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Hazem M Abushawish - One of the best experts on this subject based on the ideXlab platform.
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potentiometric flow injection analysis of dicyclomine hydrochloride in serum urine and milk
Analytica Chimica Acta, 2005Co-Authors: Hosny Ibrahim, Y M Issa, Hazem M AbushawishAbstract:Five plastic membrane electrodes for the determination of dicyclomine hydrochloride (DcCl) were fabricated and fully characterized in terms of composition, life span, usable pH range, working concentration range and temperature. The membranes of these electrodes consist of dicyclominium-silicotungstate (Dc-ST), silicomolybdate (Dc-SM), phosphotungstate (Dc-PT), phosphomolybdate (Dc-PM) or tetraphenylborate (Dc-TPB) ion-associations dispersed in PVC matrix with dibutyl Phthalate Plasticizer. The electrodes showed near-Nernstian response over the concentration range of 4.0 × 10−6 to 1.0 × 10−2 M DcCl and applied to the potentiometric determination of dicyclominium ion in pharmaceutical preparations, serum, urine and milk in batch and flow injection (FI) conditions with average recoveries of 96.1–102.7% and relative standard deviation of 0.055–1.994%. The electrodes exhibit good selectivity for DcCl with respect to a large number of inorganic cations, organic cations, sugars and amino acids. The sensitivities of these electrodes are high enough to measure as low as 1.73 μg/ml of DcCl which permit the determination of the Ksp values of the ion-associates used. The proposed potentiometric methods offer the advantages of simplicity, accuracy, automation feasibility and applicability to turbid and colored sample solutions.
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potentiometric flow injection analysis of mebeverine hydrochloride in serum and urine
Journal of Pharmaceutical and Biomedical Analysis, 2005Co-Authors: Hosny Ibrahim, Y M Issa, Hazem M AbushawishAbstract:Abstract Four PVC membrane electrodes for the determination of mebeverine hydrochloride (MvCl) were fabricated and fully characterized in terms of composition, life span, usable pH range, working concentration range and temperature. The membranes of these electrodes consist of mebeverinium-silicotungstate (Mv-ST), silicomolybdate (Mv-SM), phosphotungstate (Mv-PT), or phosphomolybdate (Mv-PM) ion-associations dispersed in PVC matrix with dibutyl Phthalate Plasticizer. The electrodes showed near-Nernstian response over the concentration range of 4.0 × 10 −6 to 1.0 × 10 −2 M MvCl and were applied to the potentiometric determination of mebeverinium ion in pharmaceutical preparations, serum and urine in steady state and flow injection (FI) conditions with average recoveries of 96.4–102 % and relative standard deviations of 0.132–1.86%. The electrodes exhibit good selectivity for MvCl with respect to a large number of inorganic cations, organic cations, sugars and amino acids. The sensitivities of these electrodes are high enough to measure as low as 1.86 μg/ml of MvCl which permit the determination of the K sp values of the ion-associates used. The proposed potentiometric methods offer the advantages of simplicity, accuracy, automation feasibility and applicability to turbid and colored sample solutions.
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potentiometric flow injection analysis of drotaverine hydrochloride in pharmaceutical preparations
Analytical Letters, 2005Co-Authors: Hosny Ibrahim, Y M Issa, Hazem M AbushawishAbstract:Abstract Five poly (vinyl chloride) (PVC) membrane electrodes for the determination of drotaverine hydrochloride (DvCl) were constructed and fully characterized in terms of composition, life span, response time, usable pH range, working concentration range, and temperature. The membranes of these electrodes consist of drotaverinium‐silicotungstate (Dv‐ST), silicomolybdate (Dv‐SM), phosphotungstate (Dv‐PT), phosphomolybdate (Dv‐PM), or tetraphenylborate (Dv‐TPB) ion associations dispersed in PVC matrix with dibutyl Phthalate Plasticizer. The electrodes showed near‐Nernstian response over the concentration range of 2.0 × 10−6 to 1.0 × 10−2 M DvCl and were applied to the potentiometric determination of drotaverinium ion in pharmaceutical preparations in steady‐state and flow injection (FI) conditions with average recoveries of 98.1–102.2% and relative standard deviation of 0.308–1.310%. The electrodes exhibit good selectivity for DvCl with respect to a large number of inorganic cations, organic cations, sug...
