The Experts below are selected from a list of 282 Experts worldwide ranked by ideXlab platform
Takashi Hashimoto - One of the best experts on this subject based on the ideXlab platform.
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IgG/IgA Pemphigus reactive with desmoglein 1 with additional undetermined reactivity with epidermal basement membrane zone
Indian journal of dermatology venereology and leprology, 2014Co-Authors: Amrinder J. Kanwar, Keshavamurthy Vinay, Uma Nahar Saikia, Hiroshi Koga, Kwesi Teye, Daisuke Tsuruta, Takashi HashimotoAbstract:IgG/IgA Pemphigus is an extremely rare subset of Pemphigus, showing anti-keratinocyte cell surface antibodies of both IgG and IgA classes. Herein, we describe a unique case of IgG/IgA Pemphigus with clinical features of edematous erythema and peripheral vesiculopustules. Histopathology showed the presence of subcorneal pustules and acantholytic blisters in the mid-epidermis with neutrophilic infiltration and eosinophilic spongiosis. Direct immunofluorescence of perilesional skin showed both IgG and IgA deposits to keratinocyte cell surfaces and unusual granular deposits of IgG, IgM, and C3 along basement membrane zone. On enzyme linked immunosorbent assay , the auto-antibodies were found to be reactive to desmoglein 1 antigen. Various clinical, histopathological, and immunological findings in our case overlapped with the features of IgA Pemphigus, Pemphigus herpetiformis, and Pemphigus foliaceus. These findings indicate that IgG/IgA Pemphigus may be a transitional form between IgA Pemphigus and Pemphigus herpetiformis, and thus provides insight into the pathogenicity of this rare disorder.
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igg iga Pemphigus reactive with desmoglein 1 with additional undetermined reactivity with epidermal basement membrane zone
Indian Journal of Dermatology Venereology and Leprology, 2014Co-Authors: Amrinder J. Kanwar, Keshavamurthy Vinay, Uma Nahar Saikia, Hiroshi Koga, Kwesi Teye, Daisuke Tsuruta, Takashi HashimotoAbstract:IgG/IgA Pemphigus is an extremely rare subset of Pemphigus, showing anti-keratinocyte cell surface antibodies of both IgG and IgA classes. Herein, we describe a unique case of IgG/IgA Pemphigus with clinical features of edematous erythema and peripheral vesiculopustules. Histopathology showed the presence of subcorneal pustules and acantholytic blisters in the mid-epidermis with neutrophilic infiltration and eosinophilic spongiosis. Direct immunofluorescence of perilesional skin showed both IgG and IgA deposits to keratinocyte cell surfaces and unusual granular deposits of IgG, IgM, and C3 along basement membrane zone. On enzyme linked immunosorbent assay , the auto-antibodies were found to be reactive to desmoglein 1 antigen. Various clinical, histopathological, and immunological findings in our case overlapped with the features of IgA Pemphigus, Pemphigus herpetiformis, and Pemphigus foliaceus. These findings indicate that IgG/IgA Pemphigus may be a transitional form between IgA Pemphigus and Pemphigus herpetiformis, and thus provides insight into the pathogenicity of this rare disorder.
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a case of igg iga Pemphigus presenting malar rash like erythema
Acta Dermato-venereologica, 2012Co-Authors: Satomi Hosoda, Masayuki Suzuki, Mayumi Komine, Satoru Murata, Takashi Hashimoto, Mamitaro OhtsukiAbstract:Pemphigus is an autoimmune mucocutaneous bullous disease characterized by auto-antibodies against cell surface antigens of epidermal keratinocytes. Pemphigus vulgaris (PV) and Pemphigus foliaceus (PF) are the major subtypes. Several other variants have been proposed, in-cluding Pemphigus erythematosus, Pemphigus vegetans, Pemphigus herpetiformis (PH), and paraneoplastic pem-phigus. Deposition of IgG on epidermal keratinocyte cell surfaces and circulating anti-cell surface antibodies are characteristic in Pemphigus. Cases involving IgA depo-sition on epidermal keratinocyte cell surfaces have been reported as IgA Pemphigus. IgA Pemphigus is divided into 4 subgroups based on clinical manifestation: subcorneal pustular dermatosis type, intraepidermal neutrophilic IgA dermatosis type, Pemphigus foliaceus type, and pemphi-gus vulgaris type. Cases involving deposition of both IgG and IgA on keratinocyte cell surfaces have been reported (1–13). Some authors describe them as IgG/IgA pemphi-gus (1). Seventeen such cases have been reported so far, and heterogeneity of clinical features and target antigen has been detected in this group of Pemphigus. CASe RePoRT
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A Case of IgG/IgA Pemphigus Presenting Malar Rash-like Erythema
