The Experts below are selected from a list of 2022 Experts worldwide ranked by ideXlab platform
Jingzhong Ding - One of the best experts on this subject based on the ideXlab platform.
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the relationship of circulating fibroblast growth factor 21 levels with Pericardial Fat the multi ethnic study of atherosclerosis
Scientific Reports, 2019Co-Authors: Jingzhong Ding, Robyn L Mcclelland, Matthew A Allison, Arsenios Magdas, Philip J BarterAbstract:Previous small studies have reported an association between circulating fibroblast growth factor 21 (FGF21) levels and Pericardial Fat volume in post-menopausal women and high cardiovascular disease (CVD) risk patients. In this study, we investigated the relationship of FGF21 levels with Pericardial Fat volume in participants free of clinical CVD at baseline. We analysed data from 5765 men and women from the Multi-Ethnic Study of Atherosclerosis (MESA) with both Pericardial Fat volume and plasma FGF21 levels measured at baseline. 4746 participants had Pericardial Fat volume measured in at least one follow-up exam. After adjusting for confounding factors, ln-transformed FGF21 levels were positively associated with Pericardial Fat volume at baseline (β = 0.055, p < 0.001). When assessing change in Pericardial Fat volume over a mean duration of 3.0 years using a linear mixed-effects model, higher baseline FGF21 levels were associated with higher Pericardial Fat volume at baseline (2.381 cm3 larger in Pericardial Fat volume per one SD increase in ln-transformed FGF21 levels), but less Pericardial Fat accumulation over time (0.191 cm3/year lower per one SD increase in ln-transformed FGF21 levels). Cross-sectionally, higher plasma FGF21 levels were significantly associated with higher Pericardial Fat volume, independent of traditional CVD risk factors and inflammatory markers. However, higher FGF21 levels tended to be associated with less Pericardial Fat accumulation over time. Nevertheless, such change in Pericardial Fat volume is very modest and could be due to measurement error. Further studies are needed to elucidate the longitudinal relationship of baseline FGF21 levels with Pericardial Fat accumulation.
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The relationship of circulating fibroblast growth factor 21 levels with Pericardial Fat: The Multi-Ethnic Study of Atherosclerosis
Scientific Reports, 2019Co-Authors: Arsenios Magdas, Jingzhong Ding, Robyn L Mcclelland, Matthew A Allison, Philip J BarterAbstract:Previous small studies have reported an association between circulating fibroblast growth factor 21 (FGF21) levels and Pericardial Fat volume in post-menopausal women and high cardiovascular disease (CVD) risk patients. In this study, we investigated the relationship of FGF21 levels with Pericardial Fat volume in participants free of clinical CVD at baseline. We analysed data from 5765 men and women from the Multi-Ethnic Study of Atherosclerosis (MESA) with both Pericardial Fat volume and plasma FGF21 levels measured at baseline. 4746 participants had Pericardial Fat volume measured in at least one follow-up exam. After adjusting for confounding factors, ln-transformed FGF21 levels were positively associated with Pericardial Fat volume at baseline (β = 0.055, p
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Pericardial Fat volume and incident atrial fibrillation in the multi ethnic study of atherosclerosis and jackson heart study
Obesity, 2017Co-Authors: Susan R Heckbert, Jingzhong Ding, Emelia J Benjamin, Kerri L Wiggins, Chad Blackshear, Yi Yang, Barbara Mcknight, Alvaro Alonso, Thomas R Austin, Lesley H CurtisAbstract:Objective To determine whether greater Pericardial Fat volume would be associated with increased risk of incident atrial fibrillation (AF). Methods In the Multi-Ethnic Study of Atherosclerosis and Jackson Heart Study, Pericardial Fat volume was quantified by computed tomography. Incident AF was identified from discharge diagnosis codes, study electrocardiograms, and Medicare claims. Results Among 7,991 participants, 40% were African American, 32% white, 18% Hispanic, and 10% Chinese American; mean age was 62 years; 55% were women. During an average of 10.0 years of follow-up in the Multi-Ethnic Study of Atherosclerosis and 4.5 years in the Jackson Heart Study, 756 incident AF cases were identified. After adjustment for age, sex, study, race/ethnicity, height, glucose status, systolic blood pressure, treated hypertension, and BMI, greater Pericardial Fat volume was associated with higher AF risk in Hispanics (hazard ratio 1.24 per SD, 95% confidence interval 1.05-1.46) but not overall (hazard ratio 1.06, 95% confidence interval 0.97-1.15). In mediation analysis, Pericardial Fat volume partially mediated the association of BMI with incident AF in Hispanics. Conclusions After adjustment for BMI, greater Pericardial Fat volume was associated with incident AF in Hispanics but not overall. Additional research is needed on the mechanisms by which Pericardial Fat volume is related to increased AF risk and possible differences by race/ethnicity.