Hosny Ibrahim - One of the best experts on this subject based on the ideXlab platform.
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potentiometric flow injection analysis of dicyclomine hydrochloride in serum urine and milk
Analytica Chimica Acta, 2005Co-Authors: Hosny Ibrahim, Y M Issa, Hazem M AbushawishAbstract:Five plastic membrane electrodes for the determination of dicyclomine hydrochloride (DcCl) were fabricated and fully characterized in terms of composition, life span, usable pH range, working concentration range and temperature. The membranes of these electrodes consist of dicyclominium-silicotungstate (Dc-ST), silicomolybdate (Dc-SM), phosphotungstate (Dc-PT), phosphomolybdate (Dc-PM) or tetraphenylborate (Dc-TPB) ion-associations dispersed in PVC matrix with dibutyl Phthalate Plasticizer. The electrodes showed near-Nernstian response over the concentration range of 4.0 × 10−6 to 1.0 × 10−2 M DcCl and applied to the potentiometric determination of dicyclominium ion in pharmaceutical preparations, serum, urine and milk in batch and flow injection (FI) conditions with average recoveries of 96.1–102.7% and relative standard deviation of 0.055–1.994%. The electrodes exhibit good selectivity for DcCl with respect to a large number of inorganic cations, organic cations, sugars and amino acids. The sensitivities of these electrodes are high enough to measure as low as 1.73 μg/ml of DcCl which permit the determination of the Ksp values of the ion-associates used. The proposed potentiometric methods offer the advantages of simplicity, accuracy, automation feasibility and applicability to turbid and colored sample solutions.
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potentiometric flow injection analysis of mebeverine hydrochloride in serum and urine
Journal of Pharmaceutical and Biomedical Analysis, 2005Co-Authors: Hosny Ibrahim, Y M Issa, Hazem M AbushawishAbstract:Abstract Four PVC membrane electrodes for the determination of mebeverine hydrochloride (MvCl) were fabricated and fully characterized in terms of composition, life span, usable pH range, working concentration range and temperature. The membranes of these electrodes consist of mebeverinium-silicotungstate (Mv-ST), silicomolybdate (Mv-SM), phosphotungstate (Mv-PT), or phosphomolybdate (Mv-PM) ion-associations dispersed in PVC matrix with dibutyl Phthalate Plasticizer. The electrodes showed near-Nernstian response over the concentration range of 4.0 × 10 −6 to 1.0 × 10 −2 M MvCl and were applied to the potentiometric determination of mebeverinium ion in pharmaceutical preparations, serum and urine in steady state and flow injection (FI) conditions with average recoveries of 96.4–102 % and relative standard deviations of 0.132–1.86%. The electrodes exhibit good selectivity for MvCl with respect to a large number of inorganic cations, organic cations, sugars and amino acids. The sensitivities of these electrodes are high enough to measure as low as 1.86 μg/ml of MvCl which permit the determination of the K sp values of the ion-associates used. The proposed potentiometric methods offer the advantages of simplicity, accuracy, automation feasibility and applicability to turbid and colored sample solutions.
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potentiometric flow injection analysis of drotaverine hydrochloride in pharmaceutical preparations
Analytical Letters, 2005Co-Authors: Hosny Ibrahim, Y M Issa, Hazem M AbushawishAbstract:Abstract Five poly (vinyl chloride) (PVC) membrane electrodes for the determination of drotaverine hydrochloride (DvCl) were constructed and fully characterized in terms of composition, life span, response time, usable pH range, working concentration range, and temperature. The membranes of these electrodes consist of drotaverinium‐silicotungstate (Dv‐ST), silicomolybdate (Dv‐SM), phosphotungstate (Dv‐PT), phosphomolybdate (Dv‐PM), or tetraphenylborate (Dv‐TPB) ion associations dispersed in PVC matrix with dibutyl Phthalate Plasticizer. The electrodes showed near‐Nernstian response over the concentration range of 2.0 × 10−6 to 1.0 × 10−2 M DvCl and were applied to the potentiometric determination of drotaverinium ion in pharmaceutical preparations in steady‐state and flow injection (FI) conditions with average recoveries of 98.1–102.2% and relative standard deviation of 0.308–1.310%. The electrodes exhibit good selectivity for DvCl with respect to a large number of inorganic cations, organic cations, sug...
