The Experts below are selected from a list of 2391 Experts worldwide ranked by ideXlab platform
Oyvind M Andersen - One of the best experts on this subject based on the ideXlab platform.
-
Anthocyanins from tubers and shoots of the purple potato, Solanum tuberosum
Journal of Horticultural Science & Biotechnology, 2000Co-Authors: Torgils Fossen, Oyvind M AndersenAbstract:SummaryThe anthocyanin content of tubers and shoots of the purple potato, Solanum tuberosum cv. Congo has been determined using various chromatographic and spectroscopic techniques to be petanin and the novel 3-O-[6-(4-ferulyl-O-α-rhamnopyranosyl)-β-glucopyranoside]-5-O-β-glucopyranosides of Petunidin and malvidin. Acylated pigments constitute more than 98% of the total anthocyanin content both in tubers and shoots.
-
Anthocyanin trisaccharides in blue berries of Vaccinium padifolium
Food Chemistry, 2000Co-Authors: Luis Cabrita, Nils Åge Frøystein, Oyvind M AndersenAbstract:Delphinidin 3-O-a-rhamnoside, malvidin 3-O-(6 00 -O-a-rhamnopyranosyl-b-glucopyranoside) and the 3-O-(6 00 -O-a-rhamnopyranosyl-2 00 -O-b-xylopyranosyl-b-glucopyranosides) of cyanidin, Petunidin and peonidin were isolated by various chromatographic techniques from the edible berries of Vaccinium padifolium. Their complete structures were elucidated mainly by one- and twodimensional nuclear magnetic resonance spectroscopy. Together they account for 7% of the anthocyanin content in this species. No anthocyanidin 3-triglycoside, 3-rutinoside or 3-rhamnoside had previously been found in the genus Vaccinium. The 3-O-(6 00 -O-arhamnopyranosyl-2 00 -O-b-xylopyranosyl-b-glucopyranosides) of Petunidin and peonidin are novel compounds. # 2000 Elsevier
-
Anthocyanins in blue berries of Vaccinium padifolium
Phytochemistry, 1999Co-Authors: Luis Cabrita, Oyvind M AndersenAbstract:Abstract Twenty anthocyanins were isolated from the extract of the edible blue berries of Vaccinium padifolium (Uveira) by a combination of chromatographic techniques. Mainly on the basis of nuclear magnetic resonance techniques ( 1 H, COSY, TOCSY, HSQC, HMBC, SEFT) they were identified as the 3- O -β - glucopyranosides, 3- O -β-galactopyranosides, 3- O -β-arabinopyranosides and 3- O -sambubiosides (2″- O -β-xylopyranosyl- O -β-glucopyranosides) of delphinidin, cyanidin, Petunidin, malvidin and peonidin. Anthocyanidin disaccharides have not been identified in the genus Vaccinium previously, and the 3-sambubiosides of peonidin, Petunidin and malvidin are novel compounds.
-
Anthocyanins from reproductive structures in Pinaceae
Biochemical Systematics and Ecology, 1992Co-Authors: Oyvind M AndersenAbstract:Abstract Flowers and/or cones of seven species of the family Pinaceae were subjected to qualitative and quantitative examination for anthocyanins. Cyanidin- and peonidin-3-glucoside were found in the general Pinus, Picea and Larix . Male flowers of Picea abies contained, in addition, small amounts of delphinidin-3-glucosde (2%) and some unknown compounds (2%). Species belonging to Abies contained the 3-monoglucosides of delphinidin, Petunidin, cyanidin, malvidin and peonidin. This is the first identification of methoxylated anthocyanins in the Pinaceae, and no Petunidin- or malvidin-derivative has previously been reported to occur outside the Angiospermae.
Zeyuan Deng - One of the best experts on this subject based on the ideXlab platform.
