The Experts below are selected from a list of 234 Experts worldwide ranked by ideXlab platform
Michael C Fitzgerald - One of the best experts on this subject based on the ideXlab platform.
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targeted mass spectrometry based approach for protein ligand binding analyses in complex biological mixtures using a Phenacyl Bromide modification strategy
Analytical Chemistry, 2016Co-Authors: Dongyu Wang, David M Gooden, Carol H Ball, Michael C FitzgeraldAbstract:The characterization of protein folding stability changes on the proteomic scale is useful for protein-target discovery and for the characterization of biological states. The Stability of Proteins from Rates of Oxidation (SPROX) technique is one of several mass spectrometry-based techniques recently established for the making proteome-wide measurements of protein folding and stability. A critical part of proteome-wide applications of SPROX is the identification and quantitation of methionine-containing peptides. Demonstrated here is a targeted mass spectrometry-based proteomics strategy for the detection and quantitation of methionine-containing peptides in SPROX experiments. The strategy involves the use of Phenacyl Bromide (PAB) for the targeted detection and quantitation of methionine-containing peptides in SPROX using selective reaction monitoring (SRM) on a triple quadrupole mass spectrometer (QQQ-MS). As proof-of-principle, the known binding interaction of Cyclosporine A with cyclophilin A protein i...
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Targeted Mass Spectrometry-Based Approach for Protein–Ligand Binding Analyses in Complex Biological Mixtures Using a Phenacyl Bromide Modification Strategy
Analytical Chemistry, 2016Co-Authors: Dongyu Wang, David M Gooden, Carol H Ball, Michael C FitzgeraldAbstract:The characterization of protein folding stability changes on the proteomic scale is useful for protein-target discovery and for the characterization of biological states. The Stability of Proteins from Rates of Oxidation (SPROX) technique is one of several mass spectrometry-based techniques recently established for the making proteome-wide measurements of protein folding and stability. A critical part of proteome-wide applications of SPROX is the identification and quantitation of methionine-containing peptides. Demonstrated here is a targeted mass spectrometry-based proteomics strategy for the detection and quantitation of methionine-containing peptides in SPROX experiments. The strategy involves the use of Phenacyl Bromide (PAB) for the targeted detection and quantitation of methionine-containing peptides in SPROX using selective reaction monitoring (SRM) on a triple quadrupole mass spectrometer (QQQ-MS). As proof-of-principle, the known binding interaction of Cyclosporine A with cyclophilin A protein i...
Padma L Nayak - One of the best experts on this subject based on the ideXlab platform.
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Synthetic resins. X. Resin copolymers from hydroxy Phenacyl Bromide, substituted benzoic acid/formaldehyde
Journal of Applied Polymer Science, 2003Co-Authors: Pramod K Nayak, Subasini Lenka, Padma L NayakAbstract:A number of resin copolymers have been synthesized by condensing p-hydroxy Phenacyl Bromide, substituted benzoic acids, and formaldehyde catalyzed by acids. The resin copolymers were characterized by IR spectra. The solution, thermal and chemical properties of the resins have been investigated. Ion exchange selectivity with respect to Cu 2+ and Co 2+ has been studied at different pH. Bacteriocidal and fungicidal properties of the resins have also been evaluated
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synthetic resins x resin copolymers from hydroxy Phenacyl Bromide substituted benzoic acid formaldehyde
Journal of Applied Polymer Science, 1990Co-Authors: Pramod K Nayak, Subasini Lenka, Padma L NayakAbstract:A number of resin copolymers have been synthesized by condensing p-hydroxy Phenacyl Bromide, substituted benzoic acids, and formaldehyde catalyzed by acids. The resin copolymers were characterized by IR spectra. The solution, thermal and chemical properties of the resins have been investigated. Ion exchange selectivity with respect to Cu 2+ and Co 2+ has been studied at different pH. Bacteriocidal and fungicidal properties of the resins have also been evaluated
Danyi Wu - One of the best experts on this subject based on the ideXlab platform.
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triphenylarsine catalyzed cyclopropanation highly stereoselective synthesis of trans 2 3 dihydro spiro cyclopropane 1 2 indan 1 3 dione from alkene and Phenacyl Bromide
Synthetic Communications, 2008Co-Authors: Weiqi Tong, Jie Chen, Hongmei Deng, Danyi WuAbstract:Abstract The triphenylarsine-catalyzed approach for the highly stereoselective synthesis of trans-2,3-dihydro-spiro[cyclopropane-1,2′-indan-1′,3′-dione] with alkenes and Phenacyl Bromide in organic solvent is described. The triphenylarsine-catalyzed cyclopropanation in water was investigated. The mixture of cis/trans isomers is provided with water as a solvent. The cis isomer is formed using water as a solvent. The reactivity of the reaction in water is higher than that in the organic solvent.
