The Experts below are selected from a list of 231 Experts worldwide ranked by ideXlab platform
Hameed Ullah - One of the best experts on this subject based on the ideXlab platform.
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prevention of hypotension associated with the induction dose of propofol a randomized controlled trial comparing equipotent doses of Phenylephrine and ephedrine
Journal of Anaesthesiology Clinical Pharmacology, 2015Co-Authors: Muhammad Farhan, Muhammad Qamarul Hoda, Hameed UllahAbstract:Background and Aims: Propofol, the most commonly used intravenous (IV) anesthetic agent is associated with hypotension on induction of anesthesia. Different methods have been used to prevent hypotension but with variable results. The objective of this study was to evaluate efficacy of equipotent doses of phenylpehrine and ephedrine in preventing the hypotensive response to the induction dose of propofol. Material and Methods: One hundred thirty five adult patients were randomised to one of the study groups: propofol-saline (PS), propofol-Phenylephrine (PP) or propofol-ephedrine (PE) by adding study drugs to propofol. Anesthesia was induced with a mixture of propofol and the study drug. Patients were manually mask-ventilated for 5 min using 40% oxygen in nitrous oxide and isoflurane at 1%. A baseline mean arterial pressure (MAP) was recorded prior to induction of anesthesia. Systolic, diastolic and mean blood pressure and heart rate were recorded every minute for up to 5 min after induction. Hypotension was defined as a 20% decrease from the baseline MAP. Results: There were no significant demographic differences between the groups. Overall incidence of hypotension in this study was 38.5% (52/135). Rate of hypotension was significantly higher in group PS than group PP (60% vs. 24.4% P = 0.001) and group PE (60% vs. 31.1% P = 0.005). In contrast, a significant difference in rate of hypotension was not observed between groups PP and group PE. Conclusion: In equipotent doses, Phenylephrine is as good as ephedrine in preventing the hypotensive response to an induction dose of propofol.
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Prevention of hypotension associated with the induction dose of propofol: A randomized controlled trial comparing equipotent doses of Phenylephrine and ephedrine.
Journal of anaesthesiology clinical pharmacology, 2015Co-Authors: Muhammad Farhan, Muhammad Qamarul Hoda, Hameed UllahAbstract:Propofol, the most commonly used intravenous (IV) anesthetic agent is associated with hypotension on induction of anesthesia. Different methods have been used to prevent hypotension but with variable results. The objective of this study was to evaluate efficacy of equipotent doses of phenylpehrine and ephedrine in preventing the hypotensive response to the induction dose of propofol. One hundred thirty five adult patients were randomised to one of the study groups: propofol-saline (PS), propofol-Phenylephrine (PP) or propofol-ephedrine (PE) by adding study drugs to propofol. Anesthesia was induced with a mixture of propofol and the study drug. Patients were manually mask-ventilated for 5 min using 40% oxygen in nitrous oxide and isoflurane at 1%. A baseline mean arterial pressure (MAP) was recorded prior to induction of anesthesia. Systolic, diastolic and mean blood pressure and heart rate were recorded every minute for up to 5 min after induction. Hypotension was defined as a 20% decrease from the baseline MAP. There were no significant demographic differences between the groups. Overall incidence of hypotension in this study was 38.5% (52/135). Rate of hypotension was significantly higher in group PS than group PP (60% vs. 24.4% P = 0.001) and group PE (60% vs. 31.1% P = 0.005). In contrast, a significant difference in rate of hypotension was not observed between groups PP and group PE. In equipotent doses, Phenylephrine is as good as ephedrine in preventing the hypotensive response to an induction dose of propofol.
Muhammad Farhan - One of the best experts on this subject based on the ideXlab platform.
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prevention of hypotension associated with the induction dose of propofol a randomized controlled trial comparing equipotent doses of Phenylephrine and ephedrine
Journal of Anaesthesiology Clinical Pharmacology, 2015Co-Authors: Muhammad Farhan, Muhammad Qamarul Hoda, Hameed UllahAbstract:Background and Aims: Propofol, the most commonly used intravenous (IV) anesthetic agent is associated with hypotension on induction of anesthesia. Different methods have been used to prevent hypotension but with variable results. The objective of this study was to evaluate efficacy of equipotent doses of phenylpehrine and ephedrine in preventing the hypotensive response to the induction dose of propofol. Material and Methods: One hundred thirty five adult patients were randomised to one of the study groups: propofol-saline (PS), propofol-Phenylephrine (PP) or propofol-ephedrine (PE) by adding study drugs to propofol. Anesthesia was induced with a mixture of propofol and the study drug. Patients were manually mask-ventilated for 5 min using 40% oxygen in nitrous oxide and isoflurane at 1%. A baseline mean arterial pressure (MAP) was recorded prior to induction of anesthesia. Systolic, diastolic and mean blood pressure and heart rate were recorded every minute for up to 5 min after induction. Hypotension was defined as a 20% decrease from the baseline MAP. Results: There were no significant demographic differences between the groups. Overall incidence of hypotension in this study was 38.5% (52/135). Rate of hypotension was significantly higher in group PS than group PP (60% vs. 24.4% P = 0.001) and group PE (60% vs. 31.1% P = 0.005). In contrast, a significant difference in rate of hypotension was not observed between groups PP and group PE. Conclusion: In equipotent doses, Phenylephrine is as good as ephedrine in preventing the hypotensive response to an induction dose of propofol.