-
synergistic antioxidant effects of Petunidin and lycopene in h9c2 cells submitted to hydrogen peroxide role of akt nrf2 pathway
Journal of Food Science, 2020Co-Authors: Shilian Zheng, Zeyuan Deng, Fang Chen, Liufeng Zheng, Yao Pan, Qian Xing, Rong TsaoAbstract:Phenolics and carotenoids coexist in fruits and vegetables and could possess interaction effects after consumption. The present study aims to elucidate the possible mechanisms of the antioxidant interactions between anthocyanins and carotenoids using Petunidin and lycopene as examples in hydrogen peroxide (H2 O2 )-induced heart myofibroblast cell (H9c2) line model. The results revealed that Petunidin and lycopene showed antioxidant effects and Petunidin in a larger proportion mixed with lycopene, for example, Petunidin: lycopene = 9:1 significantly protected against the loss of the cell viability (8.98 ± 1.03%) and intracellular antioxidant enzyme activities of superoxide dismutase (SOD, 27.07 ± 3.51%), catalase (CAT, 29.51 ± 6.12%), and glutathione peroxidase (GSH-Px, 20.33 ± 2.65%). Moreover, the messenger RNA (mRNA) and protein expressions of NAD(P)H quinone reductase (NQO1) and heme oxygenase (HO-1) of the nuclear factor erythrocyte 2-related factor 2 (Nrf2) signaling pathway were significantly induced in Petunidin, lycopene, and synergistic combinations, suggesting that the antioxidant action was through activating the Nrf2 antioxidant response pathway. This was further validated by Nrf2 siRNA, and the results that Petunidin significantly induced more of NQO1 expression and lycopene more of HO-1 suggested that the synergism may be a result of concerted actions by the two compounds on these two different target genes of the Nrf2 pathway. The two compounds also significantly increased the phosphorylation of Akt in synergistic combinations. Findings of the present study demonstrated that Petunidin and lycopene exerted synergistic antioxidant effects when Petunidin in a larger proportion in the combinations and contribute to the prevention of cellular redox homeostasis, which might provide a theoretical basis for phenolics and carotenoids playing beneficial effects on the cardiovascular risk. PRACTICAL APPLICATION: In this study, we revealed that the combined treatments of Petunidin and lycopen inhibited H2 O2 -induced oxidative damage in myocardial cells. Moreover, the treatments contributed to the Nrf2 pathway and the restoration of cellular redox homeostasis might provide a theoretical basis for phenolics and carotenoids playing beneficial effects on the cardiovascular risk.
-
Synergistic antioxidant effects of Petunidin and lycopene in H9c2 cells submitted to hydrogen peroxide: Role of Akt/Nrf2 pathway.
Journal of food science, 2020Co-Authors: Shilian Zheng, Zeyuan Deng, Fang Chen, Liufeng Zheng, Yao Pan, Qian Xing, Rong TsaoAbstract:Phenolics and carotenoids coexist in fruits and vegetables and could possess interaction effects after consumption. The present study aims to elucidate the possible mechanisms of the antioxidant interactions between anthocyanins and carotenoids using Petunidin and lycopene as examples in hydrogen peroxide (H2 O2 )-induced heart myofibroblast cell (H9c2) line model. The results revealed that Petunidin and lycopene showed antioxidant effects and Petunidin in a larger proportion mixed with lycopene, for example, Petunidin: lycopene = 9:1 significantly protected against the loss of the cell viability (8.98 ± 1.03%) and intracellular antioxidant enzyme activities of superoxide dismutase (SOD, 27.07 ± 3.51%), catalase (CAT, 29.51 ± 6.12%), and glutathione peroxidase (GSH-Px, 20.33 ± 2.65%). Moreover, the messenger RNA (mRNA) and protein expressions of NAD(P)H quinone reductase (NQO1) and heme oxygenase (HO-1) of the nuclear factor erythrocyte 2-related factor 2 (Nrf2) signaling pathway were significantly induced in Petunidin, lycopene, and synergistic combinations, suggesting that the antioxidant action was through activating the Nrf2 antioxidant response pathway. This was further validated by Nrf2 siRNA, and the results that Petunidin significantly induced more of NQO1 expression and lycopene more of HO-1 suggested that the synergism may be a result of concerted actions by the two compounds on these two different target genes of the Nrf2 pathway. The two compounds also significantly increased the phosphorylation of Akt in synergistic combinations. Findings of the present study demonstrated that Petunidin and lycopene exerted synergistic antioxidant effects when Petunidin in a larger proportion in the combinations and contribute to the prevention of cellular redox homeostasis, which might provide a theoretical basis for phenolics and carotenoids playing beneficial effects on the cardiovascular risk. PRACTICAL APPLICATION: In this study, we revealed that the combined treatments of Petunidin and lycopen inhibited H2 O2 -induced oxidative damage in myocardial cells. Moreover, the treatments contributed to the Nrf2 pathway and the restoration of cellular redox homeostasis might provide a theoretical basis for phenolics and carotenoids playing beneficial effects on the cardiovascular risk.
