The Experts below are selected from a list of 303 Experts worldwide ranked by ideXlab platform
Lisa V Goodrich - One of the best experts on this subject based on the ideXlab platform.
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morphological and Physiological Development of auditory synapses
Hearing Research, 2014Co-Authors: Weiming Yu, Lisa V GoodrichAbstract:Acoustic communication requires gathering, transforming, and interpreting diverse sound cues. To achieve this, all the spatial and temporal features of complex sound stimuli must be captured in the firing patterns of the primary sensory neurons and then accurately transmitted along auditory pathways for additional processing. The mammalian auditory system relies on several synapses with unique properties in order to meet this task: the auditory ribbon synapses, the endbulb of Held, and the calyx of Held. Each of these synapses develops morphological and electroPhysiological characteristics that enable the remarkably precise signal transmission necessary for conveying the miniscule differences in timing that underly sound localization. In this article, we review the current knowledge of how these synapses develop and mature to acquire the specialized features necessary for the sense of hearing.
Jorge Ripoll - One of the best experts on this subject based on the ideXlab platform.
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in vivo optical tomography of small scattering specimens time lapse 3d imaging of the head eversion process in drosophila melanogaster
Scientific Reports, 2015Co-Authors: Alicia Arranz, Di Dong, Charalambos Savakis, Jie Tian, Jorge RipollAbstract:Even though in vivo imaging approaches have witnessed several new and important Developments, specimens that exhibit high light scattering properties such as Drosophila melanogaster pupae are still not easily accessible with current optical imaging techniques, obtaining images only from subsurface features. This means that in order to obtain 3D volumetric information these specimens need to be studied either after fixation and a chemical clearing process, through an imaging window - thus perturbing Physiological Development -, or during early stages of Development when the scattering contribution is negligible. In this paper we showcase how Optical Projection Tomography may be used to obtain volumetric images of the head eversion process in vivo in Drosophila melanogaster pupae, both in control and headless mutant specimens. Additionally, we demonstrate the use of Helical Optical Projection Tomography (hOPT) as a tool for high throughput 4D-imaging of several specimens simultaneously.
Riccardo Barbieri - One of the best experts on this subject based on the ideXlab platform.
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EMBC - A point process model of respiratory dynamics in early Physiological Development
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and, 2011Co-Authors: Premananda Indic, David Paydarfar, Riccardo BarbieriAbstract:Interbreath interval (IBI), the time interval between breaths, and its variations in time around the mean, the IBI variability, are important measures associated with irregularity of breathing. The IBI histogram generally follows a power law distribution with its characterizing parameters changing with maturation. To assess the dynamics of breathing we propose a point process model of IBI with a lognormal parametric structure to appropriately represent the stochastic nature of the IBI distribution. We estimate the time varying evolution of the characterizing parameters to represent the dynamic nature of breathing, and thereby provide a time-varying measure of irregularity in breathing. The reliability of the model to capture the data is assessed using Kolmogorov-Smirnov (KS) and independence tests. Our results validate the novel approach in the assessment of the irregularity of breathing by analyzing respiratory recordings from newborn rats and preterm infants.
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A point process model of respiratory dynamics in early Physiological Development
2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2011Co-Authors: Premananda Indic, David Paydarfar, Riccardo BarbieriAbstract:Interbreath interval (IBI), the time interval between breaths, and its variations in time around the mean, the IBI variability, are important measures associated with irregularity of breathing. The IBI histogram generally follows a power law distribution with its characterizing parameters changing with maturation. To assess the dynamics of breathing we propose a point process model of IBI with a lognormal parametric structure to appropriately represent the stochastic nature of the IBI distribution. We estimate the time varying evolution of the characterizing parameters to represent the dynamic nature of breathing, and thereby provide a time-varying measure of irregularity in breathing. The reliability of the model to capture the data is assessed using Kolmogorov-Smirnov (KS) and independence tests. Our results validate the novel approach in the assessment of the irregularity of breathing by analyzing respiratory recordings from newborn rats and preterm infants.
Sarahjayne Blakemore - One of the best experts on this subject based on the ideXlab platform.
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a systematic review of adolescent Physiological Development and its relationship with health related behaviour a protocol
Systematic Reviews, 2016Co-Authors: Jan Pringle, Kate Mills, John Mcateer, Ruth Jepson, Emma Hogg, Neil Anand, Sarahjayne BlakemoreAbstract:Background At any one time, there are one billion people worldwide who are in the second decade of their life, and 1.8 billion in the 10–24 age range. Whilst a great deal of focus has been placed on healthy early years Development, the adolescent years are also a unique period of opportunity: exposure to health-influencing behaviours such as alcohol consumption or cigarette smoking, may serve to establish patterns that have significant health consequences in later life. Although there is often an emphasis on risk-taking and detrimental health behaviours during adolescence, these years also provide significant opportunities for behaviour to be shaped in positive ways that may improve longer term health outcomes. However, it is firstly important to understand the complex Physiological changes that are taking place within the human body during this period and their relationship with health-related behaviour. Such knowledge can help to inform health policy and intervention Development.
Ernst H K Stelzer - One of the best experts on this subject based on the ideXlab platform.
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quantitative in vivo imaging of entire embryos with digital scanned laser light sheet fluorescence microscopy
Current Opinion in Neurobiology, 2008Co-Authors: Philipp J Keller, Ernst H K StelzerAbstract:The observation of biological processes in their natural in vivo context is a key requirement for quantitative experimental studies in the life sciences. In many instances, it will be crucial to achieve high temporal and spatial resolution over long periods of time without compromising the Physiological Development of the specimen. Here, we discuss the principles underlying light sheet-based fluorescence microscopes. The most recent implementation DSLM is a tool optimized to deliver quantitative data for entire embryos at high spatio-temporal resolution. We compare DSLM to the two established light microscopy techniques: confocal and two-photon fluorescence microscopy. DSLM provides up to 50 times higher imaging speeds and a 10–100 times higher signal-to-noise ratio, while exposing the specimens to at least three orders of magnitude less light energy than confocal and two-photon fluorescence microscopes. We conclude with a perspective for future Development.