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Shyhkuan Tai - One of the best experts on this subject based on the ideXlab platform.

  • Perineural Invasion as a major determinant for the aggressiveness associated with increased tumor thickness in t1 2 oral tongue and buccal squamous cell carcinoma
    2013
    Co-Authors: Shyhkuan Tai, Muhhwa Yang, Penyuan Chu, Yifen Wang, Peter Muhsin Chang
    Abstract:

    Background Neck management for cN0 neck remains controversial for T1–2 oral tongue and buccal squamous cell carcinoma (SCC). Increased tumor thickness and Perineural Invasion (PNI) are two pathologic features that correlated with cervical lymph node (LN) metastasis and poor survival. However, the relationships between these two features remain unclear.

  • risks and clinical implications of Perineural Invasion in t1 2 oral tongue squamous cell carcinoma
    2012
    Co-Authors: Shyhkuan Tai, Penyuan Chu, Yifen Wang, Shyueyih Chang, Tunglung Tsai, Juilin Huang
    Abstract:

    Background Risks of Perineural Invasion (PNI) in T1-2 oral tongue squamous cell carcinoma (SCC) have not been specifically elucidated. Methods Pathological features, including PNI, were re-reviewed under regular hematoxylin-eosin staining in 190 patients with T1-2 oral tongue SCC. Results Tumor thickness >5 mm, PNI(+), and lymphovascular Invasion (+) independently predicted lymph node involvement. PNI(+) and neck observation also independently predicted neck recurrence, but only PNI(+) was associated with a poor disease-specific survival (DSS; p = .003). In patients who were clinically node negative (cN0), elective neck dissection contributed to a better DSS in patients with PNI(+) tumors (p = .046), but not in patients with PNI (-) tumors (p = .809). Additionally, increased tumor thickness predicted the presence of PNI. Conclusion PNI is a crucial pathological feature for T1-2 oral tongue SCC. Elective neck dissection should be performed in patients who were cN0 with PNI. Careful evaluation for PNI should be advocated in regular pathological diagnosis. © 2011 Wiley Periodicals, Inc. Head Neck, 2012

Timothy A Warren - One of the best experts on this subject based on the ideXlab platform.

  • histopathological features of clinical Perineural Invasion of cutaneous squamous cell carcinoma of the head and neck and the potential implications for treatment
    2014
    Co-Authors: Benedict Panizza, Timothy A Warren, Arturo C Solares, Glen M Boyle, Duncan Lambie, Ian Brown
    Abstract:

    BackgroundNonmelanoma skin cancer (NMSC) with Perineural Invasion (PNI) is most commonly seen in cutaneous squamous cell carcinoma of the head and neck (SCCHN). The cranial nerves are a conduit for skin cancer to reach the brainstem.

  • defining incidental Perineural Invasion the need for a national registry
    2014
    Co-Authors: Timothy A Warren, L Buchanan, Brian Deambrosis, K Deambrosis, Shyamala C Huilgol, Peter H Soyer, Benedict Panizza
    Abstract:

    This article by the Perineural Invasion (PNI) Registry Group aims to clarify clinical and histopathological ambiguities surrounding PNI in non-melanoma skin cancer (NMSC). PNI is reportedly present in approximately 2–6% of cases of NMSC and is associated with greater rates of morbidity and mortality. The distinction between clinical PNI and incidental PNI is somewhat unclear, especially in regard to management and prognosis. One important objective of the PNI Registry is to develop a standardised method of classifying Perineural Invasion. Hence, in this article we propose a definition for PNI and for its sub-classification. This article also provides a critical analysis of the current literature on the treatment of incidental PNI by evaluating the key cohort studies that have investigated the use of surgery or radiotherapy in the management of incidental PNI. At present, there are no universal clinical guidelines that specify the acceptable treatment of NMSC exhibiting incidental PNI. Consequently, patients often receive surgery with varying wider margins, or radiotherapy despite the limited evidence substantiating such management options. It is evident from the existing literature that current opinion is divided over the benefit of adjuvant radiotherapy. Certain prognostic factors have been proposed, such as the size and depth of tumour Invasion, nerve diameter, the presence of multifocal PNI and the type of tumour. The PNI Registry is a web-based registry that has been developed to assist in attaining further data pertaining to incidental PNI in NMSC. It is envisaged that this information will provide the foundation for identifying and defining best practice in managing incidental PNI.

