The Experts below are selected from a list of 15822 Experts worldwide ranked by ideXlab platform
Mohamed Abarbri - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of 5-Substituted 1,2,3-Triazolyl-4-Phosphonate through Cross-Coupling Reactions of 5-Iodo-1,2,3-triazolyl-4-Phosphonate
European Journal of Organic Chemistry, 2016Co-Authors: Emilie Thiery, Vanny You, Anne-sophie Mora, Mohamed AbarbriAbstract:Two methods for the preparation of 5-iodo-1,2,3-triazolyl-4-Phosphonate were explored. This compound was then functionalized by Suzuki and Stille cross-coupling reaction to obtain 5-aryl-, 5-heteroaryl- or 5-alkenyl-1,2,3-triazolyl-4-Phosphonates.
Emilie Thiery - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of 5-Substituted 1,2,3-Triazolyl-4-Phosphonate through Cross-Coupling Reactions of 5-Iodo-1,2,3-triazolyl-4-Phosphonate
European Journal of Organic Chemistry, 2016Co-Authors: Emilie Thiery, Vanny You, Anne-sophie Mora, Mohamed AbarbriAbstract:Two methods for the preparation of 5-iodo-1,2,3-triazolyl-4-Phosphonate were explored. This compound was then functionalized by Suzuki and Stille cross-coupling reaction to obtain 5-aryl-, 5-heteroaryl- or 5-alkenyl-1,2,3-triazolyl-4-Phosphonates.
Vanny You - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of 5-Substituted 1,2,3-Triazolyl-4-Phosphonate through Cross-Coupling Reactions of 5-Iodo-1,2,3-triazolyl-4-Phosphonate
European Journal of Organic Chemistry, 2016Co-Authors: Emilie Thiery, Vanny You, Anne-sophie Mora, Mohamed AbarbriAbstract:Two methods for the preparation of 5-iodo-1,2,3-triazolyl-4-Phosphonate were explored. This compound was then functionalized by Suzuki and Stille cross-coupling reaction to obtain 5-aryl-, 5-heteroaryl- or 5-alkenyl-1,2,3-triazolyl-4-Phosphonates.
Anne-sophie Mora - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of 5-Substituted 1,2,3-Triazolyl-4-Phosphonate through Cross-Coupling Reactions of 5-Iodo-1,2,3-triazolyl-4-Phosphonate
European Journal of Organic Chemistry, 2016Co-Authors: Emilie Thiery, Vanny You, Anne-sophie Mora, Mohamed AbarbriAbstract:Two methods for the preparation of 5-iodo-1,2,3-triazolyl-4-Phosphonate were explored. This compound was then functionalized by Suzuki and Stille cross-coupling reaction to obtain 5-aryl-, 5-heteroaryl- or 5-alkenyl-1,2,3-triazolyl-4-Phosphonates.
Ivan Rosenberg - One of the best experts on this subject based on the ideXlab platform.
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Solid-Phase Synthesis of Phosphorothioate/Phosphonothioate and Phosphoramidate/Phosphonamidate Oligonucleotides
MDPI AG, 2019Co-Authors: Ondřej Kostov, Ondřej Páv, Radek Liboska, Pavel Novák, Ivan RosenbergAbstract:We have developed a robust solid-phase protocol which allowed the synthesis of chimeric oligonucleotides modified with phosphodiester and O-methylPhosphonate linkages as well as their P-S and P-N variants. The novel O-methylPhosphonate-derived modifications were obtained by oxidation, sulfurization, and amidation of the O-methyl-(H)-phosphinate internucleotide linkage introduced into the oligonucleotide chain by H-Phosphonate chemistry using nucleoside-O-methyl-(H)-phosphinates as monomers. The H-Phosphonate coupling followed by oxidation after each cycle enabled us to successfully combine H-Phosphonate and phosphoramidite chemistries to synthesize diversely modified oligonucleotide strands
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4-Toluenesulfonyloxymethyl-(H)-phosphinate: A Reagent for the Introduction of O- and S-Methyl-(H)-phosphinate Moieties.
Organic letters, 2016Co-Authors: Ondřej Kostov, Ondřej Páv, Miloš Buděšínský, Radek Liboska, Ondřej Šimák, Magdalena Petrová, Pavel Novák, Ivan RosenbergAbstract:The straightforward synthesis of sodium 4-toluenesulfonyloxymethyl-(H)-phosphinate and (H)-phosphinomethylisothiouronium tosylate as new reagents for the preparation of O- and S-methyl-(H)-phosphinic acid derivatives, respectively, is described. The reactivity of both reagents was demonstrated by the preparation of protected 2′-deoxyribonucleoside-O-methyl-(H)-phosphinates in the 5′- and 3′-series and 2′,5′-dideoxyribonucleoside-5′-S-methyl-(H)-phosphinates. These compounds represent a new class of monomers compatible with the solid phase synthesis of oligonucleotides by H-Phosphonate chemistry, as it was proved with the synthesis of a fully Phosphonate heptamer.
