The Experts below are selected from a list of 105 Experts worldwide ranked by ideXlab platform
Neil Pearce - One of the best experts on this subject based on the ideXlab platform.
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sex ratio of the offspring of new zealand Phenoxy Herbicide producers exposed to 2 3 7 8 tetrachlorodibenzo p dioxin
Occupational and Environmental Medicine, 2017Co-Authors: Andrea T Mannetje, Amanda Eng, Chris Walls, Evan Dryson, Dave Mclean, Manolis Kogevinas, Soo Cheng, Collin Brooks, Allan H Smith, Neil PearceAbstract:Objectives Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has inconsistently been associated with a decreased sex ratio of the offspring (number of male births divided by total births). We conducted a study among men and women who were employed in a New Zealand Phenoxy Herbicide production plant between 1969 and 1984, to study their offspring sex ratio in relation to their back-calculated TCDD serum concentrations determined in 2007/2008. Methods A total of 127 men and 21 women reported that 355 children were conceived after starting employment at the plant. The association between their lipid-standardised TCDD serum concentrations back-calculated to the time of their offspring9s birth and the probability of a male birth was estimated through logistic regression, adjusting for the age of the exposed parent at birth, current body mass index and smoking. Results The overall sex ratio was 0.55 (197 boys, 158 girls). For fathers with serum TCDD concentrations ≥20 pg/g lipid at time of birth, the sex ratio was 0.47 (OR 0.49; 95% CI 0.30 to 0.79). The probability of a male birth decreased with higher paternal serum TCDD at time of birth ( Conclusions This study indicates that paternal serum TCDD concentrations in excess of an estimated 20 pg/g lipid at time of conception are associated with a reduced sex ratio.
Marilyn Fingerhut - One of the best experts on this subject based on the ideXlab platform.
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spontaneous abortion sex ratio and paternal occupational exposure to 2 3 7 8 tetrachlorodibenzo p dioxin
Environmental Health Perspectives, 2001Co-Authors: Teresa M Schnorr, Christina C Lawson, Elizabeth A Whelan, David A Dankovic, James A Deddens, Laurie A Piacitelli, Jennita Reefhuis, Marie Haring Sweeney, L B Connally, Marilyn FingerhutAbstract:There is conflicting research regarding an association between fetal death and paternal exposure to Agent Orange, a Phenoxy Herbicide widely used in Vietnam that was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Men who worked in the U.S. factories that produced Agent Orange were exposed to TCDD at levels hundreds of times higher than TCDD levels in the general population. Wives of TCDD-exposed chemical workers and wives of nonexposed neighborhood referents were interviewed to determine reproductive history. Paternal serum TCDD level at time of conception was estimated for each pregnancy using serum samples taken in 1987. Estimated TCDD levels of workers during or after exposure were high (median, 254 ppt; range, 3-16,340 ppt) compared to referent levels (median, 6 ppt; range, 2-19 ppt). No association between paternal TCDD level at the time of conception and spontaneous abortion was observed among pregnancies fathered by workers with TCDD levels of or= 1,120 ppt (OR = 0.95; 95% CI, 0.42-2.17) compared to pregnancies fathered by referents. The sex ratio [males/(males + females)] of offspring also did not differ by TCDD exposure (0.53 and 0.54 among workers and referents, respectively). We did not find an association between paternal serum TCDD level and spontaneous abortion or sex ratio of offspring in this population. The estimated TCDD levels in this exposed worker population were much higher than in other studies, providing additional evidence that paternal TCDD exposure does not increase the risk of spontaneous abortion at levels above those observed in the general population. The study could not evaluate the effect of father's childhood or prenatal TCDD exposure on subsequent sex ratio.
Andrea T Mannetje - One of the best experts on this subject based on the ideXlab platform.
