The Experts below are selected from a list of 12 Experts worldwide ranked by ideXlab platform
Salah A. Ali - One of the best experts on this subject based on the ideXlab platform.
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Retrospective study of Hirschsprung's disease in Erbil city/Iraq during 2004–2016
Medical Journal of Babylon, 2020Co-Authors: Suhel Al-najjar, Jawhar Tahir Omer, Salah A. AliAbstract:Background: Hirschsprung's disease is caused by the failure of ganglion cells to migrate cephalocaudal through the neural crest during 4–12 weeks of gestation, causing an absence of ganglion cells in all or part of the colon. Most patients present in infancy, and the early diagnosis is important to avoid complications. With proper treatment, most patients live normal adult live. Objectives: The objective of this study is to investigate the incidence and severity of Hirschsprung's disease in our location (Erbil city/Iraq). Materials and Methods: In this prospective study, we collected 150 cases that referred to our private laboratory in Erbil city from January 2004 to December 2016. A total of 108 cases were studied grossly and histopathologically Stained by H and E in addition to Phosphotungstic Acid-Haematoxylin Stain (PTAH) special Stain for ganglion cells and neural plexuses. Results: The results found that Hirschsprung's disease was more common in males than females (male gender 52% and female 48%). The majority of cases were below the age of 1 year (48% of cases). The resected segment is 21–30 cm in about 46% of cases. Regarding the narrowing segment is about 5 cm in most cases (56% of cases). Finally, the number of neural plexuses in the whole narrow segment was five neural plexuses in the majority of cases (found in 24 cases [23%]). Conclusions: Hirschsprung's disease is a common disease in this locality (Erbil city/Iraq). All constipated newborn babies should be examined to exclude HD.
Josué Díaz-delgado - One of the best experts on this subject based on the ideXlab platform.
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Facial Squamous Cell Carcinoma and Abdominal Peripheral Nerve Sheath Tumour with Rhabdomyoblastic Differentiation in a Rough-toothed Dolphin (Steno bredanensis).
Journal of comparative pathology, 2020Co-Authors: M.r. Alves-motta, V. Luz-carvalho, D.c.s. Nunes-pinheiro, Kátia R. Groch, L. Gonçalves-pereira, Angélica María Sánchez-sarmiento, Carlos Sacristán, José Luiz Catão-dias, Josué Díaz-delgadoAbstract:Summary We report the pathological features of a facial squamous cell carcinoma (SCC) and an abdominal peripheral nerve sheath tumour (PNST) with rhabdomyoblastic differentiation in an aged free-ranging rough-toothed dolphin (Steno bredanensis). The animal was found stranded dead in poor body condition. On external examination, there was a 25 × 7 × 3 cm extensively ulcerated area on the right maxillary region of the rostrum, involving the oral mucocutaneous junction with prominent nodular edges, severe soft tissue loss and extensive maxillary and premaxillary bone lysis. On abdominal dissection, a 5 × 4 × 3.5 cm pale tan to red, raised mass expanded the inner aspect of the right transverse abdominis muscle. Microscopically, the aggressive facial lesion was an acantholytic SCC with extensive osteolysis; there was no evidence of metastasis in the tissues examined. The abdominal mass had cytohistomorphological features compatible with a localized PNST, including whorling, Antoni A and Antoni B areas and Verocay bodies intermixed with rhabdomyoblastic components, as suggested by Phosphotungstic acid haematoxylin Stain. This neoplasm was locally infiltrative, yet no metastases were observed in the tissues examined. No immunohistochemical investigations could be performed due to lack of tissue availability. Total DNA from the formalin-fixed and paraffin wax-embedded SCC was extracted and tested by polymerase chain reaction for herpesvirus and papillomavirus genetic material. There was no amplification for either of these genera. Other pathological findings observed in this animal were related to the ‘live-stranding stress response’. The severity and extent of the facial SCC likely related to anorexia and poor body condition and might have played a role in the stranding and death of this dolphin. These two tumour subtypes add to the relatively uncommon reports of neoplasia in cetaceans. Specifically, these appear to be the first neoplasia records for rough-toothed dolphins, including the first documentation of a PNST with features compatible with rhabdomyoblastic differentiation in a marine mammal.
Klaus Heimann - One of the best experts on this subject based on the ideXlab platform.
