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E Edinsha H Gladis - One of the best experts on this subject based on the ideXlab platform.
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transition metal chelates with multifunctional 1 10 Phenanthroline Derivative towards production of hydrogen as alternative fuel from sea water design synthesis characterization and catalytic studies
International Journal of Hydrogen Energy, 2021Co-Authors: E Edinsha H Gladis, K Nagashri, J JosephAbstract:Abstract In the present studies were focused on the preparation, characterization and catalytic behaviour of highly conjugative π-acceptor type ligand with metal ions (M = Co2+, Zn2+, Cu2+ and Ni2+) as catalyst for evolution of hydrogen as alternate fuel. Then, the activated charcoal was obtained from natural origin such as coconut & rice husk enriched with oxygen derived functionalities and effectively remove cations (Na+, Mg2+), anions (Cl-, SO42−) ions and other contaminants from sea water (saline water). The prepared metal complexes behave as catalyst for the splitting of water into hydrogen gas under photo irradiation and electrochemical approach. Because of its redox characteristics and stabilization of unusual oxidation states during the catalytic cycle, the copper complex showed higher efficiency for the production of hydrogen gas (turnover number (TON) and turnover frequency (TOF) values, 15,600 & 8100) as compared to other chelates and related chelates in the literature sources.
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enhancing the therapeutic efficacy of copper based multifunctional agents by incorporating 1 10 Phenanthroline Derivative as chelator
Materials Today: Proceedings, 2021Co-Authors: E Edinsha H Gladis, K Nagashri, Michael Ahitha J Jose, D Arthi, J JosephAbstract:Abstract Diabetes has emerged as one of the world's most severe metabolic disorders due to the severity of the associated complications and their rapid development around the world. N-heterocycles are significant building blocks in numerous drug molecules and synthetic modification on the above heterocycles impart challenging solutions for existing metabolic syndrome. In the present study, the highly conjugated nitrogen heterocyclic architectural framework encompassed of 1, 10-Phenanthroline Derivative with metal acetates to form metal chelates of the type [CuIIL] where L = 1,10- Phenanthroline Derivative. They were subjected to the composition analysis of CHN, spectral measurements for the structural elucidation. Based on spectroscopic and analytical measurements confirmed that an octahedral geometry for the Cu(II) chelates. The acetylcholinesterase (AChE) inhibitory effect of the ligand was examined to find out the therapeutic efficiency of compound in the treatment of neurodegenerative diseases. The synthesized ligand exhibited selective inhibition against AChE & BuChe with IC50 values of 0.32 and 3.20 µM as compared to standard, rivastigmine, and galantamine. Further, the in vitro anti-inflammatory efficiency of metal chelates were performed with the help of egg albumin method. The α-glucosidase and α-amylase inhibition activities were also carried out for the prepared copper complex.
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design synthesis characterization dna binding acetyl and butyryl cholinesterase activities of metal chelates with 1 10 Phenanthroline Derivative
Inorganic Chemistry Communications, 2020Co-Authors: E Edinsha H Gladis, K Nagashri, J JosephAbstract:Abstract Metal chelates comprised of highly conjugated planar 1,10-Phenanthroline Derivative, [ML] where L is ligand (1,10-Phenanthroline Derivative); M = Cu2+, Co2+, Ni2+ & Zn2+, were prepared. They were subjected to the composition measurement and different spectroscopic techniques for structural elucidation. Based on spectroscopic and analytical measurements confirmed that a distorted square planar arrangement for the Cu2+, Co2+, Ni2+ & Zn2+ chelates. The antimicrobial efficacy of prepared complexes were assessed against C. albicans, E. coli, B. subtilis, A. flavus, S. aureus, and A. niger. The anti-mycobacterial efficacy of ligand title chelates was evaluated against H37Rv and related to standard with the aid of MABA assay. The acetylcholinesterase (AChE) inhibitory effect of the ligand was examined to find out the beneficial efficiency of compound in the management of neurodegenerative syndromes. The synthesized ligand exhibited selective inhibition (AChE & BuChE), IC50 values of 0.20 and 3.20 µM as compared to standard, Rivastigmine and Galantamine. Further, the in vitro anti-inflammatory efficiency of metal chelates were performed with the help of egg albumin method. The α-glucosidase inhibition activity was also carried out for the prepared metal chelates. The inherent binding constants of metal chelates with DNA was calculated based molar extinction coefficient (Kb), 4.11, 3.62, 3.85 and 2.9 × 105 mol−1 for Cu2+, Co2+, Ni2+ & Zn2+ chelates, respectively, demonstrating that the metal chelates intensely bound to DNA. Studies of DNA cleavage were also conducted on pUC 18 DNA.
