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R K Ross - One of the best experts on this subject based on the ideXlab platform.

  • regular use of analgesics is a risk factor for renal cell carcinoma
    British Journal of Cancer, 1999
    Co-Authors: Manuela Gagodominguez, Jianmin Yuan, Jose E Castelao, R K Ross
    Abstract:

    Phenacetin-based analgesics have been linked to the development of renal Pelvis Cancer and renal cell carcinoma (RCC). The relationship between non-phenacetin types of analgesics and kidney Cancer is less clear, although laboratory evidence suggests that these drugs possess carcinogenic potential. A population-based case–control study involving 1204 non-Asian RCC patients aged 25–74 and an equal number of sex-, age- and race-matched neighbourhood controls was conducted in Los Angeles, California, to investigate the relationship between sustained use of analgesics and risk of RCC according to major formulation categories. Detailed information on medical and medication histories, and other lifestyle factors was collected through in-person interviews. Regular use of analgesics was a significant risk factor for RCC in both men and women (odds ratio (OR) = 1.6, 95% confidence interval (CI) = 1.4–1.9 for both sexes combined). Risks were elevated across all four major classes of analgesics (aspirin, non-steroidal anti-inflammatory agents other than aspirin, acetaminophen and phenacetin). Within each class of analgesics, there was statistically significant increasing risk with increasing level of exposure. Although there was some minor variability by major class of formulation, in general individuals in the highest exposure categories exhibited approximately 2.5-fold increase in risk relative to non- or irregular users of analgesics. Subjects who took one regular-strength (i.e. 325 mg) aspirin a day or less for cardiovascular disease prevention were not at an increased risk of RCC (OR = 0.9, 95% CI = 0.6–1.4). © 1999 Cancer Research Campaign

Gopal N Gupta - One of the best experts on this subject based on the ideXlab platform.

  • positive surgical margins in renal cell carcinoma translating tumor biology into clinical outcomes
    American Journal of Clinical Pathology, 2015
    Co-Authors: Maria M Picken, Lu Wang, Gopal N Gupta
    Abstract:

    In the United States, the incidence of small renal masses continues to increase, largely due to the increased use of cross-sectional imaging.1 Thus, Centers for Disease Control and Prevention data from 2011 ranked kidney and renal Pelvis Cancer seventh and ninth among male and female Cancer patients, respectively.1 The National Cancer Institute estimates that there will be 63,920 new cases in 2014.2 Radical nephrectomy (RN) has been the mainstay of treatment for malignant renal masses; however, partial nephrectomy (PN) is now widely accepted as the current “gold standard” for T1 renal masses.3 Although long-term oncologic outcomes are equivalent by both techniques, PN has several advantages.4,5 The widespread adoption of PN came largely from the observation that RN places the patient at substantial risk of progression to chronic renal insufficiency and end-stage renal disease, with consequent increased overall mortality. Nephron-sparing surgery (NSS) not only has a much lower risk of renal failure and its attendant need for dialysis but also provides a significantly better quality of life to the patient.6 This new emphasis has led to the pioneering of surgical advances in NSS that maximize nephron retention through optimization of the precision of PN and the reduction of ischemia time. Nonetheless, the permissible minimal extent of parenchymal margin and the safe warm ischemia time are still actively contested. The optimal surgical technique in elective and imperative NSS has not been established. Wedge resection, enucleoresection within a rim of healthy parenchyma, and pure enucleation all have been used.7 Hence, the issue of optimal margins in NSS is still controversial.8 A distance of 10 mm of uninvolved kidney between the tumor and the surgical margin has been accepted as the norm for NSS5; however, margins of 10 mm may represent an …

Elsebeth Lynge - One of the best experts on this subject based on the ideXlab platform.

Bengt Jarvholm - One of the best experts on this subject based on the ideXlab platform.

  • obesity hypertension and the risk of kidney Cancer in men
    The New England Journal of Medicine, 2000
    Co-Authors: Wong Ho Chow, Gloria Gridley, Joseph F Fraumeni, Bengt Jarvholm
    Abstract:

    Background Obesity and hypertension have been implicated as risk factors for the development of renal-cell Cancer. Methods We examined the health records of 363,992 Swedish men who underwent at least one physical examination from 1971 to 1992 and were followed until death or the end of 1995. Men with Cancer (renal-cell Cancer in 759 and renal-Pelvis Cancer in 136) were identified by cross-linkage of data with the nationwide Swedish Cancer Registry. Poisson regression analysis was used to estimate relative risks, with adjustments for age, smoking status, body-mass index, and diastolic blood pressure. Results As compared with men in the lowest three eighths of the cohort for body-mass index, men in the middle three eighths had a 30 to 60 percent greater risk of renal-cell Cancer, and men in the highest two eighths had nearly double the risk (P for trend, <0.001). There was also a direct association between higher blood pressures and a higher risk of renal-cell Cancer (P for trend, <0.001 for diastolic press...

Manuela Gagodominguez - One of the best experts on this subject based on the ideXlab platform.

  • regular use of analgesics is a risk factor for renal cell carcinoma
    British Journal of Cancer, 1999
    Co-Authors: Manuela Gagodominguez, Jianmin Yuan, Jose E Castelao, R K Ross
    Abstract:

    Phenacetin-based analgesics have been linked to the development of renal Pelvis Cancer and renal cell carcinoma (RCC). The relationship between non-phenacetin types of analgesics and kidney Cancer is less clear, although laboratory evidence suggests that these drugs possess carcinogenic potential. A population-based case–control study involving 1204 non-Asian RCC patients aged 25–74 and an equal number of sex-, age- and race-matched neighbourhood controls was conducted in Los Angeles, California, to investigate the relationship between sustained use of analgesics and risk of RCC according to major formulation categories. Detailed information on medical and medication histories, and other lifestyle factors was collected through in-person interviews. Regular use of analgesics was a significant risk factor for RCC in both men and women (odds ratio (OR) = 1.6, 95% confidence interval (CI) = 1.4–1.9 for both sexes combined). Risks were elevated across all four major classes of analgesics (aspirin, non-steroidal anti-inflammatory agents other than aspirin, acetaminophen and phenacetin). Within each class of analgesics, there was statistically significant increasing risk with increasing level of exposure. Although there was some minor variability by major class of formulation, in general individuals in the highest exposure categories exhibited approximately 2.5-fold increase in risk relative to non- or irregular users of analgesics. Subjects who took one regular-strength (i.e. 325 mg) aspirin a day or less for cardiovascular disease prevention were not at an increased risk of RCC (OR = 0.9, 95% CI = 0.6–1.4). © 1999 Cancer Research Campaign