-
The antioxidant activity and active sites of delphinidin and Petunidin measured by DFT, in vitro chemical‐based and cell‐based assays
Journal of food biochemistry, 2019Co-Authors: Baiying Chen, Xuan Chen, Chengyue Zhang, Hongming Wang, Zeyuan DengAbstract:A computational DFT B3LYP method with 6-311G (d,p) basis set, the in vitro chemical-based and cellular antioxidant activity (CAA) assays were applied in this study to explain the structure-antioxidant activity relationships of delphinidin and Petunidin. The compound molecular structures, spectral properties, frontier orbital energy, and transition state of delphinidin and Petunidin were compared. In transition state, the result of the active site (O21-H32 and O22-H33) was consistent with the result of bond length. The frontier orbital theory results indicated that the probable antioxidant activity order was Petunidin (0.09126 a.u.) > delphinidin (0.09175 a.u.), which agreed well with the cell-based antioxidant activity determined by CAA. However, the order of ABTS•+ and DPPH radical scavenging activity was delphinidin > Petunidin. Our study could help to provide a rational approach for the investigation of antioxidant activity of phytochemicals. PRACTICAL APPLICATIONS: As anthocyanins, delphinidin and Petunidin with great antioxidant activity are widely found in various fruits and vegetables. However, there are many kinds of methods used to measure their antioxidant activity and the antioxidant mechanism which are not concrete and clear. Therefore, it is crucial to study the antioxidant actvity of anthocyanins utilizing the DFT method combined with in vitro chemical-based and cell-based assays. Our study could contribute not only to the elucidation of chemical mechanism of antioxidants and exploration the structural features in essence, but also to promote the further development of phytochemicals in the field of food chemistry and pharmacy.
-
the antioxidant activity and active sites of delphinidin and Petunidin measured by dft in vitro chemical based and cell based assays
Journal of Food Biochemistry, 2019Co-Authors: Baiying Chen, Xuan Chen, Chengyue Zhang, Hongming Wang, Zeyuan DengAbstract:A computational DFT B3LYP method with 6-311G (d,p) basis set, the in vitro chemical-based and cellular antioxidant activity (CAA) assays were applied in this study to explain the structure-antioxidant activity relationships of delphinidin and Petunidin. The compound molecular structures, spectral properties, frontier orbital energy, and transition state of delphinidin and Petunidin were compared. In transition state, the result of the active site (O21-H32 and O22-H33) was consistent with the result of bond length. The frontier orbital theory results indicated that the probable antioxidant activity order was Petunidin (0.09126 a.u.) > delphinidin (0.09175 a.u.), which agreed well with the cell-based antioxidant activity determined by CAA. However, the order of ABTS•+ and DPPH radical scavenging activity was delphinidin > Petunidin. Our study could help to provide a rational approach for the investigation of antioxidant activity of phytochemicals. PRACTICAL APPLICATIONS: As anthocyanins, delphinidin and Petunidin with great antioxidant activity are widely found in various fruits and vegetables. However, there are many kinds of methods used to measure their antioxidant activity and the antioxidant mechanism which are not concrete and clear. Therefore, it is crucial to study the antioxidant actvity of anthocyanins utilizing the DFT method combined with in vitro chemical-based and cell-based assays. Our study could contribute not only to the elucidation of chemical mechanism of antioxidants and exploration the structural features in essence, but also to promote the further development of phytochemicals in the field of food chemistry and pharmacy.
-
Effects of heat, ultrasound, and microwave processing on the stability and antioxidant activity of delphinidin and Petunidin.
Journal of food biochemistry, 2019Co-Authors: Furong Wang, Yan Qin, Yu Mao, Bing Zhang, Zeyuan DengAbstract:The effects of conventional heating, ultrasonic, and microwave treatments on the stability and antioxidant activities of anthocyanidin standards (delphinidin and Petunidin) were studied. The antioxidant activities of delphinidin and Petunidin significantly decreased during the treatments, which suggested that the antioxidant activities of the degradation products were lower than that of anthocyanidin. In addition, the degradation of delphinidin and Petunidin followed first-order reaction kinetics. The kinetic parameters indicated that delphinidin was more stable than Petunidin. The microwave treatment led to the fastest degradation, followed by the conventional heating and ultrasonic treatments. Moreover, three types of degradation products of delphinidin were found by HPLC-Q-TOF-MS after all three treatments, and they were phloroglucinaldehyde, delphinidin chalcone, and 3,4,5-trihydroxybenzoic acid. Petunidin was broken into phloroglucinaldehyde, Petunidin chalcone, and 3-methoxy-4,5- dihydroxybenzoic acid. PRACTICAL APPLICATIONS: Anthocyanins with great antioxidant activity are widely distributed in plants. The stability of the anthocyanin affects its antioxidant activity and bioavailability. When anthocyanins are degraded, their antioxidant activities change accordingly. Therefore, it is crucial to study the structure, stability, and antioxidant activity of anthocyanins. This paper explores the structures and pyrolysis pathways of delphinidin and Petunidin and provides basic data for the utilization and preservation of anthocyanins during food processing and production.
