The Experts below are selected from a list of 1134 Experts worldwide ranked by ideXlab platform
Yuliya S Nikolova - One of the best experts on this subject based on the ideXlab platform.
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temporally and sex specific effects of maternal Perinatal Stress on offspring cortical gyrification and mood in young adulthood
Human Brain Mapping, 2020Co-Authors: Klara Mareckova, Amy Miles, Lenka Andryskova, Milan Brazdil, Yuliya S NikolovaAbstract:Maternal Stress during pregnancy and shortly thereafter is associated with altered offspring brain development that may increase risk of mood and anxiety disorders. Cortical gyrification is established during the prenatal period and the first 2 years of life and is altered in psychiatric disorders. Here, we sought to characterize the effects of Perinatal Stress exposure on offspring gyrification patterns and mood dysregulation in young adulthood. Participants included 85 young adults (56.5% women; 23-24 years) from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) with Perinatal Stress data across four distinct timepoints and structural MRI data from young adulthood. Perinatal Stress exposure was measured as maternal Stress during first and second half of pregnancy, first 6 months, and 6-18 months after birth. Cortical gyrification and mood dysregulation were quantified using local gyrification index (LGI), computed with Freesurfer, and the Profile of Mood States questionnaire, respectively. Perinatal Stress predicted cortical gyrification in young adulthood, and its timing influenced location, direction, and sex-specificity of effects. In particular, whereas early prenatal Stress was associated with sex-dependent medium-to-large effects in large temporal, parietal, and occipital regions (f2 = 0.19-0.38, p < .001), later Perinatal Stress was associated with sex-independent small-to-medium effects in smaller, more anterior regions (f2 = 0.10-0.19, p < .003). Moreover, in females, early prenatal Stress predicted higher LGI in a large temporal region, which was further associated with mood disturbance in adulthood (r = 0.399, p = .006). These findings point out the long-term implications of Perinatal Stress exposure for cortical morphology and mood dysregulation.
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Temporally and sex‐specific effects of maternal Perinatal Stress on offspring cortical gyrification and mood in young adulthood
Human Brain Mapping, 2020Co-Authors: Klara Mareckova, Amy Miles, Lenka Andryskova, Milan Brazdil, Yuliya S NikolovaAbstract:Maternal Stress during pregnancy and shortly thereafter is associated with altered offspring brain development that may increase risk of mood and anxiety disorders. Cortical gyrification is established during the prenatal period and the first 2 years of life and is altered in psychiatric disorders. Here, we sought to characterize the effects of Perinatal Stress exposure on offspring gyrification patterns and mood dysregulation in young adulthood. Participants included 85 young adults (56.5% women; 23-24 years) from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) with Perinatal Stress data across four distinct timepoints and structural MRI data from young adulthood. Perinatal Stress exposure was measured as maternal Stress during first and second half of pregnancy, first 6 months, and 6-18 months after birth. Cortical gyrification and mood dysregulation were quantified using local gyrification index (LGI), computed with Freesurfer, and the Profile of Mood States questionnaire, respectively. Perinatal Stress predicted cortical gyrification in young adulthood, and its timing influenced location, direction, and sex-specificity of effects. In particular, whereas early prenatal Stress was associated with sex-dependent medium-to-large effects in large temporal, parietal, and occipital regions (f2 = 0.19-0.38, p
Klara Mareckova - One of the best experts on this subject based on the ideXlab platform.