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multifunctional 1 10 Phenanthroline Derivative and its metal complexes as an anti alzheimer s agent structure based drug design synthesis characterization and pharmacological studies
Journal of Coordination Chemistry, 2020Co-Authors: E Edinsha H Gladis, K Nagashri, A Suman, J JosephAbstract:N-Heterocycles are structural constituents of pharmaceuticals based on FDA approved therapeutic agents with more than 60% of drugs containing N-heterocycles as building blocks. In the present study...
Ruslin Hadanu - One of the best experts on this subject based on the ideXlab platform.
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synthesis and antimalarial activity of 2 phenyl 1 10 Phenanthroline Derivative compounds
Jurnal Natur Indonesia, 2014Co-Authors: Ruslin HadanuAbstract:To develop new potential antimalarial drugs of 2-phenyl-1,10-Phenanthroline 5 Derivatives from 8-aminoquinoline as startingmaterial were synthesized in good yields. The synthesis of 2-phenyl-1,10-Phenanthroline 5 Derivatives compoundswith 8-aminoquinoline 4 as starting material through three steps has been carried out. The first step of reactions is aldolcondensation of benzaldehyde 1 with acetaldehyde 2. The result of reactions is cinnamaldehyde 3 (92.14%) in the form ofyellow solid. The second step of reactions was synthesized of 2-phenyl-1,10-Phenanthroline 5 (brown solid, 54.63%)through cyclization of 8-aminoquinoline 4 with cinnamaldehyde 3 compound. The third step of reactions is methylation andethylation of 2-phenyl-1,10-Phenanthroline using dimethyl sulphate (DMS) and diethyl sulphate (DES) reagents that it wasrefluxed for 17 and 19 h, respectively. The results of reactions are (1)-N-methyl-9-phenyl-1,10-phenanthrolinium sulphate 6and (1)-N-ethyl-9-phenyl-1,10-phenanthrolinium sulphate 7 in yield from 90.62% and 89.70%, respectively. The results oftesting in vitro antiplasmodial activity at chloroquine-resistant Plasmodium falciparum FCR3 strain to 2-phenyl-1,10-Phenanthroline 5 Derivatives obtained that (1)-N-ethyl-9-phenyl-1,10-phenanthrolinium sulphate 7 compound has higherantimalarial activity (IC 50 :0.13 ± 0.02 μM) than antimalarial activity of (1)-N-methyl-9-phenyl-1,10-phenanthrolinium sulphate6 compound (IC 50 :0.25 ± 0.01 μM) and 2-phenyl-1,10-Phenanthroline 5 compound (IC 50 :2.45 ± 0.09 μM). While, the resultsof testing in vitro antiplasmodial activity at chloroquine-resistant Plasmodium falciparum D10 strain to 2-phenyl-1,10-Phenanthroline 5 Derivatives obtained that (1)-N-methyl-9-phenyl-1,10-phenanthrolinium sulphate 6 compound has higherantimalarial activity (IC 50 :0.10± 0.04 μM) than antimalarial activity of (1)-N-ethyl-9-phenyl-1,10-phenanthrolinium sulphate7 (IC 50 :0.18 ± 0.01 μM) and 2-phenyl-1,10-Phenanthroline 5 compound (IC 50 :0.55 ± 0.07 μM). Keywords : 2-phenyl-1,10-Phenanthroline Derivatives, antimalarial activity, plasmodium, synthesis
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Synthesis and Antiplasmodial Activity of 2-(4-Methoxyphenyl)-4-Phenyl-1,10-Phenanthroline Derivative Compounds
