The Experts below are selected from a list of 1905 Experts worldwide ranked by ideXlab platform
Yue-hu Pei - One of the best experts on this subject based on the ideXlab platform.
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Isolation of a New Compound from Penicillium oxalicum
Chemistry of Natural Compounds, 2016Co-Authors: Bing Liu, Hai-feng Wang, Li-hua Zhang, Fang Liu, Jiao Bai, Hui-ming Hua, Gang Chen, Yue-hu PeiAbstract:The supernatant of the fermentation broth of Penicillium oxalicum yielded a new compound named 2,2′,6′ -trihydroxy-4-methyl-6-methoxy-acyl-diphenylmethanone (1). The isolated compound was characterized by UV, IR, NMR, and mass spectral studies.
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penioxalicin a novel 3 nor 2 3 seco labdane type diterpene from the fungus Penicillium oxalicum tw01 1
Tetrahedron Letters, 2015Co-Authors: Xiqing Bian, Jiao Bai, Hui-ming Hua, Aihong Han, Chunmei Xue, Yue-hu PeiAbstract:Penioxalicin (1), the first 3-nor-2,3-seco-labdane type diterpene featuring the fission between C-2 and C-3 in the ring A and the decarboxylation at C-3, was isolated from the fungus Penicillium oxalicum TW01-1. Its planar structure and absolute configuration were elucidated mainly by analysis of 1D and 2D-NMR, ECD spectroscopic data, and single-crystal X-ray diffraction. Compound 1 showed moderate cytotoxicity against HL-60 cell line. The possible biosynthetic pathway of 1 was also proposed.
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New compound with DNA Topo I inhibitory activity purified from Penicillium oxalicum HSY05
Natural product research, 2015Co-Authors: Bing Liu, Hai-feng Wang, Li-hua Zhang, Fang Liu, Jiao Bai, Hui-ming Hua, Gang Chen, Yue-hu PeiAbstract:Strain HSY05 was isolated from sea sediment collected from the South China Sea and was later identified as Penicillium oxalicum by 16S rDNA sequence analysis. Various chromatographic processes led to the isolation and purification of two metabolites from the fermentation culture of HSY05, including one new compound, 2,2′,4,4′-tetrahyoxy-8′-methyl-6-methoxy-acyl-ethyl-diphenylmethanone (1), and a known compound secalonic acid D (SAD, 2), as characterised by UV, IR, 1D, 2D-NMR and MS data. The inhibitory activities against topoisomerase I of these two compounds were evaluated. The result showed that in addition to the known topo I inhibitor SAD (2), compound 1 also exhibited a moderate inhibitory effect.
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Isolation, Structure Determination, In Vivo/Vitro Assay and Docking Study of a Xanthone with antitumor activity from Fungus Penicillium oxalicum
Records of Natural Products, 2015Co-Authors: Gang Chen, Hai-feng Wang, Jiao Bai, Zhe Jiang, Shuling Zhang, Yue-hu PeiAbstract:Investigation of EtOAc extract from the fermentation broth of the fungus Penicillium oxalicum led to the isolation of a xanthone, secalonic acid D, which showed good antitumor activity both in vivo and in vitro. The docking study revealed that secalonic acid D could block the active pocket of topoisomerase І with seven hydrogen bonds between secalonic acid D and ARG488, LYS532, ASP533.
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Penioxalamine A, a novel prenylated spiro-oxindole alkaloid from Penicillium oxalicum TW01-1
Tetrahedron Letters, 2014Co-Authors: Xiqing Bian, Yue-hu Pei, Hui-ming Hua, Aihong Han, Jiao BaiAbstract:Abstract Penioxalamine A ( 1 ), a novel prenylated spiro-oxindole alkaloid having a unique seven-membered nitrogen heterocycle system, was isolated from the fungus Penicillium oxalicum TW01-1. The structure of 1 was elucidated on the basis of the spectral data, single-crystal X-ray diffraction, and CD analysis. Compound 1 showed moderate cytotoxicity against HL-60 cell line. The possible biosynthetic pathway of 1 was also proposed.
