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Mengsu Zeng - One of the best experts on this subject based on the ideXlab platform.
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mri features to differentiate between Peliosis Hepatis and hepatic metastases following chemotherapy for gastrointestinal adenocarcinoma
Chinese Journal of Hepatobiliary Surgery, 2019Co-Authors: Zhijian Liu, Tingting Geng, Mingliang Wang, Rongkui Luo, Guang Dong, Hai Geng, Mengsu ZengAbstract:Objective To compare the MRI features of Peliosis Hepatis and hepatic metastases following chemotherapy for gastrointestinal adenocarcinoma with the aim to improve the differential diagnosis. Methods The clinical data of 33 patients with gastrointestinal adenocarcinoma treated from June 2014 to December 2017 at Zhongshan Hospital of Fudan University were retrospectively analyzed. Of the 26 males and 7 females aged (56.0±9.8) years, there were 11 patients with Peliosis Hepatis and 22 patients with hepatic metastases following chemotherapy in these patients. All patients underwent contrast-enhanced abdominal MRI scans. The differences in the MRI features, including morphology, margin, signal intensity on plain scanning and enhancement patterns were compared statistically. The apparent diffusion coefficient (ADC) values of Peliosis Hepatis, hepatic metastases and adjacent hepatic parenchyma were measured in an ADC map. Results In 14 lesions of the 11 patients with Peliosis Hepatis, 10 lesions were ill-defined and 4 lesions were well-defined. In 31 lesions of the 22 patients with hepatic metastases, 5 lesions were ill-defined and 26 lesions were well-defined. Significant differences existed between Peliosis Hepatis and hepatic metastases in the margin (P<0.05). The ADC value of hepatic metastases was significantly lower than that of Peliosis Hepatis and the adjacent hepatic parenchyma (P<0.05). In all the 14 lesions of Peliosis Hepatis, 10 lesions showed gradual filling enhancement, and 4 lesions showed marked and persistent enhancement. In all the 31 lesions of hepatic metastases, 28 lesions showed a ring-shaped enhancement, and 3 lesions showed "quick in and quick out" enhancement. Conclusions The lesions of Peliosis Hepatis following chemotherapy for gastrointestinal adenocarcinoma were ill-defined, with no restriction of water diffusion in the diffusion weighted imagings, and with progressive enhancement. The MRI manifestations of Peliosis Hepatis helped to differentiate Peliosis Hepatis from hepatic metastases of gastrointestinal adenocarcinoma. Key words: Stomach neoplasms; Colorectal neoplasms; Magnetic resonance imaging; Peliosis Hepatis; Hepatic metastases
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MRI features to differentiate between Peliosis Hepatis and hepatic metastases following chemotherapy for gastrointestinal adenocarcinoma
Chinese Journal of Hepatobiliary Surgery, 2019Co-Authors: Zhijian Liu, Tingting Geng, Mingliang Wang, Rongkui Luo, Guang Dong, Hai Geng, Mengsu ZengAbstract:Objective To compare the MRI features of Peliosis Hepatis and hepatic metastases following chemotherapy for gastrointestinal adenocarcinoma with the aim to improve the differential diagnosis. Methods The clinical data of 33 patients with gastrointestinal adenocarcinoma treated from June 2014 to December 2017 at Zhongshan Hospital of Fudan University were retrospectively analyzed. Of the 26 males and 7 females aged (56.0±9.8) years, there were 11 patients with Peliosis Hepatis and 22 patients with hepatic metastases following chemotherapy in these patients. All patients underwent contrast-enhanced abdominal MRI scans. The differences in the MRI features, including morphology, margin, signal intensity on plain scanning and enhancement patterns were compared statistically. The apparent diffusion coefficient (ADC) values of Peliosis Hepatis, hepatic metastases and adjacent hepatic parenchyma were measured in an ADC map. Results In 14 lesions of the 11 patients with Peliosis Hepatis, 10 lesions were ill-defined and 4 lesions were well-defined. In 31 lesions of the 22 patients with hepatic metastases, 5 lesions were ill-defined and 26 lesions were well-defined. Significant differences existed between Peliosis Hepatis and hepatic metastases in the margin (P
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magnetic resonance imaging and diffusion weighted imaging features of focal Peliosis Hepatis