Directorate of Research and Community Engagement Universitas Indonesia, 2012Co-Authors: Ruslin HadanuAbstract:A unique of synthetic methods was employed to prepare 2-(4-methoxyphenyl)-4-phenyl-1,10-Phenanthroline (5) Derivatives from 4-methoxy-benzaldehyde (1), acetophenone (2), and 8-aminoquinoline (4) with aldol condensation and cyclization reactions. The Derivatives were tested through antiplasmodial test. The synthesis of Derivatives compound 5 was conducted in three steps. The 3-(4-methoxyphenyl)-1-phenylpropenone 3 was synthesized through aldol condensation of 1 and 2 which has a yield of 96.42%. The compound 5 was synthesized through cyclization of compound 4 and 3 with 84.55% yield. The Derivative of compound 5 was synthesized from compound 5 using DMS and DES reagents which refluxed for 21 and 22 h, to produce (1)-N-methyl-9-(4-methoxyphenyl)-7-phenyl-1,10-phenanthrolinium sulfate (6) and (1)-N-ethyl-9-(4-methoxyphenyl)-7-phenyl-1,10-phenanthrolinium sulfate (7) with 91.42 and 86.36% yields, respectively. Results of in vitro testing of antiplasmodial activity of compound 5 Derivatives (i.e., compound 6 and 7) against chloroquine-resistant P. falciparum FCR3 strain showed that compound 7 had higher antimalarial activity than compounds 5 and 6. Whereas, results of in vitro testing against chloroquine-sensitive P. falciparum D10 strain showed that compound 6 has higher antimalarial activity than compounds 5 and 7.Keywords: antimalarial activity, synthesis, 2-methoxyphenyl-4-phenyl-1,10-Phenanthroline Derivative
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Synthesis and Antiplasmodial Activity of 2-(4-Methoxyphenyl)-4-Phenyl-1,10-Phenanthroline Derivative Compounds
Universitas Indonesia, 2012Co-Authors: Ruslin HadanuAbstract:A unique of synthetic methods was employed to prepare 2-(4-methoxyphenyl)-4-phenyl-1,10-Phenanthroline (5) Derivatives from 4-methoxy-benzaldehyde (1), acetophenone (2), and 8-aminoquinoline (4) with aldol condensation and cyclization reactions. The Derivatives were tested through antiplasmodial test. The synthesis of Derivatives compound 5 was conducted in three steps. The 3-(4-methoxyphenyl)-1-phenylpropenone 3 was synthesized through aldol condensation of 1 and 2 which has a yield of 96.42%. The compound 5 was synthesized through cyclization of compound 4 and 3 with 84.55% yield. The Derivative of compound 5 was synthesized from compound 5 using DMS and DES reagents which refluxed for 21 and 22 h, to produce (1)-N-methyl-9-(4-methoxyphenyl)-7-phenyl-1,10-phenanthrolinium sulfate (6) and (1)-N-ethyl-9-(4-methoxyphenyl)-7-phenyl-1,10-phenanthrolinium sulfate (7) with 91.42 and 86.36% yields, respectively. Results of in vitro testing of antiplasmodial activity of compound 5 Derivatives (i.e., compound 6 and 7) against chloroquine-resistant P. falciparum FCR3 strain showed that compound 7 had higher antimalarial activity than compounds 5 and 6. Whereas, results of in vitro testing against chloroquine-sensitive P. falciparum D10 strain showed that compound 6 has higher antimalarial activity than compounds 5 and 7
J Joseph - One of the best experts on this subject based on the ideXlab platform.
