The Experts below are selected from a list of 222 Experts worldwide ranked by ideXlab platform
Véronique Santé-lhoutellier - One of the best experts on this subject based on the ideXlab platform.
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The "sisters" α-helices of collagen, elastin and keratin recovered from animal by-products: Functionality, bioactivity and trends of application
Trends in Food Science and Technology, 2016Co-Authors: Vincenza Ferraro, Marc Anton, Véronique Santé-lhoutellierAbstract:Background: Huge amounts of animal by-products are generated along processing for human consumption. This material adds up to 50% of the animal weight, representing a serious economic and environmental concern. Scope and approach: A shift to a molecular level of utilisation of those residues could be a viable and cost-effective option, where the biomolecules recovered would be applied outside the agricultural sector. In this regards, the structural fibrous proteins collagen, elastin and keratin, and respective hydrolysates and small peptides, can be recovered from fisheries, poultry and red meat slaughter residues and employed in high-priority fields such as food, biomedicine and pharmaceutics, and in highly profitable areas such as cosmetics. Bones (from fish and meat), skin (from pig and fish) and fish scales are a source of collagen; ligaments (from cattle, pig and poultry) are a source of elastin while keratin could be recovered from poultry feathers and pig hair. Beside the documented relevance of collagen, elastin and keratin in cosmetic and pharmaceutics, and of gelatine in the food and Photographic Industry, a number of new applications can look at them as promising ingredients. Key findings and conclusions: The spontaneous self-assembly of the native α-helix of collagen, elastin and keratin allows conceiving biomaterials, emulsions, foams, stable colloids, as well as micro- and nanocapsules. Alongside this, the biological activities of small peptides, such as the antihypertensive, antimicrobial, antioxidant, wound-healing, osteogenic, haemostatic and chelating capacity, give the possibility to look at animal by-products as a remarkable source of functional compounds, whose application will contribute to the agro-food Industry sustainability.
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The "sisters" alpha-helices of collagen, elastin and keratin recovered from animal by-products: Functionality, bioactivity and trends of application
Trends in Food Science and Technology, 2016Co-Authors: Vincenza Ferraro, Marc Anton, Véronique Santé-lhoutellierAbstract:Huge amounts of animal by-products are generated along processing for human consumption. This material adds up to 50% of the animal weight, representing a serious economic and environmental concern. Scope and approach: A shift to a molecular level of utilisation of those residues could be a viable and cost-effective option, where the biomolecules recovered would be applied outside the agricultural sector. In this regards, the structural fibrous proteins collagen, elastin and keratin, and respective hydrolysates and small peptides, can be recovered from fisheries, poultry and red meat slaughter residues and employed in high-priority fields such as food, biomedicine and pharmaceutics, and in highly profitable areas such as cosmetics. Bones (from fish and meat), skin (from pig and fish) and fish scales are a source of collagen; ligaments (from cattle, pig and poultry) are a source of elastin while keratin could be recovered from poultry feathers and pig hair. Beside the documented relevance of collagen, elastin and keratin in cosmetic and pharmaceutics, and of gelatine in the food and Photographic Industry, a number of new applications can look at them as promising ingredients. Key findings and conclusions: The spontaneous self-assembly of the native alpha-helix of collagen, elastin and keratin allows conceiving biomaterials, emulsions, foams, stable colloids, as well as micro- and nano capsules. Alongside this, the biological activities of small peptides, such as the antihypertensive, antimicrobial, antioxidant, wound-healing, osteogenic, haemostatic and chelating capacity, give the possibility to look at animal by-products as a remarkable source of functional compounds, whose application will contribute to the agro-food Industry sustainability.
Chung-shing Lee - One of the best experts on this subject based on the ideXlab platform.
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A typology of technological change: : Technological paradigm theory with validation and generalization from case studies
Technological Forecasting and Social Change, 2015Co-Authors: Chung-shing LeeAbstract:Abstract Shifts in technological paradigms simultaneously disrupt existing industrial organization and raise opportunities for entrepreneurial companies. However, research on technological innovation centers the development of new technological solutions, while largely neglecting changes in customer problems or needs. This paper develops a typology for use as an analytical framework covering technological innovations and variations in market demand. The typology is then applied to the Photographic Industry, specifically the development of digital imaging technologies which disrupted existing film material and chemistry technologies in a paradigm shift from analog film to digital cameras. Taking a systematic view of product technologies, the typology identifies seven types of technological changes during the photography Industry's process of digitalization. Case studies show that disruption of incumbent competencies can be attributed to the interactive effects of technological innovations and variations to market demand. Adaptive strategies corresponding to the identified types of technological changes are reported and discussed. The proposed typology is designed as a generic framework and is validated using an additional set of case studies from the media industrial sector.
