The Experts below are selected from a list of 156 Experts worldwide ranked by ideXlab platform

Seung Woo Cho - One of the best experts on this subject based on the ideXlab platform.

  • Osteoconductive hybrid hyaluronic acid hydrogel patch for effective bone formation.
    Journal of controlled release : official journal of the Controlled Release Society, 2020
    Co-Authors: Soojeong Choi, Jong Seung Lee, Jisoo Shin, Min Suk Lee, Donyoung Kang, Nathaniel S. Hwang, Hyungsuk Lee, Hee Seok Yang, Seung Woo Cho
    Abstract:

    Bio-inspired Adhesive hydrogels have been applied to cell and drug delivery systems to address various tissue defects and disorders. However, Adhesive hydrogels functionalized with Phenolic moieties often lack osteoconductive capacity and mechanical properties for bone regeneration. In this study, we utilized the versatile chemical interactions of Phenolic moieties to overcome such limitations in bone tissue engineering efforts. Highly osteoconductive hybrid hydrogel patches were fabricated by incorporating inorganic minerals, hydroxyapatite (HAP), or whitlockite (WKT), into pyrogallol-conjugated hyaluronic acid (HA-PG). The hybrid HA-PG patches exhibited improved mechanical strength and reinforced structural/physical properties owing to additional intermolecular complexation between oxidized PG moieties and ions released from inorganic particles. The sustained release of bone morphogenetic protein-2 (BMP-2) from hybrid patches was prolonged by combination of the inherent nucleophilic affinity of oxidized PG and electrostatic interactions between inorganic particles and BMP-2. With increased osteoconductivity, hybrid patches with HAP or WKT enhanced the osteogenic differentiation of human stem cells while also promoting new bone formation in a critical-sized calvarial defect. Our study demonstrates a translational potential of Phenolic Adhesive hydrogels engineered with inorganic minerals for orthopedic applications.

  • Tissue Tapes—Phenolic Hyaluronic Acid Hydrogel Patches for Off-the-Shelf Therapy
    WILEY-V C H VERLAG GMBH, 2019
    Co-Authors: Jisoo Shin, Soojeong Choi, Jung Hyun Kim, Jung Ho Cho, Yoonhee Jin, S. Kim, Sungjin Min, Su Kyeom Kim, Donghoon Choi, Seung Woo Cho
    Abstract:

    © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimHydrogels have been applied to improve stem cell therapy and drug delivery, but current hydrogel-based delivery methods are inefficient in clinical settings due to difficulty in handling and treatment processes, and low off-the-shelf availability. To overcome these limitations, an Adhesive hyaluronic acid (HA) hydrogel patch is developed that acts as a ready-to-use tissue tape for therapeutic application. The HA hydrogel patches functionalized with Phenolic moieties (e.g., catechol, pyrogallol) exhibit stronger tissue Adhesiveness, greater elastic modulus, and increased off-the-shelf availability, compared with their bulk solution gel form. With this strategy, stem cells are efficiently engrafted onto beating ischemic hearts without injection, resulting in enhanced angiogenesis in ischemic regions and improving cardiac functions. HA hydrogel patches facilitate the in vivo engraftment of stem cell–derived organoids. The off-the-shelf availability of the hydrogel patch is also demonstrated as a drug-loaded ready-made tissue tape for topical drug delivery to promote wound healing. Importantly, the applicability of the cross-linker-free HA patch is validated for therapeutic cell and drug delivery. The study suggests that bioinspired Phenolic Adhesive hydrogel patches can provide an innovative method for simple but highly effective cell and drug delivery, increasing the off-the-shelf availability—a critically important component for translation to clinical setting

  • Tissue Tapes—Phenolic Hyaluronic Acid Hydrogel Patches for Off‐the‐Shelf Therapy
    Advanced Functional Materials, 2019
    Co-Authors: Jisoo Shin, Soojeong Choi, Jung Hyun Kim, Jung Ho Cho, Yoonhee Jin, S. Kim, Sungjin Min, Su Kyeom Kim, Donghoon Choi, Seung Woo Cho
    Abstract:

    Hydrogels have been applied to improve stem cell therapy and drug delivery, but current hydrogel�륿ased delivery methods are inefficient in clinical settings due to difficulty in handling and treatment processes, and low off�릘he�릗helf availability. To overcome these limitations, an Adhesive hyaluronic acid (HA) hydrogel patch is developed that acts as a ready�릘o�릙se tissue tape for therapeutic application. The HA hydrogel patches functionalized with Phenolic moieties (e.g., catechol, pyrogallol) exhibit stronger tissue Adhesiveness, greater elastic modulus, and increased off�릘he�릗helf availability, compared with their bulk solution gel form. With this strategy, stem cells are efficiently engrafted onto beating ischemic hearts without injection, resulting in enhanced angiogenesis in ischemic regions and improving cardiac functions. HA hydrogel patches facilitate the in vivo engraftment of stem cell�밺erived organoids. The off�릘he�릗helf availability of the hydrogel patch is also demonstrated as a drug�릐oaded ready�릑ade tissue tape for topical drug delivery to promote wound healing. Importantly, the applicability of the cross�릐inker�릃ree HA patch is validated for therapeutic cell and drug delivery. The study suggests that bioinspired Phenolic Adhesive hydrogel patches can provide an innovative method for simple but highly effective cell and drug delivery, increasing the off�릘he�릗helf availability�봞 critically important component for translation to clinical settings.restrictio

Huijuan Zhang - One of the best experts on this subject based on the ideXlab platform.

  • effect of plasma treatment of kevlar fabric on the tribological behavior of kevlar fabric Phenolic composites
    Tribology International, 2009
    Co-Authors: Fenghua Su, Huijuan Zhang
    Abstract:

    Abstract Pure and plasma-treated Kevlar fabrics were used to prepare Kevlar fabric/Phenolic composites by consecutive dipping of the fabric in Phenolic Adhesive resin. The friction and wear performance of the resulting composites has been evaluated in a pin-on-disk wear tester at various dry-sliding conditions. The surface changes occurring on Kevlar fibers treated with air–plasma were analyzed by using X-ray photoelectron spectroscope (XPS), Fourier transform infrared spectroscope (FT-IR) and scanning electron microscope (SEM). Moreover, the impact of air–plasma treatment time and power on the friction and wear behavior of Kevlar fabric/Phenolic composites composed of the air–plasma-treated Kevlar fabrics was systematically studied. It was found that plasma treatment can significantly improve the tribological performance of the prepared Kevlar fabric/Phenolic composites; the best performance was after a plasma treatment at 50 W for 15 min. The plasma treatment generates oxygenic and nitrogenous groups on the surface of the fabric, coupled with an increase of the surface roughness, strengthening the bond between the Kevlar fabric and Phenolic Adhesive resin and hence improving the tribological properties of the Kevlar fabric/Phenolic composites.

  • Effect of plasma treatment of Kevlar fabric on the tribological behavior of Kevlar fabric/Phenolic composites
    Tribology International, 2009
    Co-Authors: Fenghua Su, Huijuan Zhang
    Abstract:

    Abstract Pure and plasma-treated Kevlar fabrics were used to prepare Kevlar fabric/Phenolic composites by consecutive dipping of the fabric in Phenolic Adhesive resin. The friction and wear performance of the resulting composites has been evaluated in a pin-on-disk wear tester at various dry-sliding conditions. The surface changes occurring on Kevlar fibers treated with air–plasma were analyzed by using X-ray photoelectron spectroscope (XPS), Fourier transform infrared spectroscope (FT-IR) and scanning electron microscope (SEM). Moreover, the impact of air–plasma treatment time and power on the friction and wear behavior of Kevlar fabric/Phenolic composites composed of the air–plasma-treated Kevlar fabrics was systematically studied. It was found that plasma treatment can significantly improve the tribological performance of the prepared Kevlar fabric/Phenolic composites; the best performance was after a plasma treatment at 50 W for 15 min. The plasma treatment generates oxygenic and nitrogenous groups on the surface of the fabric, coupled with an increase of the surface roughness, strengthening the bond between the Kevlar fabric and Phenolic Adhesive resin and hence improving the tribological properties of the Kevlar fabric/Phenolic composites.