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transition metal chelates with multifunctional 1 10 Phenanthroline Derivative towards production of hydrogen as alternative fuel from sea water design synthesis characterization and catalytic studies
International Journal of Hydrogen Energy, 2021Co-Authors: E Edinsha H Gladis, K Nagashri, J JosephAbstract:Abstract In the present studies were focused on the preparation, characterization and catalytic behaviour of highly conjugative π-acceptor type ligand with metal ions (M = Co2+, Zn2+, Cu2+ and Ni2+) as catalyst for evolution of hydrogen as alternate fuel. Then, the activated charcoal was obtained from natural origin such as coconut & rice husk enriched with oxygen derived functionalities and effectively remove cations (Na+, Mg2+), anions (Cl-, SO42−) ions and other contaminants from sea water (saline water). The prepared metal complexes behave as catalyst for the splitting of water into hydrogen gas under photo irradiation and electrochemical approach. Because of its redox characteristics and stabilization of unusual oxidation states during the catalytic cycle, the copper complex showed higher efficiency for the production of hydrogen gas (turnover number (TON) and turnover frequency (TOF) values, 15,600 & 8100) as compared to other chelates and related chelates in the literature sources.
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enhancing the therapeutic efficacy of copper based multifunctional agents by incorporating 1 10 Phenanthroline Derivative as chelator
Materials Today: Proceedings, 2021Co-Authors: E Edinsha H Gladis, K Nagashri, Michael Ahitha J Jose, D Arthi, J JosephAbstract:Abstract Diabetes has emerged as one of the world's most severe metabolic disorders due to the severity of the associated complications and their rapid development around the world. N-heterocycles are significant building blocks in numerous drug molecules and synthetic modification on the above heterocycles impart challenging solutions for existing metabolic syndrome. In the present study, the highly conjugated nitrogen heterocyclic architectural framework encompassed of 1, 10-Phenanthroline Derivative with metal acetates to form metal chelates of the type [CuIIL] where L = 1,10- Phenanthroline Derivative. They were subjected to the composition analysis of CHN, spectral measurements for the structural elucidation. Based on spectroscopic and analytical measurements confirmed that an octahedral geometry for the Cu(II) chelates. The acetylcholinesterase (AChE) inhibitory effect of the ligand was examined to find out the therapeutic efficiency of compound in the treatment of neurodegenerative diseases. The synthesized ligand exhibited selective inhibition against AChE & BuChe with IC50 values of 0.32 and 3.20 µM as compared to standard, rivastigmine, and galantamine. Further, the in vitro anti-inflammatory efficiency of metal chelates were performed with the help of egg albumin method. The α-glucosidase and α-amylase inhibition activities were also carried out for the prepared copper complex.
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design synthesis characterization dna binding acetyl and butyryl cholinesterase activities of metal chelates with 1 10 Phenanthroline Derivative
Inorganic Chemistry Communications, 2020Co-Authors: E Edinsha H Gladis, K Nagashri, J JosephAbstract:Abstract Metal chelates comprised of highly conjugated planar 1,10-Phenanthroline Derivative, [ML] where L is ligand (1,10-Phenanthroline Derivative); M = Cu2+, Co2+, Ni2+ & Zn2+, were prepared. They were subjected to the composition measurement and different spectroscopic techniques for structural elucidation. Based on spectroscopic and analytical measurements confirmed that a distorted square planar arrangement for the Cu2+, Co2+, Ni2+ & Zn2+ chelates. The antimicrobial efficacy of prepared complexes were assessed against C. albicans, E. coli, B. subtilis, A. flavus, S. aureus, and A. niger. The anti-mycobacterial efficacy of ligand title chelates was evaluated against H37Rv and related to standard with the aid of MABA assay. The acetylcholinesterase (AChE) inhibitory effect of the ligand was examined to find out the beneficial efficiency of compound in the management of neurodegenerative syndromes. The synthesized ligand exhibited selective inhibition (AChE & BuChE), IC50 values of 0.20 and 3.20 µM as compared to standard, Rivastigmine and Galantamine. Further, the in vitro anti-inflammatory efficiency of metal chelates were performed with the help of egg albumin method. The α-glucosidase inhibition activity was also carried out for the prepared metal chelates. The inherent binding constants of metal chelates with DNA was calculated based molar extinction coefficient (Kb), 4.11, 3.62, 3.85 and 2.9 × 105 mol−1 for Cu2+, Co2+, Ni2+ & Zn2+ chelates, respectively, demonstrating that the metal chelates intensely bound to DNA. Studies of DNA cleavage were also conducted on pUC 18 DNA.