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temporally and sex specific effects of maternal Perinatal Stress on offspring cortical gyrification and mood in young adulthood
Human Brain Mapping, 2020Co-Authors: Klara Mareckova, Amy Miles, Lenka Andryskova, Milan Brazdil, Yuliya S NikolovaAbstract:Maternal Stress during pregnancy and shortly thereafter is associated with altered offspring brain development that may increase risk of mood and anxiety disorders. Cortical gyrification is established during the prenatal period and the first 2 years of life and is altered in psychiatric disorders. Here, we sought to characterize the effects of Perinatal Stress exposure on offspring gyrification patterns and mood dysregulation in young adulthood. Participants included 85 young adults (56.5% women; 23-24 years) from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) with Perinatal Stress data across four distinct timepoints and structural MRI data from young adulthood. Perinatal Stress exposure was measured as maternal Stress during first and second half of pregnancy, first 6 months, and 6-18 months after birth. Cortical gyrification and mood dysregulation were quantified using local gyrification index (LGI), computed with Freesurfer, and the Profile of Mood States questionnaire, respectively. Perinatal Stress predicted cortical gyrification in young adulthood, and its timing influenced location, direction, and sex-specificity of effects. In particular, whereas early prenatal Stress was associated with sex-dependent medium-to-large effects in large temporal, parietal, and occipital regions (f2 = 0.19-0.38, p < .001), later Perinatal Stress was associated with sex-independent small-to-medium effects in smaller, more anterior regions (f2 = 0.10-0.19, p < .003). Moreover, in females, early prenatal Stress predicted higher LGI in a large temporal region, which was further associated with mood disturbance in adulthood (r = 0.399, p = .006). These findings point out the long-term implications of Perinatal Stress exposure for cortical morphology and mood dysregulation.
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Temporally and sex‐specific effects of maternal Perinatal Stress on offspring cortical gyrification and mood in young adulthood
Human Brain Mapping, 2020Co-Authors: Klara Mareckova, Amy Miles, Lenka Andryskova, Milan Brazdil, Yuliya S NikolovaAbstract:Maternal Stress during pregnancy and shortly thereafter is associated with altered offspring brain development that may increase risk of mood and anxiety disorders. Cortical gyrification is established during the prenatal period and the first 2 years of life and is altered in psychiatric disorders. Here, we sought to characterize the effects of Perinatal Stress exposure on offspring gyrification patterns and mood dysregulation in young adulthood. Participants included 85 young adults (56.5% women; 23-24 years) from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) with Perinatal Stress data across four distinct timepoints and structural MRI data from young adulthood. Perinatal Stress exposure was measured as maternal Stress during first and second half of pregnancy, first 6 months, and 6-18 months after birth. Cortical gyrification and mood dysregulation were quantified using local gyrification index (LGI), computed with Freesurfer, and the Profile of Mood States questionnaire, respectively. Perinatal Stress predicted cortical gyrification in young adulthood, and its timing influenced location, direction, and sex-specificity of effects. In particular, whereas early prenatal Stress was associated with sex-dependent medium-to-large effects in large temporal, parietal, and occipital regions (f2 = 0.19-0.38, p
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Perinatal Stress and human hippocampal volume: Findings from typically developing young adults.
Scientific Reports, 2018Co-Authors: Klara Mareckova, Radek Mareček, Petra Bencurova, Jana Klánová, Ladislav Dušek, Milan BrazdilAbstract:The main objective of this study was to investigate the impact of prenatal and early postnatal Stress on hippocampal volume in young adulthood. In sharp contrast to numerous results in animal models, our data from a neuroimaging follow-up (n = 131) of a community-based birth cohort from the Czech Republic (European Longitudinal Study of Pregnancy and Childhood) showed that in typically developing young adults, hippocampal volume was not associated with birth weight, Stressful life events during the prenatal or early postnatal period, or dysregulated mood and wellbeing in the mother during the early postnatal period. Interestingly, mother’s anxiety/co-dependence during the first weeks after birth did show long-lasting effects on the hippocampal volume in young adult offspring irrespective of sex. Further analyses revealed that these effects were subfield-specific; present in CA1, CA2/3, CA4, GC-DG, subiculum, molecular layer, and HATA, hippocampal subfields identified by translational research as most Stress- and glucocorticoid-sensitive, but not in the remaining subfields. Our findings provide evidence that the type of early Stress is critical when studying its effects on the human brain.
Catherine Sellenet - One of the best experts on this subject based on the ideXlab platform.
