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P D Chaudhari - One of the best experts on this subject based on the ideXlab platform.
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anti snake venom activities of ethanolic extract of fruits of Piper longum l Piperaceae against russell s viper venom characterization of Piperine as active principle
Journal of Ethnopharmacology, 2013Co-Authors: P A Shenoy, S S Nipate, J M Sonpetkar, N C Salvi, A B Waghmare, P D ChaudhariAbstract:ETHNOPHARMACOLOGICAL RELEVANCE: Piper longum L. fruits have been traditionally used against snakebites in north-eastern and southern region of India. AIM OF THE STUDY: To examine the ability of ethanolic extract of fruits of Piper longum L., Piperaceae (PLE) and Piperine, one of the main active principles of Piper longum, to inhibit the Russell's viper (Doboia russelii, Viperidae) snake venom activities. MATERIALS AND METHODS: Anti-snake venom activities of ethanolic extract of fruits of Piper longum L. (Piperaceae) and Piperine against Russell's viper venom was studied in embryonated fertile chicken eggs, mice and rats by using various models as follows: inhibition of venom lethal action, inhibition of venom haemorrhagic action (in vitro), inhibition of venom haemorrhagic action (in vivo), inhibition of venom necrotizing action, inhibition of venom defibrinogenating action, inhibition of venom induced paw edema, inhibition of venom induced mast cell degranulation, creatine kinase assay and assay for catalase activity. RESULTS: PLE was found to inhibit the venom induced haemorrhage in embryonated fertile chicken eggs. Administration of PLE and Piperine significantly (p<0.01) inhibited venom induced lethality, haemorrhage, necrosis, defibrinogenation and inflammatory paw edema in mice in a dose dependent manner. PLE and Piperine also significantly (p<0.01) reduced venom induced mast cell degranulation in rats. Venom induced decrease in catalase enzyme levels in mice kidney tissue and increase in creatine kinase enzyme levels in mice serum were significantly (p<0.01) reversed by administration of both PLE and Piperine. CONCLUSIONS: PLE possesses good anti-snake venom properties and Piperine is one of the compounds responsible for the effective venom neutralizing ability of the plant.
Sri Lestari - One of the best experts on this subject based on the ideXlab platform.
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Efektivitas Antibakteri Ekstrak Daun Sirih Merah (Piper Crocatum) dan Sirih Hijau (Piper Betle L.) sebagai Bahan Alternatif Irigasi Saluran Akar (The Efectiveness of Red Piper Betle (Piper Crocatum) Leaf and Green Piper Betle (Piper Bettle L) Leaf Ex
2014Co-Authors: Hafida Mariyatin, Ekiyantini Widyowati, Sri LestariAbstract:Background: Root canal irrigation is one, of important in endodonti treatment because if ignored can lead to failure. 3% Hydrogen peroxide ( H 2 O 2 ) is one of irrigation solution is often used. To reduce the effects of toxicity of root canal irrigation, it can be used for alternative materials canal irrigation are safe to use. One is Piper betle plant. Based on previous research phytochemical test, the Piper betle leaf has anti-bacterial effect. Purpose: This study aimed to determine the antibacterial effect, difference antibacterial effect and effectiveness of red Piper betle leaf extract and green Piper betle leaf compared with 3% H 2 O 2 solution to Streptococcus viridans. Methods: This study is an experimental laboratory with research design post only control design. This study uses pitting. Each petridish divided into 6 holes, spilled A 3% H 2 O 2 , B sterile distilled water, C 50% red Piper betle leaf extract, D 50% green Piper betle leaf extract, E 100% leaf extract a red Piper betle and F 100% green Piper betle leaf extract. All incubated for 24 hours at 37 ° C and the inhibition zone diameter measured. Results: The results showed significant difference between the extracts of green and red Piper betle. Statistical test with Mann Whitney test showed a significant difference between each group except 3% H 2 O 2 and 50% green Piper betle extract. Conclusions and Recommendations: Conclusions from this research are green Piper betle leaf extract and red Piper betle leaf extract can inhibit the growth of bacteria S. viridans. There were significant differences antibacterial effect between green Piper betle leaf extract and red Piper betle leaf extract with 3% H 2 O 2 to S. Viridans. 100% Green Piper betle leaf extract effective as an antibacterial against S. viridans. Need more research on the use of green Piper betle leaf extract and red Piper betle leaf extract as an alternative material of root canal irrigation. Keywords: a ntibacterial, red Piper betle leaf, green Piper betle leaf, H 2 O 2 3%, root canal irrigation
