diagnostic criteria for RSD have been developed, which are intended to improve clinical practice and promote further research.
Lourdes M. Delrosso - One of the best experts on this subject based on the ideXlab platform.
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comparison between oral ferrous sulfate and intravenous ferric carboxymaltose in children with restless Sleep Disorder
Sleep, 2021Co-Authors: Lourdes M. Delrosso, Daniel L. Picchietti, Raffaele FerriAbstract:STUDY OBJECTIVES Recent work has identified clinical and polysomnographic features of a newly defined Pediatric Sleep Disorder, restless Sleep Disorder (RSD). One of these features is low serum ferritin. In this retrospective, pilot study, we assess the response to iron supplementation. Children were given oral ferrous sulfate (FS) or intravenous ferric carboxymaltose (IV FCM). METHODS Children 5-18 years old with a diagnosis of RSD were evaluated clinically. Serum ferritin, iron profile, and video-polysomnography were obtained at baseline. Oral or IV iron supplementation was offered as part of routine care. Oral FS was one 325 mg tablet daily or 3 mg/kg/day liquid for 3 months. IV FCM was 15 mg/kg, up to 750 mg as a single infusion. Adverse effects were assessed. Ferritin and iron profile were checked after 2-3 months. Eight weeks after FCM, the phosphorus level was checked. Clinical Global Impression (CGI) scale was obtained pre- and posttreatment. RESULTS A total of 15 children received oral FS and 15 IV FCM. Baseline RSD severity, age, gender, or pretreatment lab values did not differ significantly between groups. CGI-improvement median score was "minimally improved" after oral FS and "much improved" after IV FCM (effect size 1.008, p < 0.023). All iron parameters were found to be significantly higher after intravenous iron treatment than oral iron, especially ferritin (effect size 3.743, p < 0.00003). Adverse effects: constipation, three with FS; noncompliance, one with FS; syncope, one with FCM infusion; and hypophosphatemia, zero post-FCM. CONCLUSIONS In this retrospective, clinical case series, RSD responded to iron supplementation with improvement in both clinical and laboratory parameters. The response was greater with IV FCM than oral FS.
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Restless Sleep Disorder, restless legs syndrome, and periodic limb movement Disorder-Sleep in motion!
Pediatric pulmonology, 2021Co-Authors: Lourdes M. Delrosso, Maria Paola Mogavero, Raffaele FerriAbstract:Sleep-related movement Disorders (SRMDs) represent an important part of Pediatric Sleep Disorders. The most common complaint in SRMD is restless Sleep at night. Restless Sleep is reported in up to 80% of children with restless legs syndrome (RLS) and children with periodic limb movements of Sleep (PLMS) Disorder (PLMD). However, restless Sleep causing daytime behavioral consequences can be seen in children without another apparent condition and has recently been identified as a new independent primary Pediatric Sleep Disorder, called restless Sleep Disorder (RSD). This study describes these three main SRMDs (RSD, RLS, and PLMD), explains the new consensus criteria for RSD, emphasizes the rapidly evolving areas of research in this field, and proposes recommendations for future research. In particular, the published data constitute convincing evidence that Sleep-related movements are disruptors of Sleep quality and continuity. However, while important advancements have recently been reported in adults, a detailed analysis of the phenomenology and consequences of Sleep-related movements has just started in children. New approaches, standardized diagnostic methods, and specific guidelines are needed in the field of Pediatric SRMD.
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Consensus diagnostic criteria for a newly defined Pediatric Sleep Disorder: restless Sleep Disorder (RSD).