Xiqing Bian - One of the best experts on this subject based on the ideXlab platform.
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penioxalicin a novel 3 nor 2 3 seco labdane type diterpene from the fungus Penicillium oxalicum tw01 1
Tetrahedron Letters, 2015Co-Authors: Xiqing Bian, Jiao Bai, Hui-ming Hua, Aihong Han, Chunmei Xue, Yue-hu PeiAbstract:Penioxalicin (1), the first 3-nor-2,3-seco-labdane type diterpene featuring the fission between C-2 and C-3 in the ring A and the decarboxylation at C-3, was isolated from the fungus Penicillium oxalicum TW01-1. Its planar structure and absolute configuration were elucidated mainly by analysis of 1D and 2D-NMR, ECD spectroscopic data, and single-crystal X-ray diffraction. Compound 1 showed moderate cytotoxicity against HL-60 cell line. The possible biosynthetic pathway of 1 was also proposed.
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penioxalicin a novel 3 nor 2 3 seco labdane type diterpene from the fungus Penicillium oxalicum tw01 1
Tetrahedron Letters, 2015Co-Authors: Xiqing Bian, Xiaolan Hu, Xin Wu, Guangyue SuAbstract:Penioxalicin (1), the first 3-nor-2,3-seco-labdane type diterpene featuring the fission between C-2 and C-3 in the ring A and the decarboxylation at C-3, was isolated from the fungus Penicillium oxalicum TW01-1. Its planar structure and absolute configuration were elucidated mainly by analysis of 1D and 2D-NMR, ECD spectroscopic data, and single-crystal X-ray diffraction. Compound 1 showed moderate cytotoxicity against HL-60 cell line. The possible biosynthetic pathway of 1 was also proposed.
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Penioxalamine A, a novel prenylated spiro-oxindole alkaloid from Penicillium oxalicum TW01-1
Tetrahedron Letters, 2014Co-Authors: Xiqing Bian, Yue-hu Pei, Hui-ming Hua, Aihong Han, Jiao BaiAbstract:Abstract Penioxalamine A ( 1 ), a novel prenylated spiro-oxindole alkaloid having a unique seven-membered nitrogen heterocycle system, was isolated from the fungus Penicillium oxalicum TW01-1. The structure of 1 was elucidated on the basis of the spectral data, single-crystal X-ray diffraction, and CD analysis. Compound 1 showed moderate cytotoxicity against HL-60 cell line. The possible biosynthetic pathway of 1 was also proposed.
Jiao Bai - One of the best experts on this subject based on the ideXlab platform.
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Isolation of a New Compound from Penicillium oxalicum
Chemistry of Natural Compounds, 2016Co-Authors: Bing Liu, Hai-feng Wang, Li-hua Zhang, Fang Liu, Jiao Bai, Hui-ming Hua, Gang Chen, Yue-hu PeiAbstract:The supernatant of the fermentation broth of Penicillium oxalicum yielded a new compound named 2,2′,6′ -trihydroxy-4-methyl-6-methoxy-acyl-diphenylmethanone (1). The isolated compound was characterized by UV, IR, NMR, and mass spectral studies.
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penioxalicin a novel 3 nor 2 3 seco labdane type diterpene from the fungus Penicillium oxalicum tw01 1
Tetrahedron Letters, 2015Co-Authors: Xiqing Bian, Jiao Bai, Hui-ming Hua, Aihong Han, Chunmei Xue, Yue-hu PeiAbstract:Penioxalicin (1), the first 3-nor-2,3-seco-labdane type diterpene featuring the fission between C-2 and C-3 in the ring A and the decarboxylation at C-3, was isolated from the fungus Penicillium oxalicum TW01-1. Its planar structure and absolute configuration were elucidated mainly by analysis of 1D and 2D-NMR, ECD spectroscopic data, and single-crystal X-ray diffraction. Compound 1 showed moderate cytotoxicity against HL-60 cell line. The possible biosynthetic pathway of 1 was also proposed.
