The Experts below are selected from a list of 34953 Experts worldwide ranked by ideXlab platform
Alejandro Sosnik - One of the best experts on this subject based on the ideXlab platform.
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poly ethylene oxide poly propylene oxide block copolymer micelles as drug delivery agents improved hydrosolubility stability and bioavailability of drugs
European Journal of Pharmaceutics and Biopharmaceutics, 2007Co-Authors: Diego A Chiappetta, Alejandro SosnikAbstract:The low solubility in biological fluids displayed by about 50% of the drugs still remains the main limitation in oral, parenteral, and transdermal administration. Among the existing strategies to overcome these drawbacks, inclusion of hydrophobic drugs into polymeric micelles is one of the most attractive alternatives. Amphiphilic poly(ethylene oxide)-poly(propylene oxide) block copolymers are thermoresponsive materials that display unique aggregation properties in aqueous medium. Due to their ability to form stable micellar systems in water, these materials are broadly studied as hydrosolubilizers for poorly water-soluble drugs. The present review provides a concise description of the most important applications of PEO-PPO-based copolymers in the Pharmaceutical Technology field as means for attaining improved solubility, stability, release, and bioavailability of drugs.
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poly ethylene oxide poly propylene oxide block copolymer micelles as drug delivery agents improved hydrosolubility stability and bioavailability of drugs
European Journal of Pharmaceutics and Biopharmaceutics, 2007Co-Authors: Diego A Chiappetta, Alejandro SosnikAbstract:The low solubility in biological fluids displayed by about 50% of the drugs still remains the main limitation in oral, parenteral, and transdermal administration. Among the existing strategies to overcome these drawbacks, inclusion of hydrophobic drugs into polymeric micelles is one of the most attractive alternatives. Amphiphilic poly(ethylene oxide)–poly(propylene oxide) block copolymers are thermoresponsive materials that display unique aggregation properties in aqueous medium. Due to their ability to form stable micellar systems in water, these materials are broadly studied as hydrosolubilizers for poorly water-soluble drugs. The present review provides a concise description of the most important applications of PEO–PPO-based copolymers in the Pharmaceutical Technology field as means for attaining improved solubility, stability, release, and bioavailability of drugs. � 2007 Elsevier B.V. All rights reserved.
Diego A Chiappetta - One of the best experts on this subject based on the ideXlab platform.
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poly ethylene oxide poly propylene oxide block copolymer micelles as drug delivery agents improved hydrosolubility stability and bioavailability of drugs
European Journal of Pharmaceutics and Biopharmaceutics, 2007Co-Authors: Diego A Chiappetta, Alejandro SosnikAbstract:The low solubility in biological fluids displayed by about 50% of the drugs still remains the main limitation in oral, parenteral, and transdermal administration. Among the existing strategies to overcome these drawbacks, inclusion of hydrophobic drugs into polymeric micelles is one of the most attractive alternatives. Amphiphilic poly(ethylene oxide)-poly(propylene oxide) block copolymers are thermoresponsive materials that display unique aggregation properties in aqueous medium. Due to their ability to form stable micellar systems in water, these materials are broadly studied as hydrosolubilizers for poorly water-soluble drugs. The present review provides a concise description of the most important applications of PEO-PPO-based copolymers in the Pharmaceutical Technology field as means for attaining improved solubility, stability, release, and bioavailability of drugs.
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poly ethylene oxide poly propylene oxide block copolymer micelles as drug delivery agents improved hydrosolubility stability and bioavailability of drugs
European Journal of Pharmaceutics and Biopharmaceutics, 2007Co-Authors: Diego A Chiappetta, Alejandro SosnikAbstract:The low solubility in biological fluids displayed by about 50% of the drugs still remains the main limitation in oral, parenteral, and transdermal administration. Among the existing strategies to overcome these drawbacks, inclusion of hydrophobic drugs into polymeric micelles is one of the most attractive alternatives. Amphiphilic poly(ethylene oxide)–poly(propylene oxide) block copolymers are thermoresponsive materials that display unique aggregation properties in aqueous medium. Due to their ability to form stable micellar systems in water, these materials are broadly studied as hydrosolubilizers for poorly water-soluble drugs. The present review provides a concise description of the most important applications of PEO–PPO-based copolymers in the Pharmaceutical Technology field as means for attaining improved solubility, stability, release, and bioavailability of drugs. � 2007 Elsevier B.V. All rights reserved.
