Retrospective Cohort Study

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Walter P Wodchis - One of the best experts on this subject based on the ideXlab platform.

  • atypical antipsychotic drugs and risk of ischaemic stroke population based Retrospective Cohort Study
    Journal of Neurology Neurosurgery and Psychiatry, 2005
    Co-Authors: Sudeep S Gill, Kathy Sykora, Paula A Rochon, Sharon-lise T. Normand, Nathan Herrmann, Philip E Lee, Nadia Gunraj, Jerry H Gurwitz, Connie Marras, Walter P Wodchis
    Abstract:

    To compare the incidence of admissions to hospital for stroke among older adults with dementia receiving atypical or typical antipsychotics. Design: Population based Retrospective Cohort Study. Setting: Ontario, Canada. patients: 32 710 older adults (⩾65 years) …

  • atypical antipsychotic drugs and risk of ischaemic stroke population based Retrospective Cohort Study
    BMJ, 2005
    Co-Authors: Sudeep S Gill, Kathy Sykora, Paula A Rochon, Sharon-lise T. Normand, Nathan Herrmann, Philip E Lee, Nadia Gunraj, Jerry H Gurwitz, Connie Marras, Walter P Wodchis
    Abstract:

    Abstract Objective To compare the incidence of admissions to hospital for stroke among older adults with dementia receiving atypical or typical antipsychotics. Design Population based Retrospective Cohort Study. Setting Ontario, Canada. Patients 32 710 older adults (≤ 65 years) with dementia (17 845 dispensed an atypical antipsychotic and 14 865 dispensed a typical antipsychotic). Main outcome measures Admission to hospital with the most responsible diagnosis (single most important condition responsible for the patient9s admission) of ischaemic stroke. Observation of patients until they were either admitted to hospital with ischaemic stroke, stopped taking antipsychotics, died, or the Study ended. Results After adjustment for potential confounders, participants receiving atypical antipsychotics showed no significant increase in risk of ischaemic stroke compared with those receiving typical antipsychotics (adjusted hazard ratio 1.01, 95% confidence interval 0.81 to 1.26). This finding was consistent in a series of subgroup analyses, including ones of individual atypical antipsychotic drugs (risperidone, olanzapine, and quetiapine) and selected subpopulations of the main Cohorts. Conclusion Older adults with dementia who take atypical antipsychotics have a similar risk of ischaemic stroke to those taking typical antipsychotics.

Sudeep S Gill - One of the best experts on this subject based on the ideXlab platform.

  • atypical antipsychotic drugs and risk of ischaemic stroke population based Retrospective Cohort Study
    Journal of Neurology Neurosurgery and Psychiatry, 2005
    Co-Authors: Sudeep S Gill, Kathy Sykora, Paula A Rochon, Sharon-lise T. Normand, Nathan Herrmann, Philip E Lee, Nadia Gunraj, Jerry H Gurwitz, Connie Marras, Walter P Wodchis
    Abstract:

    To compare the incidence of admissions to hospital for stroke among older adults with dementia receiving atypical or typical antipsychotics. Design: Population based Retrospective Cohort Study. Setting: Ontario, Canada. patients: 32 710 older adults (⩾65 years) …

  • atypical antipsychotic drugs and risk of ischaemic stroke population based Retrospective Cohort Study
    BMJ, 2005
    Co-Authors: Sudeep S Gill, Kathy Sykora, Paula A Rochon, Sharon-lise T. Normand, Nathan Herrmann, Philip E Lee, Nadia Gunraj, Jerry H Gurwitz, Connie Marras, Walter P Wodchis
    Abstract:

    Abstract Objective To compare the incidence of admissions to hospital for stroke among older adults with dementia receiving atypical or typical antipsychotics. Design Population based Retrospective Cohort Study. Setting Ontario, Canada. Patients 32 710 older adults (≤ 65 years) with dementia (17 845 dispensed an atypical antipsychotic and 14 865 dispensed a typical antipsychotic). Main outcome measures Admission to hospital with the most responsible diagnosis (single most important condition responsible for the patient9s admission) of ischaemic stroke. Observation of patients until they were either admitted to hospital with ischaemic stroke, stopped taking antipsychotics, died, or the Study ended. Results After adjustment for potential confounders, participants receiving atypical antipsychotics showed no significant increase in risk of ischaemic stroke compared with those receiving typical antipsychotics (adjusted hazard ratio 1.01, 95% confidence interval 0.81 to 1.26). This finding was consistent in a series of subgroup analyses, including ones of individual atypical antipsychotic drugs (risperidone, olanzapine, and quetiapine) and selected subpopulations of the main Cohorts. Conclusion Older adults with dementia who take atypical antipsychotics have a similar risk of ischaemic stroke to those taking typical antipsychotics.

Kathy W Belk - One of the best experts on this subject based on the ideXlab platform.