  • Perineural Invasion of head and neck skin cancer diagnostic and therapeutic implications
    2013
    Co-Authors: Benedict Panizza, Timothy A Warren
    Abstract:

    Perineural Invasion of head and neck skin cancer is a poorly understood and often misdiagnosed pathological entity. Incidental or microscopic Perineural Invasion is identified by the pathologist and often leads to confusion as to how the patient should be further treated. The less common but more aggressive clinical Perineural spread presents with a clinical deficit, which is too commonly misinterpreted by the clinician. This review will try to clarify the terminology that exists in the literature and explore the mechanisms of Invasion and spread. It will look at the recent advances in diagnosis and comment on the limitations inherent in current classification schemes. A review of outcomes will be included and current treatment strategies utilized discussed.

Peter Muhsin Chang - One of the best experts on this subject based on the ideXlab platform.

Eric W Olcott - One of the best experts on this subject based on the ideXlab platform.

  • extrapancreatic Perineural Invasion in pancreatic adenocarcinoma
    2018
    Co-Authors: Bhavik N Patel, Eric W Olcott, Brooke R Jeffrey
    Abstract:

    Pancreatic ductal adenocarcinoma continues to be a highly lethal disease, despite advances in modern medicine. Curative surgical options continue to carry significant morbidity and offer little improvement in overall 5-year survival. Currently, imaging plays an essential role in the pre-operative evaluation of patients who are undergoing evaluation for resection. However, some pancreatic cancers have particularly aggressive biology, despite appearing resectable by conventional imaging criteria. Imaging biomarkers that serve as surrogates for tumors with such aggressive phenotype have been recently described, namely duodenal Invasion and extrapancreatic Perineural Invasion. In this pictorial review, we will summarize key concepts of extrapancreatic Perineural Invasion, describe its association with a poor prognosis, and highlight the role of imaging in its detection.

  • mdct diagnosis of Perineural Invasion involving the celiac plexus in intrahepatic cholangiocarcinoma preliminary observations and clinical implications
    2015
    Co-Authors: Kesav Raghavan, Bhavik N Patel, Eric W Olcott, Brooke R Jeffrey, Michael A Dimaio, Juergen K Willmann
    Abstract:

    OBJECTIVE. The purpose of this study was to test the hypothesis that soft-tissue infiltra tion along the celiac plexus and delayed enhancement exceeding two-thirds of the tumor area on preoperative MDCT correlate with histologic evidence of Perineural Invasion in resected intrahepatic cholangiocarcinomas. MATERIALS AND METHODS. Two experienced abdominal radiologists retrospectively reviewed preoperative multiphasic MDCT scans of 20 patients who underwent resection of intrahepatic cholangiocarcinoma, identifying soft-tissue infiltration along the celiac plexus, delayed enhancement exceeding two-thirds of the tumor area, and maximum tumor diameter. Consensus findings were compared with intratumoral Perineural Invasion in resect ed intrahepatic cholangiocarcinomas using the Fisher exact test. RESULTS. Six patients had histologic intratumoral Perineural Invasion, five of whom had soft-tissue infiltration along the celiac plexus on preoperative MDCT, with corresponding 83.3% sensitivity and 92.9% specificity for Perineural Invasion and significant association be tween these MDCT and histologic findings ( p = 0.002). No patients with histologic Perineural Invasion had enhancement exceeding two-thirds of the tumor area on MDCT; sensitivity was 0.0% for this finding. Tumor diameter on MDCT was not significantly associated with peri neural Invasion at histopathology (p = 0.530). CONCLUSION. Soft-tissue infiltration along the celiac plexus on MDCT is an indica tor of Perineural Invasion in patients with intrahepatic cholangiocarcinoma. The data did not confirm an association between delayed enhancement exceeding two-thirds of the tumor area and Perineural Invasion. Because Perineural Invasion from intrahepatic cholangiocarcinoma is associated with a very poor prognosis and is generally a contraindication to surgery, the MDCT diagnosis of celiac plexus Perineural Invasion in patients with intrahepatic cholangiocarcinoma may have important implications for prognosis and treatment planning.

