The Experts below are selected from a list of 51 Experts worldwide ranked by ideXlab platform
Andrew H Dawson - One of the best experts on this subject based on the ideXlab platform.
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cardiotoxicity more common in thioridazine overdose than with other neuroleptics
Clinical Toxicology, 1995Co-Authors: Nicholas A Buckley, Ian M Whyte, Andrew H DawsonAbstract:On the basis of case reports and small non-comparative series it has been suggested that thioridazine has greater cardiotoxic in overdose. Limited evidence also suggests an increased association with sudden death in therapeutic doses. The aim of our study is to examine the clinical and electrocardiographic features associated with neuroleptic poisoning and compare thioridazine with other neuroleptics. Consecutive adult patients with neuroleptic poisoning presenting to metropolitan hospitals in Newcastle between 1987 and 1993 were studied. The main outcome measures examined were ECG changes (QRS, QT and QTc intervals), arrhythmias, seizures, degree of sedation, heart rate and blood pressure. Two-hundred ninety-nine patients had ingested thioridazine (104), chlorpromazine (69), trifluoperazine (36), Pericyazine (35), haloperidol (33), prochlorperazine (18), fluphenazine (8), or other neurleptics (7). Sixteen patients had ingested more than one neuroleptic and were excluded from comparative analysis. Thiorid...
Nicholas A Buckley - One of the best experts on this subject based on the ideXlab platform.
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cardiotoxicity more common in thioridazine overdose than with other neuroleptics
Clinical Toxicology, 1995Co-Authors: Nicholas A Buckley, Ian M Whyte, Andrew H DawsonAbstract:On the basis of case reports and small non-comparative series it has been suggested that thioridazine has greater cardiotoxic in overdose. Limited evidence also suggests an increased association with sudden death in therapeutic doses. The aim of our study is to examine the clinical and electrocardiographic features associated with neuroleptic poisoning and compare thioridazine with other neuroleptics. Consecutive adult patients with neuroleptic poisoning presenting to metropolitan hospitals in Newcastle between 1987 and 1993 were studied. The main outcome measures examined were ECG changes (QRS, QT and QTc intervals), arrhythmias, seizures, degree of sedation, heart rate and blood pressure. Two-hundred ninety-nine patients had ingested thioridazine (104), chlorpromazine (69), trifluoperazine (36), Pericyazine (35), haloperidol (33), prochlorperazine (18), fluphenazine (8), or other neurleptics (7). Sixteen patients had ingested more than one neuroleptic and were excluded from comparative analysis. Thiorid...
Ian M Whyte - One of the best experts on this subject based on the ideXlab platform.
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cardiotoxicity more common in thioridazine overdose than with other neuroleptics
Clinical Toxicology, 1995Co-Authors: Nicholas A Buckley, Ian M Whyte, Andrew H DawsonAbstract:On the basis of case reports and small non-comparative series it has been suggested that thioridazine has greater cardiotoxic in overdose. Limited evidence also suggests an increased association with sudden death in therapeutic doses. The aim of our study is to examine the clinical and electrocardiographic features associated with neuroleptic poisoning and compare thioridazine with other neuroleptics. Consecutive adult patients with neuroleptic poisoning presenting to metropolitan hospitals in Newcastle between 1987 and 1993 were studied. The main outcome measures examined were ECG changes (QRS, QT and QTc intervals), arrhythmias, seizures, degree of sedation, heart rate and blood pressure. Two-hundred ninety-nine patients had ingested thioridazine (104), chlorpromazine (69), trifluoperazine (36), Pericyazine (35), haloperidol (33), prochlorperazine (18), fluphenazine (8), or other neurleptics (7). Sixteen patients had ingested more than one neuroleptic and were excluded from comparative analysis. Thiorid...
Pamela Humphreys - One of the best experts on this subject based on the ideXlab platform.