Krzysztof Cal - One of the best experts on this subject based on the ideXlab platform.
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spray drying technique ii current applications in Pharmaceutical Technology
Journal of Pharmaceutical Sciences, 2010Co-Authors: Krzysztof Sollohub, Krzysztof CalAbstract:This review presents current applications of spray drying in Pharmaceutical Technology. The topics discussed include the obtention of excipients and cospray dried composites, methods for increasing the aqueous solubility and bioavailability of active substances, and modified release profiles from spray-dried particles. This review also describes the use of the spray drying technique in the context of biological therapies, such as the spray drying of proteins, inhalable powders, and viable organisms, and the modification of the physical properties of dry plant extracts. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:587–597, 2010
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spray drying technique i hardware and process parameters
Journal of Pharmaceutical Sciences, 2010Co-Authors: Krzysztof Cal, Krzysztof SollohubAbstract:Spray drying is a transformation of feed from a fluid state into a dried particulate form by spraying the feed into a hot drying medium. The main aim of drying by this method in Pharmaceutical Technology is to obtain dry particles with desired properties. This review presents the hardware and process parameters that affect the properties of the dried product. The atomization devices, drying chambers, air-droplet contact systems, the collection of dried product, auxiliary devices, the conduct of the spray drying process, and the significance of the individual parameters in the drying process, as well as the obtained product, are described and discussed.
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spray drying technique i hardware and process parameters
Journal of Pharmaceutical Sciences, 2010Co-Authors: Krzysztof Cal, Krzysztof SollohubAbstract:Spray drying is a transformation of feed from a fluid state into a dried particulate form by spraying the feed into a hot drying medium. The main aim of drying by this method in Pharmaceutical Technology is to obtain dry particles with desired properties. This review presents the hardware and process parameters that affect the properties of the dried product. The atomization devices, drying chambers, air–droplet contact systems, the collection of dried product, auxiliary devices, the conduct of the spray drying process, and the significance of the individual parameters in the drying process, as well as the obtained product, are described and discussed. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:575–586, 2010
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spray drying technique ii current applications in Pharmaceutical Technology
Journal of Pharmaceutical Sciences, 2010Co-Authors: Krzysztof Sollohub, Krzysztof CalAbstract:This review presents current applications of spray drying in Pharmaceutical Technology. The topics discussed include the obtention of excipients and cospray dried composites, methods for increasing the aqueous solubility and bioavailability of active substances, and modified release profiles from spray-dried particles. This review also describes the use of the spray drying technique in the context of biological therapies, such as the spray drying of proteins, inhalable powders, and viable organisms, and the modification of the physical properties of dry plant extracts.
Krzysztof Sollohub - One of the best experts on this subject based on the ideXlab platform.
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spray drying technique ii current applications in Pharmaceutical Technology
Journal of Pharmaceutical Sciences, 2010Co-Authors: Krzysztof Sollohub, Krzysztof CalAbstract:This review presents current applications of spray drying in Pharmaceutical Technology. The topics discussed include the obtention of excipients and cospray dried composites, methods for increasing the aqueous solubility and bioavailability of active substances, and modified release profiles from spray-dried particles. This review also describes the use of the spray drying technique in the context of biological therapies, such as the spray drying of proteins, inhalable powders, and viable organisms, and the modification of the physical properties of dry plant extracts. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:587–597, 2010
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spray drying technique i hardware and process parameters
Journal of Pharmaceutical Sciences, 2010Co-Authors: Krzysztof Cal, Krzysztof SollohubAbstract:Spray drying is a transformation of feed from a fluid state into a dried particulate form by spraying the feed into a hot drying medium. The main aim of drying by this method in Pharmaceutical Technology is to obtain dry particles with desired properties. This review presents the hardware and process parameters that affect the properties of the dried product. The atomization devices, drying chambers, air-droplet contact systems, the collection of dried product, auxiliary devices, the conduct of the spray drying process, and the significance of the individual parameters in the drying process, as well as the obtained product, are described and discussed.
