The Experts below are selected from a list of 159 Experts worldwide ranked by ideXlab platform

Gary C. Sieck - One of the best experts on this subject based on the ideXlab platform.

  • Physiology in Perspective: Aging and Underlying PathoPhysiology
    Physiology (Bethesda Md.), 2017
    Co-Authors: Gary C. Sieck
    Abstract:

    As Mark Twain said, “Age is an issue of mind over matter. If you don't mind, it doesn't matter.” But with the demographic shifts in our population, it is time for us to mind and pay more attention to the Physiology of Aging. In 2014, >46 million people in the U.S. (14.4% of the population) were

  • Physiology of Aging.
    Journal of Applied Physiology, 2003
    Co-Authors: Gary C. Sieck
    Abstract:

    Aging is inevitable, and as life expectancy increases it becomes more important to understand physiological mechanisms associated with the normal Aging process so that quality of life can be sustained. Maintaining physiological function or “health” in an Aging population will help to reduce the

  • Selected contribution: Long-lived drosophila melanogaster lines exhibit normal metabolic rates. Commentary : Physiology of Aging
    Journal of Applied Physiology, 2003
    Co-Authors: Wayne A. Van Voorhies, Aziz A. Khazaeli, James W. Curtsinger, Gary C. Sieck
    Abstract:

    The use of model organisms, such as Drosophila melanogaster, provides a powerful method for studying mechanisms of Aging. Here we report on a large set of recombinant inbred (RI) D. melanogaster lines that exhibit approximately a fivefold range of average adult longevities. Understanding the factors responsible for the differences in longevity, particularly the characteristics of the longest-lived lines, can provide fundamental insights into the mechanistic correlates of Aging. In ectothermic organisms, longevity is often inversely correlated with metabolic rate, suggesting the a priori hypothesis that long-lived lines will have low resting metabolic rates. We conducted ∼6,000 measurements of CO 2 production in individual male flies aged 5, 16, 29, and 47 days postemergence and simultaneously measured the weight of individual flies and life spans in populations of each line. Even though there was a wide range of longevities, there was no evidence of an inverse relationship between the variables. The increased longevity of long-lived lines is not mediated through reduction of metabolic activity. In Drosophila, it is possible to both maintain a normal metabolic rate and achieve long life. These results are evaluated in the context of 100 years of research on the relationship between metabolic rate and life span.

  • Selected contribution: Chronic intermittent hypoxia enhances respiratory long-term facilitation in geriatric female rats. Commentary : Physiology of Aging
    Journal of Applied Physiology, 2003
    Co-Authors: A. G. Zabka, Gordon S. Mitchell, E. B. Olson, Mary Behan, Gary C. Sieck
    Abstract:

    Age and the estrus cycle affect time-dependent respiratory responses to episodic hypoxia in female rats. Respiratory long-term facilitation (LTF) is enhanced in middle-aged vs. young female rats (72). We tested the hypothesis that phrenic and hypoglossal (XII) LTF are diminished in acyclic geriatric rats when fluctuating sex hormone levels no longer establish conditions that enhance LTF. Chronic intermittent hypoxia (CIH) enhances LTF (41); thus we further predicted that CIH would restore LTF in geriatric female rats. LTF was measured in young (3-4 mo) and geriatric (20-22 mo) female Sasco Sprague-Dawley rats and in a group of geriatric rats exposed to 1 wk of nocturnal CIH (11 vs. 21% O 2 at 5-min intervals, 12 h/night). In anesthetized, paralyzed, vagotomized, and ventilated rats, time-dependent hypoxic phrenic and XII responses were assessed. The short-term hypoxic response was measured during the first of three 5-min episodes of isocapnic hypoxia (arterial Po 2 35-45 Torr). LTF was assessed 15, 30, and 60 min postepisodic hypoxia. Phrenic and XII short-term hypoxic response was not different among groups, regardless of CIH treatment (P > 0.05). LTF in geriatric female rats was smaller than previously reported for middle-aged rats but comparable to that in young female rats. CIH augmented phrenic and XII LTF to levels similar to those of middle-aged female rats without CIH (P < 0.05). The magnitude of phrenic and XII LTF in all groups was inversely related to the ratio of progesterone to estradiol serum levels (P < 0.05). Thus CIH and sex hormones influence the magnitude of LTF in geriatric female rats.

Lisa A. Thompson - One of the best experts on this subject based on the ideXlab platform.

