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Michael Karampelas - One of the best experts on this subject based on the ideXlab platform.

  • quantitative analysis of Peripheral vasculitis Ischemia and vascular leakage in uveitis using ultra widefield fluorescein angiography
    American Journal of Ophthalmology, 2015
    Co-Authors: Dawn A Sim, Pearse A. Keane, Michael Karampelas, Colin J Chu, Ester Carreno, Javier Zarranzventura
    Abstract:

    Purpose To investigate the relationships between Peripheral vasculitis, Ischemia, and vascular leakage in uveitis using ultra-widefield fluorescein angiography (FA). Design Cross-sectional, consecutive case series. Methods Consecutive ultra-widefield FA images were collected from 82 uveitis patients (82 eyes) in a single center. The extent of Peripheral vasculitis, capillary nonperfusion, and vessel leakage were quantified. Parameters included: (1) foveal avascular zone area and macular leakage, (2) Peripheral diffuse capillary leakage and Ischemia, (3) Peripheral vasculitis, and (4) leakage from neovascularization. Central macular thickness measurements were derived with optical coherence tomography. Main outcome measures were correlations between central and Peripheral fluorangiographic changes as well as associations between visual function, ultra-widefield FA–derived metrics, and central macular thickness. Results Although central leakage was associated with Peripheral leakage (r = 0.553, P  = .001), there was no association between foveal avascular zone size and Peripheral Ischemia (r = 0.114, P  = .324), regardless of the underlying uveitic diagnosis. Peripheral Ischemia was, however, correlated to neovascularization-related leakage (r = 0.462, P  = .001) and focal vasculitis (r = 0.441, P  = .001). Stepwise multiple regression analysis revealed that a poor visual acuity was independently associated with foveal avascular zone size and central macular thickness (R 2 -adjusted = 0.45, P  = .001). Conclusions We present a large cohort of patients with uveitis imaged with ultra-widefield FA and further describe novel methods for quantification of Peripheral vascular pathology, in an attempt to identify visually significant parameters. Although we observed that relationships exist between Peripheral vessel leakage, vasculitis, and Ischemia, it was only macular Ischemia and increased macular thickness that were independently associated with a reduced visual acuity.

  • Patterns of Peripheral Retinal and Central Macula Ischemia in Diabetic Retinopathy as Evaluated by Ultra-widefield Fluorescein Angiography
    American journal of ophthalmology, 2014
    Co-Authors: Dawn A Sim, Pearse A. Keane, Ranjan Rajendram, Michael Karampelas, Senthil Selvam, Michael B. Powner, Marcus Fruttiger, Adnan Tufail, Catherine A Egan
    Abstract:

    Purpose To investigate the association between Peripheral and central Ischemia in diabetic retinopathy. Design Retrospective, cross-sectional. Methods Consecutive ultra-widefield fluorescein angiography images were collected from patients with diabetes over a 12-month period. Parameters quantified include the foveal avascular zone (FAZ) area, Peripheral ischemic index, Peripheral leakage index, and central retinal thickness measurements, as well as visual acuity. The Peripheral Ischemia or leakage index was calculated as the area of capillary nonperfusion or leakage, expressed as a percentage of the total retinal area. Results Forty-seven eyes of 47 patients were included. A moderate correlation was observed between the Peripheral Ischemia index and FAZ area (r = 0.49, P  = .0001). A moderate correlation was also observed between the Peripheral leakage index and FAZ area, but only in eyes that were laser naive (r = 0.44, P  = .02). A thinner retina was observed in eyes with macular Ischemia (217 ± 81.8 μm vs 272 ± 36.0 μm) ( P  = .02), but not Peripheral Ischemia (258 ± 76.3 μm vs 276 ± 68.0 μm) ( P  = .24). The relationships between different patterns of Peripheral and central macular pathology and visual acuity were evaluated in a step-wise multivariable regression model, and the variables that remained independently associated were age (r = 0.33, P  = .03), FAZ area (r = 0.45, P  = .02), and central retinal thickness (r = 0.38, P  = .01), (R 2 -adjusted = 0.36). Conclusions Ultra-widefield fluorescein angiography provides an insight into the relationships between diabetic vascular complications in the retinal periphery and central macula. Although we observed relationships between Ischemia and vascular leakage in the macula and periphery, it was only macular Ischemia and retinal thinning that was independently associated with a reduced visual function.

Dawn A Sim - One of the best experts on this subject based on the ideXlab platform.