Y M Issa - One of the best experts on this subject based on the ideXlab platform.
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potentiometric flow injection analysis of dicyclomine hydrochloride in serum urine and milk
Analytica Chimica Acta, 2005Co-Authors: Hosny Ibrahim, Y M Issa, Hazem M AbushawishAbstract:Five plastic membrane electrodes for the determination of dicyclomine hydrochloride (DcCl) were fabricated and fully characterized in terms of composition, life span, usable pH range, working concentration range and temperature. The membranes of these electrodes consist of dicyclominium-silicotungstate (Dc-ST), silicomolybdate (Dc-SM), phosphotungstate (Dc-PT), phosphomolybdate (Dc-PM) or tetraphenylborate (Dc-TPB) ion-associations dispersed in PVC matrix with dibutyl Phthalate Plasticizer. The electrodes showed near-Nernstian response over the concentration range of 4.0 × 10−6 to 1.0 × 10−2 M DcCl and applied to the potentiometric determination of dicyclominium ion in pharmaceutical preparations, serum, urine and milk in batch and flow injection (FI) conditions with average recoveries of 96.1–102.7% and relative standard deviation of 0.055–1.994%. The electrodes exhibit good selectivity for DcCl with respect to a large number of inorganic cations, organic cations, sugars and amino acids. The sensitivities of these electrodes are high enough to measure as low as 1.73 μg/ml of DcCl which permit the determination of the Ksp values of the ion-associates used. The proposed potentiometric methods offer the advantages of simplicity, accuracy, automation feasibility and applicability to turbid and colored sample solutions.
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potentiometric flow injection analysis of mebeverine hydrochloride in serum and urine
Journal of Pharmaceutical and Biomedical Analysis, 2005Co-Authors: Hosny Ibrahim, Y M Issa, Hazem M AbushawishAbstract:Abstract Four PVC membrane electrodes for the determination of mebeverine hydrochloride (MvCl) were fabricated and fully characterized in terms of composition, life span, usable pH range, working concentration range and temperature. The membranes of these electrodes consist of mebeverinium-silicotungstate (Mv-ST), silicomolybdate (Mv-SM), phosphotungstate (Mv-PT), or phosphomolybdate (Mv-PM) ion-associations dispersed in PVC matrix with dibutyl Phthalate Plasticizer. The electrodes showed near-Nernstian response over the concentration range of 4.0 × 10 −6 to 1.0 × 10 −2 M MvCl and were applied to the potentiometric determination of mebeverinium ion in pharmaceutical preparations, serum and urine in steady state and flow injection (FI) conditions with average recoveries of 96.4–102 % and relative standard deviations of 0.132–1.86%. The electrodes exhibit good selectivity for MvCl with respect to a large number of inorganic cations, organic cations, sugars and amino acids. The sensitivities of these electrodes are high enough to measure as low as 1.86 μg/ml of MvCl which permit the determination of the K sp values of the ion-associates used. The proposed potentiometric methods offer the advantages of simplicity, accuracy, automation feasibility and applicability to turbid and colored sample solutions.
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potentiometric flow injection analysis of drotaverine hydrochloride in pharmaceutical preparations
Analytical Letters, 2005Co-Authors: Hosny Ibrahim, Y M Issa, Hazem M AbushawishAbstract:Abstract Five poly (vinyl chloride) (PVC) membrane electrodes for the determination of drotaverine hydrochloride (DvCl) were constructed and fully characterized in terms of composition, life span, response time, usable pH range, working concentration range, and temperature. The membranes of these electrodes consist of drotaverinium‐silicotungstate (Dv‐ST), silicomolybdate (Dv‐SM), phosphotungstate (Dv‐PT), phosphomolybdate (Dv‐PM), or tetraphenylborate (Dv‐TPB) ion associations dispersed in PVC matrix with dibutyl Phthalate Plasticizer. The electrodes showed near‐Nernstian response over the concentration range of 2.0 × 10−6 to 1.0 × 10−2 M DvCl and were applied to the potentiometric determination of drotaverinium ion in pharmaceutical preparations in steady‐state and flow injection (FI) conditions with average recoveries of 98.1–102.2% and relative standard deviation of 0.308–1.310%. The electrodes exhibit good selectivity for DvCl with respect to a large number of inorganic cations, organic cations, sug...