  • Physiology of Aging of Older Adults: Systemic and Oral Health Considerations-2021 Update.
    Dental clinics of North America, 2021
    Co-Authors: Lisa A. Thompson, Helen Chen
    Abstract:

    Most oral health care providers encounter older adults in their practices and can play a critical role in supporting independence and quality of life for this Aging cohort. Physiologic and structural oral cavity changes associated with normal Aging may affect the presentation and oral health care of older adults. This article reviews the normative Aging of dentition and oral structures and physiologic changes associated with normal Aging, including cardiovascular, metabolic, and musculoskeletal changes, and how they may affect oral health. Oral health providers should be aware of normal Aging processes when they plan care or schedule procedures for older adults.

  • Physiology of Aging of Older Adults: Systemic and Oral Health Considerations
    Dental clinics of North America, 2014
    Co-Authors: Alan Abrams, Lisa A. Thompson
    Abstract:

    This article reviews the concepts of physiologic reserve, the principles of the normative Aging process as exemplified by the cardiovascular, neurologic, and musculoskeletal systems. How these principles apply to oral health, and age-related changes in the oral cavity itself, is reviewed and suggests how they may affect disease management by oral health care providers. It does not focus on diseases related to Aging, but rather aims to explore the normal physiologic changes associated with Aging dentition and systemic changes related to age, thus enabling clinicians to obtain a better understanding of the presentation of older adults and how it may change their approach to diagnosis and treatment.

Wayne A. Van Voorhies - One of the best experts on this subject based on the ideXlab platform.

  • Physiology of Aging Selected Contribution: Long-lived Drosophila melanogaster lines exhibit normal metabolic rates
    2003
    Co-Authors: Wayne A. Van Voorhies, Aziz A. Khazaeli, James W. Curtsinger
    Abstract:

    Van Voorhies, Wayne A., Aziz A. Khazaeli, and James W. Curtsinger. Selected Contribution: Long-lived Drosophila melanogaster lines exhibit normal metabolic rates. J Appl Physiol 95: 2605–2613, 2003. First published August 29, 2003; 10.1152/japplphysiol.00448.2003.—The use of model organisms, such as Drosophila melanogaster, provides a powerful method for studying mechanisms of Aging. Here we report on a large set of recombinant inbred (RI) D. melanogaster lines that exhibit approximately a fivefold range of average adult longevities. Understanding the factors responsible for the differences in longevity, particularly the characteristics of the longest-lived lines, can provide fundamental insights into the mechanistic correlates of Aging. In ectothermic organisms, longevity is often inversely correlated with metabolic rate, suggesting the a priori hypothesis that longlived lines will have low resting metabolic rates. We conducted 6,000 measurements of CO2 production in individual male flies aged 5, 16, 29, and 47 days postemergence and simultaneously measured the weight of individual flies and life spans in populations of each line. Even though there was a wide range of longevities, there was no evidence of an inverse relationship between the variables. The increased longevity of long-lived lines is not mediated through reduction of metabolic activity. In Drosophila, it is possible to both maintain a normal metabolic rate and achieve long life. These results are evaluated in the context of 100 years of research on the relationship between metabolic rate and life span.

  • Selected contribution: Long-lived drosophila melanogaster lines exhibit normal metabolic rates. Commentary : Physiology of Aging
    Journal of Applied Physiology, 2003
    Co-Authors: Wayne A. Van Voorhies, Aziz A. Khazaeli, James W. Curtsinger, Gary C. Sieck
    Abstract:

    The use of model organisms, such as Drosophila melanogaster, provides a powerful method for studying mechanisms of Aging. Here we report on a large set of recombinant inbred (RI) D. melanogaster lines that exhibit approximately a fivefold range of average adult longevities. Understanding the factors responsible for the differences in longevity, particularly the characteristics of the longest-lived lines, can provide fundamental insights into the mechanistic correlates of Aging. In ectothermic organisms, longevity is often inversely correlated with metabolic rate, suggesting the a priori hypothesis that long-lived lines will have low resting metabolic rates. We conducted ∼6,000 measurements of CO 2 production in individual male flies aged 5, 16, 29, and 47 days postemergence and simultaneously measured the weight of individual flies and life spans in populations of each line. Even though there was a wide range of longevities, there was no evidence of an inverse relationship between the variables. The increased longevity of long-lived lines is not mediated through reduction of metabolic activity. In Drosophila, it is possible to both maintain a normal metabolic rate and achieve long life. These results are evaluated in the context of 100 years of research on the relationship between metabolic rate and life span.

P Ritz - One of the best experts on this subject based on the ideXlab platform.

