The Experts below are selected from a list of 261 Experts worldwide ranked by ideXlab platform

Tsukasa Koyama - One of the best experts on this subject based on the ideXlab platform.

Christer Allgulander - One of the best experts on this subject based on the ideXlab platform.

  • Paroxetine in social anxiety disorder: a randomized Placebo-Controlled Study
    Acta psychiatrica Scandinavica, 1999
    Co-Authors: Christer Allgulander
    Abstract:

    Allgulander C. Paroxetine in social anxiety disorder: a randomized Placebo-Controlled Study. Acta Psychiatr Scand 1999: 100: 193–198. © Munksgaard 1999. Objective: The aim of this Study was to evaluate the utility of paroxetine treatment in social anxiety disorder. Method: Previously undiagnosed and untreated subjects with social anxiety disorder (generalized social phobia) were selected from among responders to a newspaper advertisement. They were randomized to double-blind treatment with paroxetine 20–50 mg daily or placebo for 3 months. Outcome measures were self-rated social anxiety and avoidance behaviour, and clinician-rated global assessment of improvement. Results: Significant differences in efficacy between treatments (intent-to-treat analysis: 44 subjects on paroxetine and 48 subjects on placebo) were noted after 4–6 weeks, increasing through the treatment period in the paroxetine group. Nine subjects on paroxetine and 3 subjects on placebo discontinued the treatment due to adverse events. Sexual side-effects were noted by 18 subjects on paroxetine and 4 subjects on placebo. Conclusion: Paroxetine was effective in alleviating symptoms and avoidance behaviour in social anxiety disorder.

Satoshi Asakura - One of the best experts on this subject based on the ideXlab platform.

Peter G Kremsner - One of the best experts on this subject based on the ideXlab platform.

  • randomised placebo controlled Study of atovaquone plus proguanil for malaria prophylaxis in children
    The Lancet, 1998
    Co-Authors: Bertrand Lell, Doris Luckner, Maryse Ndjave, Trevor Scott, Peter G Kremsner
    Abstract:

    Summary Background The combination of atovaquone and proguanil is highly effective and safe for the treatment of Plasmodium falciparum malaria. We aimed in this randomised, double-blind, Placebo-Controlled Study to assess the efficacy and safety of this combination for malaria prophylaxis. Methods 320 children who lived in a hyperendemic area for P falciparum malaria were stratified by weight and randomly assigned atovaquone plus proguanil or placebo once daily for 12 weeks. All children received initial curative treatment with atovaquone and proguanil before the start of chemosuppression. We recorded adverse events daily and collected thick blood smears once a week. The primary endpoint was a positive blood smear. Findings 25 of 140 children in the placebo group and none of the 125 children in the atovaquone plus proguanil group had positive smears during chemosuppression (p Interpretation The combination of atovaquone plus proguanil is a highly effective and well-tolerated chemosuppressive antimalarial in children. This drug combination could replace current regimens.

Dag S. Thelle - One of the best experts on this subject based on the ideXlab platform.