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sex ratio of the offspring of new zealand Phenoxy Herbicide producers exposed to 2 3 7 8 tetrachlorodibenzo p dioxin
Occupational and Environmental Medicine, 2017Co-Authors: Andrea T Mannetje, Amanda Eng, Chris Walls, Evan Dryson, Dave Mclean, Manolis Kogevinas, Soo Cheng, Collin Brooks, Allan H Smith, Neil PearceAbstract:Objectives Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has inconsistently been associated with a decreased sex ratio of the offspring (number of male births divided by total births). We conducted a study among men and women who were employed in a New Zealand Phenoxy Herbicide production plant between 1969 and 1984, to study their offspring sex ratio in relation to their back-calculated TCDD serum concentrations determined in 2007/2008. Methods A total of 127 men and 21 women reported that 355 children were conceived after starting employment at the plant. The association between their lipid-standardised TCDD serum concentrations back-calculated to the time of their offspring9s birth and the probability of a male birth was estimated through logistic regression, adjusting for the age of the exposed parent at birth, current body mass index and smoking. Results The overall sex ratio was 0.55 (197 boys, 158 girls). For fathers with serum TCDD concentrations ≥20 pg/g lipid at time of birth, the sex ratio was 0.47 (OR 0.49; 95% CI 0.30 to 0.79). The probability of a male birth decreased with higher paternal serum TCDD at time of birth ( Conclusions This study indicates that paternal serum TCDD concentrations in excess of an estimated 20 pg/g lipid at time of conception are associated with a reduced sex ratio.
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serum concentrations of chlorinated dibenzo p dioxins furans and pcbs among former Phenoxy Herbicide production workers and firefighters in new zealand
International Archives of Occupational and Environmental Health, 2016Co-Authors: Andrea T Mannetje, Amanda Eng, Chris Walls, Evan Dryson, Dave Mclean, Manolis Kogevinas, Jeff Fowles, Barry Borman, Patrick Oconnor, Soo ChengAbstract:To quantify serum concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and dioxin-like compounds in former Phenoxy Herbicide production plant workers and firefighters, 20 years after 2,4,5-T production ceased. Of 1025 workers employed any time during 1969–1984, 430 were randomly selected and invited to take part in a morbidity survey and provide a blood sample; 244 (57 %) participated. Firefighters stationed in close proximity of the plant and/or engaged in call-outs to the plant between 1962 and 1987 also participated (39 of 70 invited). Reported here are the serum concentrations of TCDD and other chlorinated dibenzo-dioxins, dibenzofurans, and polychlorinated biphenyls (PCBs). Determinants of the serum concentrations were assessed using linear regression. The 60 men who had worked in the Phenoxy/TCP production area had a mean TCDD serum concentration of 19.1 pg/g lipid, three times the mean concentration of the 141 men and 43 women employed in other parts of the plant (6.3 and 6.0 pg/g respectively), and more than 10 times the mean for the firefighters (1.6 pg/g). Duration of employment in Phenoxy Herbicide synthesis, maintenance work, and work as a boilerman, chemist, and packer were associated with increased serum concentrations of TCDD and 1,2,3,4,7-pentachlorodibenzo-p-dioxin (PeCDD). Employment as a boilerman was also associated with elevated serum concentrations of PCBs. Occupations in the plant associated with Phenoxy Herbicide synthesis had elevated levels of TCDD and PeCDD. Most other people working within the plant, and the local firefighters, had serum concentrations of dioxin-like compounds comparable to those of the general population.
Teresa M Schnorr - One of the best experts on this subject based on the ideXlab platform.
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spontaneous abortion sex ratio and paternal occupational exposure to 2 3 7 8 tetrachlorodibenzo p dioxin
Environmental Health Perspectives, 2001Co-Authors: Teresa M Schnorr, Christina C Lawson, Elizabeth A Whelan, David A Dankovic, James A Deddens, Laurie A Piacitelli, Jennita Reefhuis, Marie Haring Sweeney, L B Connally, Marilyn FingerhutAbstract:There is conflicting research regarding an association between fetal death and paternal exposure to Agent Orange, a Phenoxy Herbicide widely used in Vietnam that was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Men who worked in the U.S. factories that produced Agent Orange were exposed to TCDD at levels hundreds of times higher than TCDD levels in the general population. Wives of TCDD-exposed chemical workers and wives of nonexposed neighborhood referents were interviewed to determine reproductive history. Paternal serum TCDD level at time of conception was estimated for each pregnancy using serum samples taken in 1987. Estimated TCDD levels of workers during or after exposure were high (median, 254 ppt; range, 3-16,340 ppt) compared to referent levels (median, 6 ppt; range, 2-19 ppt). No association between paternal TCDD level at the time of conception and spontaneous abortion was observed among pregnancies fathered by workers with TCDD levels of or= 1,120 ppt (OR = 0.95; 95% CI, 0.42-2.17) compared to pregnancies fathered by referents. The sex ratio [males/(males + females)] of offspring also did not differ by TCDD exposure (0.53 and 0.54 among workers and referents, respectively). We did not find an association between paternal serum TCDD level and spontaneous abortion or sex ratio of offspring in this population. The estimated TCDD levels in this exposed worker population were much higher than in other studies, providing additional evidence that paternal TCDD exposure does not increase the risk of spontaneous abortion at levels above those observed in the general population. The study could not evaluate the effect of father's childhood or prenatal TCDD exposure on subsequent sex ratio.