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relationship between perceived Perinatal Stress and depressive symptoms anxiety and parental self efficacy in primiparous mothers and the role of social support
Women & Health, 2017Co-Authors: Chantal Razurel, Barbara Kaiser, Jeanphilippe Antonietti, Manuela Epiney, Catherine SellenetAbstract:The aim of the authors in this study was to evaluate the relationships between perceived Perinatal Stress and social support to psychological health outcomes in mothers. A longitudinal, quantitative study was conducted in Geneva, Switzerland on 235 primiparous mothers from September 2010 to January 2012. Data were collected between gestational weeks 37 and 41 (T1), 2 days post-delivery (T2), and at 6 weeks postpartum (T3). Perinatal Stress was associated with depressive symptoms (R(2) = 0.223), anxiety (R(2) = 0.242), and a low sense of parental self-efficacy (R(2) = 0.21). However, satisfaction with social support moderated the relationship of Stress to the health of mothers. In particular, the authors noted that the more women were provided with support from their partners, the less depressive symptoms and elevated levels of anxiety they reported, even under Stressful conditions, while the satisfaction of support from their mothers boosted their sense of competency. Furthermore, satisfaction with emotional support from professionals tempered the Stress during the post-partum period (∆R(2) = 0.032; p < .05). The results revealed that Perinatal Stress was related to the psychological health of mothers, but social support may modulate these effects. A number of approaches could be implemented to manage this Stress.
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Relationship between perceived Perinatal Stress and depressive symptoms, anxiety, and parental self-efficacy in primiparous mothers and the role of social support
Women & Health, 2016Co-Authors: Chantal Razurel, Barbara Kaiser, Jeanphilippe Antonietti, Manuela Epiney, Catherine SellenetAbstract:The aim of the authors in this study was to evaluate the relationships between perceived Perinatal Stress and social support to psychological health outcomes in mothers. A longitudinal, quantitative study was conducted in Geneva, Switzerland on 235 primiparous mothers from September 2010 to January 2012. Data were collected between gestational weeks 37 and 41 (T1), 2 days post-delivery (T2), and at 6 weeks postpartum (T3). Perinatal Stress was associated with depressive symptoms (R(2) = 0.223), anxiety (R(2) = 0.242), and a low sense of parental self-efficacy (R(2) = 0.21). However, satisfaction with social support moderated the relationship of Stress to the health of mothers. In particular, the authors noted that the more women were provided with support from their partners, the less depressive symptoms and elevated levels of anxiety they reported, even under Stressful conditions, while the satisfaction of support from their mothers boosted their sense of competency. Furthermore, satisfaction with emotional support from professionals tempered the Stress during the post-partum period (∆R(2) = 0.032; p
Rosalind J Wright - One of the best experts on this subject based on the ideXlab platform.
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Perinatal Stress and early life programming of lung structure and function
Biological Psychology, 2010Co-Authors: Rosalind J WrightAbstract:Abstract Exposure to environmental toxins during critical periods of prenatal and/or postnatal development may alter the normal course of lung morphogenesis and maturation, potentially resulting in changes that affect both structure and function of the respiratory system. Moreover, these early effects may persist into adult life magnifying the potential public health impact. Aberrant or excessive pro-inflammatory immune responses, occurring both locally and systemically, that result in inflammatory damage to the airway are a central determinant of lung structure–function changes throughout life. Disruption of neuroendocrine function in early development, specifically the hypothalamic–pituitary–adrenal (HPA) axis, may alter functional status of the immune system. Autonomic nervous system (ANS) function (sympathovagal imbalance) is another integral component of airway function and immunity in childhood. This overview discusses the evidence linking psychological factors to alterations in these interrelated physiological processes that may, in turn, influence childhood lung function and identifies gaps in our understanding.
Milan Brazdil - One of the best experts on this subject based on the ideXlab platform.