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A typology of technological changes: Theory of technological paradigm, trajectory and regime with a case study on the Photographic industrial sector
2013Co-Authors: Chung-shing LeeAbstract:Shifts in technological paradigms simultaneously disrupt existing industrial organization and raise opportunities for entrepreneurial companies. Analyzing the process of paradigm shift requires a systematic framework involves a variety of factors related to market conditions, industrial organization, and the broader technical environment. This research develops a typology as an analytical framework covering technological paradigm, trajectory and regime, and applies it to the Photographic Industry. The development of digital optical technologies disrupted existing film material and chemistry technologies in a paradigm shift from analog film cameras to digital cameras. This finding is in contrast to the dichotomy that technological competence can only either be disrupted or accumulated. A case study shows that separating a firm's sustainable competence from the disrupted aspect is critical during periods of technological change. Depending on its technology strategy, a firm could turn from technological innovator to technological defender when its technological competence is disrupted. Additionally, changes in the technological regime increase innovation opportunity, which attracts fiercer technological competition, thus decreasing appropriability. In the new paradigm, collective innovation has emerged as a new pattern in technological trajectory. The proposed typology is designed as a generic framework and should be applicable to technological changes in other industrial sectors.
Vincenza Ferraro - One of the best experts on this subject based on the ideXlab platform.
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The "sisters" α-helices of collagen, elastin and keratin recovered from animal by-products: Functionality, bioactivity and trends of application
Trends in Food Science and Technology, 2016Co-Authors: Vincenza Ferraro, Marc Anton, Véronique Santé-lhoutellierAbstract:Background: Huge amounts of animal by-products are generated along processing for human consumption. This material adds up to 50% of the animal weight, representing a serious economic and environmental concern. Scope and approach: A shift to a molecular level of utilisation of those residues could be a viable and cost-effective option, where the biomolecules recovered would be applied outside the agricultural sector. In this regards, the structural fibrous proteins collagen, elastin and keratin, and respective hydrolysates and small peptides, can be recovered from fisheries, poultry and red meat slaughter residues and employed in high-priority fields such as food, biomedicine and pharmaceutics, and in highly profitable areas such as cosmetics. Bones (from fish and meat), skin (from pig and fish) and fish scales are a source of collagen; ligaments (from cattle, pig and poultry) are a source of elastin while keratin could be recovered from poultry feathers and pig hair. Beside the documented relevance of collagen, elastin and keratin in cosmetic and pharmaceutics, and of gelatine in the food and Photographic Industry, a number of new applications can look at them as promising ingredients. Key findings and conclusions: The spontaneous self-assembly of the native α-helix of collagen, elastin and keratin allows conceiving biomaterials, emulsions, foams, stable colloids, as well as micro- and nanocapsules. Alongside this, the biological activities of small peptides, such as the antihypertensive, antimicrobial, antioxidant, wound-healing, osteogenic, haemostatic and chelating capacity, give the possibility to look at animal by-products as a remarkable source of functional compounds, whose application will contribute to the agro-food Industry sustainability.
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The "sisters" alpha-helices of collagen, elastin and keratin recovered from animal by-products: Functionality, bioactivity and trends of application
Trends in Food Science and Technology, 2016Co-Authors: Vincenza Ferraro, Marc Anton, Véronique Santé-lhoutellierAbstract:Huge amounts of animal by-products are generated along processing for human consumption. This material adds up to 50% of the animal weight, representing a serious economic and environmental concern. Scope and approach: A shift to a molecular level of utilisation of those residues could be a viable and cost-effective option, where the biomolecules recovered would be applied outside the agricultural sector. In this regards, the structural fibrous proteins collagen, elastin and keratin, and respective hydrolysates and small peptides, can be recovered from fisheries, poultry and red meat slaughter residues and employed in high-priority fields such as food, biomedicine and pharmaceutics, and in highly profitable areas such as cosmetics. Bones (from fish and meat), skin (from pig and fish) and fish scales are a source of collagen; ligaments (from cattle, pig and poultry) are a source of elastin while keratin could be recovered from poultry feathers and pig hair. Beside the documented relevance of collagen, elastin and keratin in cosmetic and pharmaceutics, and of gelatine in the food and Photographic Industry, a number of new applications can look at them as promising ingredients. Key findings and conclusions: The spontaneous self-assembly of the native alpha-helix of collagen, elastin and keratin allows conceiving biomaterials, emulsions, foams, stable colloids, as well as micro- and nano capsules. Alongside this, the biological activities of small peptides, such as the antihypertensive, antimicrobial, antioxidant, wound-healing, osteogenic, haemostatic and chelating capacity, give the possibility to look at animal by-products as a remarkable source of functional compounds, whose application will contribute to the agro-food Industry sustainability.