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spray drying technique i hardware and process parameters
Journal of Pharmaceutical Sciences, 2010Co-Authors: Krzysztof Cal, Krzysztof SollohubAbstract:Spray drying is a transformation of feed from a fluid state into a dried particulate form by spraying the feed into a hot drying medium. The main aim of drying by this method in Pharmaceutical Technology is to obtain dry particles with desired properties. This review presents the hardware and process parameters that affect the properties of the dried product. The atomization devices, drying chambers, air–droplet contact systems, the collection of dried product, auxiliary devices, the conduct of the spray drying process, and the significance of the individual parameters in the drying process, as well as the obtained product, are described and discussed. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:575–586, 2010
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spray drying technique ii current applications in Pharmaceutical Technology
Journal of Pharmaceutical Sciences, 2010Co-Authors: Krzysztof Sollohub, Krzysztof CalAbstract:This review presents current applications of spray drying in Pharmaceutical Technology. The topics discussed include the obtention of excipients and cospray dried composites, methods for increasing the aqueous solubility and bioavailability of active substances, and modified release profiles from spray-dried particles. This review also describes the use of the spray drying technique in the context of biological therapies, such as the spray drying of proteins, inhalable powders, and viable organisms, and the modification of the physical properties of dry plant extracts.
Eliana B. Souto - One of the best experts on this subject based on the ideXlab platform.
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lipid nanoparticles sln nlc overcoming the anatomical and physiological barriers of the eye part i barriers and determining factors in ocular delivery
European Journal of Pharmaceutics and Biopharmaceutics, 2017Co-Authors: Elena Sanchezlopez, Eliana B. Souto, Marta Espina, Slavomira Doktorovova, M L GarciaAbstract:Abstract Ocular drug delivery is still a challenge for researchers in the field of Pharmaceutical Technology due to anatomical and physiological eye characteristics. The tissue barriers (such as cornea, conjunctiva, blood aqueous barrier, and blood–retinal barrier) limit the access of drugs to their targets. Taking into account the short retention time in the precorneal area of classical ocular dosage forms (e.g. solutions, suspensions or ointments) which are rapidly eliminated by tears and eyelid movement, only less than five percent of the administered drug attains intraocular structures. With the aim to overcome ocular barriers, drug delivery systems, able to increase ocular bioavailability reducing side effects, are recognized as promising alternative. In this review, the main barriers and strategies to increase drug transport in ocular delivery are comprehensively discussed, highlighting the factors involved in ocular transport of SLN and NLC.
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Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery
Journal of Drug Delivery, 2012Co-Authors: Patricia Severino, Maria Helena A. Santana, Joana F Fangueiro, Tatiana Andreani, Ana Sofia Macedo, Amelia M Silva, Eliana B. SoutoAbstract:Lipids and lipid nanoparticles are extensively employed as oral-delivery systems for drugs and other active ingredients. These have been exploited for many features in the field of Pharmaceutical Technology. Lipids usually enhance drug absorption in the gastrointestinal tract (GIT), and when formulated as nanoparticles, these molecules improve mucosal adhesion due to small particle size and increasing their GIT residence time. In addition, lipid nanoparticles may also protect the loaded drugs from chemical and enzymatic degradation and gradually release drug molecules from the lipid matrix into blood, resulting in improved therapeutic profiles compared to free drug. Therefore, due to their physiological and biodegradable properties, lipid molecules may decrease adverse side effects and chronic toxicity of the drug-delivery systems when compared to other of polymeric nature. This paper highlights the importance of lipid nanoparticles to modify the release profile and the pharmacokinetic parameters of drugs when administrated through oral route.
