The Experts below are selected from a list of 3018 Experts worldwide ranked by ideXlab platform
Dongcheng Dai - One of the best experts on this subject based on the ideXlab platform.
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inverse electron demand diels alder reactions for the synthesis of Pyridazines on dna
Organic Letters, 2018Co-Authors: Zhen Sun, Xuan Wang, Mingqiang Zhang, Wenge Zhong, Dongcheng DaiAbstract:The synthesis of Pyridazines on DNA has been developed on the basis of inverse-electron-demand Diels–Alder (IEDDA) reactions of 1,2,4,5-tetrazines. The broad substrate scope is explored. Functionalized Pyridazine products are selected for subsequent DNA-compatible Suzuki–Miyaura coupling, acylation, and SNAr substitution reactions, demonstrating the feasibility and versatility of IEDDA reactions for DNA-encoded library synthesis.
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Inverse-Electron-Demand Diels–Alder Reactions for the Synthesis of Pyridazines on DNA
2018Co-Authors: Zhen Sun, Xuan Wang, Mingqiang Zhang, Wenge Zhong, Dongcheng DaiAbstract:The synthesis of Pyridazines on DNA has been developed on the basis of inverse-electron-demand Diels–Alder (IEDDA) reactions of 1,2,4,5-tetrazines. The broad substrate scope is explored. Functionalized Pyridazine products are selected for subsequent DNA-compatible Suzuki–Miyaura coupling, acylation, and SNAr substitution reactions, demonstrating the feasibility and versatility of IEDDA reactions for DNA-encoded library synthesis
Piet Herdewijn - One of the best experts on this subject based on the ideXlab platform.
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Strategy for the synthesis of Pyridazine heterocycles and their derivatives.
The Journal of organic chemistry, 2013Co-Authors: Hassan Bel Abed, Oscar Mammoliti, Omprakash Bande, Guy Van Lommen, Piet HerdewijnAbstract:The first synthesis of novel fused Pyridazines has been realized starting from 1,3-diketones involving a Diaza–Wittig reaction as a key step. A convenient strategy was elaborated to access versatile Pyridazine derivatives allowing the variation of substituents at position 6 of the heterocyclic ring. In a first part, Pyridazines bearing an ester group were synthesized as a model to evaluate the methodology. In a second part, an improved procedure has been used for the synthesis of Pyridazines bearing a ketone group and different methods of cyclization were carried out, leading to several hitherto unknown biheterocyclic compounds. This reaction scheme represents an attractive methodology for the synthesis of novel fused Pyridazine derivatives.
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a short and convenient strategy for the synthesis of Pyridazines via diaza wittig reaction
Tetrahedron Letters, 2012Co-Authors: Hassen Bel Abed, Oscar Mammoliti, Guy Van Lommen, Piet HerdewijnAbstract:Abstract A convenient and selective synthesis of 6-substituted-4-hydroxy-3-methoxycarbonyl Pyridazines has been developed via a diaza-Wittig reaction. The desired products substituted at the C6 position can be obtained from readily available starting materials under mild conditions. This represents an attractive new method for the synthesis of Pyridazine derivatives.
Xuan Wang - One of the best experts on this subject based on the ideXlab platform.
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inverse electron demand diels alder reactions for the synthesis of Pyridazines on dna
Organic Letters, 2018Co-Authors: Zhen Sun, Xuan Wang, Mingqiang Zhang, Wenge Zhong, Dongcheng DaiAbstract:The synthesis of Pyridazines on DNA has been developed on the basis of inverse-electron-demand Diels–Alder (IEDDA) reactions of 1,2,4,5-tetrazines. The broad substrate scope is explored. Functionalized Pyridazine products are selected for subsequent DNA-compatible Suzuki–Miyaura coupling, acylation, and SNAr substitution reactions, demonstrating the feasibility and versatility of IEDDA reactions for DNA-encoded library synthesis.
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Inverse-Electron-Demand Diels–Alder Reactions for the Synthesis of Pyridazines on DNA
2018Co-Authors: Zhen Sun, Xuan Wang, Mingqiang Zhang, Wenge Zhong, Dongcheng DaiAbstract:The synthesis of Pyridazines on DNA has been developed on the basis of inverse-electron-demand Diels–Alder (IEDDA) reactions of 1,2,4,5-tetrazines. The broad substrate scope is explored. Functionalized Pyridazine products are selected for subsequent DNA-compatible Suzuki–Miyaura coupling, acylation, and SNAr substitution reactions, demonstrating the feasibility and versatility of IEDDA reactions for DNA-encoded library synthesis
Mona Hosny - One of the best experts on this subject based on the ideXlab platform.
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Pyridazine derivatives and related compounds part 13 synthesis and antimicrobial activity of some pyridazino 3 4 3 4 pyrazolo 5 1 c 1 2 4 triazines
Bioorganic & Medicinal Chemistry Letters, 2004Co-Authors: Ali Deeb, Fatma Elmariah, Mona HosnyAbstract:Abstract A general method for the preparation of substituted pyridazinopyrazolotriazines is reported. 3-Aminopyrazolo[3,4- d ]Pyridazine was diazotized and coupled with active methylene reagents to afford the tricyclic pyridazino[3′,4′:3,4]pyrazolo[5,1- c ]-1,2,4-triazines with substituents such as methyl, phenyl, ethoxycarbonyl, acetyl or benzoyl, depending on the methylene reagent used. In addition several condensation reactions with hydrazines gave the corresponding acid hydrazide and/or hydrazones. Reactions of 3 with aromatic aldehydes afforded hydrazones. The products were screened for their antimicrobial activity against five microorganisms.
Mohamed Elagawany - One of the best experts on this subject based on the ideXlab platform.
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palladium catalyzed synthesis of substituted pyrido 2 3 d Pyridazines at positions 5 and 8
Synthesis, 2012Co-Authors: Mohamed A Ibrahim, Emilie Blaise, Olivier Lozach, Claude Szalata, Martine Schmitt, Abdallah S Eletrawy, Mohamed ElagawanyAbstract:Several synthetic strategies were developed for the preparation of highly substituted pyrido[2,3- d ]Pyridazines. We particularly focused on the impact of the pyridine nitrogen atom on Pyridazine ring reactivity toward aromatic substitutions, alkylations, or pallado-catalyzed cross-coupling reactions.