Rong Tsao - One of the best experts on this subject based on the ideXlab platform.
-
Synergistic antioxidant effects of Petunidin and lycopene in H9c2 cells submitted to hydrogen peroxide: Role of Akt/Nrf2 pathway.
Journal of food science, 2020Co-Authors: Shilian Zheng, Zeyuan Deng, Fang Chen, Liufeng Zheng, Yao Pan, Qian Xing, Rong TsaoAbstract:Phenolics and carotenoids coexist in fruits and vegetables and could possess interaction effects after consumption. The present study aims to elucidate the possible mechanisms of the antioxidant interactions between anthocyanins and carotenoids using Petunidin and lycopene as examples in hydrogen peroxide (H2 O2 )-induced heart myofibroblast cell (H9c2) line model. The results revealed that Petunidin and lycopene showed antioxidant effects and Petunidin in a larger proportion mixed with lycopene, for example, Petunidin: lycopene = 9:1 significantly protected against the loss of the cell viability (8.98 ± 1.03%) and intracellular antioxidant enzyme activities of superoxide dismutase (SOD, 27.07 ± 3.51%), catalase (CAT, 29.51 ± 6.12%), and glutathione peroxidase (GSH-Px, 20.33 ± 2.65%). Moreover, the messenger RNA (mRNA) and protein expressions of NAD(P)H quinone reductase (NQO1) and heme oxygenase (HO-1) of the nuclear factor erythrocyte 2-related factor 2 (Nrf2) signaling pathway were significantly induced in Petunidin, lycopene, and synergistic combinations, suggesting that the antioxidant action was through activating the Nrf2 antioxidant response pathway. This was further validated by Nrf2 siRNA, and the results that Petunidin significantly induced more of NQO1 expression and lycopene more of HO-1 suggested that the synergism may be a result of concerted actions by the two compounds on these two different target genes of the Nrf2 pathway. The two compounds also significantly increased the phosphorylation of Akt in synergistic combinations. Findings of the present study demonstrated that Petunidin and lycopene exerted synergistic antioxidant effects when Petunidin in a larger proportion in the combinations and contribute to the prevention of cellular redox homeostasis, which might provide a theoretical basis for phenolics and carotenoids playing beneficial effects on the cardiovascular risk. PRACTICAL APPLICATION: In this study, we revealed that the combined treatments of Petunidin and lycopen inhibited H2 O2 -induced oxidative damage in myocardial cells. Moreover, the treatments contributed to the Nrf2 pathway and the restoration of cellular redox homeostasis might provide a theoretical basis for phenolics and carotenoids playing beneficial effects on the cardiovascular risk.
