The Experts below are selected from a list of 289167 Experts worldwide ranked by ideXlab platform
De Dong Xin - One of the best experts on this subject based on the ideXlab platform.
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identification characteristic and Phylogenetic Analysis of type ii dna topoisomerase gene in giardia lamblia
Cell Research, 2005Co-Authors: Jian Fan Wen, Wan Qun Chen, De Dong XinAbstract:The genes encoding type II DNA topoisomerases were investigated in Giardia lamblia genome, and a type IIA gene, GlTop 2 was identified. It is a single copy gene with a 4476 bp long ORF without intron. The deduced amino acid sequence shows strong homology to eukaryotic DNA Top 2. However, some distortions were found, such as six insertions in the ATPase domain and the central domain, a approximately 100 aa longer central domain; a approximately 200 aa shorter C-terminal domain containing rich charged residues. These features revealed by comparing with Top 2 of the host, human, might be helpful in exploiting drug selectivity for antigiardial therapy. Phylogenetic Analysis of eukaryotic enzymes showed that kinetoplastids, plants, fungi, and animals were monophyletic groups, and the animal and fungi lineages shared a more recent common ancestor than either did with the plant lineage; microsporidia grouped with fungi. However, unlike many previous Phylogenetic analyses, the "amitochondriate"G. lamblia was not the earliest branch but diverged after mitochondriate kinetoplastids in our trees. Both the finding of typical eukaryotic type IIA topoisomerase and the Phylogenetic Analysis suggest G. lamblia is not possibly as primitive as was regarded before and might diverge after the acquisition of mitochondria. This is consistent with the recent discovery of mitochondrial remnant organelles in G. lamblia.
Stefano Rusconi - One of the best experts on this subject based on the ideXlab platform.
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genomic characterization and Phylogenetic Analysis of sars cov 2 in italy
Journal of Medical Virology, 2020Co-Authors: Gianguglielmo Zehender, Alessia Lai, Annalisa Bergna, Luca Meroni, Agostino Riva, Claudia Balotta, Maciej Tarkowski, Arianna Gabrieli, Dario Bernacchia, Stefano RusconiAbstract:This report describes the isolation, molecular characterization, and Phylogenetic Analysis of the first three complete genomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) isolated from three patients involved in the first outbreak of COVID-19 in Lombardy, Italy. Early molecular epidemiological tracing suggests that SARS-CoV-2 was present in Italy weeks before the first reported cases of infection.
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genomic characterisation and Phylogenetic Analysis of sars cov 2 in italy
medRxiv, 2020Co-Authors: Gianguglielmo Zehender, Alessia Lai, Annalisa Bergna, Luca Meroni, Agostino Riva, Claudia Balotta, Maciej Tarkowski, Arianna Gabrieli, Dario Bernacchia, Stefano RusconiAbstract:This report describes the isolation, the molecular characterization and the Phylogenetic Analysis of the first three complete genomes of SARS-CoV-2 isolated from three patients involved in the first outbreak of COVID-19 in Lombardy, Italy. Early molecular epidemiological tracing suggests that SARS-CoV-2 was present in Italy weeks before the first reported cases of infection.
Daniel Thiel - One of the best experts on this subject based on the ideXlab platform.
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Phylogenetic Analysis of secretin type neuropeptide GPCRs using RAxML.
2018Co-Authors: Daniel ThielAbstract:Phylogenetic Analysis of aligned secretin type neuropeptide GPCRs, belonging to Xenacoelomorpha, Deuterostomia, Protostomia. Programm: RAxML v.8.2.9, amino acid substitution model: LG
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Phylogenetic Analysis of secretin type neuropeptide GPCRs using FastTree.