Acta dermato-venereologica, 2012Co-Authors: Satomi Hosoda, Masayuki Suzuki, Mayumi Komine, Satoru Murata, Takashi Hashimoto, Mamitaro OhtsukiAbstract:Pemphigus is an autoimmune mucocutaneous bullous disease characterized by auto-antibodies against cell surface antigens of epidermal keratinocytes. Pemphigus vulgaris (PV) and Pemphigus foliaceus (PF) are the major subtypes. Several other variants have been proposed, in-cluding Pemphigus erythematosus, Pemphigus vegetans, Pemphigus herpetiformis (PH), and paraneoplastic pem-phigus. Deposition of IgG on epidermal keratinocyte cell surfaces and circulating anti-cell surface antibodies are characteristic in Pemphigus. Cases involving IgA depo-sition on epidermal keratinocyte cell surfaces have been reported as IgA Pemphigus. IgA Pemphigus is divided into 4 subgroups based on clinical manifestation: subcorneal pustular dermatosis type, intraepidermal neutrophilic IgA dermatosis type, Pemphigus foliaceus type, and pemphi-gus vulgaris type. Cases involving deposition of both IgG and IgA on keratinocyte cell surfaces have been reported (1–13). Some authors describe them as IgG/IgA pemphi-gus (1). Seventeen such cases have been reported so far, and heterogeneity of clinical features and target antigen has been detected in this group of Pemphigus. CASe RePoRT
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Diagnosis and treatment of Pemphigus
Immunotherapy, 2012Co-Authors: Daisuke Tsuruta, Norito Ishii, Takashi HashimotoAbstract:Pemphigus is an autoimmune bullous disease, in which autoantibodies react with the cell-cell adhesion structures, desmosomes, causing blisters and erosions on the oral mucosa and skin. Pemphigus is divided into two major subtypes: Pemphigus vulgaris and Pemphigus foliaceus. Oral corticosteroids are the primary treatment modality for Pemphigus, while other therapeutic options, such as steroid pulse therapy, immunosuppressants, intravenous immunoglobulins, plasmapheresis and anti-CD20 monoclonal antibody therapy, are occasionally employed. Immunosuppressants used to treat Pemphigus include azathioprine, cyclophosphamide, cyclosporine, mycophenolate mofetil and mizoribine. In this review, we summarize the current concepts of immunotherapy for the treatment of Pemphigus in the Japanese population.
T P Chorzelski - One of the best experts on this subject based on the ideXlab platform.
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Unusual acantholytic bullous dermatosis associated with neoplasia and IgG and IgA antibodies against bovine desmocollins I and II.
Journal of the American Academy of Dermatology, 1994Co-Authors: T P Chorzelski, T Hashimoto, T Nishikawa, T Ebihara, M Dmochowski, M Ismail, S JabłońskaAbstract:There are unusual cases of Pemphigus that have antibodies nonreactive with either Pemphigus vulgaris or Pemphigus foliaceus antigens. We describe a patient with an acantholytic bullous dermatosis and lung cancer with intercellular IgG and IgA antibodies that differed in specificity from those of Pemphigus vulgaris and Pemphigus foliaceus and reacted with bovine desmocollins I and II and recombinant desmocollin protein.
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Unusual acantholytic bullous dermatosis associated with neoplasia and IgG and IgA antibodies against bovine desmocollins I and II
Journal of the American Academy of Dermatology, 1994Co-Authors: T P Chorzelski, Takeji Nishikawa, Marian Dmochowski, T Ebihara, M Ismail, Stefania JablonskaAbstract:There are unusual cases of Pemphigus that have antibodies nonreactive with either Pemphigus vulgaris or Pemphigus foliaceus antigens. We describe a patient with an acantholytic bullous dermatosis and lung cancer with intercellular IgG and IgA antibodies that differed in specificity from those of Pemphigus vulgaris and Pemphigus foliaceus and reacted with bovine desmocollins I and II and recombinant desmocollin protein. (J Am Acad Dermatol 1994;31:351-5.)
Takeji Nishikawa - One of the best experts on this subject based on the ideXlab platform.
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Unusual acantholytic bullous dermatosis associated with neoplasia and IgG and IgA antibodies against bovine desmocollins I and II
Journal of the American Academy of Dermatology, 1994Co-Authors: T P Chorzelski, Takeji Nishikawa, Marian Dmochowski, T Ebihara, M Ismail, Stefania JablonskaAbstract:There are unusual cases of Pemphigus that have antibodies nonreactive with either Pemphigus vulgaris or Pemphigus foliaceus antigens. We describe a patient with an acantholytic bullous dermatosis and lung cancer with intercellular IgG and IgA antibodies that differed in specificity from those of Pemphigus vulgaris and Pemphigus foliaceus and reacted with bovine desmocollins I and II and recombinant desmocollin protein. (J Am Acad Dermatol 1994;31:351-5.)