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Prevention of hypotension associated with the induction dose of propofol: A randomized controlled trial comparing equipotent doses of Phenylephrine and ephedrine.
Journal of anaesthesiology clinical pharmacology, 2015Co-Authors: Muhammad Farhan, Muhammad Qamarul Hoda, Hameed UllahAbstract:Propofol, the most commonly used intravenous (IV) anesthetic agent is associated with hypotension on induction of anesthesia. Different methods have been used to prevent hypotension but with variable results. The objective of this study was to evaluate efficacy of equipotent doses of phenylpehrine and ephedrine in preventing the hypotensive response to the induction dose of propofol. One hundred thirty five adult patients were randomised to one of the study groups: propofol-saline (PS), propofol-Phenylephrine (PP) or propofol-ephedrine (PE) by adding study drugs to propofol. Anesthesia was induced with a mixture of propofol and the study drug. Patients were manually mask-ventilated for 5 min using 40% oxygen in nitrous oxide and isoflurane at 1%. A baseline mean arterial pressure (MAP) was recorded prior to induction of anesthesia. Systolic, diastolic and mean blood pressure and heart rate were recorded every minute for up to 5 min after induction. Hypotension was defined as a 20% decrease from the baseline MAP. There were no significant demographic differences between the groups. Overall incidence of hypotension in this study was 38.5% (52/135). Rate of hypotension was significantly higher in group PS than group PP (60% vs. 24.4% P = 0.001) and group PE (60% vs. 31.1% P = 0.005). In contrast, a significant difference in rate of hypotension was not observed between groups PP and group PE. In equipotent doses, Phenylephrine is as good as ephedrine in preventing the hypotensive response to an induction dose of propofol.
Adrian Glasser - One of the best experts on this subject based on the ideXlab platform.
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The Effects of Phenylephrine on Pupil Diameter and Accommodation in Rhesus Monkeys
Investigative Ophthalmology & Visual Science, 2004Co-Authors: Lisa A. Ostrin, Adrian GlasserAbstract:PURPOSE. Phenylephrine is used to dilate the iris through α-adrenergic stimulation of the iris dilator muscle. Sympathetic stimulation of the ciliary muscle is believed to be inhibitory, decreasing accommodative amplitude. Investigations in humans have suggested some loss of functional accommodation after Phenylephrine. It is unclear whether this loss is due to direct action of Phenylephrine on the ciliary muscle or to secondary optical factors associated with mydriasis. The purpose of this study was to determine whether Phenylephrine affects Edinger-Westphal (EW)-stimulated accommodation in rhesus monkeys. METHODS. The time course for maximum mydriasis was determined by videographic pupillography after Phenylephrine instillation in 10 normal rhesus monkeys. Static and dynamic EW-stimulated accommodative responses were studied in five iridectomized rhesus monkeys before and after Phenylephrine instillation. Accommodative amplitude was measured with a Hartinger coincidence refractometer. Dynamic accommodative responses were measured with infrared photorefraction, and functions were fitted to the data to determine peak velocity versus accommodative response relationships. RESULTS. The maximum dilated pupil diameter of 8.39 ± 0.23 mm occurred 15 minutes after administration of Phenylephrine. In iridectomized monkeys, postPhenylephrine accommodative amplitudes were similar to prePhenylephrine amplitudes. Dynamic analysis of the accommodative responses showed linear peak velocity versus accommodative amplitude relationships that were not statistically different before and after Phenylephrine. CONCLUSIONS. α-Adrenergic stimulation causes a strong pupil dilation in noniridectomized monkey eyes but does not affect EW-stimulated accommodative amplitude or dynamics in anesthetized, iridectomized rhesus monkeys.
Kyung Hwa Kwak - One of the best experts on this subject based on the ideXlab platform.
