The Experts below are selected from a list of 31761 Experts worldwide ranked by ideXlab platform
Heidi M Mansour - One of the best experts on this subject based on the ideXlab platform.
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organic solution advanced spray dried microparticulate nanoparticulate dry powders of lactomorphin for respiratory delivery Physicochemical Characterization in vitro aerosol dispersion and cellular studies
Pharmaceutics, 2020Co-Authors: Wafaa Alabsi, Fahad Alobeidi, Robin Polt, Heidi M MansourAbstract:The purpose of this study was to formulate Lactomorphin (MMP2200) in its pure state as spray-dried(SD) powders, and with the excipient Trehalose as co-spray-dried(co-SD) powders; for intranasal and deep lung administration with Dry Powder Inhalers (DPI). Lactomorphin is a glycopeptide which was developed for the control of moderate to severe pain. Particles were rationally designed and produced by advanced spray drying particle engineering in a closed mode from a dilute organic solution. Comprehensive Physicochemical Characterization using different analytical techniques was carried out to analyze the particle size, particle morphology, particle surface morphology, solid-state transitions, crystallinity/non-crystallinity, and residual water content. The particle chemical composition was confirmed using attenuated total reflectance-Fourier-transform infrared (ATR-FTIR), and Confocal Raman Microscopy (CRM) confirmed the particles' chemical homogeneity. The solubility and Partition coefficient (LogP) of Lactomorphin were determined by the analytical and computational methodology and revealed the hydrophilicity of Lactomorphin. A thermal degradation study was performed by exposing samples of solid-state Lactomorphin to a high temperature (62 °C) combined with zero relative humidity (RH) and to a high temperature (62 °C) combined with a high RH (75%) to evaluate the stability of Lactomorphin under these two different conditions. The solid-state processed particles exhibited excellent aerosol dispersion performance with an FDA-approved human DPI device to reach lower airways. The cell viability resazurin assay showed that Lactomorphin is safe up to 1000 μg/mL on nasal epithelium cells, lung cells, endothelial, and astrocyte brain cells.
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advanced spray dried design Physicochemical Characterization and aerosol dispersion performance of vancomycin and clarithromycin multifunctional controlled release particles for targeted respiratory delivery as dry powder inhalation aerosols
International Journal of Pharmaceutics, 2013Co-Authors: Chunwoong Park, Don Hayes, Heidi M Mansour, Frederick G Vogt, Joseph B Zwischenberger, Eunseok ParkAbstract:Respirable microparticles/nanoparticles of the antibiotics vancomycin (VCM) and clarithromycin (CLM) were successfully designed and developed by novel organic solution advanced spray drying from methanol solution. Formulation optimization was achieved through statistical experimental design of pump feeding rates of 25% (Low P), 50% (Medium P) and 75% (High P). Systematic and comprehensive Physicochemical Characterization and imaging were carried out using scanning electron microscopy (SEM), hot-stage microscopy (HSM), differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), Karl Fischer titration (KFT), laser size diffraction (LSD), gravimetric vapor sorption (GVS), confocal Raman microscopy (CRM) and spectroscopy for chemical imaging mapping. These novel spray-dried (SD) microparticulate/nanoparticulate dry powders displayed excellent aerosol dispersion performance as dry powder inhalers (DPIs) with high values in emitted dose (ED), respirable fraction (RF), and fine particle fraction (FPF). VCM DPIs displayed better aerosol dispersion performance compared to CLM DPIs which was related to differences in the Physicochemical and particle properties of VCM and CLM. In addition, organic solution advanced co-spray drying particle engineering design was employed to successfully produce co-spray-dried (co-SD) multifunctional microparticulate/nanoparticulate aerosol powder formulations of VCM and CLM with the essential lung surfactant phospholipid, dipalmitoylphosphatidylcholine (DPPC), for controlled release pulmonary nanomedicine delivery as inhalable dry powder aerosols. Formulation optimization was achieved through statistical experimental design of molar ratios of co-SD VCM:DPPC and co-SD CLM:DPPC. XRPD and DSC confirmed that the phospholipid bilayer structure in the solid-state was preserved following spray drying. Co-SD VCM:DPPC and co-SD CLM:DPPC dry powder aerosols demonstrated controlled release of antibiotic drug that was fitted to various controlled release mathematical fitting models. The Korsmeyer-Peppas model described the best data fit for all powders suggesting super case-II transport mechanism of controlled release. Excellent aerosol dispersion performance for all co-SD microparticulate/nanoparticulate DPIs was higher than the SD antibiotic drugs suggesting that DPPC acts as an aerosol performance enhancer for these antibiotic aerosol dry powders. Co-SD VCM:DPPC DPIs had higher aerosol dispersion parameters compared to co-SD CLM:DPPC which was related to differences in the Physicochemical properties of VCM and CLM.