Sleep medicine, 2020Co-Authors: Lourdes M. Delrosso, Raffaele Ferri, Richard P. Allen, Oliviero Bruni, Diego Garcia-borreguero, Suresh Kotagal, Judith A. Owens, Patricio Peirano, Narong Simakajornboon, Daniel L. PicchiettiAbstract:Abstract Background Restless Sleep is a frequent complaint in clinical practice and has been reported in the medical literature since the 1970s. Most often, it has been described in association with specific Sleep or medical conditions. However, more recently, publications have emerged that describe a Disorder characterized by restless Sleep as the core feature. To assess this further, the International Restless Legs Syndrome Study Group (IRLSSG) appointed a task force composed of international Sleep experts. Methods A committee of 10 Sleep clinicians developed a set of 16 consensus questions to review, conducted a comprehensive literature search, and extensively discussed potential diagnostic criteria. The committee recommendations were reviewed and endorsed by the IRLSSG Executive Committee. Results Based on the medical literature and expert clinical experience, the task force found sufficient evidence to formulate diagnostic criteria for a clinical entity designated “restless Sleep Disorder” (RSD). Eight essential criteria were agreed upon, which include a complaint of restless Sleep, observed large body movements during Sleep, video-polysomnographic documentation of 5 or more large body movements/hour, occurrence at least three times a week for at least three months, clinically significant impairment, and differentiation from other conditions that might secondarily cause restless Sleep. However, the current evidence limits application to ages 6-18 years. Diagnostic coding, addition to existing diagnostic nosologies, and name selection are discussed. Conclusions Consensus diagnostic criteria for RSD have been developed, which are intended to improve clinical practice and promote further research.
Trupti Rao - One of the best experts on this subject based on the ideXlab platform.
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Pediatric Sleep Disorders and special educational need at 8 years a population based cohort study
Pediatrics, 2012Co-Authors: Karen A Bonuck, Trupti RaoAbstract:OBJECTIVES: To examine associations between Sleep-Disordered breathing (SDB) and behavioral Sleep problems (BSPs) through 5 years of age and special educational need (SEN) at 8 years. METHODS: Parents in the Avon Longitudinal Study of Parents and Children reported on children’s snoring, witnessed apnea, and mouth-breathing at 6, 18, 30, 42, and 57 months, from which SDB symptom trajectories, or clusters, were derived. BSPs were based on report of ≥5 of 7 Sleep behaviors at each of the 18-, 30-, 42-, and 57-month questionnaires. Parent report of SEN (yes/no) at 8 years was available for 11 049 children with SDB data and 11 467 children with BSP data. Multivariable logistic regression models were used to predict SEN outcome by SDB cluster and by cumulative report of SEN. RESULTS: Controlling for 16 putative confounders, previous history of SDB and BSPs was significantly associated with an SEN. BSPs were associated with a 7% increased odds of SEN (95% confidence interval [CI] 1.01–1.15), for each ∼1-year interval at which a BSP was reported. SDB, overall, was associated with a near 40% increased odds of SEN (95% CI 1.18–1.62). Children in the worst symptom cluster were 60% more likely to have an SEN (95% CI 1.23–2.08). CONCLUSIONS: In this population-based longitudinal study, history of either SDB or BSPs in the first 5 years of life was associated with increased likelihood of SEN at 8 years of age. Findings highlight the need for Pediatric Sleep Disorder screening by early interventionists, early childhood educators, and health professionals.
Karen A Bonuck - One of the best experts on this subject based on the ideXlab platform.
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Pediatric Sleep Disorders and special educational need at 8 years a population based cohort study
Pediatrics, 2012Co-Authors: Karen A Bonuck, Trupti RaoAbstract:OBJECTIVES: To examine associations between Sleep-Disordered breathing (SDB) and behavioral Sleep problems (BSPs) through 5 years of age and special educational need (SEN) at 8 years. METHODS: Parents in the Avon Longitudinal Study of Parents and Children reported on children’s snoring, witnessed apnea, and mouth-breathing at 6, 18, 30, 42, and 57 months, from which SDB symptom trajectories, or clusters, were derived. BSPs were based on report of ≥5 of 7 Sleep behaviors at each of the 18-, 30-, 42-, and 57-month questionnaires. Parent report of SEN (yes/no) at 8 years was available for 11 049 children with SDB data and 11 467 children with BSP data. Multivariable logistic regression models were used to predict SEN outcome by SDB cluster and by cumulative report of SEN. RESULTS: Controlling for 16 putative confounders, previous history of SDB and BSPs was significantly associated with an SEN. BSPs were associated with a 7% increased odds of SEN (95% confidence interval [CI] 1.01–1.15), for each ∼1-year interval at which a BSP was reported. SDB, overall, was associated with a near 40% increased odds of SEN (95% CI 1.18–1.62). Children in the worst symptom cluster were 60% more likely to have an SEN (95% CI 1.23–2.08). CONCLUSIONS: In this population-based longitudinal study, history of either SDB or BSPs in the first 5 years of life was associated with increased likelihood of SEN at 8 years of age. Findings highlight the need for Pediatric Sleep Disorder screening by early interventionists, early childhood educators, and health professionals.