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Triphenylarsine-Catalyzed Cyclopropanation: Highly Stereoselective Synthesis of Trans -2,3-Dihydro-Spiro[Cyclopropane-1,2′-Indan-1′,3′-dione] from Alkene and Phenacyl Bromide
Synthetic Communications, 2008Co-Authors: Weiqi Tong, Jie Chen, Hongmei Deng, Danyi WuAbstract:Abstract The triphenylarsine-catalyzed approach for the highly stereoselective synthesis of trans-2,3-dihydro-spiro[cyclopropane-1,2′-indan-1′,3′-dione] with alkenes and Phenacyl Bromide in organic solvent is described. The triphenylarsine-catalyzed cyclopropanation in water was investigated. The mixture of cis/trans isomers is provided with water as a solvent. The cis isomer is formed using water as a solvent. The reactivity of the reaction in water is higher than that in the organic solvent.
Dongyu Wang - One of the best experts on this subject based on the ideXlab platform.
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targeted mass spectrometry based approach for protein ligand binding analyses in complex biological mixtures using a Phenacyl Bromide modification strategy
Analytical Chemistry, 2016Co-Authors: Dongyu Wang, David M Gooden, Carol H Ball, Michael C FitzgeraldAbstract:The characterization of protein folding stability changes on the proteomic scale is useful for protein-target discovery and for the characterization of biological states. The Stability of Proteins from Rates of Oxidation (SPROX) technique is one of several mass spectrometry-based techniques recently established for the making proteome-wide measurements of protein folding and stability. A critical part of proteome-wide applications of SPROX is the identification and quantitation of methionine-containing peptides. Demonstrated here is a targeted mass spectrometry-based proteomics strategy for the detection and quantitation of methionine-containing peptides in SPROX experiments. The strategy involves the use of Phenacyl Bromide (PAB) for the targeted detection and quantitation of methionine-containing peptides in SPROX using selective reaction monitoring (SRM) on a triple quadrupole mass spectrometer (QQQ-MS). As proof-of-principle, the known binding interaction of Cyclosporine A with cyclophilin A protein i...
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Targeted Mass Spectrometry-Based Approach for Protein–Ligand Binding Analyses in Complex Biological Mixtures Using a Phenacyl Bromide Modification Strategy
Analytical Chemistry, 2016Co-Authors: Dongyu Wang, David M Gooden, Carol H Ball, Michael C FitzgeraldAbstract:The characterization of protein folding stability changes on the proteomic scale is useful for protein-target discovery and for the characterization of biological states. The Stability of Proteins from Rates of Oxidation (SPROX) technique is one of several mass spectrometry-based techniques recently established for the making proteome-wide measurements of protein folding and stability. A critical part of proteome-wide applications of SPROX is the identification and quantitation of methionine-containing peptides. Demonstrated here is a targeted mass spectrometry-based proteomics strategy for the detection and quantitation of methionine-containing peptides in SPROX experiments. The strategy involves the use of Phenacyl Bromide (PAB) for the targeted detection and quantitation of methionine-containing peptides in SPROX using selective reaction monitoring (SRM) on a triple quadrupole mass spectrometer (QQQ-MS). As proof-of-principle, the known binding interaction of Cyclosporine A with cyclophilin A protein i...
Pramod K Nayak - One of the best experts on this subject based on the ideXlab platform.
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Synthetic resins. X. Resin copolymers from hydroxy Phenacyl Bromide, substituted benzoic acid/formaldehyde
Journal of Applied Polymer Science, 2003Co-Authors: Pramod K Nayak, Subasini Lenka, Padma L NayakAbstract:A number of resin copolymers have been synthesized by condensing p-hydroxy Phenacyl Bromide, substituted benzoic acids, and formaldehyde catalyzed by acids. The resin copolymers were characterized by IR spectra. The solution, thermal and chemical properties of the resins have been investigated. Ion exchange selectivity with respect to Cu 2+ and Co 2+ has been studied at different pH. Bacteriocidal and fungicidal properties of the resins have also been evaluated
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synthetic resins x resin copolymers from hydroxy Phenacyl Bromide substituted benzoic acid formaldehyde
Journal of Applied Polymer Science, 1990Co-Authors: Pramod K Nayak, Subasini Lenka, Padma L NayakAbstract:A number of resin copolymers have been synthesized by condensing p-hydroxy Phenacyl Bromide, substituted benzoic acids, and formaldehyde catalyzed by acids. The resin copolymers were characterized by IR spectra. The solution, thermal and chemical properties of the resins have been investigated. Ion exchange selectivity with respect to Cu 2+ and Co 2+ has been studied at different pH. Bacteriocidal and fungicidal properties of the resins have also been evaluated
