The Experts below are selected from a list of 220314 Experts worldwide ranked by ideXlab platform
Aaron M. Zorn - One of the best experts on this subject based on the ideXlab platform.
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A Molecular atlas of Xenopus Respiratory System development
Developmental Dynamics, 2014Co-Authors: Scott A. Rankin, Hong Thi Tran, Marcin Wlizla, Pamela Mancini, Emily T. Shifley, Sean D. Bloor, Kris Vleminckx, Susan E. Wert, Aaron M. ZornAbstract:Background: Respiratory System development is regulated by a complex series of endoderm–mesoderm interactions that are not fully understood. Recently Xenopus has emerged as an alternative model to investigate early Respiratory System development, but the extent to which the morphogenesis and molecular pathways involved are conserved between Xenopus and mammals has not been Systematically documented. Results: In this study, we provide a histological and molecular atlas of Xenopus Respiratory System development, focusing on Nkx2.1+ Respiratory cell fate specification in the developing foregut. We document the expression patterns of Wnt/β-catenin, fibroblast growth factor (FGF), and bone morphogenetic protein (BMP) signaling components in the foregut and show that the molecular mechanisms of Respiratory lineage induction are remarkably conserved between Xenopus and mice. Finally, using several functional experiments we refine the epistatic relationships among FGF, Wnt, and BMP signaling in early Xenopus Respiratory System development. Conclusions: We demonstrate that Xenopus trachea and lung development, before metamorphosis, is comparable at the cellular and molecular levels to embryonic stages of mouse Respiratory System development between embryonic days 8.5 and 10.5. This molecular atlas provides a fundamental starting point for further studies using Xenopus as a model to define the conserved genetic programs controlling early Respiratory System development. Developmental Dynamics 244:69–85, 2015. © 2014 Wiley Periodicals, Inc.
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A molecular atlas of Xenopus Respiratory System development
Developmental dynamics : an official publication of the American Association of Anatomists, 2014Co-Authors: Scott A. Rankin, Hong Thi Tran, Marcin Wlizla, Pamela Mancini, Emily T. Shifley, Sean D. Bloor, Kris Vleminckx, Susan E. Wert, Lu Han, Aaron M. ZornAbstract:Background Respiratory System development is regulated by a complex series of endoderm-mesoderm interactions that are not fully understood. Recently Xenopus has emerged as an alternative model to investigate early Respiratory System development, but the extent to which the morphogenesis and molecular pathways involved are conserved between Xenopus and mammals has not been Systematically documented. Results In this study, we provide a histological and molecular atlas of Xenopus Respiratory System development, focusing on Nkx2.1+ Respiratory cell fate specification in the developing foregut. We document the expression patterns of Wnt/β-catenin, fibroblast growth factor (FGF), and bone morphogenetic protein (BMP) signaling components in the foregut and show that the molecular mechanisms of Respiratory lineage induction are remarkably conserved between Xenopus and mice. Finally, using several functional experiments we refine the epistatic relationships among FGF, Wnt, and BMP signaling in early Xenopus Respiratory System development. Conclusions We demonstrate that Xenopus trachea and lung development, before metamorphosis, is comparable at the cellular and molecular levels to embryonic stages of mouse Respiratory System development between embryonic days 8.5 and 10.5. This molecular atlas provides a fundamental starting point for further studies using Xenopus as a model to define the conserved genetic programs controlling early Respiratory System development.
Scott A. Rankin - One of the best experts on this subject based on the ideXlab platform.
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A Molecular atlas of Xenopus Respiratory System development
Developmental Dynamics, 2014Co-Authors: Scott A. Rankin, Hong Thi Tran, Marcin Wlizla, Pamela Mancini, Emily T. Shifley, Sean D. Bloor, Kris Vleminckx, Susan E. Wert, Aaron M. ZornAbstract:Background: Respiratory System development is regulated by a complex series of endoderm–mesoderm interactions that are not fully understood. Recently Xenopus has emerged as an alternative model to investigate early Respiratory System development, but the extent to which the morphogenesis and molecular pathways involved are conserved between Xenopus and mammals has not been Systematically documented. Results: In this study, we provide a histological and molecular atlas of Xenopus Respiratory System development, focusing on Nkx2.1+ Respiratory cell fate specification in the developing foregut. We document the expression patterns of Wnt/β-catenin, fibroblast growth factor (FGF), and bone morphogenetic protein (BMP) signaling components in the foregut and show that the molecular mechanisms of Respiratory lineage induction are remarkably conserved between Xenopus and mice. Finally, using several functional experiments we refine the epistatic relationships among FGF, Wnt, and BMP signaling in early Xenopus Respiratory System development. Conclusions: We demonstrate that Xenopus trachea and lung development, before metamorphosis, is comparable at the cellular and molecular levels to embryonic stages of mouse Respiratory System development between embryonic days 8.5 and 10.5. This molecular atlas provides a fundamental starting point for further studies using Xenopus as a model to define the conserved genetic programs controlling early Respiratory System development. Developmental Dynamics 244:69–85, 2015. © 2014 Wiley Periodicals, Inc.