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Efektivitas Antibakteri Ekstrak Daun Sirih Merah (Piper Crocatum) dan Sirih Hijau (Piper Betle L.) sebagai Bahan Alternatif Irigasi Saluran Akar (The Efectiveness of Red Piper Betle (Piper Crocatum) Leaf and Green Piper Betle (Piper Bettle L) Leaf Ex
2012Co-Authors: Hafida Mariyatin, Sri Lestari, Pendidikan Dokter GigiAbstract:Background: Measures of irrigation canals is one important step endodonti care because if ignored can lead to treatment failure. The most important irrigation solution is to have a maximum power of antimicrobials with minimal toxicity. H 2 O 2 3% irrigation one ingredient that is often used. Disadvantages H 2 O 2 3% as a root canal irrigation is antibacterial power limitations of the material and is very toxic to cells. To reduce the effects of toxicity of root canal irrigation, hence in this study using alternative materials Piper betel leaf extract as an ingredient irrigation canals are safe to use. It is known that the content contained in the essential oil of Piper betel leaf has antibacterial effects. Methods: This study is an experimental laboratory with research design post only control design. This study uses total sample wells with 8 samples. Observations are then tested using statistical analysis test for normality with the Kolmogorov-Smirnov, and then conducted tests of homogeneity with Levene Test. Analytical results obtained are not normal and are not homogeneous then followed by non-parametric statistical tests, using different test followed by Kruskall wallis and Mann-Whitney test statistic. Results: The results showed that the extract of red Piper betle leaf and green Piper betle leaf extract has antibacterial effect against S. viridans. Conclusions and Recommendations: The result largest to smallest inhibition zone is green Piper betle leaf extract 100%, green Piper betle leaf extract 50%, H 2 O 2 3% , red Piper betle leaf extract 100%, red Piper betle leaf extract 50% and aquades steril. Need more research on the use of green betel leaf extract and red betel leaf extract as an alternative to root canal irrigation material.
Hafida Mariyatin - One of the best experts on this subject based on the ideXlab platform.
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Efektivitas Antibakteri Ekstrak Daun Sirih Merah (Piper Crocatum) dan Sirih Hijau (Piper Betle L.) sebagai Bahan Alternatif Irigasi Saluran Akar (The Efectiveness of Red Piper Betle (Piper Crocatum) Leaf and Green Piper Betle (Piper Bettle L) Leaf Ex
2014Co-Authors: Hafida Mariyatin, Ekiyantini Widyowati, Sri LestariAbstract:Background: Root canal irrigation is one, of important in endodonti treatment because if ignored can lead to failure. 3% Hydrogen peroxide ( H 2 O 2 ) is one of irrigation solution is often used. To reduce the effects of toxicity of root canal irrigation, it can be used for alternative materials canal irrigation are safe to use. One is Piper betle plant. Based on previous research phytochemical test, the Piper betle leaf has anti-bacterial effect. Purpose: This study aimed to determine the antibacterial effect, difference antibacterial effect and effectiveness of red Piper betle leaf extract and green Piper betle leaf compared with 3% H 2 O 2 solution to Streptococcus viridans. Methods: This study is an experimental laboratory with research design post only control design. This study uses pitting. Each petridish divided into 6 holes, spilled A 3% H 2 O 2 , B sterile distilled water, C 50% red Piper betle leaf extract, D 50% green Piper betle leaf extract, E 100% leaf extract a red Piper betle and F 100% green Piper betle leaf extract. All incubated for 24 hours at 37 ° C and the inhibition zone diameter measured. Results: The results showed significant difference between the extracts of green and red Piper betle. Statistical test with Mann Whitney test showed a significant difference between each group except 3% H 2 O 2 and 50% green Piper betle extract. Conclusions and Recommendations: Conclusions from this research are green Piper betle leaf extract and red Piper betle leaf extract can inhibit the growth of bacteria S. viridans. There were significant differences antibacterial effect between green Piper betle leaf extract and red Piper betle leaf extract with 3% H 2 O 2 to S. Viridans. 100% Green Piper betle leaf extract effective as an antibacterial against S. viridans. Need more research on the use of green Piper betle leaf extract and red Piper betle leaf extract as an alternative material of root canal irrigation. Keywords: a ntibacterial, red Piper betle leaf, green Piper betle leaf, H 2 O 2 3%, root canal irrigation
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Efektivitas Antibakteri Ekstrak Daun Sirih Merah (Piper Crocatum) dan Sirih Hijau (Piper Betle L.) sebagai Bahan Alternatif Irigasi Saluran Akar (The Efectiveness of Red Piper Betle (Piper Crocatum) Leaf and Green Piper Betle (Piper Bettle L) Leaf Ex