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The effect of the intravenous Phenylephrine on the level of spinal anesthesia
Korean Journal of Anesthesiology, 2011Co-Authors: Young Hoon Park, Seong Wook Hong, Kyung Hwa KwakAbstract:Background: Spinal anesthesia causes hypotension and bradycardia due to sympathetic nerve block and it is difficult to predict the level of sensory block and the duration of blockade. Recent studies have reported that intravenous Phenylephrine can reduce the rostral spread of spinal anesthesia in pregnant women. We think a Phenylephrine infusion will be useful for maintaining the baseline blood pressure by reducing the rostral spread of spinal anesthesia during the elective surgery of non-obstetric patients. Methods: Sixty patients who were undergoing urologic surgery were randomized into two groups: Group C (the control group without Phenylephrine) and Group P (with the addition of Phenylephrine). After a bolus infusion of 50 μg Phenylephrine following the spinal injection, Phenylephrine was continuously infused at the rate of 200 μg/hr. We compared the dermatomal spreads of spinal anesthesia, the hemodynamic parameters (blood pressure, heart rate) and the incidences of hypotension between the two groups. Results: At 20 minutes, the level of the upper dermatome blocked against cold sensation was a median of T8 (interquartile range: T8-T10) for the Phenylephrine group, as compared with T4 (interquartile range: T4-T6) for the control group (P < 0.001). Conclusions: Intravenous Phenylephrine can decrease the rostral spread of spinal anesthesia during urologic surgery. (Korean J Anesthesiol 2011; 61: 372-376)
Muhammad Qamarul Hoda - One of the best experts on this subject based on the ideXlab platform.
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prevention of hypotension associated with the induction dose of propofol a randomized controlled trial comparing equipotent doses of Phenylephrine and ephedrine
Journal of Anaesthesiology Clinical Pharmacology, 2015Co-Authors: Muhammad Farhan, Muhammad Qamarul Hoda, Hameed UllahAbstract:Background and Aims: Propofol, the most commonly used intravenous (IV) anesthetic agent is associated with hypotension on induction of anesthesia. Different methods have been used to prevent hypotension but with variable results. The objective of this study was to evaluate efficacy of equipotent doses of phenylpehrine and ephedrine in preventing the hypotensive response to the induction dose of propofol. Material and Methods: One hundred thirty five adult patients were randomised to one of the study groups: propofol-saline (PS), propofol-Phenylephrine (PP) or propofol-ephedrine (PE) by adding study drugs to propofol. Anesthesia was induced with a mixture of propofol and the study drug. Patients were manually mask-ventilated for 5 min using 40% oxygen in nitrous oxide and isoflurane at 1%. A baseline mean arterial pressure (MAP) was recorded prior to induction of anesthesia. Systolic, diastolic and mean blood pressure and heart rate were recorded every minute for up to 5 min after induction. Hypotension was defined as a 20% decrease from the baseline MAP. Results: There were no significant demographic differences between the groups. Overall incidence of hypotension in this study was 38.5% (52/135). Rate of hypotension was significantly higher in group PS than group PP (60% vs. 24.4% P = 0.001) and group PE (60% vs. 31.1% P = 0.005). In contrast, a significant difference in rate of hypotension was not observed between groups PP and group PE. Conclusion: In equipotent doses, Phenylephrine is as good as ephedrine in preventing the hypotensive response to an induction dose of propofol.
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Prevention of hypotension associated with the induction dose of propofol: A randomized controlled trial comparing equipotent doses of Phenylephrine and ephedrine.
Journal of anaesthesiology clinical pharmacology, 2015Co-Authors: Muhammad Farhan, Muhammad Qamarul Hoda, Hameed UllahAbstract:Propofol, the most commonly used intravenous (IV) anesthetic agent is associated with hypotension on induction of anesthesia. Different methods have been used to prevent hypotension but with variable results. The objective of this study was to evaluate efficacy of equipotent doses of phenylpehrine and ephedrine in preventing the hypotensive response to the induction dose of propofol. One hundred thirty five adult patients were randomised to one of the study groups: propofol-saline (PS), propofol-Phenylephrine (PP) or propofol-ephedrine (PE) by adding study drugs to propofol. Anesthesia was induced with a mixture of propofol and the study drug. Patients were manually mask-ventilated for 5 min using 40% oxygen in nitrous oxide and isoflurane at 1%. A baseline mean arterial pressure (MAP) was recorded prior to induction of anesthesia. Systolic, diastolic and mean blood pressure and heart rate were recorded every minute for up to 5 min after induction. Hypotension was defined as a 20% decrease from the baseline MAP. There were no significant demographic differences between the groups. Overall incidence of hypotension in this study was 38.5% (52/135). Rate of hypotension was significantly higher in group PS than group PP (60% vs. 24.4% P = 0.001) and group PE (60% vs. 31.1% P = 0.005). In contrast, a significant difference in rate of hypotension was not observed between groups PP and group PE. In equipotent doses, Phenylephrine is as good as ephedrine in preventing the hypotensive response to an induction dose of propofol.