Jisoo Shin - One of the best experts on this subject based on the ideXlab platform.

  • Osteoconductive hybrid hyaluronic acid hydrogel patch for effective bone formation.
    Journal of controlled release : official journal of the Controlled Release Society, 2020
    Co-Authors: Soojeong Choi, Jong Seung Lee, Jisoo Shin, Min Suk Lee, Donyoung Kang, Nathaniel S. Hwang, Hyungsuk Lee, Hee Seok Yang, Seung Woo Cho
    Abstract:

    Bio-inspired Adhesive hydrogels have been applied to cell and drug delivery systems to address various tissue defects and disorders. However, Adhesive hydrogels functionalized with Phenolic moieties often lack osteoconductive capacity and mechanical properties for bone regeneration. In this study, we utilized the versatile chemical interactions of Phenolic moieties to overcome such limitations in bone tissue engineering efforts. Highly osteoconductive hybrid hydrogel patches were fabricated by incorporating inorganic minerals, hydroxyapatite (HAP), or whitlockite (WKT), into pyrogallol-conjugated hyaluronic acid (HA-PG). The hybrid HA-PG patches exhibited improved mechanical strength and reinforced structural/physical properties owing to additional intermolecular complexation between oxidized PG moieties and ions released from inorganic particles. The sustained release of bone morphogenetic protein-2 (BMP-2) from hybrid patches was prolonged by combination of the inherent nucleophilic affinity of oxidized PG and electrostatic interactions between inorganic particles and BMP-2. With increased osteoconductivity, hybrid patches with HAP or WKT enhanced the osteogenic differentiation of human stem cells while also promoting new bone formation in a critical-sized calvarial defect. Our study demonstrates a translational potential of Phenolic Adhesive hydrogels engineered with inorganic minerals for orthopedic applications.

  • Tissue Tapes—Phenolic Hyaluronic Acid Hydrogel Patches for Off-the-Shelf Therapy
    WILEY-V C H VERLAG GMBH, 2019
    Co-Authors: Jisoo Shin, Soojeong Choi, Jung Hyun Kim, Jung Ho Cho, Yoonhee Jin, S. Kim, Sungjin Min, Su Kyeom Kim, Donghoon Choi, Seung Woo Cho
    Abstract:

    © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimHydrogels have been applied to improve stem cell therapy and drug delivery, but current hydrogel-based delivery methods are inefficient in clinical settings due to difficulty in handling and treatment processes, and low off-the-shelf availability. To overcome these limitations, an Adhesive hyaluronic acid (HA) hydrogel patch is developed that acts as a ready-to-use tissue tape for therapeutic application. The HA hydrogel patches functionalized with Phenolic moieties (e.g., catechol, pyrogallol) exhibit stronger tissue Adhesiveness, greater elastic modulus, and increased off-the-shelf availability, compared with their bulk solution gel form. With this strategy, stem cells are efficiently engrafted onto beating ischemic hearts without injection, resulting in enhanced angiogenesis in ischemic regions and improving cardiac functions. HA hydrogel patches facilitate the in vivo engraftment of stem cell–derived organoids. The off-the-shelf availability of the hydrogel patch is also demonstrated as a drug-loaded ready-made tissue tape for topical drug delivery to promote wound healing. Importantly, the applicability of the cross-linker-free HA patch is validated for therapeutic cell and drug delivery. The study suggests that bioinspired Phenolic Adhesive hydrogel patches can provide an innovative method for simple but highly effective cell and drug delivery, increasing the off-the-shelf availability—a critically important component for translation to clinical setting

  • Tissue Tapes—Phenolic Hyaluronic Acid Hydrogel Patches for Off‐the‐Shelf Therapy
    Advanced Functional Materials, 2019
    Co-Authors: Jisoo Shin, Soojeong Choi, Jung Hyun Kim, Jung Ho Cho, Yoonhee Jin, S. Kim, Sungjin Min, Su Kyeom Kim, Donghoon Choi, Seung Woo Cho
    Abstract:

    Hydrogels have been applied to improve stem cell therapy and drug delivery, but current hydrogel�륿ased delivery methods are inefficient in clinical settings due to difficulty in handling and treatment processes, and low off�릘he�릗helf availability. To overcome these limitations, an Adhesive hyaluronic acid (HA) hydrogel patch is developed that acts as a ready�릘o�릙se tissue tape for therapeutic application. The HA hydrogel patches functionalized with Phenolic moieties (e.g., catechol, pyrogallol) exhibit stronger tissue Adhesiveness, greater elastic modulus, and increased off�릘he�릗helf availability, compared with their bulk solution gel form. With this strategy, stem cells are efficiently engrafted onto beating ischemic hearts without injection, resulting in enhanced angiogenesis in ischemic regions and improving cardiac functions. HA hydrogel patches facilitate the in vivo engraftment of stem cell�밺erived organoids. The off�릘he�릗helf availability of the hydrogel patch is also demonstrated as a drug�릐oaded ready�릑ade tissue tape for topical drug delivery to promote wound healing. Importantly, the applicability of the cross�릐inker�릃ree HA patch is validated for therapeutic cell and drug delivery. The study suggests that bioinspired Phenolic Adhesive hydrogel patches can provide an innovative method for simple but highly effective cell and drug delivery, increasing the off�릘he�릗helf availability�봞 critically important component for translation to clinical settings.restrictio

Fenghua Su - One of the best experts on this subject based on the ideXlab platform.

  • effect of plasma treatment of kevlar fabric on the tribological behavior of kevlar fabric Phenolic composites
    Tribology International, 2009
    Co-Authors: Fenghua Su, Huijuan Zhang
    Abstract:

    Abstract Pure and plasma-treated Kevlar fabrics were used to prepare Kevlar fabric/Phenolic composites by consecutive dipping of the fabric in Phenolic Adhesive resin. The friction and wear performance of the resulting composites has been evaluated in a pin-on-disk wear tester at various dry-sliding conditions. The surface changes occurring on Kevlar fibers treated with air–plasma were analyzed by using X-ray photoelectron spectroscope (XPS), Fourier transform infrared spectroscope (FT-IR) and scanning electron microscope (SEM). Moreover, the impact of air–plasma treatment time and power on the friction and wear behavior of Kevlar fabric/Phenolic composites composed of the air–plasma-treated Kevlar fabrics was systematically studied. It was found that plasma treatment can significantly improve the tribological performance of the prepared Kevlar fabric/Phenolic composites; the best performance was after a plasma treatment at 50 W for 15 min. The plasma treatment generates oxygenic and nitrogenous groups on the surface of the fabric, coupled with an increase of the surface roughness, strengthening the bond between the Kevlar fabric and Phenolic Adhesive resin and hence improving the tribological properties of the Kevlar fabric/Phenolic composites.

  • Effect of plasma treatment of Kevlar fabric on the tribological behavior of Kevlar fabric/Phenolic composites
    Tribology International, 2009
    Co-Authors: Fenghua Su, Huijuan Zhang
    Abstract:

    Abstract Pure and plasma-treated Kevlar fabrics were used to prepare Kevlar fabric/Phenolic composites by consecutive dipping of the fabric in Phenolic Adhesive resin. The friction and wear performance of the resulting composites has been evaluated in a pin-on-disk wear tester at various dry-sliding conditions. The surface changes occurring on Kevlar fibers treated with air–plasma were analyzed by using X-ray photoelectron spectroscope (XPS), Fourier transform infrared spectroscope (FT-IR) and scanning electron microscope (SEM). Moreover, the impact of air–plasma treatment time and power on the friction and wear behavior of Kevlar fabric/Phenolic composites composed of the air–plasma-treated Kevlar fabrics was systematically studied. It was found that plasma treatment can significantly improve the tribological performance of the prepared Kevlar fabric/Phenolic composites; the best performance was after a plasma treatment at 50 W for 15 min. The plasma treatment generates oxygenic and nitrogenous groups on the surface of the fabric, coupled with an increase of the surface roughness, strengthening the bond between the Kevlar fabric and Phenolic Adhesive resin and hence improving the tribological properties of the Kevlar fabric/Phenolic composites.