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Pericardial Fat and right ventricular morphology the multi ethnic study of atherosclerosis right ventricle study mesa rv
PLOS ONE, 2016Co-Authors: David Wenger, Jingzhong Ding, David A Bluemke, Steven M Kawut, Catherine L Hough, Richard A Kronmal, Joao A C Lima, Peter J LearyAbstract:Background Pericardial Fat has been implicated in the pathogenesis of obesity-related cardiovascular disease. Proposed mechanisms may be relevant in right heart failure, but relationships between Pericardial Fat and right ventricular (RV) morphology have not been explored. Methods The Multi-Ethnic Study of Atherosclerosis is a prospective cohort that enrolled participants without clinical cardiovascular disease. Pericardial Fat was measured using computed tomography and RV parameters using cardiac MRI. Linear regression estimated associations of Pericardial Fat with RV mass, RV end diastolic volume (RV-EDV), RV end systolic volume (RV-ESV), RV stroke volume (RV-SV), and RV ejection fraction (RV-EF). Limited models adjusted for age, gender, race, height, and study site with and without weight. Fully adjusted models also accounted for socioeconomic parameters and health behaviors. Adjustment for left ventricular morphology, metabolic syndrome, and systemic inflammation was also performed. Results The study sample included 3988 participants with complete assessment of RV morphology, Pericardial Fat and all covariates. Greater Pericardial Fat volume was associated with reduced RV mass (-0.3g per 40 cm3 increase in Pericardial Fat, p<0.001), smaller RV-EDV (-3.7ml per 40 cm3 increase in Pericardial Fat, p<0.001), smaller RV-ESV (-1.0ml per 40cm3 increase in Pericardial Fat, p<0.001), and smaller RV-SV (-2.7mL per 40 cm3 increase in Pericardial Fat, p<0.001) in participants after adjustment for weight. Associations were unchanged when accounting for health behaviors, markers of systemic inflammation, and the metabolic syndrome. Conclusions Greater Pericardial Fat was associated with reduced RV mass, smaller RV-EDV, smaller RV-ESV, and smaller RV-SV in participants after adjustment for weight. Relationships between Pericardial Fat and RV morphology could be relevant to diseases of right heart failure.
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Pericardial Fat and Right Ventricular Morphology: The Multi-Ethnic Study of Atherosclerosis- Right Ventricle Study (MESA-RV).
PLOS ONE, 2016Co-Authors: David S. Wenger, Jingzhong Ding, David A Bluemke, Steven M Kawut, Catherine L Hough, Richard A Kronmal, Joao A C Lima, Peter J LearyAbstract:Background Pericardial Fat has been implicated in the pathogenesis of obesity-related cardiovascular disease. Proposed mechanisms may be relevant in right heart failure, but relationships between Pericardial Fat and right ventricular (RV) morphology have not been explored. Methods The Multi-Ethnic Study of Atherosclerosis is a prospective cohort that enrolled participants without clinical cardiovascular disease. Pericardial Fat was measured using computed tomography and RV parameters using cardiac MRI. Linear regression estimated associations of Pericardial Fat with RV mass, RV end diastolic volume (RV-EDV), RV end systolic volume (RV-ESV), RV stroke volume (RV-SV), and RV ejection fraction (RV-EF). Limited models adjusted for age, gender, race, height, and study site with and without weight. Fully adjusted models also accounted for socioeconomic parameters and health behaviors. Adjustment for left ventricular morphology, metabolic syndrome, and systemic inflammation was also performed. Results The study sample included 3988 participants with complete assessment of RV morphology, Pericardial Fat and all covariates. Greater Pericardial Fat volume was associated with reduced RV mass (-0.3g per 40 cm3 increase in Pericardial Fat, p
Christopher J Odonnell - One of the best experts on this subject based on the ideXlab platform.