Lucia Toniolo - One of the best experts on this subject based on the ideXlab platform.
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the degradation of poly vinyl acetate as a material for design objects a multi analytical study of the effect of dibutyl Phthalate Plasticizer part 1
Polymer Degradation and Stability, 2012Co-Authors: F Toja, Daniela Saviello, Austin Nevin, Daniela Comelli, Massimo Lazzari, Marinella Levi, Lucia TonioloAbstract:Abstract The influence of dibutyl Phthalate (DBP) Plasticizer on poly(vinyl acetate) (PVAc) degradation was investigated. A multi-analytical approach (combining FTIR and Fluorescence spectroscopy, NMR and DSC analyses) was used to study how thermal- and photo-oxidative ageing treatments act on the polymer and assess the role of the additive in the degradation pattern. Standard and plasticized PVAc films were artificially aged at 60 °C in a thermal regime and irradiated at wavelengths above 290 nm in a photo-oxidative ageing regime, with exposure between 100 and 2000 h. The two types of ageing differ mainly in the formation of C C double bonds along the polymer backbone, enhanced by thermal ageing, and the formation of aldehydic structures, following photo-oxidative treatment and in the degree to which Plasticizer is lost. The integration of results from different analytical methods highlights the utility in combining complementary analyses for the study of PVAc degradation.
Russ Hauser - One of the best experts on this subject based on the ideXlab platform.
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urinary concentrations of cyclohexane 1 2 dicarboxylic acid monohydroxy isononyl ester a metabolite of the non Phthalate Plasticizer di isononyl cyclohexane 1 2 dicarboxylate dinch and markers of ovarian response among women attending a fertility center
Environmental Research, 2016Co-Authors: Lidia Minguezalarcon, Irene Souter, Yuhan Chiu, Paige L Williams, Jennifer B Ford, Xiaoyun Ye, Antonia M Calafat, Russ HauserAbstract:Di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH), a non-Phthalate Plasticizer, was introduced commercially in 2002 as an alternative to ortho-Phthalate esters because of its favorable toxicological profile. However, the potential health effects from DINCH exposure remain largely unknown. We explored the associations between urinary concentrations of metabolites of DINCH on markers of ovarian response among women undergoing in vitro fertilization (IVF) treatments. Between 2011 and 2015, 113 women enrolled a prospective cohort study at the Massachusetts General Hospital Fertility Center and provided up to two urine samples prior to oocyte retrieval. The urinary concentrations of two DINCH metabolites, cyclohexane-1,2-dicarboxylic acid monohydroxy isononyl ester (MHiNCH) and cyclohexane-1,2-dicarboxylic acid monocarboxyisooctyl ester (MCOCH), were quantified by isotope dilution tandem mass spectrometry. We used generalized linear mixed models to evaluate the association between urinary metabolite concentrations and markers of ovarian response, accounting for multiple IVF cycles per woman via random intercepts. On average, women with detectable urinary MHiNCH concentrations, as compared to those below LOD, had a lower estradiol levels (−325 pmol/l, p=0.09) and number of retrieved oocytes (−1.8, p=0.08), with a stronger association among older women. However, urinary MHiNCH concentrations were unrelated to mature oocyte yield and endometrial wall thickness. In conclusion, we found suggestive negative associations between urinary MHiNCH concentrations and peak estradiol levels and number of total oocyte yields. This is the first study evaluating the effect of DINCH exposure on human reproductive health and raises the need for further experimental and epidemiological studies to better understand the potential effects of this chemical on health.