-
synergistic antioxidant effects of Petunidin and lycopene in h9c2 cells submitted to hydrogen peroxide role of akt nrf2 pathway
Journal of Food Science, 2020Co-Authors: Shilian Zheng, Zeyuan Deng, Fang Chen, Liufeng Zheng, Yao Pan, Qian Xing, Rong TsaoAbstract:Phenolics and carotenoids coexist in fruits and vegetables and could possess interaction effects after consumption. The present study aims to elucidate the possible mechanisms of the antioxidant interactions between anthocyanins and carotenoids using Petunidin and lycopene as examples in hydrogen peroxide (H2 O2 )-induced heart myofibroblast cell (H9c2) line model. The results revealed that Petunidin and lycopene showed antioxidant effects and Petunidin in a larger proportion mixed with lycopene, for example, Petunidin: lycopene = 9:1 significantly protected against the loss of the cell viability (8.98 ± 1.03%) and intracellular antioxidant enzyme activities of superoxide dismutase (SOD, 27.07 ± 3.51%), catalase (CAT, 29.51 ± 6.12%), and glutathione peroxidase (GSH-Px, 20.33 ± 2.65%). Moreover, the messenger RNA (mRNA) and protein expressions of NAD(P)H quinone reductase (NQO1) and heme oxygenase (HO-1) of the nuclear factor erythrocyte 2-related factor 2 (Nrf2) signaling pathway were significantly induced in Petunidin, lycopene, and synergistic combinations, suggesting that the antioxidant action was through activating the Nrf2 antioxidant response pathway. This was further validated by Nrf2 siRNA, and the results that Petunidin significantly induced more of NQO1 expression and lycopene more of HO-1 suggested that the synergism may be a result of concerted actions by the two compounds on these two different target genes of the Nrf2 pathway. The two compounds also significantly increased the phosphorylation of Akt in synergistic combinations. Findings of the present study demonstrated that Petunidin and lycopene exerted synergistic antioxidant effects when Petunidin in a larger proportion in the combinations and contribute to the prevention of cellular redox homeostasis, which might provide a theoretical basis for phenolics and carotenoids playing beneficial effects on the cardiovascular risk. PRACTICAL APPLICATION: In this study, we revealed that the combined treatments of Petunidin and lycopen inhibited H2 O2 -induced oxidative damage in myocardial cells. Moreover, the treatments contributed to the Nrf2 pathway and the restoration of cellular redox homeostasis might provide a theoretical basis for phenolics and carotenoids playing beneficial effects on the cardiovascular risk.
Luis Cabrita - One of the best experts on this subject based on the ideXlab platform.
-
Anthocyanin trisaccharides in blue berries of Vaccinium padifolium
Food Chemistry, 2000Co-Authors: Luis Cabrita, Nils Åge Frøystein, Oyvind M AndersenAbstract:Delphinidin 3-O-a-rhamnoside, malvidin 3-O-(6 00 -O-a-rhamnopyranosyl-b-glucopyranoside) and the 3-O-(6 00 -O-a-rhamnopyranosyl-2 00 -O-b-xylopyranosyl-b-glucopyranosides) of cyanidin, Petunidin and peonidin were isolated by various chromatographic techniques from the edible berries of Vaccinium padifolium. Their complete structures were elucidated mainly by one- and twodimensional nuclear magnetic resonance spectroscopy. Together they account for 7% of the anthocyanin content in this species. No anthocyanidin 3-triglycoside, 3-rutinoside or 3-rhamnoside had previously been found in the genus Vaccinium. The 3-O-(6 00 -O-arhamnopyranosyl-2 00 -O-b-xylopyranosyl-b-glucopyranosides) of Petunidin and peonidin are novel compounds. # 2000 Elsevier
-
Anthocyanins in blue berries of Vaccinium padifolium
Phytochemistry, 1999Co-Authors: Luis Cabrita, Oyvind M AndersenAbstract:Abstract Twenty anthocyanins were isolated from the extract of the edible blue berries of Vaccinium padifolium (Uveira) by a combination of chromatographic techniques. Mainly on the basis of nuclear magnetic resonance techniques ( 1 H, COSY, TOCSY, HSQC, HMBC, SEFT) they were identified as the 3- O -β - glucopyranosides, 3- O -β-galactopyranosides, 3- O -β-arabinopyranosides and 3- O -sambubiosides (2″- O -β-xylopyranosyl- O -β-glucopyranosides) of delphinidin, cyanidin, Petunidin, malvidin and peonidin. Anthocyanidin disaccharides have not been identified in the genus Vaccinium previously, and the 3-sambubiosides of peonidin, Petunidin and malvidin are novel compounds.
Shilian Zheng - One of the best experts on this subject based on the ideXlab platform.
-
Synergistic antioxidant effects of Petunidin and lycopene in H9c2 cells submitted to hydrogen peroxide: Role of Akt/Nrf2 pathway.