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Pericardial Fat thickness increases with greater burden of adverse metabolic factors among adults with normal range body mass index the framingham heart study
Circulation, 2017Co-Authors: Philimon Gona, Carol J Salton, Warren J Manning, Noriko Oyamamanabe, Michael L Chuang, Christopher J OdonnellAbstract:Introduction: Greater burden of Pericardial Fat is associated with increased body mass index (BMI). Obesity is associated with unfavorable metabolic characteristics such as hypertension, dyslipidem...
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Pericardial Fat is associated with prevalent atrial fibrillationclinical perspective
Circulation-arrhythmia and Electrophysiology, 2010Co-Authors: George Thanassoulis, Joseph M Massaro, Christopher J Odonnell, Udo Hoffmann, Daniel Levy, Patrick T Ellinor, Thomas J Wang, Renate B Schnabel, Ramachandran S Vasan, Emelia J BenjaminAbstract:Background— Obesity represents an important risk factor for atrial fibrillation (AF). We tested the hypothesis that Pericardial Fat, a unique Fat deposit in close anatomic proximity to cardiac structures and autonomic fibers, is associated with prevalent AF. Methods and Results— Participants from the Framingham Heart Study underwent multidetector computed tomography from 2002 to 2005. We estimated the association between quantitative Pericardial, intrathoracic and visceral adipose tissue volumes (per standard deviation of volume) with prevalent AF adjusting for established AF risk factors (age, sex, systolic blood pressure, blood pressure treatment, PR interval, and clinically significant valvular disease). Of the 3217 eligible participants (mean age, 50.6±10.1 years; 48% women), 54 had a confirmed diagnosis of AF. Pericardial Fat but not intrathoracic or visceral abdominal Fat was associated with prevalent AF in multivariable-adjusted models (odds ratio per standard deviation of Pericardial Fat volume, 1.28; 95% confidence intervals, 1.03 to 1.58). Further adjustments for body mass index, heart failure, myocardial infarction, and intrathoracic Fat volume did not materially change the association between Pericardial Fat and AF. Conclusions— Pericardial Fat was associated with prevalent AF even after adjustment for AF risk factors, including body mass index. If this association is replicated, further investigations into the mechanisms linking Pericardial Fat to AF are merited.
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Pericardial Fat is associated with prevalent atrial fibrillationclinical perspective the framingham heart study
Circulation-arrhythmia and Electrophysiology, 2010Co-Authors: George Thanassoulis, Joseph M Massaro, Christopher J Odonnell, Udo Hoffmann, Daniel Levy, Patrick T Ellinor, Thomas J Wang, Renate B Schnabel, Ramachandran S Vasan, Emelia J BenjaminAbstract:Background— Obesity represents an important risk factor for atrial fibrillation (AF). We tested the hypothesis that Pericardial Fat, a unique Fat deposit in close anatomic proximity to cardiac structures and autonomic fibers, is associated with prevalent AF. Methods and Results— Participants from the Framingham Heart Study underwent multidetector computed tomography from 2002 to 2005. We estimated the association between quantitative Pericardial, intrathoracic and visceral adipose tissue volumes (per standard deviation of volume) with prevalent AF adjusting for established AF risk factors (age, sex, systolic blood pressure, blood pressure treatment, PR interval, and clinically significant valvular disease). Of the 3217 eligible participants (mean age, 50.6±10.1 years; 48% women), 54 had a confirmed diagnosis of AF. Pericardial Fat but not intrathoracic or visceral abdominal Fat was associated with prevalent AF in multivariable-adjusted models (odds ratio per standard deviation of Pericardial Fat volume, 1.28; 95% confidence intervals, 1.03 to 1.58). Further adjustments for body mass index, heart failure, myocardial infarction, and intrathoracic Fat volume did not materially change the association between Pericardial Fat and AF. Conclusions— Pericardial Fat was associated with prevalent AF even after adjustment for AF risk factors, including body mass index. If this association is replicated, further investigations into the mechanisms linking Pericardial Fat to AF are merited.