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temporally and sex specific effects of maternal Perinatal Stress on offspring cortical gyrification and mood in young adulthood
Human Brain Mapping, 2020Co-Authors: Klara Mareckova, Amy Miles, Lenka Andryskova, Milan Brazdil, Yuliya S NikolovaAbstract:Maternal Stress during pregnancy and shortly thereafter is associated with altered offspring brain development that may increase risk of mood and anxiety disorders. Cortical gyrification is established during the prenatal period and the first 2 years of life and is altered in psychiatric disorders. Here, we sought to characterize the effects of Perinatal Stress exposure on offspring gyrification patterns and mood dysregulation in young adulthood. Participants included 85 young adults (56.5% women; 23-24 years) from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) with Perinatal Stress data across four distinct timepoints and structural MRI data from young adulthood. Perinatal Stress exposure was measured as maternal Stress during first and second half of pregnancy, first 6 months, and 6-18 months after birth. Cortical gyrification and mood dysregulation were quantified using local gyrification index (LGI), computed with Freesurfer, and the Profile of Mood States questionnaire, respectively. Perinatal Stress predicted cortical gyrification in young adulthood, and its timing influenced location, direction, and sex-specificity of effects. In particular, whereas early prenatal Stress was associated with sex-dependent medium-to-large effects in large temporal, parietal, and occipital regions (f2 = 0.19-0.38, p < .001), later Perinatal Stress was associated with sex-independent small-to-medium effects in smaller, more anterior regions (f2 = 0.10-0.19, p < .003). Moreover, in females, early prenatal Stress predicted higher LGI in a large temporal region, which was further associated with mood disturbance in adulthood (r = 0.399, p = .006). These findings point out the long-term implications of Perinatal Stress exposure for cortical morphology and mood dysregulation.
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Temporally and sex‐specific effects of maternal Perinatal Stress on offspring cortical gyrification and mood in young adulthood
Human Brain Mapping, 2020Co-Authors: Klara Mareckova, Amy Miles, Lenka Andryskova, Milan Brazdil, Yuliya S NikolovaAbstract:Maternal Stress during pregnancy and shortly thereafter is associated with altered offspring brain development that may increase risk of mood and anxiety disorders. Cortical gyrification is established during the prenatal period and the first 2 years of life and is altered in psychiatric disorders. Here, we sought to characterize the effects of Perinatal Stress exposure on offspring gyrification patterns and mood dysregulation in young adulthood. Participants included 85 young adults (56.5% women; 23-24 years) from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) with Perinatal Stress data across four distinct timepoints and structural MRI data from young adulthood. Perinatal Stress exposure was measured as maternal Stress during first and second half of pregnancy, first 6 months, and 6-18 months after birth. Cortical gyrification and mood dysregulation were quantified using local gyrification index (LGI), computed with Freesurfer, and the Profile of Mood States questionnaire, respectively. Perinatal Stress predicted cortical gyrification in young adulthood, and its timing influenced location, direction, and sex-specificity of effects. In particular, whereas early prenatal Stress was associated with sex-dependent medium-to-large effects in large temporal, parietal, and occipital regions (f2 = 0.19-0.38, p
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Perinatal Stress and human hippocampal volume: Findings from typically developing young adults.
Scientific Reports, 2018Co-Authors: Klara Mareckova, Radek Mareček, Petra Bencurova, Jana Klánová, Ladislav Dušek, Milan BrazdilAbstract:The main objective of this study was to investigate the impact of prenatal and early postnatal Stress on hippocampal volume in young adulthood. In sharp contrast to numerous results in animal models, our data from a neuroimaging follow-up (n = 131) of a community-based birth cohort from the Czech Republic (European Longitudinal Study of Pregnancy and Childhood) showed that in typically developing young adults, hippocampal volume was not associated with birth weight, Stressful life events during the prenatal or early postnatal period, or dysregulated mood and wellbeing in the mother during the early postnatal period. Interestingly, mother’s anxiety/co-dependence during the first weeks after birth did show long-lasting effects on the hippocampal volume in young adult offspring irrespective of sex. Further analyses revealed that these effects were subfield-specific; present in CA1, CA2/3, CA4, GC-DG, subiculum, molecular layer, and HATA, hippocampal subfields identified by translational research as most Stress- and glucocorticoid-sensitive, but not in the remaining subfields. Our findings provide evidence that the type of early Stress is critical when studying its effects on the human brain.