Yuji Nimura - One of the best experts on this subject based on the ideXlab platform.

  • Perineural Invasion is a prognostic factor in intrahepatic cholangiocarcinoma
    2008
    Co-Authors: Kazuhisa Shirai, Yuji Nimura, Tomoki Ebata, Koji Oda, Hideki Nishio, Tetsuro Nagasaka, Masato Nagino
    Abstract:

    Background Perineural Invasion is commonly observed in biliary tract cancer and is an independent prognostic factor. Since intrahepatic cholangiocarcinoma (ICC) develops from biliary epithelia in the liver, ICC may share the same characteristics in terms of the prognostic implications of Perineural Invasion. The aim of this study was to evaluate the clinical significance of Perineural Invasion in ICC. Methods A total of 59 patients with ICC who underwent hepatectomy were retrospectively reviewed. The numbers of nerves with and without tumor involvement were counted. The Perineural Invasion index (PNI) was calculated as the number of involved nerves divided by the total number of nerves examined. Predictors for Perineural Invasion and prognostic factors were analyzed. Results Perineural Invasion was observed in 47 of 59 (80%) patients, and the median PNI was 0.082. The macroscopic tumor appearance and tumor location were significantly associated with Perineural Invasion (p = 0.013 and 0.032, respectively). Univariate and multivariate analyses (excluding seven in-hospital deaths) revealed that histologic grade, the presence of Perineural Invasion, nodal metastasis, and intrahepatic metastasis were independent prognostic factors. The survival rate of the patients with (n = 42) or without (n = 10) Perineural Invasion was 17 and 80% at 3 years; and 17 and 70% at 5 years, respectively (p = 0.001). Conclusion Perineural Invasion is frequently found in patients with ICC and is an independent prognostic factor. ICC is an aggressive tumor similar to other biliary tract cancers. Because Perineural Invasion is a histologic marker of aggressiveness, it potentially has a role as a determinant of patient selection for adjuvant therapy.

  • establishment of Perineural Invasion models and analysis of gene expression revealed an invariant chain cd74 as a possible molecule involved in Perineural Invasion in pancreatic cancer
    2006
    Co-Authors: Norimasa Koide, Taketo Yamada, Rie Shibata, Taisuke Mori, Mariko Fukuma, Ken Yamazaki, Koichi Aiura, Motohide Shimazu, Setsuo Hirohashi, Yuji Nimura
    Abstract:

    PURPOSE: Perineural Invasion causes frequent local recurrence even after resection and a poor prognosis for pancreatic cancer. We established Perineural Invasion models and analyzed the molecular mechanism of Perineural Invasion in pancreatic cancer. EXPERIMENTAL DESIGN: Seven pancreatic cancer cell lines with or without human peripheral nerves were s.c. implanted in nonobese diabetes/severe combined immunodeficient mice. We compared expression profiles among high and low Perineural Invasion cell lines by using an oligonucleotide microarray. We examined up-regulation of the invariant chain (CD74) in high Perineural Invasion cell lines in mRNA and protein levels and surgical cases immunohistochemically. RESULTS: Four of seven pancreatic cancer cell lines (CaPan1, CaPan2, CFPAC, and MPanc96) showed Perineural Invasion to s.c. transplanted human peripheral nerves. Moreover, CaPan1 and CaPan2 (high Perineural Invasion group) also resulted in a high frequency of Perineural Invasion to mouse s.c. peripheral nerves, whereas three pancreatic cancer cell lines HPAFII, AsPC1, and Panc1 (low Perineural Invasion group) did not show Perineural Invasion to either human or mouse nerves. We identified 37 up-regulated genes and 12 down-regulated genes in the high Perineural Invasion group compared with the low Perineural Invasion group. Among them, CD74 was up-regulated in the high Perineural Invasion group in mRNA and protein levels. Furthermore, immunohistochemical expression of CD74 in clinical cases revealed its significant overexpression in pancreatic cancer with Perineural Invasion (P < 0.008). CONCLUSIONS: This is the first report of Perineural Invasion models using human pancreatic cancer cell lines. In combination with gene expression profiling, it was indicated that CD74 could be a candidate molecule involved in Perineural Invasion. These models provide new approaches for study of Perineural Invasion in pancreatic cancer.