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Physicochemical Characterization and aerosol dispersion performance of organic solution advanced spray dried cyclosporine a multifunctional particles for dry powder inhalation aerosol delivery
International Journal of Nanomedicine, 2013Co-Authors: Weifen Zhang, Don Hayes, Heidi M MansourAbstract:In this systematic and comprehensive study, inhalation powders of the polypeptide immunosuppressant drug – cyclosporine A – for lung delivery as dry powder inhalers (DPIs) were successfully designed, developed, and optimized. Several spray drying pump rates were rationally chosen. Comprehensive Physicochemical Characterization and imaging was carried out using scanning electron microscopy, hot-stage microscopy, differential scanning calorimetry, powder X-ray diffraction, Karl Fischer titration, laser size diffraction, and gravimetric vapor sorption. Aerosol dispersion performance was conducted using a next generation impactor with a Food and Drug Administration-approved DPI device. These DPIs displayed excellent aerosol dispersion performance with high values in emitted dose, respirable fraction, and fine particle fraction. In addition, novel multifunctional inhalation aerosol powder formulations of cyclosporine A with lung surfactant-mimic phospholipids were also successfully designed and developed by advanced organic solution cospray drying in closed mode. The lung surfactantmimic phospholipids were 1,2-dipalmitoyl-sn-glycero-3-phosphocholine and 1,2-dipalmitoyl-snglycero- 3-(phosphor-rac-1-glycerol). These cyclosporine A lung surfactant-mimic aerosol powder formulations were comprehensively characterized. Powder X-ray diffraction and differential scanning calorimetry confirmed that the phospholipid bilayer structure in the solid state was preserved following advanced organic solution spray drying in closed mode. These novel multifunctional inhalation powders were optimized for DPI delivery with excellent aerosol dispersion performance and high aerosol performance parameters.
Weifen Zhang - One of the best experts on this subject based on the ideXlab platform.
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Physicochemical Characterization and aerosol dispersion performance of organic solution advanced spray dried cyclosporine a multifunctional particles for dry powder inhalation aerosol delivery
International Journal of Nanomedicine, 2013Co-Authors: Weifen Zhang, Don Hayes, Heidi M MansourAbstract:In this systematic and comprehensive study, inhalation powders of the polypeptide immunosuppressant drug – cyclosporine A – for lung delivery as dry powder inhalers (DPIs) were successfully designed, developed, and optimized. Several spray drying pump rates were rationally chosen. Comprehensive Physicochemical Characterization and imaging was carried out using scanning electron microscopy, hot-stage microscopy, differential scanning calorimetry, powder X-ray diffraction, Karl Fischer titration, laser size diffraction, and gravimetric vapor sorption. Aerosol dispersion performance was conducted using a next generation impactor with a Food and Drug Administration-approved DPI device. These DPIs displayed excellent aerosol dispersion performance with high values in emitted dose, respirable fraction, and fine particle fraction. In addition, novel multifunctional inhalation aerosol powder formulations of cyclosporine A with lung surfactant-mimic phospholipids were also successfully designed and developed by advanced organic solution cospray drying in closed mode. The lung surfactantmimic phospholipids were 1,2-dipalmitoyl-sn-glycero-3-phosphocholine and 1,2-dipalmitoyl-snglycero- 3-(phosphor-rac-1-glycerol). These cyclosporine A lung surfactant-mimic aerosol powder formulations were comprehensively characterized. Powder X-ray diffraction and differential scanning calorimetry confirmed that the phospholipid bilayer structure in the solid state was preserved following advanced organic solution spray drying in closed mode. These novel multifunctional inhalation powders were optimized for DPI delivery with excellent aerosol dispersion performance and high aerosol performance parameters.