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multifunctional 1 10 Phenanthroline Derivative and its metal complexes as an anti alzheimer s agent structure based drug design synthesis characterization and pharmacological studies
Journal of Coordination Chemistry, 2020Co-Authors: E Edinsha H Gladis, K Nagashri, A Suman, J JosephAbstract:N-Heterocycles are structural constituents of pharmaceuticals based on FDA approved therapeutic agents with more than 60% of drugs containing N-heterocycles as building blocks. In the present study...
Linfang Shi - One of the best experts on this subject based on the ideXlab platform.
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a series of cui complexes containing 1 10 Phenanthroline Derivative ligands synthesis characterization photophysical and oxygen sensing properties
European Journal of Inorganic Chemistry, 2009Co-Authors: Linfang ShiAbstract:Five novel copper(I) complexes with the general formula [Cu(dpephos)(NN)]BF4 {dpephos = bis[2-(diphenylphosphanyl)phenyl] ether, NN = 2-phenyl-1H-imidazo[4,5-f]-[1,10]Phenanthroline (pip, 1), 1-ethyl-2-phenyl-1H-imidazo[4,5-f][1,10]Phenanthroline (epip, 2), 2-(naphthalen-1-yl)-1H-imidazo[4,5-f][1,10]Phenanthroline (nip, 3), 1-ethyl-2(naphthalen-1-yl)-1H-imidazo[4,5-f][1,10]Phenanthroline (enip, 4), 2-(anthracen-9-yl)-1-ethyl-1H-imidazo[4,5-f] [1,10]Phenanthroline (aeip, 5)) were rationally designed and synthesized, and these complexes were characterized by H-1 NMR and IR spectroscopy and elemental analysis. X-ray crystal-structure analysis of 3 and 4 are also presented. Their photophysical properties at room temperature were examined by using a combination of cyclic voltammetry and electronic absorption spectroscopy. It was found that 1-4 display broadband emission in the solid state upon excitation at lambda = 400nm, and the emission maxima are located in the range 530-558 nm; the excited-state lifetimes of these complexes are 8.24, 1.97, 6.99, and 2.43 mu s, respectively. As a result, the emission intensity of complexes 1-4 is sensitive to oxygen concentration, and they display oxygen-sensing properties after they are encapsulated into mesoporous silica MCM-41 or SBA-15. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Fenglei Yang - One of the best experts on this subject based on the ideXlab platform.
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synthesis structures and aggregation induced emissive properties of copper i complexes with 1h imidazo 4 5 f 1 10 Phenanthroline Derivative and diphosphine as ligands
Inorganica Chimica Acta, 2015Co-Authors: Rong Liu, Miaomiao Huang, Xixi Yao, Fenglei YangAbstract:Abstract Reaction of 4-bromo-2-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)phenol (BIPP), chelating diphosphine ligands and [Cu(MeCN)4]ClO4 afforded five mononuclear [Cu(BIPP)(PP)]ClO4 (PP = dppe, 1; dppp, 2; bdpp, 3; POP, 4; xantphos, 5) complexes with good phosphorescent emission in the solid state. All the complexes are characterized by elemental analyses, electrospray Ionization mass spectra, 1H and 31P NMR spectra and X-ray single crystallography. The photoluminescence quantum yields of complexes 1–5 are from less than 0.010 to 0.262 in the solid state under air atmosphere, which increase with the increasing rigidity of diphosphine ligands and the increasing strength of intermolecular and intramolecular π⋯π interactions. The aggregation-induced emission of complexes 4 and 5 at room temperature was investigated.