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M. Michael Cohen - One of the best experts on this subject based on the ideXlab platform.

  • Hypothesis: Patient with Possible Disturbance in Programmed Cell Death
    European Journal of Human Genetics, 1995
    Co-Authors: Raoul C. M. Hennekam, M. Michael Cohen
    Abstract:

    Programmed cell death is a Physiological Process in mammalian development by which specific types of cells are eliminated, and, hence, is of fundamental importance in normal human embryogenesis. A patient is described with multiple congenital anomalies that may be explained by a disturbance of programmed cell death. Anomalies included macrocephaly, hypoplastic lacrimal ducts, narrow external ear canals, pharyngeal mucous membrane fold, unilateral cryptorchidism, cord-like vasa deferentia, and complete cutaneous syndactyly of the hands and feet.

Seong Hoe Park - One of the best experts on this subject based on the ideXlab platform.

  • Generation of PLZF+ CD4+ T cells via MHC class II–dependent thymocyte–thymocyte interaction is a Physiological Process in humans.
    'Rockefeller University Press', 2019
    Co-Authors: Lee, You Jeong, Yoon Kyung Jeon, Byung Hyun Kang, Doo Hyun Chung, Chunggyu Park, Hee Young Shin, Kyeong Cheon Jung, Seong Hoe Park
    Abstract:

    Human thymocytes, unlike mouse thymocytes, express major histocompatibility complex (MHC) class II molecules on their surface, especially during the fetal and perinatal stages. Based on this observation, we previously identified a novel developmental pathway for the generation of CD4(+) T cells via interactions between MHC class II-expressing thymocytes (thymocyte-thymocyte [T-T] interactions) with a transgenic mouse system. However, the developmental dissection of this T-T interaction in humans has not been possible because of the lack of known cellular molecules specific for T-T CD4(+) T cells. We show that promyelocytic leukemia zinc finger protein (PLZF) is a useful marker for the identification of T-T CD4(+) T cells. With this analysis, we determined that a substantial number of fetal thymocytes and splenocytes express PLZF and acquire innate characteristics during their development in humans. Although these characteristics are quite similar to invariant NKT (iNKT) cells, they clearly differ from iNKT cells in that they have a diverse T cell receptor repertoire and are restricted by MHC class II molecules. These findings define a novel human CD4(+) T cell subset that develops via an MHC class II-dependent T-T interaction.14

  • generation of plzf cd4 t cells via mhc class ii dependent thymocyte thymocyte interaction is a Physiological Process in humans
    Journal of Experimental Medicine, 2010
    Co-Authors: Yoon Kyung Jeon, Byung Hyun Kang, Doo Hyun Chung, Chunggyu Park, Hee Young Shin, Kyeong Cheon Jung, Seong Hoe Park
    Abstract:

    Human thymocytes, unlike mouse thymocytes, express major histocompatibility complex (MHC) class II molecules on their surface, especially during the fetal and perinatal stages. Based on this observation, we previously identified a novel developmental pathway for the generation of CD4+ T cells via interactions between MHC class II–expressing thymocytes (thymocyte–thymocyte [T–T] interactions) with a transgenic mouse system. However, the developmental dissection of this T–T interaction in humans has not been possible because of the lack of known cellular molecules specific for T–T CD4+ T cells. We show that promyelocytic leukemia zinc finger protein (PLZF) is a useful marker for the identification of T–T CD4+ T cells. With this analysis, we determined that a substantial number of fetal thymocytes and splenocytes express PLZF and acquire innate characteristics during their development in humans. Although these characteristics are quite similar to invariant NKT (iNKT) cells, they clearly differ from iNKT cells in that they have a diverse T cell receptor repertoire and are restricted by MHC class II molecules. These findings define a novel human CD4+ T cell subset that develops via an MHC class II–dependent T–T interaction.

Konstantinos Kamperis - One of the best experts on this subject based on the ideXlab platform.

Maureen E. Clayton - One of the best experts on this subject based on the ideXlab platform.

Raoul C. M. Hennekam - One of the best experts on this subject based on the ideXlab platform.

  • Hypothesis: Patient with Possible Disturbance in Programmed Cell Death
    European Journal of Human Genetics, 1995
    Co-Authors: Raoul C. M. Hennekam, M. Michael Cohen
    Abstract:

    Programmed cell death is a Physiological Process in mammalian development by which specific types of cells are eliminated, and, hence, is of fundamental importance in normal human embryogenesis. A patient is described with multiple congenital anomalies that may be explained by a disturbance of programmed cell death. Anomalies included macrocephaly, hypoplastic lacrimal ducts, narrow external ear canals, pharyngeal mucous membrane fold, unilateral cryptorchidism, cord-like vasa deferentia, and complete cutaneous syndactyly of the hands and feet.