The Experts below are selected from a list of 186 Experts worldwide ranked by ideXlab platform
Gyula Stotz - One of the best experts on this subject based on the ideXlab platform.
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comparative scanning of thyroid nodules with technetium 99m Pertechnetate and technetium 99m methoxyisobutylisonitrile
European Journal of Nuclear Medicine and Molecular Imaging, 1993Co-Authors: Ivan Foldes, Annamaria Levay, Gyula StotzAbstract:Thyroid imaging was performed using technetium-99m methoxyisobutylisonitrile and technetium-99m Pertechnetate in 58 patients. The 99mTc-Pertechnetate scans showed a total of 77 nodules: 60 cold, 13 hot and 4 of normal activity. There was no 99mTc-MIBI accumulation in 46.4% of 99mTc-Pertechnetate cold nodules; 27 (45%) of these nodules showed 99mTc-MIBI uptake with the same intensity as the surrounding normal tissue, and five (8.6%) became hot with 99mTc-MIBI. Of the 99mTc-Pertechnetate hot nodules 11 (84.6%) could not be differentiated from the normal extranodular tissue on the 99mTc-MIBI scan. The histopathology of 34 surgically removed nodules proved that increased, normal or decreased 99mTc-MIBI accumulation is not specific for thyroid malignancy and that the 99mTc-MIBI uptake depends mainly on the viability of thyroid tissue.
Ralf C Clauss - One of the best experts on this subject based on the ideXlab platform.
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evaluation of thyroid nodules with technetium 99m mibi and technetium 99m Pertechnetate
Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2001Co-Authors: Michael M Sathekge, Ralph B Mageza, Nelson M Muthuphei, Charles M M Modiba, Ralf C ClaussAbstract:Background Most thyroid centers use fine-needle aspiration (FNA) and technetium-99m Pertechnetate for the preoperative assessment of thyroid nodules. This approach is sufficient in most cases other than follicular neoplasm, and follicular carcinoma is more common than papillary carcinoma in developing countries such as in our center. Technetium 99m-methoxyisobutylisonitrile (MIBI) proposed for myocardial perfusion was also found to be taken up by a variety of tumors including thyroid cancer. Methods We evaluated MIBI uptake of nodular thyroid disease and compared it with Pertechnetate scan, FNA, and histologic findings for the differentiation of malignant thyroid nodules from benign lesions. Seventy-one patients were included in the study. Three-phase Pertechnetate scintigraphy was completed after a single injection of 150 MBq. Perfusion/uptake mismatch (uniform perfusion with cold uptake) was regarded as positive for malignancy, whereas perfusion/uptake match (cold perfusion with cold uptake) was regarded as negative. After 1 week, 400 MBq of MIBI was injected, images were obtained at 20 minutes and 2 hours, and evaluated semiquantitatively by use of a 4-point (0–3) scoring system. MIBI scans were considered positive if there was uptake superior to normal thyroid tissue on early and delayed images (score = 3). In the following days and weeks, all patients underwent FNA followed by surgery. Results Histopathologic diagnosis revealed a total of 23 thyroid carcinomas, 21 (91%) and 19 (83%) were positive on MIBI and Pertechnetate, respectively. Of the 48 patients with benign nodules, 11 (23%) and 29 (60%) were positive on MIBI and Pertechnetate, respectively. The specificity of MIBI, Pertechnetate, and FNA is 77%, 40%, and 90%, respectively. Conclusions In combination with FNA and three-phase Pertechnetate scan, MIBI could be helpful in preoperative assessment of thyroid nodules. Intense MIBI activity increases the probability of thyroid cancer, whereas reduced activity drastically decreases the probability of malignancy. © 2001 John Wiley & Sons, Inc. Head Neck 23: 305–310, 2001.
Frederik A Verburg - One of the best experts on this subject based on the ideXlab platform.