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Pericardial Fat is associated with prevalent atrial fibrillation the framingham heart study
Circulation-arrhythmia and Electrophysiology, 2010Co-Authors: George Thanassoulis, Joseph M Massaro, Christopher J Odonnell, Udo Hoffmann, Daniel Levy, Patrick T Ellinor, Thomas J Wang, Renate B Schnabel, Ramachandran S Vasan, Emelia J BenjaminAbstract:Atrial fibrillation (AF) is expected to affect over 6 million individuals in the US by 20101 and is associated with significant morbidity and mortality. Obesity represents an important risk factor for new-onset AF.2–4 Even after adjustment for hypertension and heart failure (HF), measures of obesity remain significant predictors of AF, suggesting that obesity may predispose to AF. Pericardial Fat represents a unique ectopic Fat deposit due its proximity to cardiac structures and its shared blood supply with the cardiac microcirculation.5 Pericardial Fat is highly metabolically active6,7 and may be a potential mechanism by which obesity increases the risk of AF.5,8 To our knowledge the association between Pericardial Fat and AF has not been evaluated previously. The aim of our study was to evaluate the cross-sectional associations between Pericardial Fat volume and other regional Fat deposits, measured by multi-detector computed tomography (MDCT), with AF in the Framingham Heart Study, a middle-aged to elderly community-based cohort. Due to its contiguity to cardiac structures, we hypothesized that Pericardial Fat would be cross-sectionally associated with AF, even after adjustment for known AF risk factors, including body mass index (BMI) and other Fat depots.
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Pericardial Fat is associated with prevalent atrial fibrillation
Circulation-arrhythmia and Electrophysiology, 2010Co-Authors: George Thanassoulis, Joseph M Massaro, Christopher J Odonnell, Udo Hoffmann, Daniel Levy, Patrick T Ellinor, Thomas J Wang, Renate B Schnabel, Ramachandran S Vasan, Emelia J BenjaminAbstract:Background—Obesity represents an important risk factor for atrial fibrillation (AF). We tested the hypothesis that Pericardial Fat, a unique Fat deposit in close anatomic proximity to cardiac struc...
Joseph M Massaro - One of the best experts on this subject based on the ideXlab platform.
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Pericardial Fat is associated with atrial conduction the framingham heart study
Journal of the American Heart Association, 2014Co-Authors: Daniel J Friedman, Joseph M Massaro, Udo Hoffmann, Na Wang, James B Meigs, Jared W MagnaniAbstract:Background Obesity is associated with altered atrial electrophysiology and a prominent risk factor for atrial fibrillation. Body mass index, the most widely used adiposity measure, has been related to atrial electrical remodeling. We tested the hypothesis that Pericardial Fat is independently associated with electrocardiographic measures of atrial conduction. Methods and Results We performed a cross-sectional analysis of 1946 Framingham Heart Study participants (45% women) to determine the relation between Pericardial Fat and atrial conduction as measured by P wave indices (PWI): PR interval, P wave duration (P-duration), P wave amplitude (P-amplitude), P wave area (P-area), and P wave terminal force (P-terminal). We performed sex-stratified linear regression analyses adjusted for relevant clinical variables and ectopic Fat depots. Each 1-SD increase in Pericardial Fat was significantly associated with PR interval (β=1.7 ms, P =0.049), P-duration (β=2.3 ms, P <0.001), and P-terminal (β=297 μV·ms, P <0.001) among women; and P-duration (β=1.2 ms, P =0.002), P-amplitude (β=−2.5 μV, P <0. 001), and P-terminal (β=160 μV·ms, P =0.002) among men. Among both sexes, Pericardial Fat was significantly associated with P-duration in analyses additionally adjusting for visceral Fat or intrathoracic Fat; a similar but non-significant trend existed with P-terminal. Among women, Pericardial Fat was significantly associated with P wave area after adjustment for visceral and intrathoracic Fat. Conclusions Pericardial Fat is associated with atrial conduction as quantified by PWI, even with adjustment for extracardiac Fat depots. Further studies are warranted to identify the mechanisms through which Pericardial Fat may modify atrial electrophysiology and promote subsequent risk for arrhythmogenesis.
