The Experts below are selected from a list of 387 Experts worldwide ranked by ideXlab platform

Yoko Yamaguchi - One of the best experts on this subject based on the ideXlab platform.

  • development of a novel Penetration Enhancing Agent for hair products
    Journal of Cosmetics Dermatological Sciences and Applications, 2013
    Co-Authors: Teruaki Nagasawa, Hiroyuki Suzuki, Masako Koyama, Toshiko Sato, Kimio Kawamura, Yoko Yamaguchi
    Abstract:

    HAIRCARECUBETM (HCC) is a new additive for hair products that allows the active ingredient to penetrate into the hair. During the course of percutaneous absorption studies, we discovered that lyotropic liquid crystal promotes the skin’s absorptiveness to medicines. We conducted a study to determine whether or not lyotropic liquid crystal could be applied as a Penetration-Enhancing Agent in hair, and as a result we have succeeded in developing HCC. In place of hair dye, we used fluorescein-HCC to evaluate hair permeability, and strong fluorescence was observed as deep as the core of the hair. Moreover, the strength of the fluorescence was dependent on HCC concentration. This result did not change under acidic or basic conditions. In addition, the same trends were observed when using an oxidative hair dye. Furthermore, when HCC was used together with hydrolyzed keratin, which repairs hair damage, a stronger restorative effect was observed. These results confirmed that HCC has the effect of promoting the permeation of pigments and other active ingredients into hair. HCC is expected to be very useful as an additive for developing functional cosmetic hair products.

Jacob Levitt - One of the best experts on this subject based on the ideXlab platform.

  • Urea: a comprehensive review of the clinical literature.
    Dermatology online journal, 2013
    Co-Authors: Michael Pan, Gillian Heinecke, Sebastian Bernardo, Cindy Tsui, Jacob Levitt
    Abstract:

    Introduction: Urea is an organic compound that has been used clinically for dermatological diseases for more than a century. Urea is a potent emollient and keratolytic Agent, making urea an effective monotherapy for conditions associated with dry and scaly skin. A systematic review of the literature is needed to provide clinicians with evidence-based applications of urea in the treatment of dermatological diseases. Methods: A PubMed search was conducted using the term “urea” combined with “skin,” “ichthyosis,” “psoriasis,” “xerosis,” “emollient,” “onychomycosis,” “dermatitis,” and “avulsion.” A total of 81 publications met inclusion criteria and were evaluated. Treatment indication(s), test Agents, number of subjects, treatment protocols, results, and side effects were recorded. Results: Effective treatment with urea has been reported for the following conditions: ichthyosis, xerosis, atopic dermatitis/eczema, contact dermatitis, radiation induced dermatitis, psoriasis/seborrheic dermatitis, onychomycosis, tinea pedis, keratosis, pruritus, and dystrophic nails. Furthermore, urea has been used with other medications as a Penetration Enhancing Agent. Mild irritation is the most common adverse event, proving urea to be a safe and tolerable topical drug without systemic toxicity. Discussion/Conclusion: Urea is a safe, effective dermatologic therapy with wide-ranging clinical utility and minimal, non-systemic side effects. In order to optimize patient care, dermatologists should be well informed with regards to urea’s indications and efficacy.

Teruaki Nagasawa - One of the best experts on this subject based on the ideXlab platform.

  • development of a novel Penetration Enhancing Agent for hair products
    Journal of Cosmetics Dermatological Sciences and Applications, 2013
    Co-Authors: Teruaki Nagasawa, Hiroyuki Suzuki, Masako Koyama, Toshiko Sato, Kimio Kawamura, Yoko Yamaguchi
    Abstract:

    HAIRCARECUBETM (HCC) is a new additive for hair products that allows the active ingredient to penetrate into the hair. During the course of percutaneous absorption studies, we discovered that lyotropic liquid crystal promotes the skin’s absorptiveness to medicines. We conducted a study to determine whether or not lyotropic liquid crystal could be applied as a Penetration-Enhancing Agent in hair, and as a result we have succeeded in developing HCC. In place of hair dye, we used fluorescein-HCC to evaluate hair permeability, and strong fluorescence was observed as deep as the core of the hair. Moreover, the strength of the fluorescence was dependent on HCC concentration. This result did not change under acidic or basic conditions. In addition, the same trends were observed when using an oxidative hair dye. Furthermore, when HCC was used together with hydrolyzed keratin, which repairs hair damage, a stronger restorative effect was observed. These results confirmed that HCC has the effect of promoting the permeation of pigments and other active ingredients into hair. HCC is expected to be very useful as an additive for developing functional cosmetic hair products.

Michael Pan - One of the best experts on this subject based on the ideXlab platform.

  • Urea: a comprehensive review of the clinical literature.
    Dermatology online journal, 2013
    Co-Authors: Michael Pan, Gillian Heinecke, Sebastian Bernardo, Cindy Tsui, Jacob Levitt
    Abstract:

    Introduction: Urea is an organic compound that has been used clinically for dermatological diseases for more than a century. Urea is a potent emollient and keratolytic Agent, making urea an effective monotherapy for conditions associated with dry and scaly skin. A systematic review of the literature is needed to provide clinicians with evidence-based applications of urea in the treatment of dermatological diseases. Methods: A PubMed search was conducted using the term “urea” combined with “skin,” “ichthyosis,” “psoriasis,” “xerosis,” “emollient,” “onychomycosis,” “dermatitis,” and “avulsion.” A total of 81 publications met inclusion criteria and were evaluated. Treatment indication(s), test Agents, number of subjects, treatment protocols, results, and side effects were recorded. Results: Effective treatment with urea has been reported for the following conditions: ichthyosis, xerosis, atopic dermatitis/eczema, contact dermatitis, radiation induced dermatitis, psoriasis/seborrheic dermatitis, onychomycosis, tinea pedis, keratosis, pruritus, and dystrophic nails. Furthermore, urea has been used with other medications as a Penetration Enhancing Agent. Mild irritation is the most common adverse event, proving urea to be a safe and tolerable topical drug without systemic toxicity. Discussion/Conclusion: Urea is a safe, effective dermatologic therapy with wide-ranging clinical utility and minimal, non-systemic side effects. In order to optimize patient care, dermatologists should be well informed with regards to urea’s indications and efficacy.

Hiroyuki Suzuki - One of the best experts on this subject based on the ideXlab platform.

  • development of a novel Penetration Enhancing Agent for hair products
    Journal of Cosmetics Dermatological Sciences and Applications, 2013
    Co-Authors: Teruaki Nagasawa, Hiroyuki Suzuki, Masako Koyama, Toshiko Sato, Kimio Kawamura, Yoko Yamaguchi
    Abstract:

    HAIRCARECUBETM (HCC) is a new additive for hair products that allows the active ingredient to penetrate into the hair. During the course of percutaneous absorption studies, we discovered that lyotropic liquid crystal promotes the skin’s absorptiveness to medicines. We conducted a study to determine whether or not lyotropic liquid crystal could be applied as a Penetration-Enhancing Agent in hair, and as a result we have succeeded in developing HCC. In place of hair dye, we used fluorescein-HCC to evaluate hair permeability, and strong fluorescence was observed as deep as the core of the hair. Moreover, the strength of the fluorescence was dependent on HCC concentration. This result did not change under acidic or basic conditions. In addition, the same trends were observed when using an oxidative hair dye. Furthermore, when HCC was used together with hydrolyzed keratin, which repairs hair damage, a stronger restorative effect was observed. These results confirmed that HCC has the effect of promoting the permeation of pigments and other active ingredients into hair. HCC is expected to be very useful as an additive for developing functional cosmetic hair products.