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A molecular atlas of Xenopus Respiratory System development
Developmental dynamics : an official publication of the American Association of Anatomists, 2014Co-Authors: Scott A. Rankin, Hong Thi Tran, Marcin Wlizla, Pamela Mancini, Emily T. Shifley, Sean D. Bloor, Kris Vleminckx, Susan E. Wert, Lu Han, Aaron M. ZornAbstract:Background Respiratory System development is regulated by a complex series of endoderm-mesoderm interactions that are not fully understood. Recently Xenopus has emerged as an alternative model to investigate early Respiratory System development, but the extent to which the morphogenesis and molecular pathways involved are conserved between Xenopus and mammals has not been Systematically documented. Results In this study, we provide a histological and molecular atlas of Xenopus Respiratory System development, focusing on Nkx2.1+ Respiratory cell fate specification in the developing foregut. We document the expression patterns of Wnt/β-catenin, fibroblast growth factor (FGF), and bone morphogenetic protein (BMP) signaling components in the foregut and show that the molecular mechanisms of Respiratory lineage induction are remarkably conserved between Xenopus and mice. Finally, using several functional experiments we refine the epistatic relationships among FGF, Wnt, and BMP signaling in early Xenopus Respiratory System development. Conclusions We demonstrate that Xenopus trachea and lung development, before metamorphosis, is comparable at the cellular and molecular levels to embryonic stages of mouse Respiratory System development between embryonic days 8.5 and 10.5. This molecular atlas provides a fundamental starting point for further studies using Xenopus as a model to define the conserved genetic programs controlling early Respiratory System development.
Jeffrey J Fredberg - One of the best experts on this subject based on the ideXlab platform.
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oscillation mechanics of the Respiratory System
Comprehensive Physiology, 2011Co-Authors: R Peslin, Jeffrey J FredbergAbstract:The sections in this article are: 1 Modeling the Respiratory System as a Linear System 1.1 Models 1.2 Elemental Equations 1.3 Sinusoidal Forcing and Complex Impedance 1.4 Continuity and Compatibility Conditions 1.5 General Formulation of System Models 1.6 System Functions 1.7 Equivalent Circuits 1.8 Distributed-Parameter Models 2 History 3 Experimental Methods 3.1 Equipment 3.2 Inputs and Data Processing 3.3 Upper Airway Variability and Shunt 4 Frequency Responses Below 100 HZ 4.1 Total Respiratory System 4.2 Input Impedance Forcing at the Airway Opening 4.3 Transfer Impedance Forcing at the Chest 4.4 Transfer Impedance Forcing at the Mouth 4.5 Pressure and Flow Transfer Functions 4.6 Lung Impedance 4.7 Chest Wall Impedance 4.8 Airway Impedance 5 Frequency Responses Above 100 HZ 5.1 Wave Propagation in the Airways 5.2 Input Impedance Forcing at the Airway Opening 5.3 Pressure Transfer Functions 5.4 Airway Area by Acoustic Reflections 6 Clinical Applications 6.1 Pulmonary Function in Children 6.2 Obstructive Lung Diseases 6.3 Restrictive Lung Diseases 6.4 Miscellaneous Lung Diseases
Marcin Wlizla - One of the best experts on this subject based on the ideXlab platform.
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A Molecular atlas of Xenopus Respiratory System development
Developmental Dynamics, 2014Co-Authors: Scott A. Rankin, Hong Thi Tran, Marcin Wlizla, Pamela Mancini, Emily T. Shifley, Sean D. Bloor, Kris Vleminckx, Susan E. Wert, Aaron M. ZornAbstract:Background: Respiratory System development is regulated by a complex series of endoderm–mesoderm interactions that are not fully understood. Recently Xenopus has emerged as an alternative model to investigate early Respiratory System development, but the extent to which the morphogenesis and molecular pathways involved are conserved between Xenopus and mammals has not been Systematically documented. Results: In this study, we provide a histological and molecular atlas of Xenopus Respiratory System development, focusing on Nkx2.1+ Respiratory cell fate specification in the developing foregut. We document the expression patterns of Wnt/β-catenin, fibroblast growth factor (FGF), and bone morphogenetic protein (BMP) signaling components in the foregut and show that the molecular mechanisms of Respiratory lineage induction are remarkably conserved between Xenopus and mice. Finally, using several functional experiments we refine the epistatic relationships among FGF, Wnt, and BMP signaling in early Xenopus Respiratory System development. Conclusions: We demonstrate that Xenopus trachea and lung development, before metamorphosis, is comparable at the cellular and molecular levels to embryonic stages of mouse Respiratory System development between embryonic days 8.5 and 10.5. This molecular atlas provides a fundamental starting point for further studies using Xenopus as a model to define the conserved genetic programs controlling early Respiratory System development. Developmental Dynamics 244:69–85, 2015. © 2014 Wiley Periodicals, Inc.