Jung Hyun Kim - One of the best experts on this subject based on the ideXlab platform.

  • Tissue Tapes—Phenolic Hyaluronic Acid Hydrogel Patches for Off-the-Shelf Therapy
    WILEY-V C H VERLAG GMBH, 2019
    Co-Authors: Jisoo Shin, Soojeong Choi, Jung Hyun Kim, Jung Ho Cho, Yoonhee Jin, S. Kim, Sungjin Min, Su Kyeom Kim, Donghoon Choi, Seung Woo Cho
    Abstract:

    © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimHydrogels have been applied to improve stem cell therapy and drug delivery, but current hydrogel-based delivery methods are inefficient in clinical settings due to difficulty in handling and treatment processes, and low off-the-shelf availability. To overcome these limitations, an Adhesive hyaluronic acid (HA) hydrogel patch is developed that acts as a ready-to-use tissue tape for therapeutic application. The HA hydrogel patches functionalized with Phenolic moieties (e.g., catechol, pyrogallol) exhibit stronger tissue Adhesiveness, greater elastic modulus, and increased off-the-shelf availability, compared with their bulk solution gel form. With this strategy, stem cells are efficiently engrafted onto beating ischemic hearts without injection, resulting in enhanced angiogenesis in ischemic regions and improving cardiac functions. HA hydrogel patches facilitate the in vivo engraftment of stem cell–derived organoids. The off-the-shelf availability of the hydrogel patch is also demonstrated as a drug-loaded ready-made tissue tape for topical drug delivery to promote wound healing. Importantly, the applicability of the cross-linker-free HA patch is validated for therapeutic cell and drug delivery. The study suggests that bioinspired Phenolic Adhesive hydrogel patches can provide an innovative method for simple but highly effective cell and drug delivery, increasing the off-the-shelf availability—a critically important component for translation to clinical setting

  • Tissue Tapes—Phenolic Hyaluronic Acid Hydrogel Patches for Off‐the‐Shelf Therapy
    Advanced Functional Materials, 2019
    Co-Authors: Jisoo Shin, Soojeong Choi, Jung Hyun Kim, Jung Ho Cho, Yoonhee Jin, S. Kim, Sungjin Min, Su Kyeom Kim, Donghoon Choi, Seung Woo Cho
    Abstract:

    Hydrogels have been applied to improve stem cell therapy and drug delivery, but current hydrogel�륿ased delivery methods are inefficient in clinical settings due to difficulty in handling and treatment processes, and low off�릘he�릗helf availability. To overcome these limitations, an Adhesive hyaluronic acid (HA) hydrogel patch is developed that acts as a ready�릘o�릙se tissue tape for therapeutic application. The HA hydrogel patches functionalized with Phenolic moieties (e.g., catechol, pyrogallol) exhibit stronger tissue Adhesiveness, greater elastic modulus, and increased off�릘he�릗helf availability, compared with their bulk solution gel form. With this strategy, stem cells are efficiently engrafted onto beating ischemic hearts without injection, resulting in enhanced angiogenesis in ischemic regions and improving cardiac functions. HA hydrogel patches facilitate the in vivo engraftment of stem cell�밺erived organoids. The off�릘he�릗helf availability of the hydrogel patch is also demonstrated as a drug�릐oaded ready�릑ade tissue tape for topical drug delivery to promote wound healing. Importantly, the applicability of the cross�릐inker�릃ree HA patch is validated for therapeutic cell and drug delivery. The study suggests that bioinspired Phenolic Adhesive hydrogel patches can provide an innovative method for simple but highly effective cell and drug delivery, increasing the off�릘he�릗helf availability�봞 critically important component for translation to clinical settings.restrictio