2018Co-Authors: Daniel ThielAbstract:Phylogenetic Analysis of aligned secretin type neuropeptide GPCRs, belonging to Xenacoelomorpha, Deuterostomia, Protostomia. Programm: FastTree v.2.1, amino acid substitution model: LG
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Phylogenetic Analysis of rhodopsin type neuropeptide GPCRs using FastTree
2018Co-Authors: Daniel ThielAbstract:Phylogenetic Analysis of aligned rhodopsin type neuropeptide GPCRs, belonging to Xenacoelomorpha, Deuterostomia, Protostomia, Cnidaria. Programm: FastTree v.2.1, amino acid substitution model: LG
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Phylogenetic Analysis of rhodopsin type neuropeptide GPCRs using RAxML
2018Co-Authors: Daniel ThielAbstract:Phylogenetic Analysis of aligned rhodopsin type neuropeptide GPCRs, belonging to Xenacoelomorpha, Deuterostomia, Protostomia, Cnidaria. Programm: RAxML v.8.2.9, amino acid substitution model: LG
Gianguglielmo Zehender - One of the best experts on this subject based on the ideXlab platform.
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genomic characterization and Phylogenetic Analysis of sars cov 2 in italy
Journal of Medical Virology, 2020Co-Authors: Gianguglielmo Zehender, Alessia Lai, Annalisa Bergna, Luca Meroni, Agostino Riva, Claudia Balotta, Maciej Tarkowski, Arianna Gabrieli, Dario Bernacchia, Stefano RusconiAbstract:This report describes the isolation, molecular characterization, and Phylogenetic Analysis of the first three complete genomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) isolated from three patients involved in the first outbreak of COVID-19 in Lombardy, Italy. Early molecular epidemiological tracing suggests that SARS-CoV-2 was present in Italy weeks before the first reported cases of infection.
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genomic characterisation and Phylogenetic Analysis of sars cov 2 in italy
medRxiv, 2020Co-Authors: Gianguglielmo Zehender, Alessia Lai, Annalisa Bergna, Luca Meroni, Agostino Riva, Claudia Balotta, Maciej Tarkowski, Arianna Gabrieli, Dario Bernacchia, Stefano RusconiAbstract:This report describes the isolation, the molecular characterization and the Phylogenetic Analysis of the first three complete genomes of SARS-CoV-2 isolated from three patients involved in the first outbreak of COVID-19 in Lombardy, Italy. Early molecular epidemiological tracing suggests that SARS-CoV-2 was present in Italy weeks before the first reported cases of infection.
Jian Fan Wen - One of the best experts on this subject based on the ideXlab platform.
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identification characteristic and Phylogenetic Analysis of type ii dna topoisomerase gene in giardia lamblia
Cell Research, 2005Co-Authors: Jian Fan Wen, Wan Qun Chen, De Dong XinAbstract:The genes encoding type II DNA topoisomerases were investigated in Giardia lamblia genome, and a type IIA gene, GlTop 2 was identified. It is a single copy gene with a 4476 bp long ORF without intron. The deduced amino acid sequence shows strong homology to eukaryotic DNA Top 2. However, some distortions were found, such as six insertions in the ATPase domain and the central domain, a approximately 100 aa longer central domain; a approximately 200 aa shorter C-terminal domain containing rich charged residues. These features revealed by comparing with Top 2 of the host, human, might be helpful in exploiting drug selectivity for antigiardial therapy. Phylogenetic Analysis of eukaryotic enzymes showed that kinetoplastids, plants, fungi, and animals were monophyletic groups, and the animal and fungi lineages shared a more recent common ancestor than either did with the plant lineage; microsporidia grouped with fungi. However, unlike many previous Phylogenetic analyses, the "amitochondriate"G. lamblia was not the earliest branch but diverged after mitochondriate kinetoplastids in our trees. Both the finding of typical eukaryotic type IIA topoisomerase and the Phylogenetic Analysis suggest G. lamblia is not possibly as primitive as was regarded before and might diverge after the acquisition of mitochondria. This is consistent with the recent discovery of mitochondrial remnant organelles in G. lamblia.