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Pericardial Fat is Associated With Atrial Conduction: The Framingham Heart Study
Journal of the American Heart Association, 2014Co-Authors: Daniel J Friedman, Joseph M Massaro, Udo Hoffmann, Na Wang, James B Meigs, Jared W MagnaniAbstract:Background Obesity is associated with altered atrial electrophysiology and a prominent risk factor for atrial fibrillation. Body mass index, the most widely used adiposity measure, has been related to atrial electrical remodeling. We tested the hypothesis that Pericardial Fat is independently associated with electrocardiographic measures of atrial conduction. Methods and Results We performed a cross-sectional analysis of 1946 Framingham Heart Study participants (45% women) to determine the relation between Pericardial Fat and atrial conduction as measured by P wave indices (PWI): PR interval, P wave duration (P-duration), P wave amplitude (P-amplitude), P wave area (P-area), and P wave terminal force (P-terminal). We performed sex-stratified linear regression analyses adjusted for relevant clinical variables and ectopic Fat depots. Each 1-SD increase in Pericardial Fat was significantly associated with PR interval (β=1.7 ms, P =0.049), P-duration (β=2.3 ms, P
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Pericardial Fat is associated with prevalent atrial fibrillationclinical perspective
Circulation-arrhythmia and Electrophysiology, 2010Co-Authors: George Thanassoulis, Joseph M Massaro, Christopher J Odonnell, Udo Hoffmann, Daniel Levy, Patrick T Ellinor, Thomas J Wang, Renate B Schnabel, Ramachandran S Vasan, Emelia J BenjaminAbstract:Background— Obesity represents an important risk factor for atrial fibrillation (AF). We tested the hypothesis that Pericardial Fat, a unique Fat deposit in close anatomic proximity to cardiac structures and autonomic fibers, is associated with prevalent AF. Methods and Results— Participants from the Framingham Heart Study underwent multidetector computed tomography from 2002 to 2005. We estimated the association between quantitative Pericardial, intrathoracic and visceral adipose tissue volumes (per standard deviation of volume) with prevalent AF adjusting for established AF risk factors (age, sex, systolic blood pressure, blood pressure treatment, PR interval, and clinically significant valvular disease). Of the 3217 eligible participants (mean age, 50.6±10.1 years; 48% women), 54 had a confirmed diagnosis of AF. Pericardial Fat but not intrathoracic or visceral abdominal Fat was associated with prevalent AF in multivariable-adjusted models (odds ratio per standard deviation of Pericardial Fat volume, 1.28; 95% confidence intervals, 1.03 to 1.58). Further adjustments for body mass index, heart failure, myocardial infarction, and intrathoracic Fat volume did not materially change the association between Pericardial Fat and AF. Conclusions— Pericardial Fat was associated with prevalent AF even after adjustment for AF risk factors, including body mass index. If this association is replicated, further investigations into the mechanisms linking Pericardial Fat to AF are merited.
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Pericardial Fat is associated with prevalent atrial fibrillationclinical perspective the framingham heart study
Circulation-arrhythmia and Electrophysiology, 2010Co-Authors: George Thanassoulis, Joseph M Massaro, Christopher J Odonnell, Udo Hoffmann, Daniel Levy, Patrick T Ellinor, Thomas J Wang, Renate B Schnabel, Ramachandran S Vasan, Emelia J BenjaminAbstract:Background— Obesity represents an important risk factor for atrial fibrillation (AF). We tested the hypothesis that Pericardial Fat, a unique Fat deposit in close anatomic proximity to cardiac structures and autonomic fibers, is associated with prevalent AF. Methods and Results— Participants from the Framingham Heart Study underwent multidetector computed tomography from 2002 to 2005. We estimated the association between quantitative Pericardial, intrathoracic and visceral adipose tissue volumes (per standard deviation of volume) with prevalent AF adjusting for established AF risk factors (age, sex, systolic blood pressure, blood pressure treatment, PR interval, and clinically significant valvular disease). Of the 3217 eligible participants (mean age, 50.6±10.1 years; 48% women), 54 had a confirmed diagnosis of AF. Pericardial Fat but not intrathoracic or visceral abdominal Fat was associated with prevalent AF in multivariable-adjusted models (odds ratio per standard deviation of Pericardial Fat volume, 1.28; 95% confidence intervals, 1.03 to 1.58). Further adjustments for body mass index, heart failure, myocardial infarction, and intrathoracic Fat volume did not materially change the association between Pericardial Fat and AF. Conclusions— Pericardial Fat was associated with prevalent AF even after adjustment for AF risk factors, including body mass index. If this association is replicated, further investigations into the mechanisms linking Pericardial Fat to AF are merited.