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Desmocollins I and II are recognized by certain sera from patients with various types of Pemphigus, particularly Brazilian Pemphigus foliaceus
The Journal of investigative dermatology, 1993Co-Authors: Marian Dmochowski, David R. Garrod, Takeji NishikawaAbstract:Recently, it has been shown that desmoglein, Pemphigus foliaceus target antigen, and a 130-kD Pemphigus vulgaris antigen belong to the cadherin family of cell adhesion molecules. We tried to determine whether desmocollins I/II, other cadherin-like transmembranous glycoproteins present in desmosomes, are also recognized by Pemphigus autoantibodies of the IgG class. We examined 16 Pemphigus vulgaris sera, 15 Pemphigus foliaceus sera, 15 Brazilian Pemphigus foliaceus sera, five bullous pemphigoid sera, and 65 normal sera. Four (25%) Pemphigus vulgaris sera, one (7%) Pemphigus foliaceus serum, eight (53%) Brazilian Pemphigus foliaceus sera, and three (5%) normal sera reacted with desmocollins I/II on immunoblots of bovine desmosome preparation. The affinity-purified desmocollins I/II Pemphigus autoantibodies were shown to bind the epidermal cell surface by indirect immunofluorescence. Immunoblot analysis revealed one Pemphigus vulgaris serum, one Brazilian Pemphigus foliaceus serum, and one normal serum recognizing a recombinant protein produced by a desmocollin cDNA clone. Moreover, immunoblot analysis of reactivity of a Brazilian Pemphigus foliaceus serum with recombinant proteins produced by deletion mutants of the desmocollin cDNA clone showed that the extracellular portion of desmocollin is immunogenic in this Pemphigus patient. We conclude that desmocollins I/II are recognized by certain sera from patients with various types of Pemphigus, particularly Brazilian Pemphigus foliaceus. However, the significance of this reactivity remains to be defined.
Marian Dmochowski - One of the best experts on this subject based on the ideXlab platform.
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Unusual acantholytic bullous dermatosis associated with neoplasia and IgG and IgA antibodies against bovine desmocollins I and II
Journal of the American Academy of Dermatology, 1994Co-Authors: T P Chorzelski, Takeji Nishikawa, Marian Dmochowski, T Ebihara, M Ismail, Stefania JablonskaAbstract:There are unusual cases of Pemphigus that have antibodies nonreactive with either Pemphigus vulgaris or Pemphigus foliaceus antigens. We describe a patient with an acantholytic bullous dermatosis and lung cancer with intercellular IgG and IgA antibodies that differed in specificity from those of Pemphigus vulgaris and Pemphigus foliaceus and reacted with bovine desmocollins I and II and recombinant desmocollin protein. (J Am Acad Dermatol 1994;31:351-5.)
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Desmocollins I and II are recognized by certain sera from patients with various types of Pemphigus, particularly Brazilian Pemphigus foliaceus
The Journal of investigative dermatology, 1993Co-Authors: Marian Dmochowski, David R. Garrod, Takeji NishikawaAbstract:Recently, it has been shown that desmoglein, Pemphigus foliaceus target antigen, and a 130-kD Pemphigus vulgaris antigen belong to the cadherin family of cell adhesion molecules. We tried to determine whether desmocollins I/II, other cadherin-like transmembranous glycoproteins present in desmosomes, are also recognized by Pemphigus autoantibodies of the IgG class. We examined 16 Pemphigus vulgaris sera, 15 Pemphigus foliaceus sera, 15 Brazilian Pemphigus foliaceus sera, five bullous pemphigoid sera, and 65 normal sera. Four (25%) Pemphigus vulgaris sera, one (7%) Pemphigus foliaceus serum, eight (53%) Brazilian Pemphigus foliaceus sera, and three (5%) normal sera reacted with desmocollins I/II on immunoblots of bovine desmosome preparation. The affinity-purified desmocollins I/II Pemphigus autoantibodies were shown to bind the epidermal cell surface by indirect immunofluorescence. Immunoblot analysis revealed one Pemphigus vulgaris serum, one Brazilian Pemphigus foliaceus serum, and one normal serum recognizing a recombinant protein produced by a desmocollin cDNA clone. Moreover, immunoblot analysis of reactivity of a Brazilian Pemphigus foliaceus serum with recombinant proteins produced by deletion mutants of the desmocollin cDNA clone showed that the extracellular portion of desmocollin is immunogenic in this Pemphigus patient. We conclude that desmocollins I/II are recognized by certain sera from patients with various types of Pemphigus, particularly Brazilian Pemphigus foliaceus. However, the significance of this reactivity remains to be defined.
S Jabłońska - One of the best experts on this subject based on the ideXlab platform.
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Unusual acantholytic bullous dermatosis associated with neoplasia and IgG and IgA antibodies against bovine desmocollins I and II.
Journal of the American Academy of Dermatology, 1994Co-Authors: T P Chorzelski, T Hashimoto, T Nishikawa, T Ebihara, M Dmochowski, M Ismail, S JabłońskaAbstract:There are unusual cases of Pemphigus that have antibodies nonreactive with either Pemphigus vulgaris or Pemphigus foliaceus antigens. We describe a patient with an acantholytic bullous dermatosis and lung cancer with intercellular IgG and IgA antibodies that differed in specificity from those of Pemphigus vulgaris and Pemphigus foliaceus and reacted with bovine desmocollins I and II and recombinant desmocollin protein.