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Pericyazine for schizophrenia
Cochrane Database of Systematic Reviews, 2014Co-Authors: Hosam E Matar, Muhammad Qutayba Almerie, Samer Makhoul, Jun Xia, Pamela HumphreysAbstract:BACKGROUND Pericyazine is a 3-cyano-10 (3-4'-hydroxypiperidinopropyl) phenothiazine. It is overall pharmacologically similar with chlorpromazine, though particularly sedating. Dopamine receptor subtype analysis has not been performed for Pericyazine, but the drug appears to induce greater noradrenergic than dopaminergic blockade. Compared to chlorpromazine, Pericyazine reportedly has more potent antiemetic, antiserotonin, and anticholinergic activity. OBJECTIVES To evaluate the clinical effects and safety of Pericyazine in comparison with placebo, typical and atypical antipsychotic agents and standard care for people with schizophrenia. SEARCH METHODS We searched the Cochrane Schizophrenia Group Trials Register (February 2013) which is based on regular searches of CINAHL, EMBASE, MEDLINE and PsycINFO. We inspected references of all identified studies for further trials. SELECTION CRITERIA All relevant randomised controlled trials focusing on Pericyazine for schizophrenia and other types of schizophrenia-like psychoses (schizophreniform and schizoaffective disorders). We excluded quasi-randomised trials. DATA COLLECTION AND ANALYSIS Data were extracted independently from included papers by at least two review authors. Risk ratios (RR) and 95% confidence intervals (CI) of homogeneous dichotomous data were calculated. We assessed risk of bias for included studies and used GRADE to judge quality of evidence. MAIN RESULTS We could only include five studies conducted between 1965 and 1980. Most of the included studies did not report details of randomisation, allocation concealment, details of blinding and we could not assess the impact of attrition due to poor reporting.For the primary outcome of Global state - not improved, the confidence interval was compatible with a small benefit and increased risk of not improving with Pericyazine compared with typical antipsychotics (2 RCTs, n = 122, RR 1.24 CI 0.93 to 1.66, very low quality of evidence) or atypical antipsychotics (1 RCT, n = 93, RR 0.97 CI 0.67 to 1.42, very low quality of evidence).When compared with typical antipsychotics relapse was only experienced by one person taking Pericyazine (1 RCT, n = 80, RR 2.59 CI 0.11 to 61.75, very low quality of evidence).Pericyazine was associated with more extrapyramidal side effects than typical antipsychotics (3 RCTs, n = 163, RR 0.52 CI 0.34 to 0.80, very low quality of evidence) and atypical antipsychotics (1 RCT, n = 93, RR 2.69 CI 1.35 to 5.36, very low quality of evidence).The estimated risk of leaving the study early for specific reasons was imprecise for the comparisons of Pericyazine with typical antipsychotics (2 RCTs, n = 71, RR 0.46 CI 0.11 to 1.90, very low quality of evidence), and with atypical antipsychotics (1 RCT, n = 93, RR 0.13 CI 0.01 to 2.42, very low quality of evidence). AUTHORS' CONCLUSIONS On the basis of very low quality evidence we are unable to determine the effects of Pericyazine in comparison with typical or atypical antipsychotics for the treatment of schizophrenia. However, there is some evidence that Pericyazine may be associated with a higher incidence of extrapyramidal side effects than other antipsychotics, and again this was judged to be very low quality evidence. Large, robust studies are still needed before any firm conclusions can be drawn.
Paulo Virgolino Da Nóbrega - One of the best experts on this subject based on the ideXlab platform.
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Wilson's disease: clinical diagnosis and "faces of panda" signs in magnetic resonance imaging. Case report
Academia Brasileira de Neurologia - ABNEURO, 2005Co-Authors: Brito, José Correia De Farias, Hermano José Falcone De Almeida, Coutinho, Mário De Almeida Pereira, Paulo Virgolino Da NóbregaAbstract:Homem de 25 anos de idade foi internado com sintomatologia polimorfa típica das afecções dos gânglios da base, associada a manifestações psiquiátricas. Fez uso de periciazina; no entanto, a suspensão do medicamento não melhorou a sintomatologia. Foi estabelecido o diagnóstico de doença de Wilson pela visualização do anel de Kayser-Fleischer através de exame com lâmpada de fenda e pelos exames laboratoriais que mostraram diminuição da ceruloplasmina plasmática e aumento de excreção de cobre urinário. A ressonância magnética, ponderada em T2, em cortes axiais do mesencéfalo e ponte, evidenciou imagens das "faces do panda".A 25 year-old man was admitted with polimorph symptomatology resembling basal ganglia disease associated with psychiatric manifestations. The patient had been treated with Pericyazine. The drug was stopped but the symptomatology did not improve. The diagnosis of Wilson's disease was established through ophthalmologic examination with slit-lamp that revealed the Kayser-Fleischer ring and laboratory abnomalities showing a low serum ceruloplasmin level and increased urinary copper excretion. T2-weighted axial magnetic resonance imaging demonstrated the " face of panda signs" in the midbrain and pons
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Doença de Wilson: diagnóstico clínico e sinais das "faces do panda" à ressonância magnética. Relato de caso Wilson's disease: clinical diagnosis and "faces of panda" signs in magnetic resonance imaging. Case report
Academia Brasileira de Neurologia (ABNEURO), 2005Co-Authors: José Correia De Farias Brito, Mário De Almeida Pereira Coutinho, Hermano José Falcone De Almeida, Paulo Virgolino Da NóbregaAbstract:Homem de 25 anos de idade foi internado com sintomatologia polimorfa típica das afecções dos gânglios da base, associada a manifestações psiquiátricas. Fez uso de periciazina; no entanto, a suspensão do medicamento não melhorou a sintomatologia. Foi estabelecido o diagnóstico de doença de Wilson pela visualização do anel de Kayser-Fleischer através de exame com lâmpada de fenda e pelos exames laboratoriais que mostraram diminuição da ceruloplasmina plasmática e aumento de excreção de cobre urinário. A ressonância magnética, ponderada em T2, em cortes axiais do mesencéfalo e ponte, evidenciou imagens das "faces do panda".A 25 year-old man was admitted with polimorph symptomatology resembling basal ganglia disease associated with psychiatric manifestations. The patient had been treated with Pericyazine. The drug was stopped but the symptomatology did not improve. The diagnosis of Wilson's disease was established through ophthalmologic examination with slit-lamp that revealed the Kayser-Fleischer ring and laboratory abnomalities showing a low serum ceruloplasmin level and increased urinary copper excretion. T2-weighted axial magnetic resonance imaging demonstrated the " face of panda signs" in the midbrain and pons