National Medical Journal of China, 2019Co-Authors: Zhijian Liu, Tingting Geng, Mingliang Wang, Guang Dong, Jiamei Yao, Mengsu ZengAbstract:Objective To investigate the MRI and diffusion weighted imaging (DWI) features of focal Peliosis Hepatis. Methods The clinical data and MRI of 19 cases with focal Peliosis Hepatis confirmed by pathology from January 2012 to March 2018 in Zhongshan Hospital of Fudan University were retrospectively analyzed. The number, location, size, shape, signal intensity of plain scan of lesions, enhancement pattern of lesions, vessels within lesions, and perfusion disorders of hepatic parenchyma were analyzed. The apparent diffusion coefficient (ADC) values of the lesions and adjacent hepatic parenchyma were measured, then the differences between them were explored statistically. All 24 lesions were categorized into group A with tumor-related chemotherapy and group B without tumor-related chemotherapy. The differences of MR features between the two groups were explored statistically. Results In all 24 lesions, 22 lesions were located in the right lobe, 2 lesions in the left lobe. The median size was 7.5-72.0 (24.4±17.2) mm.On T1WI,21 lesions showed slightly hypointensity, 1 lesion showed slightly hyperintensity and 2 lesions were isointensity; all 24 lesions showed slightly hyperintensity on T2WI, and isointensity or slightly hyperintensity on DWI. The mean ADC value was (1.511±0.415)×10-3 mm2/s in the lesions and (1.769±0.690)×10-3 mm2/s in the adjacent hepatic parenchyma, which showed no difference between the two groups (P>0.05). On dynamic MR images, 20 lesions showed gradually filling enhancement, 4 lesions showed markedly and persistent enhancement. Punctiform or filiform vessels were found in 9 lesions. Adjacent hepatic perfusion disorders showed in 8 lesions. The median lesion size was 7.5-38.5(17.6±9.8) mm in the tumor-related-chemotherapy group and 9.0-72.0(33.8±21.2) mm in the no chemotherapy group.There was significant difference between the two groups (P<0.05). Conclusions The MRI performance of focal Peliosis Hepatis had a certain characteristic. MRI combined with diffusion weighted imaging could help to make diagnoses. Key words: Diffusion magnetic resonance imaging; Peliosis Hepatis
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MRI features of Peliosis Hepatis
Chinese journal of radiology, 2018Co-Authors: Binqi Lou, Mingliang Wang, Jiamei Yao, Mengsu ZengAbstract:Objective To investigate the MRI features of Peliosis Hepatis (PH). Methods Nine patients with pathologically proven PH were retrospectively included. Plain scan and contrast-enhanced MRI of the abdomen were performed on all patients before operation. All clinical, pathological and MR imaging data of patients were collected. The MR image analysis of the lesion included the number, location, size, shape, lesion margins, signal intensity, and enhancement pattern. Results Eleven lesions were detected in 9 patients, with 10 lesions in the right lobe of the liver and 1 lesion in the left lobe. The maximum diameter of the 11 lesions was 0.7 cm to 8.8 cm (mean 3.7 cm). All 11 lesions were round or oval in the shape. Seven lesions had clear boundaries and 4 lesions had blurred boundaries. Signal intensity of 2 lesions were homogeneous, while 9 lesions had heterogenous signal intensity on plain san. Ten lesions showed slightly hypointense on T1WI, slightly hyperintense on T2WI and mildly progressive enhancement. These lesions were weakly enhanced and showed slight cluster-like mild enhancement in the arterial phase. The enhancement scope of the lesions gradually filled into the interior in the portal vein phase and the signal intensity was slightly higher than liver in delay phase. One lesion showed hypointense on T1WI and hyperintensity on T2WI. After the enhancement, the lesion was evenly enhanced and showed continuous enhancement. On DWI, 11 lesions were slightly hyperintense. The signal intensity of 9 lesions were equal to that of the liver, and the signal intensity of the 2 lesions was slightly higher than that of the liver on the ADC map. Conclusion MRI signs of PH have certain characteristics, which can help diagnosis and differential diagnosis. Key words: Peliosis Hepatis; Magnetic resonance imaging; Pathology
Jong Jin Lee - One of the best experts on this subject based on the ideXlab platform.