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Pericardial Fat is associated with prevalent atrial fibrillation the framingham heart study
Circulation-arrhythmia and Electrophysiology, 2010Co-Authors: George Thanassoulis, Joseph M Massaro, Christopher J Odonnell, Udo Hoffmann, Daniel Levy, Patrick T Ellinor, Thomas J Wang, Renate B Schnabel, Ramachandran S Vasan, Emelia J BenjaminAbstract:Atrial fibrillation (AF) is expected to affect over 6 million individuals in the US by 20101 and is associated with significant morbidity and mortality. Obesity represents an important risk factor for new-onset AF.2–4 Even after adjustment for hypertension and heart failure (HF), measures of obesity remain significant predictors of AF, suggesting that obesity may predispose to AF. Pericardial Fat represents a unique ectopic Fat deposit due its proximity to cardiac structures and its shared blood supply with the cardiac microcirculation.5 Pericardial Fat is highly metabolically active6,7 and may be a potential mechanism by which obesity increases the risk of AF.5,8 To our knowledge the association between Pericardial Fat and AF has not been evaluated previously. The aim of our study was to evaluate the cross-sectional associations between Pericardial Fat volume and other regional Fat deposits, measured by multi-detector computed tomography (MDCT), with AF in the Framingham Heart Study, a middle-aged to elderly community-based cohort. Due to its contiguity to cardiac structures, we hypothesized that Pericardial Fat would be cross-sectionally associated with AF, even after adjustment for known AF risk factors, including body mass index (BMI) and other Fat depots.
David A Bluemke - One of the best experts on this subject based on the ideXlab platform.
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Pericardial Fat and right ventricular morphology the multi ethnic study of atherosclerosis right ventricle study mesa rv
PLOS ONE, 2016Co-Authors: David Wenger, Jingzhong Ding, David A Bluemke, Steven M Kawut, Catherine L Hough, Richard A Kronmal, Joao A C Lima, Peter J LearyAbstract:Background Pericardial Fat has been implicated in the pathogenesis of obesity-related cardiovascular disease. Proposed mechanisms may be relevant in right heart failure, but relationships between Pericardial Fat and right ventricular (RV) morphology have not been explored. Methods The Multi-Ethnic Study of Atherosclerosis is a prospective cohort that enrolled participants without clinical cardiovascular disease. Pericardial Fat was measured using computed tomography and RV parameters using cardiac MRI. Linear regression estimated associations of Pericardial Fat with RV mass, RV end diastolic volume (RV-EDV), RV end systolic volume (RV-ESV), RV stroke volume (RV-SV), and RV ejection fraction (RV-EF). Limited models adjusted for age, gender, race, height, and study site with and without weight. Fully adjusted models also accounted for socioeconomic parameters and health behaviors. Adjustment for left ventricular morphology, metabolic syndrome, and systemic inflammation was also performed. Results The study sample included 3988 participants with complete assessment of RV morphology, Pericardial Fat and all covariates. Greater Pericardial Fat volume was associated with reduced RV mass (-0.3g per 40 cm3 increase in Pericardial Fat, p<0.001), smaller RV-EDV (-3.7ml per 40 cm3 increase in Pericardial Fat, p<0.001), smaller RV-ESV (-1.0ml per 40cm3 increase in Pericardial Fat, p<0.001), and smaller RV-SV (-2.7mL per 40 cm3 increase in Pericardial Fat, p<0.001) in participants after adjustment for weight. Associations were unchanged when accounting for health behaviors, markers of systemic inflammation, and the metabolic syndrome. Conclusions Greater Pericardial Fat was associated with reduced RV mass, smaller RV-EDV, smaller RV-ESV, and smaller RV-SV in participants after adjustment for weight. Relationships between Pericardial Fat and RV morphology could be relevant to diseases of right heart failure.
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Pericardial Fat and Right Ventricular Morphology: The Multi-Ethnic Study of Atherosclerosis- Right Ventricle Study (MESA-RV).