  • real world outcomes associated with idarucizumab population based Retrospective Cohort Study
    American Journal of Cardiovascular Drugs, 2020
    Co-Authors: Sonal Singh, Amit Nautiyal, Kathy W Belk
    Abstract:

    Idarucizumab reverses the anticoagulant effect of dabigatran, but few comparative studies have reported on clinical outcomes with idarucizumab. Our objective was to determine the effect of idarucizumab on clinical outcomes. We conducted a Retrospective Cohort Study in a nationally representative sample of hospitals in the United States. The Study population included adults ≥ 18 years who were hospitalized for dabigatran-associated major bleeding between January 1, 2015 and December 31, 2017. We compared idarucizumab-exposed patients to the unexposed group. Our primary outcome of interest was in-hospital mortality. We included 266 exposed and 1345 non-exposed participants across 271 hospitals. Among participants with gastrointestinal bleeding, there was no statistically significant difference in the odds of in-hospital mortality [9/153 (5.9%) vs 37/1124 (3.3%); adjusted odds ratio = 1.39, 95% confidence interval 0.51–3.45] between the idarucizumab-exposed and non-exposed groups. Among participants with intracranial bleeding, there was an excess of in-hospital mortality [13/112 (11.6%) vs 6/217 (2.8%)] associated with idarucizumab exposure, but limitations include sparse data and the inability to rule out residual confounding or confounding by disease severity. Among a large nationally representative sample of adult patients with dabigatran-associated major bleeding in the United States, we found no difference in in-hospital mortality among patients with gastrointestinal bleeding associated with idarucizumab exposure. An excess risk of in-hospital mortality associated with idarucizumab exposure among participants with intracranial bleeding deserves further exploration.

Sharon-lise T. Normand - One of the best experts on this subject based on the ideXlab platform.

  • atypical antipsychotic drugs and risk of ischaemic stroke population based Retrospective Cohort Study
    Journal of Neurology Neurosurgery and Psychiatry, 2005
    Co-Authors: Sudeep S Gill, Kathy Sykora, Paula A Rochon, Sharon-lise T. Normand, Nathan Herrmann, Philip E Lee, Nadia Gunraj, Jerry H Gurwitz, Connie Marras, Walter P Wodchis
    Abstract:

    To compare the incidence of admissions to hospital for stroke among older adults with dementia receiving atypical or typical antipsychotics. Design: Population based Retrospective Cohort Study. Setting: Ontario, Canada. patients: 32 710 older adults (⩾65 years) …

  • atypical antipsychotic drugs and risk of ischaemic stroke population based Retrospective Cohort Study
    BMJ, 2005
    Co-Authors: Sudeep S Gill, Kathy Sykora, Paula A Rochon, Sharon-lise T. Normand, Nathan Herrmann, Philip E Lee, Nadia Gunraj, Jerry H Gurwitz, Connie Marras, Walter P Wodchis
    Abstract:

    Abstract Objective To compare the incidence of admissions to hospital for stroke among older adults with dementia receiving atypical or typical antipsychotics. Design Population based Retrospective Cohort Study. Setting Ontario, Canada. Patients 32 710 older adults (≤ 65 years) with dementia (17 845 dispensed an atypical antipsychotic and 14 865 dispensed a typical antipsychotic). Main outcome measures Admission to hospital with the most responsible diagnosis (single most important condition responsible for the patient9s admission) of ischaemic stroke. Observation of patients until they were either admitted to hospital with ischaemic stroke, stopped taking antipsychotics, died, or the Study ended. Results After adjustment for potential confounders, participants receiving atypical antipsychotics showed no significant increase in risk of ischaemic stroke compared with those receiving typical antipsychotics (adjusted hazard ratio 1.01, 95% confidence interval 0.81 to 1.26). This finding was consistent in a series of subgroup analyses, including ones of individual atypical antipsychotic drugs (risperidone, olanzapine, and quetiapine) and selected subpopulations of the main Cohorts. Conclusion Older adults with dementia who take atypical antipsychotics have a similar risk of ischaemic stroke to those taking typical antipsychotics.

Kathy Sykora - One of the best experts on this subject based on the ideXlab platform.

  • atypical antipsychotic drugs and risk of ischaemic stroke population based Retrospective Cohort Study
    Journal of Neurology Neurosurgery and Psychiatry, 2005
    Co-Authors: Sudeep S Gill, Kathy Sykora, Paula A Rochon, Sharon-lise T. Normand, Nathan Herrmann, Philip E Lee, Nadia Gunraj, Jerry H Gurwitz, Connie Marras, Walter P Wodchis
    Abstract:

    To compare the incidence of admissions to hospital for stroke among older adults with dementia receiving atypical or typical antipsychotics. Design: Population based Retrospective Cohort Study. Setting: Ontario, Canada. patients: 32 710 older adults (⩾65 years) …

  • atypical antipsychotic drugs and risk of ischaemic stroke population based Retrospective Cohort Study
    BMJ, 2005
    Co-Authors: Sudeep S Gill, Kathy Sykora, Paula A Rochon, Sharon-lise T. Normand, Nathan Herrmann, Philip E Lee, Nadia Gunraj, Jerry H Gurwitz, Connie Marras, Walter P Wodchis
    Abstract:

    Abstract Objective To compare the incidence of admissions to hospital for stroke among older adults with dementia receiving atypical or typical antipsychotics. Design Population based Retrospective Cohort Study. Setting Ontario, Canada. Patients 32 710 older adults (≤ 65 years) with dementia (17 845 dispensed an atypical antipsychotic and 14 865 dispensed a typical antipsychotic). Main outcome measures Admission to hospital with the most responsible diagnosis (single most important condition responsible for the patient9s admission) of ischaemic stroke. Observation of patients until they were either admitted to hospital with ischaemic stroke, stopped taking antipsychotics, died, or the Study ended. Results After adjustment for potential confounders, participants receiving atypical antipsychotics showed no significant increase in risk of ischaemic stroke compared with those receiving typical antipsychotics (adjusted hazard ratio 1.01, 95% confidence interval 0.81 to 1.26). This finding was consistent in a series of subgroup analyses, including ones of individual atypical antipsychotic drugs (risperidone, olanzapine, and quetiapine) and selected subpopulations of the main Cohorts. Conclusion Older adults with dementia who take atypical antipsychotics have a similar risk of ischaemic stroke to those taking typical antipsychotics.