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New compound with DNA Topo I inhibitory activity purified from Penicillium oxalicum HSY05
Natural product research, 2015Co-Authors: Bing Liu, Hai-feng Wang, Li-hua Zhang, Fang Liu, Jiao Bai, Hui-ming Hua, Gang Chen, Yue-hu PeiAbstract:Strain HSY05 was isolated from sea sediment collected from the South China Sea and was later identified as Penicillium oxalicum by 16S rDNA sequence analysis. Various chromatographic processes led to the isolation and purification of two metabolites from the fermentation culture of HSY05, including one new compound, 2,2′,4,4′-tetrahyoxy-8′-methyl-6-methoxy-acyl-ethyl-diphenylmethanone (1), and a known compound secalonic acid D (SAD, 2), as characterised by UV, IR, 1D, 2D-NMR and MS data. The inhibitory activities against topoisomerase I of these two compounds were evaluated. The result showed that in addition to the known topo I inhibitor SAD (2), compound 1 also exhibited a moderate inhibitory effect.
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Isolation, Structure Determination, In Vivo/Vitro Assay and Docking Study of a Xanthone with antitumor activity from Fungus Penicillium oxalicum
Records of Natural Products, 2015Co-Authors: Gang Chen, Hai-feng Wang, Jiao Bai, Zhe Jiang, Shuling Zhang, Yue-hu PeiAbstract:Investigation of EtOAc extract from the fermentation broth of the fungus Penicillium oxalicum led to the isolation of a xanthone, secalonic acid D, which showed good antitumor activity both in vivo and in vitro. The docking study revealed that secalonic acid D could block the active pocket of topoisomerase І with seven hydrogen bonds between secalonic acid D and ARG488, LYS532, ASP533.
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Penioxalamine A, a novel prenylated spiro-oxindole alkaloid from Penicillium oxalicum TW01-1
Tetrahedron Letters, 2014Co-Authors: Xiqing Bian, Yue-hu Pei, Hui-ming Hua, Aihong Han, Jiao BaiAbstract:Abstract Penioxalamine A ( 1 ), a novel prenylated spiro-oxindole alkaloid having a unique seven-membered nitrogen heterocycle system, was isolated from the fungus Penicillium oxalicum TW01-1. The structure of 1 was elucidated on the basis of the spectral data, single-crystal X-ray diffraction, and CD analysis. Compound 1 showed moderate cytotoxicity against HL-60 cell line. The possible biosynthetic pathway of 1 was also proposed.
Guangyue Su - One of the best experts on this subject based on the ideXlab platform.
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penioxalicin a novel 3 nor 2 3 seco labdane type diterpene from the fungus Penicillium oxalicum tw01 1
Tetrahedron Letters, 2015Co-Authors: Xiqing Bian, Xiaolan Hu, Xin Wu, Guangyue SuAbstract:Penioxalicin (1), the first 3-nor-2,3-seco-labdane type diterpene featuring the fission between C-2 and C-3 in the ring A and the decarboxylation at C-3, was isolated from the fungus Penicillium oxalicum TW01-1. Its planar structure and absolute configuration were elucidated mainly by analysis of 1D and 2D-NMR, ECD spectroscopic data, and single-crystal X-ray diffraction. Compound 1 showed moderate cytotoxicity against HL-60 cell line. The possible biosynthetic pathway of 1 was also proposed.
Xiaolan Hu - One of the best experts on this subject based on the ideXlab platform.
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penioxalicin a novel 3 nor 2 3 seco labdane type diterpene from the fungus Penicillium oxalicum tw01 1
Tetrahedron Letters, 2015Co-Authors: Xiqing Bian, Xiaolan Hu, Xin Wu, Guangyue SuAbstract:Penioxalicin (1), the first 3-nor-2,3-seco-labdane type diterpene featuring the fission between C-2 and C-3 in the ring A and the decarboxylation at C-3, was isolated from the fungus Penicillium oxalicum TW01-1. Its planar structure and absolute configuration were elucidated mainly by analysis of 1D and 2D-NMR, ECD spectroscopic data, and single-crystal X-ray diffraction. Compound 1 showed moderate cytotoxicity against HL-60 cell line. The possible biosynthetic pathway of 1 was also proposed.