PLOS ONE, 2016Co-Authors: David S. Wenger, Jingzhong Ding, David A Bluemke, Steven M Kawut, Catherine L Hough, Richard A Kronmal, Joao A C Lima, Peter J LearyAbstract:Background Pericardial Fat has been implicated in the pathogenesis of obesity-related cardiovascular disease. Proposed mechanisms may be relevant in right heart failure, but relationships between Pericardial Fat and right ventricular (RV) morphology have not been explored. Methods The Multi-Ethnic Study of Atherosclerosis is a prospective cohort that enrolled participants without clinical cardiovascular disease. Pericardial Fat was measured using computed tomography and RV parameters using cardiac MRI. Linear regression estimated associations of Pericardial Fat with RV mass, RV end diastolic volume (RV-EDV), RV end systolic volume (RV-ESV), RV stroke volume (RV-SV), and RV ejection fraction (RV-EF). Limited models adjusted for age, gender, race, height, and study site with and without weight. Fully adjusted models also accounted for socioeconomic parameters and health behaviors. Adjustment for left ventricular morphology, metabolic syndrome, and systemic inflammation was also performed. Results The study sample included 3988 participants with complete assessment of RV morphology, Pericardial Fat and all covariates. Greater Pericardial Fat volume was associated with reduced RV mass (-0.3g per 40 cm3 increase in Pericardial Fat, p
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Pericardial Fat and myocardial perfusion in asymptomatic adults from the multi ethnic study of atherosclerosis
PLOS ONE, 2011Co-Authors: Tina E Brinkley, Gregory L Burke, Moyses Szklo, Jeffrey J Carr, Matthew A Allison, Michael Jeroschherold, Aaron R Folsom, Gregory W Hundley, David A Bluemke, Jingzhong DingAbstract:Background Pericardial Fat has adverse effects on the surrounding vasculature. Previous studies suggest that Pericardial Fat may contribute to myocardial ischemia in symptomatic individuals. However, it is unknown if Pericardial Fat has similar effects in asymptomatic individuals.
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the association of Pericardial Fat with coronary artery plaque index at mr imaging the multi ethnic study of atherosclerosis mesa
Radiology, 2011Co-Authors: Cuilian Miao, Jingzhong Ding, David A Bluemke, Joao A C Lima, Debiao Li, Shaoguang Chen, Robson Macedo, Jens Vogelclaussen, Elizabeth R BrownAbstract:Pericardial Fat volume was associated with coronary atherosclerotic plaque burden in asymptomatic individuals, and the relationship between Pericardial Fat volume and plaque burden was stronger in men than in women.
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abstract 1192 the association of Pericardial Fat with coronary artery plaque by mri the multi ethnic study of atherosclerosis mesa
Circulation, 2009Co-Authors: Cuilian Miao, Jingzhong Ding, Jeffrey J Carr, Joao A C Lima, Debiao Li, Shaoguang Chen, Robson Macedo, Elizabeth R Brown, Jens Vogelclausen, David A BluemkeAbstract:Background: Pericardial Fat releases more inflammatory cytokines compared to subcutaneous Fat, which may lead to coronary atherosclerosis. The purpose of this study is to evaluate the relationship of coronary artery plaque, expressed by the eccentricity of coronary artery wall thickness, versus volume of Pericardial Fat. Methods and materials: Coronary artery MRI for 94 male participants without clinical cardiovascular disease (61± 9 yrs) in the Multi-Ethnic Study of Atherosclerosis (MESA) was performed at 1.5 T. Coronary artery wall images were acquired from left main (LM), the proximal portions of left anterior descending (LAD) and right coronary artery (RCA) using a black-blood TSE technique. Coronary artery wall images were analyzed and the maximum and minimum wall thicknesses were measured. Coronary artery plaque eccentricity was defined as maximum/minimum wall thickness. The volume of Pericardial Fat and coronary artery calcium score (CAC) were measured by CT scans. Carotid artery intima-media thickness (IMT) was obtained by ultrasound. Linear regression was used to determine the relationship of coronary plaque eccentricity to height-adjusted Pericardial Fat, cardiovascular risk factors, body mass index (BMI), waist circumference, C-reactive protein (CRP), CAC, and carotid IMT. Results: Mean coronary plaque eccentricity was 2.4± 0.9, mean volume of Pericardial Fat 88.8±53.8 cm 3 . There was a significant relationship of plaque eccentricity to Pericardial Fat volume (p=0.0007). An increment of 1 s.d. (53.8 cm 3 ) in height-adjusted Pericardial Fat was associated with a 0.3 increase of the plaque eccentricity. The relationship remained significant in multi-variable models (p=0.004) after adjusting for BMI, height-adjusted waist circumference, and cardiovascular risk factors. These relationships remained significant after further adjustment for CAC and IMT (P=0.01). Height-adjusted waist circumference and BMI were not related to coronary plaque eccentricity. CRP was positively related to the plaque eccentricity in univariate model (p=0.01). Conclusion: Pericardial Fat was associated with coronary plaque eccentricity in male participants with subclinical atherosclerosis, independent of BMI and cardiovascular risk factors.