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A molecular atlas of Xenopus Respiratory System development
Developmental dynamics : an official publication of the American Association of Anatomists, 2014Co-Authors: Scott A. Rankin, Hong Thi Tran, Marcin Wlizla, Pamela Mancini, Emily T. Shifley, Sean D. Bloor, Kris Vleminckx, Susan E. Wert, Lu Han, Aaron M. ZornAbstract:Background Respiratory System development is regulated by a complex series of endoderm-mesoderm interactions that are not fully understood. Recently Xenopus has emerged as an alternative model to investigate early Respiratory System development, but the extent to which the morphogenesis and molecular pathways involved are conserved between Xenopus and mammals has not been Systematically documented. Results In this study, we provide a histological and molecular atlas of Xenopus Respiratory System development, focusing on Nkx2.1+ Respiratory cell fate specification in the developing foregut. We document the expression patterns of Wnt/β-catenin, fibroblast growth factor (FGF), and bone morphogenetic protein (BMP) signaling components in the foregut and show that the molecular mechanisms of Respiratory lineage induction are remarkably conserved between Xenopus and mice. Finally, using several functional experiments we refine the epistatic relationships among FGF, Wnt, and BMP signaling in early Xenopus Respiratory System development. Conclusions We demonstrate that Xenopus trachea and lung development, before metamorphosis, is comparable at the cellular and molecular levels to embryonic stages of mouse Respiratory System development between embryonic days 8.5 and 10.5. This molecular atlas provides a fundamental starting point for further studies using Xenopus as a model to define the conserved genetic programs controlling early Respiratory System development.
Hong Thi Tran - One of the best experts on this subject based on the ideXlab platform.
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A Molecular atlas of Xenopus Respiratory System development
Developmental Dynamics, 2014Co-Authors: Scott A. Rankin, Hong Thi Tran, Marcin Wlizla, Pamela Mancini, Emily T. Shifley, Sean D. Bloor, Kris Vleminckx, Susan E. Wert, Aaron M. ZornAbstract:Background: Respiratory System development is regulated by a complex series of endoderm–mesoderm interactions that are not fully understood. Recently Xenopus has emerged as an alternative model to investigate early Respiratory System development, but the extent to which the morphogenesis and molecular pathways involved are conserved between Xenopus and mammals has not been Systematically documented. Results: In this study, we provide a histological and molecular atlas of Xenopus Respiratory System development, focusing on Nkx2.1+ Respiratory cell fate specification in the developing foregut. We document the expression patterns of Wnt/β-catenin, fibroblast growth factor (FGF), and bone morphogenetic protein (BMP) signaling components in the foregut and show that the molecular mechanisms of Respiratory lineage induction are remarkably conserved between Xenopus and mice. Finally, using several functional experiments we refine the epistatic relationships among FGF, Wnt, and BMP signaling in early Xenopus Respiratory System development. Conclusions: We demonstrate that Xenopus trachea and lung development, before metamorphosis, is comparable at the cellular and molecular levels to embryonic stages of mouse Respiratory System development between embryonic days 8.5 and 10.5. This molecular atlas provides a fundamental starting point for further studies using Xenopus as a model to define the conserved genetic programs controlling early Respiratory System development. Developmental Dynamics 244:69–85, 2015. © 2014 Wiley Periodicals, Inc.
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A molecular atlas of Xenopus Respiratory System development
Developmental dynamics : an official publication of the American Association of Anatomists, 2014Co-Authors: Scott A. Rankin, Hong Thi Tran, Marcin Wlizla, Pamela Mancini, Emily T. Shifley, Sean D. Bloor, Kris Vleminckx, Susan E. Wert, Lu Han, Aaron M. ZornAbstract:Background Respiratory System development is regulated by a complex series of endoderm-mesoderm interactions that are not fully understood. Recently Xenopus has emerged as an alternative model to investigate early Respiratory System development, but the extent to which the morphogenesis and molecular pathways involved are conserved between Xenopus and mammals has not been Systematically documented. Results In this study, we provide a histological and molecular atlas of Xenopus Respiratory System development, focusing on Nkx2.1+ Respiratory cell fate specification in the developing foregut. We document the expression patterns of Wnt/β-catenin, fibroblast growth factor (FGF), and bone morphogenetic protein (BMP) signaling components in the foregut and show that the molecular mechanisms of Respiratory lineage induction are remarkably conserved between Xenopus and mice. Finally, using several functional experiments we refine the epistatic relationships among FGF, Wnt, and BMP signaling in early Xenopus Respiratory System development. Conclusions We demonstrate that Xenopus trachea and lung development, before metamorphosis, is comparable at the cellular and molecular levels to embryonic stages of mouse Respiratory System development between embryonic days 8.5 and 10.5. This molecular atlas provides a fundamental starting point for further studies using Xenopus as a model to define the conserved genetic programs controlling early Respiratory System development.