Alexandr Hrabálek - One of the best experts on this subject based on the ideXlab platform.
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One-pot synthesis of 1-substituted-5-alkylselanyl-1 H -tetrazoles from isoselenocyanates: unexpected formation of N -alkyl- N -arylcyanamides and ( Z )- Se -alkyl- N -cyano- N , N′ -diarylisoselenoureas
Tetrahedron, 2013Co-Authors: Galina Karabanovich, Kateřina Vávrová, Jaroslav Roh, Zdeňka Padělková, Zdeněk Novák, Alexandr HrabálekAbstract:Abstract 1-Substituted-5-alkylsulfanyl-1H-tetrazoles are well known class of organic substances with various applications in medicinal chemistry or Photographic Industry. Their selenium analogues, 1-substituted-5-alkylselanyl-1H-tetrazoles are, however, much less explored because of the lack of suitable methods for their preparation. In this work we investigated the synthesis of 1-alkyl/aryl-5-alkylselanyl-1H-tetrazoles from synthetically available alkyl/arylisoselenocyanates. One-pot reactions of arylisoselenocyanates with sodium azide and alkylating agent led to the target 5-alkylselanyl-1-aryl-1H-tetrazoles but also to interesting side products, namely N-alkyl-N-arylcyanamides and (Z)-Se-alkyl-N-cyano-N,N′-diarylisoselenoureas. Nevertheless, when alkylisoselenocyanates were utilized as the substrates, the reactions led exclusively to the formation of 1-alkyl-5-alkylselanyl-1H-tetrazoles in good yields. This simple one-pot procedure brings new possibilities for the preparation of variously substituted selenium compounds. It also opens the way to further investigations of selenium isosteres of the widely utilized 5-thiotetrazole moiety in biomedical applications.
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Synthesis and Functionalization of 5‐Substituted Tetrazoles
European Journal of Organic Chemistry, 2012Co-Authors: Kateřina Vávrová, Alexandr HrabálekAbstract:Tetrazoles are synthetic heterocycles with numerous applications in organic chemistry, coordination chemistry, the Photographic Industry, explosives, and, in particular, medicinal chemistry. In organic chemistry, 5-substituted tetrazoles are used as advantageous intermediates in the synthesis of other heterocycles and as activators in oligonucleotide synthesis. In drug design, 5-monosubstituted tetrazoles are the most important tetrazole derivatives because they represent non-classical bioisosteres of carboxylic acids, with similar acidities but higher lipophilicities and metabolic resistance. In this review we focus on the preparation and further functionalization of these heterocycles. Firstly, the role of 5-substituted tetrazoles in medicinal chemistry is described, including examples of their effects on pharmacokinetics, pharmacodynamics, and metabolism of the associated drugs. Then, the main synthetic approaches to 5-substituted tetrazoles – consisting of methods based on acidic media/proton catalysis, Lewis acids, and organometallic or organosilicon azides – are presented, from the early procedures to the most recent ones, with special attention paid to the reaction mechanisms. Functionalization of 5-substituted tetrazoles is a challenging task because it usually leads to the formation of two isomers, 1,5- and 2,5-disubstituted tetrazoles, in various ratios. In this overview, reactions with high or unusual regioselectivities are described, with comments on the possible mechanisms. Microwave-assisted approaches to the synthesis and functionalization of 5-substituted tetrazoles are also included.
Francesco Vegliò - One of the best experts on this subject based on the ideXlab platform.
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Overview on hydrometallurgical procedures for silver recovery from various wastes
Journal of Environmental Chemical Engineering, 2018Co-Authors: Ionela Birloaga, Francesco VegliòAbstract:Abstract The core of this paper is to expose the current situation on generation and treatment of five streams that present Ag in their composition. During the last two decades, large amounts of silver recovered from primary ores has been used in the manufacturing of electrical and electronic devices. Between these devices, the current situation for printed circuit boards (component which is found in each device that make use of an electrical field) and spent plasma monitors is shown. Moreover, the button cells, which are a special category of waste at the end of their life, are also presented within this article. The spent effluents of Photographic Industry, X-Ray films and laboratory waste represent two other important secondary resource of silver and therefore their situation and current hydrometallurgical methods of processing will be also present within this paper.