  • quantitative analysis of Peripheral vasculitis Ischemia and vascular leakage in uveitis using ultra widefield fluorescein angiography
    American Journal of Ophthalmology, 2015
    Co-Authors: Dawn A Sim, Pearse A. Keane, Michael Karampelas, Colin J Chu, Ester Carreno, Javier Zarranzventura
    Abstract:

    Purpose To investigate the relationships between Peripheral vasculitis, Ischemia, and vascular leakage in uveitis using ultra-widefield fluorescein angiography (FA). Design Cross-sectional, consecutive case series. Methods Consecutive ultra-widefield FA images were collected from 82 uveitis patients (82 eyes) in a single center. The extent of Peripheral vasculitis, capillary nonperfusion, and vessel leakage were quantified. Parameters included: (1) foveal avascular zone area and macular leakage, (2) Peripheral diffuse capillary leakage and Ischemia, (3) Peripheral vasculitis, and (4) leakage from neovascularization. Central macular thickness measurements were derived with optical coherence tomography. Main outcome measures were correlations between central and Peripheral fluorangiographic changes as well as associations between visual function, ultra-widefield FA–derived metrics, and central macular thickness. Results Although central leakage was associated with Peripheral leakage (r = 0.553, P  = .001), there was no association between foveal avascular zone size and Peripheral Ischemia (r = 0.114, P  = .324), regardless of the underlying uveitic diagnosis. Peripheral Ischemia was, however, correlated to neovascularization-related leakage (r = 0.462, P  = .001) and focal vasculitis (r = 0.441, P  = .001). Stepwise multiple regression analysis revealed that a poor visual acuity was independently associated with foveal avascular zone size and central macular thickness (R 2 -adjusted = 0.45, P  = .001). Conclusions We present a large cohort of patients with uveitis imaged with ultra-widefield FA and further describe novel methods for quantification of Peripheral vascular pathology, in an attempt to identify visually significant parameters. Although we observed that relationships exist between Peripheral vessel leakage, vasculitis, and Ischemia, it was only macular Ischemia and increased macular thickness that were independently associated with a reduced visual acuity.

  • Patterns of Peripheral Retinal and Central Macula Ischemia in Diabetic Retinopathy as Evaluated by Ultra-widefield Fluorescein Angiography
    American journal of ophthalmology, 2014
    Co-Authors: Dawn A Sim, Pearse A. Keane, Ranjan Rajendram, Michael Karampelas, Senthil Selvam, Michael B. Powner, Marcus Fruttiger, Adnan Tufail, Catherine A Egan
    Abstract:

    Purpose To investigate the association between Peripheral and central Ischemia in diabetic retinopathy. Design Retrospective, cross-sectional. Methods Consecutive ultra-widefield fluorescein angiography images were collected from patients with diabetes over a 12-month period. Parameters quantified include the foveal avascular zone (FAZ) area, Peripheral ischemic index, Peripheral leakage index, and central retinal thickness measurements, as well as visual acuity. The Peripheral Ischemia or leakage index was calculated as the area of capillary nonperfusion or leakage, expressed as a percentage of the total retinal area. Results Forty-seven eyes of 47 patients were included. A moderate correlation was observed between the Peripheral Ischemia index and FAZ area (r = 0.49, P  = .0001). A moderate correlation was also observed between the Peripheral leakage index and FAZ area, but only in eyes that were laser naive (r = 0.44, P  = .02). A thinner retina was observed in eyes with macular Ischemia (217 ± 81.8 μm vs 272 ± 36.0 μm) ( P  = .02), but not Peripheral Ischemia (258 ± 76.3 μm vs 276 ± 68.0 μm) ( P  = .24). The relationships between different patterns of Peripheral and central macular pathology and visual acuity were evaluated in a step-wise multivariable regression model, and the variables that remained independently associated were age (r = 0.33, P  = .03), FAZ area (r = 0.45, P  = .02), and central retinal thickness (r = 0.38, P  = .01), (R 2 -adjusted = 0.36). Conclusions Ultra-widefield fluorescein angiography provides an insight into the relationships between diabetic vascular complications in the retinal periphery and central macula. Although we observed relationships between Ischemia and vascular leakage in the macula and periphery, it was only macular Ischemia and retinal thinning that was independently associated with a reduced visual function.

Pearse A. Keane - One of the best experts on this subject based on the ideXlab platform.

  • quantitative analysis of Peripheral vasculitis Ischemia and vascular leakage in uveitis using ultra widefield fluorescein angiography
    American Journal of Ophthalmology, 2015
    Co-Authors: Dawn A Sim, Pearse A. Keane, Michael Karampelas, Colin J Chu, Ester Carreno, Javier Zarranzventura
    Abstract:

    Purpose To investigate the relationships between Peripheral vasculitis, Ischemia, and vascular leakage in uveitis using ultra-widefield fluorescein angiography (FA). Design Cross-sectional, consecutive case series. Methods Consecutive ultra-widefield FA images were collected from 82 uveitis patients (82 eyes) in a single center. The extent of Peripheral vasculitis, capillary nonperfusion, and vessel leakage were quantified. Parameters included: (1) foveal avascular zone area and macular leakage, (2) Peripheral diffuse capillary leakage and Ischemia, (3) Peripheral vasculitis, and (4) leakage from neovascularization. Central macular thickness measurements were derived with optical coherence tomography. Main outcome measures were correlations between central and Peripheral fluorangiographic changes as well as associations between visual function, ultra-widefield FA–derived metrics, and central macular thickness. Results Although central leakage was associated with Peripheral leakage (r = 0.553, P  = .001), there was no association between foveal avascular zone size and Peripheral Ischemia (r = 0.114, P  = .324), regardless of the underlying uveitic diagnosis. Peripheral Ischemia was, however, correlated to neovascularization-related leakage (r = 0.462, P  = .001) and focal vasculitis (r = 0.441, P  = .001). Stepwise multiple regression analysis revealed that a poor visual acuity was independently associated with foveal avascular zone size and central macular thickness (R 2 -adjusted = 0.45, P  = .001). Conclusions We present a large cohort of patients with uveitis imaged with ultra-widefield FA and further describe novel methods for quantification of Peripheral vascular pathology, in an attempt to identify visually significant parameters. Although we observed that relationships exist between Peripheral vessel leakage, vasculitis, and Ischemia, it was only macular Ischemia and increased macular thickness that were independently associated with a reduced visual acuity.