  • Physiology of Aging with respect to gastrointestinal, circulatory and immune system changes and their significance for energy and protein metabolism
    European Journal of Clinical Nutrition, 2000
    Co-Authors: P Ritz
    Abstract:

    Age-related changes in body composition can be considered the consequence of changes in energy and protein metabolism, while also having a leverage effect on protein and energy requirements. Changes in organ and systems weights obviously affect energy balance regulation. Considered at the system level, age-related changes are numerous, but it is still debated whether they are related to Aging per se or to conditions (such as poor nutrition, disease, drug treatments etc.) that prevail in elderly persons. It is likely that most changes occuring in the gastrointestinal, circulatory and immune system do not affect energy and protein requirements at rest. However, Aging is associated with difficulties in adapting to new environmental conditions that lead to stress. Repeated episodes of stress might lead to accumulation of deficits that can affect energy and protein balances. European Journal of Clinical Nutrition (2000) 54 , Suppl 3, S21–S25

  • Physiology of Aging with respect to gastrointestinal, circulatory and immune system changes and their significance for energy and protein metabolism.
    European journal of clinical nutrition, 2000
    Co-Authors: P Ritz
    Abstract:

    Age-related changes in body composition can be considered the consequence of changes in energy and protein metabolism, while also having a leverage effect on protein and energy requirements. Changes in organ and systems weights obviously affect energy balance regulation. Considered at the system level, age-related changes are numerous, but it is still debated whether they are related to Aging per se or to conditions (such as poor nutrition, disease, drug treatments etc.) that prevail in elderly persons. It is likely that most changes occuring in the gastrointestinal, circulatory and immune system do not affect energy and protein requirements at rest. However, Aging is associated with difficulties in adapting to new environmental conditions that lead to stress. Repeated episodes of stress might lead to accumulation of deficits that can affect energy and protein balances.

James W. Curtsinger - One of the best experts on this subject based on the ideXlab platform.

  • Physiology of Aging Selected Contribution: Long-lived Drosophila melanogaster lines exhibit normal metabolic rates
    2003
    Co-Authors: Wayne A. Van Voorhies, Aziz A. Khazaeli, James W. Curtsinger
    Abstract:

    Van Voorhies, Wayne A., Aziz A. Khazaeli, and James W. Curtsinger. Selected Contribution: Long-lived Drosophila melanogaster lines exhibit normal metabolic rates. J Appl Physiol 95: 2605–2613, 2003. First published August 29, 2003; 10.1152/japplphysiol.00448.2003.—The use of model organisms, such as Drosophila melanogaster, provides a powerful method for studying mechanisms of Aging. Here we report on a large set of recombinant inbred (RI) D. melanogaster lines that exhibit approximately a fivefold range of average adult longevities. Understanding the factors responsible for the differences in longevity, particularly the characteristics of the longest-lived lines, can provide fundamental insights into the mechanistic correlates of Aging. In ectothermic organisms, longevity is often inversely correlated with metabolic rate, suggesting the a priori hypothesis that longlived lines will have low resting metabolic rates. We conducted 6,000 measurements of CO2 production in individual male flies aged 5, 16, 29, and 47 days postemergence and simultaneously measured the weight of individual flies and life spans in populations of each line. Even though there was a wide range of longevities, there was no evidence of an inverse relationship between the variables. The increased longevity of long-lived lines is not mediated through reduction of metabolic activity. In Drosophila, it is possible to both maintain a normal metabolic rate and achieve long life. These results are evaluated in the context of 100 years of research on the relationship between metabolic rate and life span.

  • Selected contribution: Long-lived drosophila melanogaster lines exhibit normal metabolic rates. Commentary : Physiology of Aging
    Journal of Applied Physiology, 2003
    Co-Authors: Wayne A. Van Voorhies, Aziz A. Khazaeli, James W. Curtsinger, Gary C. Sieck
    Abstract:

    The use of model organisms, such as Drosophila melanogaster, provides a powerful method for studying mechanisms of Aging. Here we report on a large set of recombinant inbred (RI) D. melanogaster lines that exhibit approximately a fivefold range of average adult longevities. Understanding the factors responsible for the differences in longevity, particularly the characteristics of the longest-lived lines, can provide fundamental insights into the mechanistic correlates of Aging. In ectothermic organisms, longevity is often inversely correlated with metabolic rate, suggesting the a priori hypothesis that long-lived lines will have low resting metabolic rates. We conducted ∼6,000 measurements of CO 2 production in individual male flies aged 5, 16, 29, and 47 days postemergence and simultaneously measured the weight of individual flies and life spans in populations of each line. Even though there was a wide range of longevities, there was no evidence of an inverse relationship between the variables. The increased longevity of long-lived lines is not mediated through reduction of metabolic activity. In Drosophila, it is possible to both maintain a normal metabolic rate and achieve long life. These results are evaluated in the context of 100 years of research on the relationship between metabolic rate and life span.