Journal of food science, 2020Co-Authors: Shilian Zheng, Zeyuan Deng, Fang Chen, Liufeng Zheng, Yao Pan, Qian Xing, Rong TsaoAbstract:Phenolics and carotenoids coexist in fruits and vegetables and could possess interaction effects after consumption. The present study aims to elucidate the possible mechanisms of the antioxidant interactions between anthocyanins and carotenoids using Petunidin and lycopene as examples in hydrogen peroxide (H2 O2 )-induced heart myofibroblast cell (H9c2) line model. The results revealed that Petunidin and lycopene showed antioxidant effects and Petunidin in a larger proportion mixed with lycopene, for example, Petunidin: lycopene = 9:1 significantly protected against the loss of the cell viability (8.98 ± 1.03%) and intracellular antioxidant enzyme activities of superoxide dismutase (SOD, 27.07 ± 3.51%), catalase (CAT, 29.51 ± 6.12%), and glutathione peroxidase (GSH-Px, 20.33 ± 2.65%). Moreover, the messenger RNA (mRNA) and protein expressions of NAD(P)H quinone reductase (NQO1) and heme oxygenase (HO-1) of the nuclear factor erythrocyte 2-related factor 2 (Nrf2) signaling pathway were significantly induced in Petunidin, lycopene, and synergistic combinations, suggesting that the antioxidant action was through activating the Nrf2 antioxidant response pathway. This was further validated by Nrf2 siRNA, and the results that Petunidin significantly induced more of NQO1 expression and lycopene more of HO-1 suggested that the synergism may be a result of concerted actions by the two compounds on these two different target genes of the Nrf2 pathway. The two compounds also significantly increased the phosphorylation of Akt in synergistic combinations. Findings of the present study demonstrated that Petunidin and lycopene exerted synergistic antioxidant effects when Petunidin in a larger proportion in the combinations and contribute to the prevention of cellular redox homeostasis, which might provide a theoretical basis for phenolics and carotenoids playing beneficial effects on the cardiovascular risk. PRACTICAL APPLICATION: In this study, we revealed that the combined treatments of Petunidin and lycopen inhibited H2 O2 -induced oxidative damage in myocardial cells. Moreover, the treatments contributed to the Nrf2 pathway and the restoration of cellular redox homeostasis might provide a theoretical basis for phenolics and carotenoids playing beneficial effects on the cardiovascular risk.
-
synergistic antioxidant effects of Petunidin and lycopene in h9c2 cells submitted to hydrogen peroxide role of akt nrf2 pathway
Journal of Food Science, 2020Co-Authors: Shilian Zheng, Zeyuan Deng, Fang Chen, Liufeng Zheng, Yao Pan, Qian Xing, Rong TsaoAbstract:Phenolics and carotenoids coexist in fruits and vegetables and could possess interaction effects after consumption. The present study aims to elucidate the possible mechanisms of the antioxidant interactions between anthocyanins and carotenoids using Petunidin and lycopene as examples in hydrogen peroxide (H2 O2 )-induced heart myofibroblast cell (H9c2) line model. The results revealed that Petunidin and lycopene showed antioxidant effects and Petunidin in a larger proportion mixed with lycopene, for example, Petunidin: lycopene = 9:1 significantly protected against the loss of the cell viability (8.98 ± 1.03%) and intracellular antioxidant enzyme activities of superoxide dismutase (SOD, 27.07 ± 3.51%), catalase (CAT, 29.51 ± 6.12%), and glutathione peroxidase (GSH-Px, 20.33 ± 2.65%). Moreover, the messenger RNA (mRNA) and protein expressions of NAD(P)H quinone reductase (NQO1) and heme oxygenase (HO-1) of the nuclear factor erythrocyte 2-related factor 2 (Nrf2) signaling pathway were significantly induced in Petunidin, lycopene, and synergistic combinations, suggesting that the antioxidant action was through activating the Nrf2 antioxidant response pathway. This was further validated by Nrf2 siRNA, and the results that Petunidin significantly induced more of NQO1 expression and lycopene more of HO-1 suggested that the synergism may be a result of concerted actions by the two compounds on these two different target genes of the Nrf2 pathway. The two compounds also significantly increased the phosphorylation of Akt in synergistic combinations. Findings of the present study demonstrated that Petunidin and lycopene exerted synergistic antioxidant effects when Petunidin in a larger proportion in the combinations and contribute to the prevention of cellular redox homeostasis, which might provide a theoretical basis for phenolics and carotenoids playing beneficial effects on the cardiovascular risk. PRACTICAL APPLICATION: In this study, we revealed that the combined treatments of Petunidin and lycopen inhibited H2 O2 -induced oxidative damage in myocardial cells. Moreover, the treatments contributed to the Nrf2 pathway and the restoration of cellular redox homeostasis might provide a theoretical basis for phenolics and carotenoids playing beneficial effects on the cardiovascular risk.