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Clinicopathological correlation in exudative age related macular degeneration: histological differentiation between classic and occult choroidal neovascularisation
The British journal of ophthalmology, 2000Co-Authors: B. A. Lafaut, Karl Ulrich Bartz-schmidt, C. Vanden Broecke, S. Aisenbrey, J. J. De Laey, Klaus HeimannAbstract:AIMS—To analyse the histopathology of classic and occult choroidal neovascular membrane surgical specimens in age related macular degeneration. METHODS—35 membranes, from a consecutive series of surgically removed choroidal neovascular membranes in age related macular degeneration, were classified as classic or occult following the guidelines of the Macular Photocoagulation Study. Membranes with classic as well as occult components were considered as mixed membranes. The membranes were serially sectioned and Stained with haematoxylin and eosin, Masson trichrome, periodic acid-Schiff, and Phosphotungstic acid haematoxylin Stain. The correlation has been made in a masked fashion. RESULTS—31 membranes (19 classic, 10 occult, and two mixed membranes) could be analysed histologically. 18 classic choroidal neovascular membranes had a major subretinal fibrovascular component and 10 of these had an additional, minor fibrovascular component under the retinal pigment epithelium. The 10 occult membranes contained a fibrovascular component under the retinal pigment epithelium and the two mixed membranes contained fibrovascular tissue on both sides of the retinal pigment epithelium. Fibrin and remains of outer segments tended to occur at the lateral edges of classic membranes and to cover the inner surface of occult membranes. CONCLUSION—Classic choroidal neovascularisation in age related macular degeneration is predominantly composed of subretinal fibrovascular tissue while occult choroidal neovascularisation is composed of fibrovascular tissue at the choroidal side of the retinal pigment epithelium.
Hilbe Monika - One of the best experts on this subject based on the ideXlab platform.
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Nemaline myopathy diagnosed in two young Border collies in formalin-fixed paraffin-embedded muscle samples using conventional Stains
'BMJ', 2018Co-Authors: Dettwiler, Martina Andrea, Sydler Titus, Klausmann Stefanie, Beckmann Katrin, Hilbe MonikaAbstract:Nemaline myopathy (NM) is a congenital neuromuscular disorder with heterogeneous clinical signs such as muscle weakness, affecting humans, seldom dogs and cats. For human NM, several causative gene mutations have been identified. The hallmark of this disease is the presence of sarcoplasmic inclusions (nemaline rods) in skeletal muscle fibres, which can be visualised in sections of muscle specimens. Ultrastructurally, an enlargement and streaming of the Z lines can be detected. Here, the case of two 10-week-old female Border collie littermates with progressive gait dysfunction, muscle stiffness and exercise intolerance, which were euthanased because of poor prognosis, is described. Histology of formalin-fixed paraffin-embedded muscle samples revealed sarcoplasmic rods visible in tissue sections Stained with haematoxylin and eosin, the Gomori trichrome and the Phosphotungstic acid haematoxylin Stain. In electron microscopy, the rods were confirmed as streaming of the Z lines. Therefore, a congenital NM was diagnosed
Suhel Al-najjar - One of the best experts on this subject based on the ideXlab platform.
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Retrospective study of Hirschsprung's disease in Erbil city/Iraq during 2004–2016
Medical Journal of Babylon, 2020Co-Authors: Suhel Al-najjar, Jawhar Tahir Omer, Salah A. AliAbstract:Background: Hirschsprung's disease is caused by the failure of ganglion cells to migrate cephalocaudal through the neural crest during 4–12 weeks of gestation, causing an absence of ganglion cells in all or part of the colon. Most patients present in infancy, and the early diagnosis is important to avoid complications. With proper treatment, most patients live normal adult live. Objectives: The objective of this study is to investigate the incidence and severity of Hirschsprung's disease in our location (Erbil city/Iraq). Materials and Methods: In this prospective study, we collected 150 cases that referred to our private laboratory in Erbil city from January 2004 to December 2016. A total of 108 cases were studied grossly and histopathologically Stained by H and E in addition to Phosphotungstic Acid-Haematoxylin Stain (PTAH) special Stain for ganglion cells and neural plexuses. Results: The results found that Hirschsprung's disease was more common in males than females (male gender 52% and female 48%). The majority of cases were below the age of 1 year (48% of cases). The resected segment is 21–30 cm in about 46% of cases. Regarding the narrowing segment is about 5 cm in most cases (56% of cases). Finally, the number of neural plexuses in the whole narrow segment was five neural plexuses in the majority of cases (found in 24 cases [23%]). Conclusions: Hirschsprung's disease is a common disease in this locality (Erbil city/Iraq). All constipated newborn babies should be examined to exclude HD.