Alberto Tecante - One of the best experts on this subject based on the ideXlab platform.
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Physicochemical Characterization of sodium stearoyl lactylate (SSL), polyoxyethylene sorbitan monolaurate (Tween 20) and κ-carrageenan.
Data in brief, 2018Co-Authors: M.c. Ortiz-tafoya, Alberto TecanteAbstract:Abstract Surfactant-polymer mixtures are common in food, cosmetic and pharmaceutical products. These components can interact with each other. The interactions depend on the type of polymer and surfactant, the purity of the ingredients, the ionic content and their concentration. Therefore, the data presented here provide valuable information that could be useful for those working with these mixtures in different applications, particularly in blends with polyelectrolytes and their counterions. This article contains experimental data about the Physicochemical Characterization of sodium stearoyl lactylate (SSL), polyoxyethylene sorbitan monolaurate (Tween 20) and κ-carrageenan. Techniques included atomic absorption, DSC, FTIR-ATR, NMR, and surface tension.
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Physicochemical Characterization of sodium stearoyl lactylate (SSL), polyoxyethylene sorbitan monolaurate (Tween 20) and κ-carrageenan
Elsevier, 2018Co-Authors: M.c. Ortiz-tafoya, Alberto TecanteAbstract:Surfactant-polymer mixtures are common in food, cosmetic and pharmaceutical products. These components can interact with each other. The interactions depend on the type of polymer and surfactant, the purity of the ingredients, the ionic content and their concentration. Therefore, the data presented here provide valuable information that could be useful for those working with these mixtures in different applications, particularly in blends with polyelectrolytes and their counterions. This article contains experimental data about the Physicochemical Characterization of sodium stearoyl lactylate (SSL), polyoxyethylene sorbitan monolaurate (Tween 20) and κ-carrageenan. Techniques included atomic absorption, DSC, FTIR-ATR, NMR, and surface tension. Keywords: Sodium stearoyl lactylate, Tween 20, κ-carrageenan, Surface tension, Calorimetry, IR, NM
M.c. Ortiz-tafoya - One of the best experts on this subject based on the ideXlab platform.
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Physicochemical Characterization of sodium stearoyl lactylate (SSL), polyoxyethylene sorbitan monolaurate (Tween 20) and κ-carrageenan.
Data in brief, 2018Co-Authors: M.c. Ortiz-tafoya, Alberto TecanteAbstract:Abstract Surfactant-polymer mixtures are common in food, cosmetic and pharmaceutical products. These components can interact with each other. The interactions depend on the type of polymer and surfactant, the purity of the ingredients, the ionic content and their concentration. Therefore, the data presented here provide valuable information that could be useful for those working with these mixtures in different applications, particularly in blends with polyelectrolytes and their counterions. This article contains experimental data about the Physicochemical Characterization of sodium stearoyl lactylate (SSL), polyoxyethylene sorbitan monolaurate (Tween 20) and κ-carrageenan. Techniques included atomic absorption, DSC, FTIR-ATR, NMR, and surface tension.
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Physicochemical Characterization of sodium stearoyl lactylate (SSL), polyoxyethylene sorbitan monolaurate (Tween 20) and κ-carrageenan
Elsevier, 2018Co-Authors: M.c. Ortiz-tafoya, Alberto TecanteAbstract:Surfactant-polymer mixtures are common in food, cosmetic and pharmaceutical products. These components can interact with each other. The interactions depend on the type of polymer and surfactant, the purity of the ingredients, the ionic content and their concentration. Therefore, the data presented here provide valuable information that could be useful for those working with these mixtures in different applications, particularly in blends with polyelectrolytes and their counterions. This article contains experimental data about the Physicochemical Characterization of sodium stearoyl lactylate (SSL), polyoxyethylene sorbitan monolaurate (Tween 20) and κ-carrageenan. Techniques included atomic absorption, DSC, FTIR-ATR, NMR, and surface tension. Keywords: Sodium stearoyl lactylate, Tween 20, κ-carrageenan, Surface tension, Calorimetry, IR, NM
Hangon Choi - One of the best experts on this subject based on the ideXlab platform.