Johannes W A Smit - One of the best experts on this subject based on the ideXlab platform.
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long term beneficial effect of a 16 week very low calorie diet on Pericardial Fat in obese type 2 diabetes mellitus patients
Obesity, 2012Co-Authors: Marieke Snel, Jacqueline T Jonker, Sebastian Hammer, Gijs Kerpershoek, Hildo J Lamb, Edo A Meinders, Hanno Pijl, Albert De Roos, Johannes A Romijn, Johannes W A SmitAbstract:Pericardial Fat accumulation has been associated with an increased cardiovascular risk. A very low calorie diet (VLCD) improves the cardiovascular risk profile in patients with type 2 diabetes mellitus (T2DM), by improving the metabolic profile, heart function, and triglyceride (TG) stores in (non)adipose tissues. However, long-term effects of a VLCD on Pericardial Fat volume and tissue-specific TG accumulation have not been documented. The aim of this study was therefore to assess the effects of a 16-week VLCD and of subsequent 14 months follow-up on a regular diet on Pericardial Fat in relation to other TG stores in obese T2DM patients. We included 14 obese patients with insulin-treated T2DM (mean +/- s.e.m.: age 53 +/- 2 years; BMI 35 +/- 1 kg/m(2)). Pericardial Fat and other (non)adipose TG stores were measured using magnetic resonance (MR) imaging and proton spectroscopy before and after a 16-week VLCD and after a 14-month follow-up without dietary interventions. A 16-week VLCD reduced body weight, Pericardial Fat, hepatic TG content, visceral and subcutaneous abdominal Fat volumes to 78, 83, 16, 40, and 53% of baseline values respectively, (all P < 0.05). After an additional 14 months of follow-up on a regular diet, the reduction in Pericardial Fat volume sustained, despite a substantial regain in body weight, visceral abdominal Fat, and hepatic TG content (respectively 90, 83 and 73% of baseline values). In conclusion, VLCD-induced weight loss in obese T2DM patients is accompanied by a substantial decrease in Pericardial Fat volume, which is sustained even after subsequent weight regain.
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pioglitazone compared with metformin increases Pericardial Fat volume in patients with type 2 diabetes mellitus
The Journal of Clinical Endocrinology and Metabolism, 2010Co-Authors: Jacqueline T Jonker, Hildo J Lamb, Albert De Roos, Johannes A Romijn, R W Van Der Meer, Luuk J Rijzewijk, L J Menting, Michaela Diamant, Johannes W A SmitAbstract:Context: Peroxisome proliferator-activated receptor-γ agonists are involved in Fat cell differentiation. Objective: The objective of the study was to investigate the effect of pioglitazone vs. metformin on Pericardial Fat volume in type 2 diabetic (T2DM) patients. Furthermore, we aimed to assess the relationship between Pericardial Fat volume, other Fat compartments, and myocardial function at baseline and after treatment. Design: This was a prospective, randomized, double-blind, intervention study. Setting: The study was conducted at a university hospital. Patients: Patients included 78 men with T2DM (aged 56.5 ± 0.6 yr; glycosylated hemoglobin 7.1 ± 0.1%) without structural heart disease. Intervention: Patients were randomly assigned to pioglitazone (30 mg/d) or metformin (2000 mg/d) and matching placebo during 24 wk. Main Outcome Measures: Pericardial and abdominal Fat volumes and myocardial left ventricular function were measured by magnetic resonance imaging and hepatic and myocardial triglyceride co...