  • establishment of Perineural Invasion models and analysis of gene expression revealed an invariant chain cd74 as a possible molecule involved in Perineural Invasion in pancreatic cancer
    2006
    Co-Authors: Norimasa Koide, Taketo Yamada, Rie Shibata, Taisuke Mori, Mariko Fukuma, Ken Yamazaki, Koichi Aiura, Motohide Shimazu, Setsuo Hirohashi, Yuji Nimura
    Abstract:

    Purpose: Perineural Invasion causes frequent local recurrence even after resection and a poor prognosis for pancreatic cancer. We established Perineural Invasion models and analyzed the molecular mechanism of Perineural Invasion in pancreatic cancer. Experimental Design: Seven pancreatic cancer cell lines with or without human peripheral nerves were s.c. implanted in nonobese diabetes/severe combined immunodeficient mice. We compared expression profiles among high and low Perineural Invasion cell lines by using an oligonucleotide microarray. We examined up-regulation of the invariant chain (CD74) in high Perineural Invasion cell lines in mRNA and protein levels and surgical cases immunohistochemically. Results: Four of seven pancreatic cancer cell lines (CaPan1, CaPan2, CFPAC, and MPanc96) showed Perineural Invasion to s.c. transplanted human peripheral nerves. Moreover, CaPan1 and CaPan2 (high Perineural Invasion group) also resulted in a high frequency of Perineural Invasion to mouse s.c. peripheral nerves, whereas three pancreatic cancer cell lines HPAFII, AsPC1, and Panc1 (low Perineural Invasion group) did not show Perineural Invasion to either human or mouse nerves. We identified 37 up-regulated genes and 12 down-regulated genes in the high Perineural Invasion group compared with the low Perineural Invasion group. Among them, CD74 was up-regulated in the high Perineural Invasion group in mRNA and protein levels. Furthermore, immunohistochemical expression of CD74 in clinical cases revealed its significant overexpression in pancreatic cancer with Perineural Invasion ( P Conclusions: This is the first report of Perineural Invasion models using human pancreatic cancer cell lines. In combination with gene expression profiling, it was indicated that CD74 could be a candidate molecule involved in Perineural Invasion. These models provide new approaches for study of Perineural Invasion in pancreatic cancer.

  • clinicopathologic studies on Perineural Invasion of bile duct carcinoma
    1992
    Co-Authors: Md Mukhlesur Rahman Bhuiya, Yuji Nimura, Junichi Kamiya, Satoshi Kondo, Shinji Fukata, Naokazu Hayakawa, Shigehiko Shionoya
    Abstract:

    To elucidate the clinical significance of Perineural Invasion on bile duct cancer, a clinicopathologic study was performed on 70 resected patients with bile duct carcinoma. The overall incidence of Perineural Invasion in the resected specimen was 81.4%. There seemed to be no correlation between Perineural Invasion and site, size of the tumor, and lymph node metastasis. A significant correlation was observed, however, between macroscopic type, microscopic type, depth of Invasion, and Perineural Invasion. Perineural Invasion index (PNI) was defined as the ratio between the number of nerve fibers invaded by cancer and the total number of nerve fibers with and without cancer Invasion. Perineural Invasion index was significantly higher at the center compared with the proximal and distal part of the tumor (p less than 0.001). The 5-year survival rate for patients with Perineural Invasion was significantly lower (p less than 0.05) than that for those without Perineural Invasion (67% versus 32%).