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development of a novel l sulpiride loaded quaternary microcapsule effect of tpgs as an absorption enhancer on Physicochemical Characterization and oral bioavailability
Colloids and Surfaces B: Biointerfaces, 2016Co-Authors: Dong Shik Kim, Dong Wuk Kim, Chul Soon Yong, Jong Oh Kim, Kyeong Soo Kim, Jong Seo Choi, Youn Gee Seo, Yu Seok Youn, Sung Giu Jin, Hangon ChoiAbstract:The aim of this study was to assess the effect of d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) on the Physicochemical Characterization and oral bioavailability of a novel l-sulpiride-loaded quaternary microcapsule (QMC). The effect of carriers on drug solubility was investigated. Among the carriers tested, polyvinyl pyrrolidone (PVP), sodium lauryl sulphate (SLS) and TPGS were selected as polymer, surfactant and absorption enhancer, respectively, due to their high drug solubility. Using the solvent evaporation method, numerous QMCs with different ratios of l-sulpiride, PVP, SLS and TPGS were prepared, and their Physicochemical properties, solubility and release were evaluated. In addition, the influence of TPGS concentration on the oral bioavailability of various drug doses was evaluated. All QMCs converted the crystalline drug to the amorphous form and remarkably improved the solubility, release and oral bioavailability of the drug. Furthermore, the TPGS concentration in the QMCs hardly affected the crystallinity, particle size and release, but considerably increased the solubility and oral bioavailability of the drug. In particular, as the dose of administered drug was increased, TPGS provided a greater improvement in oral drug bioavailability. Thus, TPGS played an important role in improving the oral bioavailability of l-sulpiride. Moreover, the QMC with a drug/PVP/SLS/TPGS weight ratio of 5:12:1 :20 with approximately 3.3-fold improved oral bioavailability would be recommended as a commercial pharmaceutical product for oral administration of l-sulpiride.
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enhanced oral bioavailability of fenofibrate using polymeric nanoparticulated systems Physicochemical Characterization and in vivo investigation
International Journal of Nanomedicine, 2015Co-Authors: Abid Mehmood Yousaf, Dong Wuk Kim, Chul Soon Yong, Jong Oh Kim, Hangon ChoiAbstract:Background: The intention of this research was to prepare and compare various solubility-enhancing nanoparticulated systems in order to select a nanoparticulated formulation with the most improved oral bioavailability of poorly water-soluble fenofibrate. Methods: The most appropriate excipients for different nanoparticulated preparations were selected by determining the drug solubility in 1% (w/v) aqueous solutions of each carrier. The polyvinylpyrrolidone (PVP) nanospheres, hydroxypropyl-β-cyclodextrin (HP-β-CD) nanocorpuscles, and gelatin nanocapsules were formulated as fenofibrate/PVP/sodium lauryl sulfate (SLS), fenofibrate/HP- β-CD, and fenofibrate/gelatin at the optimized weight ratios of 2.5:4.5:1, 1:4, and 1:8, respectively. The three solid-state products were achieved using the solventevaporation method through the spray-drying technique. The Physicochemical Characterization of these nanoparticles was accomplished by powder X-ray diffraction, differential scanning calorimetry, scanning electron microscopy, and Fourier-transform infrared spectroscopy. Their Physicochemical properties, aqueous solubility, dissolution rate, and pharmacokinetics in rats were investigated in comparison with the drug powder. Results: Among the tested carriers, PVP, HP-β-CD, gelatin, and SLS showed better solubility and were selected as the most appropriate constituents for various nanoparticulated systems. All of the formulations significantly improved the aqueous solubility, dissolution rate, and oral bioavailability of fenofibrate compared to the drug powder. The drug was present in the amorphous form in HP-β-CD nanocorpuscles; however, in other formulations, it existed in the crystalline state with a reduced intensity. The aqueous solubility and dissolution rates of the nanoparticles (after 30 minutes) were not significantly different from one another. Among the nanoparticulated systems tested in this study, the initial dissolution rates (up to 10 minutes) were higher with the PVP nanospheres and HP-β-CD nanocorpuscles; however, neither of them resulted in the highest oral bioavailability. Irrespective of relatively retarded dissolution rate, gelatin nanocapsules showed the highest apparent aqueous solubility and furnished the most improved oral bioavailability of the drug (~5.5-fold), owing to better wetting and diminution in crystallinity.