The Experts below are selected from a list of 33 Experts worldwide ranked by ideXlab platform
Oleksandr O. Grygorenko - One of the best experts on this subject based on the ideXlab platform.
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5 6 7 8 tetrahydropyrido 4 3 c pyridazine a lead oriented scaffold with two diversity points
ChemInform, 2014Co-Authors: A V Borisov, Volodymyr V. Voloshchuk, Maxim A. Nechayev, Oleksandr O. GrygorenkoAbstract:The five step sequence for the synthesis of the title compounds includes the reaction of 4-Piperidone Derivative (I) with glyoxylic acid and hydrazine as the key step.
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5,6,7,8-Tetrahydropyrido[4,3-c]pyridazine: A Lead-Oriented Scaffold with Two Diversity Points
Synthesis, 2013Co-Authors: Alexander V. Borisov, Volodymyr V. Voloshchuk, Maxim A. Nechayev, Oleksandr O. GrygorenkoAbstract:An approach to the Derivatives of 5,6,7,8-tetrahydropyrido[4,3- c ]pyridazine, a lead-oriented scaffold with two diversity points, was developed. The method included five steps starting from the readily available 4-Piperidone Derivatives and allowed for the preparation of the target compounds in 32–35% overall yields. The key step of the sequence included one-pot solvent-free reaction of the corresponding 4-Piperidone Derivative, glyoxylic acid, and hydrazine.
Alexander V. Borisov - One of the best experts on this subject based on the ideXlab platform.
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5,6,7,8-Tetrahydropyrido[4,3-c]pyridazine: A Lead-Oriented Scaffold with Two Diversity Points
Synthesis, 2013Co-Authors: Alexander V. Borisov, Volodymyr V. Voloshchuk, Maxim A. Nechayev, Oleksandr O. GrygorenkoAbstract:An approach to the Derivatives of 5,6,7,8-tetrahydropyrido[4,3- c ]pyridazine, a lead-oriented scaffold with two diversity points, was developed. The method included five steps starting from the readily available 4-Piperidone Derivatives and allowed for the preparation of the target compounds in 32–35% overall yields. The key step of the sequence included one-pot solvent-free reaction of the corresponding 4-Piperidone Derivative, glyoxylic acid, and hydrazine.
Maxim A. Nechayev - One of the best experts on this subject based on the ideXlab platform.
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5 6 7 8 tetrahydropyrido 4 3 c pyridazine a lead oriented scaffold with two diversity points
ChemInform, 2014Co-Authors: A V Borisov, Volodymyr V. Voloshchuk, Maxim A. Nechayev, Oleksandr O. GrygorenkoAbstract:The five step sequence for the synthesis of the title compounds includes the reaction of 4-Piperidone Derivative (I) with glyoxylic acid and hydrazine as the key step.
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5,6,7,8-Tetrahydropyrido[4,3-c]pyridazine: A Lead-Oriented Scaffold with Two Diversity Points
Synthesis, 2013Co-Authors: Alexander V. Borisov, Volodymyr V. Voloshchuk, Maxim A. Nechayev, Oleksandr O. GrygorenkoAbstract:An approach to the Derivatives of 5,6,7,8-tetrahydropyrido[4,3- c ]pyridazine, a lead-oriented scaffold with two diversity points, was developed. The method included five steps starting from the readily available 4-Piperidone Derivatives and allowed for the preparation of the target compounds in 32–35% overall yields. The key step of the sequence included one-pot solvent-free reaction of the corresponding 4-Piperidone Derivative, glyoxylic acid, and hydrazine.
Volodymyr V. Voloshchuk - One of the best experts on this subject based on the ideXlab platform.
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5 6 7 8 tetrahydropyrido 4 3 c pyridazine a lead oriented scaffold with two diversity points
ChemInform, 2014Co-Authors: A V Borisov, Volodymyr V. Voloshchuk, Maxim A. Nechayev, Oleksandr O. GrygorenkoAbstract:The five step sequence for the synthesis of the title compounds includes the reaction of 4-Piperidone Derivative (I) with glyoxylic acid and hydrazine as the key step.
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5,6,7,8-Tetrahydropyrido[4,3-c]pyridazine: A Lead-Oriented Scaffold with Two Diversity Points
Synthesis, 2013Co-Authors: Alexander V. Borisov, Volodymyr V. Voloshchuk, Maxim A. Nechayev, Oleksandr O. GrygorenkoAbstract:An approach to the Derivatives of 5,6,7,8-tetrahydropyrido[4,3- c ]pyridazine, a lead-oriented scaffold with two diversity points, was developed. The method included five steps starting from the readily available 4-Piperidone Derivatives and allowed for the preparation of the target compounds in 32–35% overall yields. The key step of the sequence included one-pot solvent-free reaction of the corresponding 4-Piperidone Derivative, glyoxylic acid, and hydrazine.
Edward R. T. Tiekink - One of the best experts on this subject based on the ideXlab platform.
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Hydrogen bonding in 2,6-bis(4-fluorophenyl)-3,5-dimethylpiperidin-4-one methanol solvate
Zeitschrift für Kristallographie - Crystalline Materials, 2016Co-Authors: T. Suresh, V. Vijayakumar, L. Jyothish Kumar, S. Sarveswari, Mukesh M. Jotani, Alberto Otero-de-la-roza, Yee Seng Tan, Edward R. T. TiekinkAbstract:AbstractThe crystal structure analysis of a 2,6-diaryl 4-Piperidone Derivative, isolated as a mono-methanol solvate, reveals that both the Piperidone and the methanol molecule lie on a crystallographic mirror plane. A chair conformation is found for the Piperidone ring with the aryl and methyl groups in equatorial positions. The most prominent feature of the molecular packing is the formation of supramolecular zigzag chains mediated by amine-N–H···O(methanol) and hydroxyl-O–H···N(amine) hydrogen bonds, i.e. the methanol molecule serves as a bridge between Piperidone molecules. The molecular structure is compared with that determined in an unsolvated form and the gas-phase equilibrium structure, obtained using density-functional theory (DFT); differences relate, in the main, to the relative dispositions of the aryl rings. An analysis of the Hirshfeld surfaces of the experimental structures indicates very similar relative contributions with the notable exception being the contribution by O···H/H···O which at 13.7% in the methanol solvate is >8.5% in the unsolvated form.