Amanda Eng - One of the best experts on this subject based on the ideXlab platform.
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sex ratio of the offspring of new zealand Phenoxy Herbicide producers exposed to 2 3 7 8 tetrachlorodibenzo p dioxin
Occupational and Environmental Medicine, 2017Co-Authors: Andrea T Mannetje, Amanda Eng, Chris Walls, Evan Dryson, Dave Mclean, Manolis Kogevinas, Soo Cheng, Collin Brooks, Allan H Smith, Neil PearceAbstract:Objectives Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has inconsistently been associated with a decreased sex ratio of the offspring (number of male births divided by total births). We conducted a study among men and women who were employed in a New Zealand Phenoxy Herbicide production plant between 1969 and 1984, to study their offspring sex ratio in relation to their back-calculated TCDD serum concentrations determined in 2007/2008. Methods A total of 127 men and 21 women reported that 355 children were conceived after starting employment at the plant. The association between their lipid-standardised TCDD serum concentrations back-calculated to the time of their offspring9s birth and the probability of a male birth was estimated through logistic regression, adjusting for the age of the exposed parent at birth, current body mass index and smoking. Results The overall sex ratio was 0.55 (197 boys, 158 girls). For fathers with serum TCDD concentrations ≥20 pg/g lipid at time of birth, the sex ratio was 0.47 (OR 0.49; 95% CI 0.30 to 0.79). The probability of a male birth decreased with higher paternal serum TCDD at time of birth ( Conclusions This study indicates that paternal serum TCDD concentrations in excess of an estimated 20 pg/g lipid at time of conception are associated with a reduced sex ratio.
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serum concentrations of chlorinated dibenzo p dioxins furans and pcbs among former Phenoxy Herbicide production workers and firefighters in new zealand
International Archives of Occupational and Environmental Health, 2016Co-Authors: Andrea T Mannetje, Amanda Eng, Chris Walls, Evan Dryson, Dave Mclean, Manolis Kogevinas, Jeff Fowles, Barry Borman, Patrick Oconnor, Soo ChengAbstract:To quantify serum concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and dioxin-like compounds in former Phenoxy Herbicide production plant workers and firefighters, 20 years after 2,4,5-T production ceased. Of 1025 workers employed any time during 1969–1984, 430 were randomly selected and invited to take part in a morbidity survey and provide a blood sample; 244 (57 %) participated. Firefighters stationed in close proximity of the plant and/or engaged in call-outs to the plant between 1962 and 1987 also participated (39 of 70 invited). Reported here are the serum concentrations of TCDD and other chlorinated dibenzo-dioxins, dibenzofurans, and polychlorinated biphenyls (PCBs). Determinants of the serum concentrations were assessed using linear regression. The 60 men who had worked in the Phenoxy/TCP production area had a mean TCDD serum concentration of 19.1 pg/g lipid, three times the mean concentration of the 141 men and 43 women employed in other parts of the plant (6.3 and 6.0 pg/g respectively), and more than 10 times the mean for the firefighters (1.6 pg/g). Duration of employment in Phenoxy Herbicide synthesis, maintenance work, and work as a boilerman, chemist, and packer were associated with increased serum concentrations of TCDD and 1,2,3,4,7-pentachlorodibenzo-p-dioxin (PeCDD). Employment as a boilerman was also associated with elevated serum concentrations of PCBs. Occupations in the plant associated with Phenoxy Herbicide synthesis had elevated levels of TCDD and PeCDD. Most other people working within the plant, and the local firefighters, had serum concentrations of dioxin-like compounds comparable to those of the general population.