Daniel L. Picchietti - One of the best experts on this subject based on the ideXlab platform.
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comparison between oral ferrous sulfate and intravenous ferric carboxymaltose in children with restless Sleep Disorder
Sleep, 2021Co-Authors: Lourdes M. Delrosso, Daniel L. Picchietti, Raffaele FerriAbstract:STUDY OBJECTIVES Recent work has identified clinical and polysomnographic features of a newly defined Pediatric Sleep Disorder, restless Sleep Disorder (RSD). One of these features is low serum ferritin. In this retrospective, pilot study, we assess the response to iron supplementation. Children were given oral ferrous sulfate (FS) or intravenous ferric carboxymaltose (IV FCM). METHODS Children 5-18 years old with a diagnosis of RSD were evaluated clinically. Serum ferritin, iron profile, and video-polysomnography were obtained at baseline. Oral or IV iron supplementation was offered as part of routine care. Oral FS was one 325 mg tablet daily or 3 mg/kg/day liquid for 3 months. IV FCM was 15 mg/kg, up to 750 mg as a single infusion. Adverse effects were assessed. Ferritin and iron profile were checked after 2-3 months. Eight weeks after FCM, the phosphorus level was checked. Clinical Global Impression (CGI) scale was obtained pre- and posttreatment. RESULTS A total of 15 children received oral FS and 15 IV FCM. Baseline RSD severity, age, gender, or pretreatment lab values did not differ significantly between groups. CGI-improvement median score was "minimally improved" after oral FS and "much improved" after IV FCM (effect size 1.008, p < 0.023). All iron parameters were found to be significantly higher after intravenous iron treatment than oral iron, especially ferritin (effect size 3.743, p < 0.00003). Adverse effects: constipation, three with FS; noncompliance, one with FS; syncope, one with FCM infusion; and hypophosphatemia, zero post-FCM. CONCLUSIONS In this retrospective, clinical case series, RSD responded to iron supplementation with improvement in both clinical and laboratory parameters. The response was greater with IV FCM than oral FS.
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Consensus diagnostic criteria for a newly defined Pediatric Sleep Disorder: restless Sleep Disorder (RSD).
Sleep medicine, 2020Co-Authors: Lourdes M. Delrosso, Raffaele Ferri, Richard P. Allen, Oliviero Bruni, Diego Garcia-borreguero, Suresh Kotagal, Judith A. Owens, Patricio Peirano, Narong Simakajornboon, Daniel L. PicchiettiAbstract:Abstract Background Restless Sleep is a frequent complaint in clinical practice and has been reported in the medical literature since the 1970s. Most often, it has been described in association with specific Sleep or medical conditions. However, more recently, publications have emerged that describe a Disorder characterized by restless Sleep as the core feature. To assess this further, the International Restless Legs Syndrome Study Group (IRLSSG) appointed a task force composed of international Sleep experts. Methods A committee of 10 Sleep clinicians developed a set of 16 consensus questions to review, conducted a comprehensive literature search, and extensively discussed potential diagnostic criteria. The committee recommendations were reviewed and endorsed by the IRLSSG Executive Committee. Results Based on the medical literature and expert clinical experience, the task force found sufficient evidence to formulate diagnostic criteria for a clinical entity designated “restless Sleep Disorder” (RSD). Eight essential criteria were agreed upon, which include a complaint of restless Sleep, observed large body movements during Sleep, video-polysomnographic documentation of 5 or more large body movements/hour, occurrence at least three times a week for at least three months, clinically significant impairment, and differentiation from other conditions that might secondarily cause restless Sleep. However, the current evidence limits application to ages 6-18 years. Diagnostic coding, addition to existing diagnostic nosologies, and name selection are discussed. Conclusions Consensus diagnostic criteria for RSD have been developed, which are intended to improve clinical practice and promote further research.