  • Patterns of Peripheral Retinal and Central Macula Ischemia in Diabetic Retinopathy as Evaluated by Ultra-widefield Fluorescein Angiography
    American journal of ophthalmology, 2014
    Co-Authors: Dawn A Sim, Pearse A. Keane, Ranjan Rajendram, Michael Karampelas, Senthil Selvam, Michael B. Powner, Marcus Fruttiger, Adnan Tufail, Catherine A Egan
    Abstract:

    Purpose To investigate the association between Peripheral and central Ischemia in diabetic retinopathy. Design Retrospective, cross-sectional. Methods Consecutive ultra-widefield fluorescein angiography images were collected from patients with diabetes over a 12-month period. Parameters quantified include the foveal avascular zone (FAZ) area, Peripheral ischemic index, Peripheral leakage index, and central retinal thickness measurements, as well as visual acuity. The Peripheral Ischemia or leakage index was calculated as the area of capillary nonperfusion or leakage, expressed as a percentage of the total retinal area. Results Forty-seven eyes of 47 patients were included. A moderate correlation was observed between the Peripheral Ischemia index and FAZ area (r = 0.49, P  = .0001). A moderate correlation was also observed between the Peripheral leakage index and FAZ area, but only in eyes that were laser naive (r = 0.44, P  = .02). A thinner retina was observed in eyes with macular Ischemia (217 ± 81.8 μm vs 272 ± 36.0 μm) ( P  = .02), but not Peripheral Ischemia (258 ± 76.3 μm vs 276 ± 68.0 μm) ( P  = .24). The relationships between different patterns of Peripheral and central macular pathology and visual acuity were evaluated in a step-wise multivariable regression model, and the variables that remained independently associated were age (r = 0.33, P  = .03), FAZ area (r = 0.45, P  = .02), and central retinal thickness (r = 0.38, P  = .01), (R 2 -adjusted = 0.36). Conclusions Ultra-widefield fluorescein angiography provides an insight into the relationships between diabetic vascular complications in the retinal periphery and central macula. Although we observed relationships between Ischemia and vascular leakage in the macula and periphery, it was only macular Ischemia and retinal thinning that was independently associated with a reduced visual function.

Catherine A Egan - One of the best experts on this subject based on the ideXlab platform.

  • Patterns of Peripheral Retinal and Central Macula Ischemia in Diabetic Retinopathy as Evaluated by Ultra-widefield Fluorescein Angiography
    American journal of ophthalmology, 2014
    Co-Authors: Dawn A Sim, Pearse A. Keane, Ranjan Rajendram, Michael Karampelas, Senthil Selvam, Michael B. Powner, Marcus Fruttiger, Adnan Tufail, Catherine A Egan
    Abstract:

    Purpose To investigate the association between Peripheral and central Ischemia in diabetic retinopathy. Design Retrospective, cross-sectional. Methods Consecutive ultra-widefield fluorescein angiography images were collected from patients with diabetes over a 12-month period. Parameters quantified include the foveal avascular zone (FAZ) area, Peripheral ischemic index, Peripheral leakage index, and central retinal thickness measurements, as well as visual acuity. The Peripheral Ischemia or leakage index was calculated as the area of capillary nonperfusion or leakage, expressed as a percentage of the total retinal area. Results Forty-seven eyes of 47 patients were included. A moderate correlation was observed between the Peripheral Ischemia index and FAZ area (r = 0.49, P  = .0001). A moderate correlation was also observed between the Peripheral leakage index and FAZ area, but only in eyes that were laser naive (r = 0.44, P  = .02). A thinner retina was observed in eyes with macular Ischemia (217 ± 81.8 μm vs 272 ± 36.0 μm) ( P  = .02), but not Peripheral Ischemia (258 ± 76.3 μm vs 276 ± 68.0 μm) ( P  = .24). The relationships between different patterns of Peripheral and central macular pathology and visual acuity were evaluated in a step-wise multivariable regression model, and the variables that remained independently associated were age (r = 0.33, P  = .03), FAZ area (r = 0.45, P  = .02), and central retinal thickness (r = 0.38, P  = .01), (R 2 -adjusted = 0.36). Conclusions Ultra-widefield fluorescein angiography provides an insight into the relationships between diabetic vascular complications in the retinal periphery and central macula. Although we observed relationships between Ischemia and vascular leakage in the macula and periphery, it was only macular Ischemia and retinal thinning that was independently associated with a reduced visual function.

Giuseppe Querques - One of the best experts on this subject based on the ideXlab platform.