2012Co-Authors: Hafida Mariyatin, Sri Lestari, Pendidikan Dokter GigiAbstract:Background: Measures of irrigation canals is one important step endodonti care because if ignored can lead to treatment failure. The most important irrigation solution is to have a maximum power of antimicrobials with minimal toxicity. H 2 O 2 3% irrigation one ingredient that is often used. Disadvantages H 2 O 2 3% as a root canal irrigation is antibacterial power limitations of the material and is very toxic to cells. To reduce the effects of toxicity of root canal irrigation, hence in this study using alternative materials Piper betel leaf extract as an ingredient irrigation canals are safe to use. It is known that the content contained in the essential oil of Piper betel leaf has antibacterial effects. Methods: This study is an experimental laboratory with research design post only control design. This study uses total sample wells with 8 samples. Observations are then tested using statistical analysis test for normality with the Kolmogorov-Smirnov, and then conducted tests of homogeneity with Levene Test. Analytical results obtained are not normal and are not homogeneous then followed by non-parametric statistical tests, using different test followed by Kruskall wallis and Mann-Whitney test statistic. Results: The results showed that the extract of red Piper betle leaf and green Piper betle leaf extract has antibacterial effect against S. viridans. Conclusions and Recommendations: The result largest to smallest inhibition zone is green Piper betle leaf extract 100%, green Piper betle leaf extract 50%, H 2 O 2 3% , red Piper betle leaf extract 100%, red Piper betle leaf extract 50% and aquades steril. Need more research on the use of green betel leaf extract and red betel leaf extract as an alternative to root canal irrigation material.
P A Shenoy - One of the best experts on this subject based on the ideXlab platform.
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anti snake venom activities of ethanolic extract of fruits of Piper longum l Piperaceae against russell s viper venom characterization of Piperine as active principle
Journal of Ethnopharmacology, 2013Co-Authors: P A Shenoy, S S Nipate, J M Sonpetkar, N C Salvi, A B Waghmare, P D ChaudhariAbstract:ETHNOPHARMACOLOGICAL RELEVANCE: Piper longum L. fruits have been traditionally used against snakebites in north-eastern and southern region of India. AIM OF THE STUDY: To examine the ability of ethanolic extract of fruits of Piper longum L., Piperaceae (PLE) and Piperine, one of the main active principles of Piper longum, to inhibit the Russell's viper (Doboia russelii, Viperidae) snake venom activities. MATERIALS AND METHODS: Anti-snake venom activities of ethanolic extract of fruits of Piper longum L. (Piperaceae) and Piperine against Russell's viper venom was studied in embryonated fertile chicken eggs, mice and rats by using various models as follows: inhibition of venom lethal action, inhibition of venom haemorrhagic action (in vitro), inhibition of venom haemorrhagic action (in vivo), inhibition of venom necrotizing action, inhibition of venom defibrinogenating action, inhibition of venom induced paw edema, inhibition of venom induced mast cell degranulation, creatine kinase assay and assay for catalase activity. RESULTS: PLE was found to inhibit the venom induced haemorrhage in embryonated fertile chicken eggs. Administration of PLE and Piperine significantly (p<0.01) inhibited venom induced lethality, haemorrhage, necrosis, defibrinogenation and inflammatory paw edema in mice in a dose dependent manner. PLE and Piperine also significantly (p<0.01) reduced venom induced mast cell degranulation in rats. Venom induced decrease in catalase enzyme levels in mice kidney tissue and increase in creatine kinase enzyme levels in mice serum were significantly (p<0.01) reversed by administration of both PLE and Piperine. CONCLUSIONS: PLE possesses good anti-snake venom properties and Piperine is one of the compounds responsible for the effective venom neutralizing ability of the plant.
Carl Erik Olsen - One of the best experts on this subject based on the ideXlab platform.
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phytochemistry of the genus Piper
Phytochemistry, 1997Co-Authors: Virinder S Parmar, Subhash C Jain, Kirpal S Bisht, Rajni Jain, Poonam Taneja, Amitabh Jha, O D Tyagi, Ashok K Prasad, Jesper Wengel, Carl Erik OlsenAbstract:Abstract The secondary metabolites isolated from Piper species for the period 1907 to June 1996 have been reviewed. Nearly six hundred chemical constituents belonging to different classes of bioactive compounds are listed together with their source(s) and references. © 1997 Elsevier Science Ltd
