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Wai Ching Lam - One of the best experts on this subject based on the ideXlab platform.
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accuracy of scleral Transillumination techniques to identify infant ciliary body for sclerostomy and intravitreal injections
Clinical and Experimental Ophthalmology, 2019Co-Authors: Abhishek Sharma, Asim Ali, Robert H Henderson, C K Patel, Cynthia Vandenhoven, Wai Ching LamAbstract:Importance: There is variation in the literature for sclerotomy and intravitreal injection placement in young children, ranging from 0.5 to 3.0 mm from the limbus. We assess the accuracy of scleral Transillumination to identify the ciliary body in infants for safe sclerotomy and intravitreal injections in young children. Background: The study compares the perilimbal “dark band” seen on scleral Transillumination (STI) with the ultrasound biomicroscopy (UBM), and compares these measurements with the current guidelines for sclerotomy in infants. Design: Prospective case series in a tertiary paediatric hospital. Participants: Children aged ≤36 months undergoing general anaesthesia for eye procedures. Methods: Scleral Transillumination was performed to measure the perilimbal dark band. UBM of the ciliary body region was then performed, and correlated with Transillumination findings. Main Outcome Measures: The midpoints of STI and UBM were compared to current cadaver-based guidelines to assess the safe point for sclerotomy. Results: Twenty children were recruited, 36 STI and 35 UBM measurements were obtained. The posterior edge of the dark band had good correlation with the posterior border of the ciliary body. Transillumination and UBM correlated well for midpoint measurements. The midpoint of the dark band on Transillumination was confirmed to be in the ciliary body by UBM in all cases. Conclusions and Relevance: The STI technique is a useful and fast technique to demonstrate the ciliary body. The midpoint of the dark band on STI correlates well with the UBM, and has a potential use for confirming safe-entry into the posterior segment if using current guidelines. The current cadaver-based paediatric guidelines safely avoid retinal injury.
S F Friedlander - One of the best experts on this subject based on the ideXlab platform.
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Transillumination blisters in a neonate.
Journal of the American Academy of Dermatology, 1999Co-Authors: F P Sajben, N F Gibbs, S F FriedlanderAbstract:Transillumination with a high-intensity fiberoptic light source is an effective means of diagnosing pneumothoraces and localizing arteries and veins for blood sampling. It has been used for these purposes in neonatal intensive care units since the 1970s. Thermal burns were reported in association with the technique initially, but this complication now occurs infrequently because of numerous safety precautions. We present a case of thermal blisters induced by Transillumination in a neonate. This entity is an important addition to the differential diagnosis of vesicobullous eruptions in the neonate.
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Transillumination blisters in a neonate
Journal of the American Academy of Dermatology, 1999Co-Authors: F P Sajben, N F Gibbs, S F FriedlanderAbstract:Abstract Transillumination with a high-intensity fiberoptic light source is an effective means of diagnosing pneumothoraces and localizing arteries and veins for blood sampling. It has been used for these purposes in neonatal intensive care units since the 1970s. Thermal burns were reported in association with the technique initially, but this complication now occurs infrequently because of numerous safety precautions. We present a case of thermal blisters induced by Transillumination in a neonate. This entity is an important addition to the differential diagnosis of vesicobullous eruptions in the neonate. (J Am Acad Dermatol 1999;41:264-5.)
Lothar Lilge - One of the best experts on this subject based on the ideXlab platform.
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optical Transillumination spectroscopy to quantify parenchymal tissue density an indicator for breast cancer risk
British Journal of Radiology, 2005Co-Authors: Michelle Simick, Lothar LilgeAbstract:Mammographic screening for early detection of breast cancer has proven valuable in improving breast cancer survival. However, breast cancer incidence is still increasing, and thus preventative oncology needs to receive more attention, with the goal of identifying women with increased risk of developing breast cancer in the future and offering them risk reduction interventions. Mammogram derived parenchymal density pattern has been shown by various authors to provide a high odds ratio for breast cancer. Near-infrared optical Transillumination spectroscopy was employed to determine physiological properties of the breast tissue to quantify differences in women with low or high breast cancer risk. Specifically in this study, women who had a recent mammogram underwent examination of their breast tissue by optical Transillumination spectroscopy. Areas of adipose and glandular tissues which give rise to mammographic density patterns also have characteristic optical Transillumination spectra. Correlation between optical Transillumination spectroscopy and mammographic density pattern was established using partial least squares analysis. Results show that predicted tissue density based on optical Transillumination spectroscopy correlates with mammographic observed tissue density, with a Spearman Rank correlation coefficient of 0.72. This suggests that optical Transillumination spectroscopy may be a promising tool to quantify and monitor changes in breast cancer risk.