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Peliosis Hepatis shows isometabolism on 18 f fdg pet ct two case reports
Nuclear Medicine and Molecular Imaging, 2014Co-Authors: Minjung Seo, Suk Hyun Lee, Sangwon Han, Changhwan Sung, Da Hye Son, Jong Jin LeeAbstract:Peliosis Hepatis (PH) is a rare benign disease that is characterized by multiple blood-filled cystic spaces in the hepatic parenchyma. It is also characterized by a range of radiologic findings that might mimic various diseases, including metastatic liver disease and hepatocellular carcinoma. The findings of PH on 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) are not well reported. We here report two cases of biopsy-proven PH. Both patients had been treated for cancer (advanced gastric carcinoma and rectal adenocarcinoma), and follow-up CT of both cases revealed hepatic lesions with the possibility of metastasis. Examination of 18F-FDG PET/CT images suggested that the lesions were isometabolic, having metabolism similar to that of adjacent hepatic parenchyma. The outcomes of hepatic core-needle biopsies were consistent with Peliosis Hepatis.
G Fechner - One of the best experts on this subject based on the ideXlab platform.
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fatal hepatic haemorrhage in a child Peliosis Hepatis versus maltreatment
International Journal of Legal Medicine, 2005Co-Authors: B Karger, K Varchminschultheis, G FechnerAbstract:A 2.5-year-old boy with known myotubular myopathy (Spiro-Shy-Gonatas syndrome) and gonadorelin intake 9 months ante-mortem was found dead in his bed at home. At autopsy a ruptured subcapsular haematoma of the liver with resulting haemoperitoneum (600 ml) was found. Both lobes of the liver showed numerous circular blood foci <1 mm–2 cm in diameter. Signs of mechanical trauma such as bruising of the abdominal wall were absent. Histologically, the blood cysts were commonly connected to the sinusoids but did not have an endothelial lining and the reticular fibres showed ruptures. These pathomorphological findings are characteristic for Peliosis Hepatis and the cause of death was therefore determined to be exsanguination due to hepatic haemorrhage from Peliosis Hepatis instead of from mechanical trauma. To our knowledge this is the youngest casualty from Peliosis reported so far.
Minjung Seo - One of the best experts on this subject based on the ideXlab platform.
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Peliosis Hepatis shows isometabolism on 18 f fdg pet ct two case reports
Nuclear Medicine and Molecular Imaging, 2014Co-Authors: Minjung Seo, Suk Hyun Lee, Sangwon Han, Changhwan Sung, Da Hye Son, Jong Jin LeeAbstract:Peliosis Hepatis (PH) is a rare benign disease that is characterized by multiple blood-filled cystic spaces in the hepatic parenchyma. It is also characterized by a range of radiologic findings that might mimic various diseases, including metastatic liver disease and hepatocellular carcinoma. The findings of PH on 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) are not well reported. We here report two cases of biopsy-proven PH. Both patients had been treated for cancer (advanced gastric carcinoma and rectal adenocarcinoma), and follow-up CT of both cases revealed hepatic lesions with the possibility of metastasis. Examination of 18F-FDG PET/CT images suggested that the lesions were isometabolic, having metabolism similar to that of adjacent hepatic parenchyma. The outcomes of hepatic core-needle biopsies were consistent with Peliosis Hepatis.
B Karger - One of the best experts on this subject based on the ideXlab platform.
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fatal hepatic haemorrhage in a child Peliosis Hepatis versus maltreatment
International Journal of Legal Medicine, 2005Co-Authors: B Karger, K Varchminschultheis, G FechnerAbstract:A 2.5-year-old boy with known myotubular myopathy (Spiro-Shy-Gonatas syndrome) and gonadorelin intake 9 months ante-mortem was found dead in his bed at home. At autopsy a ruptured subcapsular haematoma of the liver with resulting haemoperitoneum (600 ml) was found. Both lobes of the liver showed numerous circular blood foci <1 mm–2 cm in diameter. Signs of mechanical trauma such as bruising of the abdominal wall were absent. Histologically, the blood cysts were commonly connected to the sinusoids but did not have an endothelial lining and the reticular fibres showed ruptures. These pathomorphological findings are characteristic for Peliosis Hepatis and the cause of death was therefore determined to be exsanguination due to hepatic haemorrhage from Peliosis Hepatis instead of from mechanical trauma. To our knowledge this is the youngest casualty from Peliosis reported so far.