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postsurgical thyroid remnant estimation by 99mtc Pertechnetate scintigraphy predicts radioiodine ablation effectiveness in patients with differentiated thyroid carcinoma
Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2011Co-Authors: Luca Giovanella, Sergio Suriano, Riccardo Ricci, Luca Ceriani, Frederik A VerburgAbstract:Background. The purpose of this study was to evaluate the relationship between postsurgical neck 99mtechnetium (99mTc)-Pertechnetate uptake and the rate of successful remnant ablation after radioiodine treatment in patients with differentiated thyroid carcinoma (DTC). Methods. Retrospectively enrolled were 232 patients with DTC who underwent total thyroidectomy and fixed activity ablation with 3.7 GBq 131I. The 99mTc scans were performed on all patients before 131I administration. Thyroid ablation was assessed after 6 to 12 months by thyroid-stimulating hormone (TSH)-stimulated 131I-WBS and thyroglobulin measurement. The rate of successful ablation, occurrence of radioiodine-induced thyroiditis, and length of hospitalization were correlated with the 99mTc-Pertechnetate scintigraphy results. Results. A 99mTc uptake was significantly lower in ablated versus nonablated patients (p < .001). High 99mTc-Pertechnetate uptake, especially greater than 1.4%, predicted a high-risk of unsuccessful ablation. Higher 99mTc-Pertechnetate uptake was also related to prolonged hospitalization and the occurrence of radioiodine-induced thyroiditis. Conclusion. The 99mTc-Pertechnetate scintigraphy is a simple and feasible tool to evaluate thyroid remnants and to predict radioiodine ablation results in patients with DTC. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Donald S Gann - One of the best experts on this subject based on the ideXlab platform.
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comparison of parathyroid imaging with technetium 99m Pertechnetate sestamibi subtraction double phase technetium 99m sestamibi and technetium 99m sestamibi spect
The Journal of Nuclear Medicine, 1997Co-Authors: Charles C Chen, Lawrence E Holder, William A Scovill, Ann Tehan, Donald S GannAbstract:The ability of 99m Tc-Pertechnetate/sestamibi subtraction, double-phase 99m Tc-sestamibi and 99m Tc-sestamibi SPECT imaging to localize abnormal parathyroid tissue was compared. Methods: Fifty-five consecutive patients had parathyroid imaging before surgery for hyperparathyroidism. Imaging consisted of 99m Tc-Pertechnetate pinhole images of the neck followed by 99m Tc-sestamibi pinhole images of the neck and parallel-hole images of the neck and chest (early images). Within 2.5-4.0 hr later pinhole images of the neck, parallel-hole and SPECT images of the neck and chest were obtained (late images). Nodular foci of increased sestamibi activity were considered abnormal. Results: The sensitivity for abnormal parathyroid glands by visual comparison of early images and Pertechnetate images was 72%-75%, late images and Pertechnetate images was 73%-78% and double-phase (early and late) sestamibi images was 62%-65%; computer subtraction of Pertechnetate from early images was 71%-74%; and SPECT imaging was 79%. The sensitivity for parathyroid adenomas was 89%-98%, while the sensitivity for hyperplastic parathyroid glands was only 47%-58%. Conclusion: Late imaging, computer subtraction and SPECT may not be necessary since they provided only marginal improvements on visual comparison of early sestamibi with Pertechnetate images. Double-phase sestamibi imaging was less sensitive, so baseline thyroid imaging with Pertechnetate is recommended.
Thierry Pourcher - One of the best experts on this subject based on the ideXlab platform.
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distribution and dynamics of 99mtc Pertechnetate uptake in the thyroid and other organs assessed by single photon emission computed tomography in living mice
Thyroid, 2010Co-Authors: Philippe R Franken, Julien Guglielmi, Christian Vanhove, Malick Koulibaly, Michel Defrise, Jacques Darcourt, Thierry PourcherAbstract:Background: 99mTc Pertechnetate is a well-known anion, used for clinical imaging of thyroid function. This gamma emitter is transported by the sodium iodide symporter but is not incorporated into thyroglobulin. Scintigraphy using 99mTc Pertechnetate or 123iodide represents a powerful tool for the study of sodium iodide symporter activity in different organs of living animal models. However, in many studies that have been performed in mice, the thyroid could not be distinguished from the salivary glands. In this work, we have evaluated the use of a clinically dedicated single-photon emission computed tomography (SPECT) camera for thyroid imaging and assessed what improvements are necessary for the development of this technique. Methods: SPECT of the mouse neck region, with pinhole collimation and geometric calibration, was used for the individual measurement of 99mTc Pertechnetate uptake in the thyroid and the salivary glands. Uptake in the stomach was studied by planar whole-body imaging. Uptake kinetics ...