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Optical Transillumination spectroscopy of breast tissue for cancer risk assessment
Lasers in Surgery: Advanced Characterization Therapeutics and Systems XII, 2002Co-Authors: Michelle Simick, Brian C. Wilson, Lothar LilgeAbstract:Determining an individual’s cancer risk is an important step to increase the efficacy of screening procedures. Currently, breast cancer risk can be clinically assessed using tissue density patterns seen on standard x-ray mammography. These patterns reflect the ratio of glandular tissue to adipose tissue within the breast. Increased dense areas of glandular tissue indicate a higher risk category with an odds ratio of approximately 6. Near-infrared optical Transillumination spectroscopy has been shown helpful in investigating physiological and anatomical properties of the breast tissue. Similarly the adipose and glandular tissue ratio responsible for the x-ray density pattern together with other optically active tissue chromophores can result in unique optical Transillumination spectra. In this study we are considering patients who had standard mammograms and examine their breast tissue by optical Transillumination spectroscopy in order to establish a correlation between the two techniques and therefore the ability of using Transillumination for risk estimation. The Transillumination spectra show haemoglobin, water and lipid absorption characteristics. Correlation between optical Transillumination spectroscopy and mammographic density pattern are established through the use of Principal Component Analysis and Linear Discriminant Analysis. Preliminary, results indicate that x-ray dense tissue can be identified with a specificity and sensitivity above 0.87 each, for both post and pre-menopausal women.
F P Sajben - One of the best experts on this subject based on the ideXlab platform.
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Transillumination blisters in a neonate.
Journal of the American Academy of Dermatology, 1999Co-Authors: F P Sajben, N F Gibbs, S F FriedlanderAbstract:Transillumination with a high-intensity fiberoptic light source is an effective means of diagnosing pneumothoraces and localizing arteries and veins for blood sampling. It has been used for these purposes in neonatal intensive care units since the 1970s. Thermal burns were reported in association with the technique initially, but this complication now occurs infrequently because of numerous safety precautions. We present a case of thermal blisters induced by Transillumination in a neonate. This entity is an important addition to the differential diagnosis of vesicobullous eruptions in the neonate.
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Transillumination blisters in a neonate
Journal of the American Academy of Dermatology, 1999Co-Authors: F P Sajben, N F Gibbs, S F FriedlanderAbstract:Abstract Transillumination with a high-intensity fiberoptic light source is an effective means of diagnosing pneumothoraces and localizing arteries and veins for blood sampling. It has been used for these purposes in neonatal intensive care units since the 1970s. Thermal burns were reported in association with the technique initially, but this complication now occurs infrequently because of numerous safety precautions. We present a case of thermal blisters induced by Transillumination in a neonate. This entity is an important addition to the differential diagnosis of vesicobullous eruptions in the neonate. (J Am Acad Dermatol 1999;41:264-5.)
Michelle Simick - One of the best experts on this subject based on the ideXlab platform.
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optical Transillumination spectroscopy to quantify parenchymal tissue density an indicator for breast cancer risk
British Journal of Radiology, 2005Co-Authors: Michelle Simick, Lothar LilgeAbstract:Mammographic screening for early detection of breast cancer has proven valuable in improving breast cancer survival. However, breast cancer incidence is still increasing, and thus preventative oncology needs to receive more attention, with the goal of identifying women with increased risk of developing breast cancer in the future and offering them risk reduction interventions. Mammogram derived parenchymal density pattern has been shown by various authors to provide a high odds ratio for breast cancer. Near-infrared optical Transillumination spectroscopy was employed to determine physiological properties of the breast tissue to quantify differences in women with low or high breast cancer risk. Specifically in this study, women who had a recent mammogram underwent examination of their breast tissue by optical Transillumination spectroscopy. Areas of adipose and glandular tissues which give rise to mammographic density patterns also have characteristic optical Transillumination spectra. Correlation between optical Transillumination spectroscopy and mammographic density pattern was established using partial least squares analysis. Results show that predicted tissue density based on optical Transillumination spectroscopy correlates with mammographic observed tissue density, with a Spearman Rank correlation coefficient of 0.72. This suggests that optical Transillumination spectroscopy may be a promising tool to quantify and monitor changes in breast cancer risk.
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Optical Transillumination spectroscopy of breast tissue for cancer risk assessment
Lasers in Surgery: Advanced Characterization Therapeutics and Systems XII, 2002Co-Authors: Michelle Simick, Brian C. Wilson, Lothar LilgeAbstract:Determining an individual’s cancer risk is an important step to increase the efficacy of screening procedures. Currently, breast cancer risk can be clinically assessed using tissue density patterns seen on standard x-ray mammography. These patterns reflect the ratio of glandular tissue to adipose tissue within the breast. Increased dense areas of glandular tissue indicate a higher risk category with an odds ratio of approximately 6. Near-infrared optical Transillumination spectroscopy has been shown helpful in investigating physiological and anatomical properties of the breast tissue. Similarly the adipose and glandular tissue ratio responsible for the x-ray density pattern together with other optically active tissue chromophores can result in unique optical Transillumination spectra. In this study we are considering patients who had standard mammograms and examine their breast tissue by optical Transillumination spectroscopy in order to establish a correlation between the two techniques and therefore the ability of using Transillumination for risk estimation. The Transillumination spectra show haemoglobin, water and lipid absorption characteristics. Correlation between optical Transillumination spectroscopy and mammographic density pattern are established through the use of Principal Component Analysis and Linear Discriminant Analysis. Preliminary, results indicate that x-ray dense tissue can be identified with a specificity and sensitivity above 0.87 each, for both post and pre-menopausal women.
