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Jurgen Debus - One of the best experts on this subject based on the ideXlab platform.
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evaluation of salivary gland function after treatment of head and neck tumors with intensity modulated radiotherapy by quantitative pertechnetate scintigraphy
International Journal of Radiation Oncology Biology Physics, 2004Co-Authors: Marc W Munter, Simone Hoffner, Volker Rudat, Christian P Karger, Christoph Thilmann, S Nill, Michael Wannenmacher, Jurgen DebusAbstract:Abstract Purpose To evaluate salivary gland function after inversely planned stereotactic intensity-modulated radiotherapy (IMRT) for tumors of the head-and-neck region using quantitative pertechnetate scintigraphy. Methods and materials Since January 2000, 18 patients undergoing IMRT for cancer of the head and neck underwent pre- and posttherapeutic scintigraphy to examine salivary gland function. The mean dose to the primary Planning target volume was 61.5 Gy (range 50.4–73.2), and the median follow-up was 23 months. In all cases, the parotid glands were directly adjacent to the Planning target volume. The treatment Planning Goal was for at least one parotid gland to receive a mean dose of Results Using IMRT, it was possible in 16 patients to reduce the dose for at least one parotid gland to ≤26 Gy. In 7 patients, protection of both parotid glands was possible. No recurrent disease adjacent to the protected parotid glands was observed. Using the Radiation Therapy Oncology Group/European Organization for the Research and Treatment of Cancer scoring system, only 3 patients had Grade 2 xerostomia. No greater toxicity was seen for the salivary glands. The change in the relative excretion rate was significantly greater, if the parotid glands received a mean dose of ≥26 Gy or ≥30 Gy. For the change in maximal uptake, a statistically significant difference was seen only for the parotid glands and a dose threshold of 30 Gy. For the end point of a reduction in the parotid excretion rate of >50% and 75%, the dose–response curves yielded a dose at 50% complication probability of 34.8 ± 3.6 and 40.8 ± 5.3 Gy, respectively. Conclusion Using IMRT, it is possible to protect the parotid glands and reduce the incidence and severity of xerostomia in patients. Doses
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evaluation of salivary gland function after treatment of head and neck tumors with intensity modulated radiotherapy by quantitative pertechnetate scintigraphy
International Journal of Radiation Oncology Biology Physics, 2004Co-Authors: Marc W Munter, Simone Hoffner, Volker Rudat, Christian P Karger, Christoph Thilmann, S Nill, Michael Wannenmacher, Holger Hof, Jurgen DebusAbstract:Abstract Purpose To evaluate salivary gland function after inversely planned stereotactic intensity-modulated radiotherapy (IMRT) for tumors of the head-and-neck region using quantitative pertechnetate scintigraphy. Methods and materials Since January 2000, 18 patients undergoing IMRT for cancer of the head and neck underwent pre- and posttherapeutic scintigraphy to examine salivary gland function. The mean dose to the primary Planning target volume was 61.5 Gy (range 50.4–73.2), and the median follow-up was 23 months. In all cases, the parotid glands were directly adjacent to the Planning target volume. The treatment Planning Goal was for at least one parotid gland to receive a mean dose of Results Using IMRT, it was possible in 16 patients to reduce the dose for at least one parotid gland to ≤26 Gy. In 7 patients, protection of both parotid glands was possible. No recurrent disease adjacent to the protected parotid glands was observed. Using the Radiation Therapy Oncology Group/European Organization for the Research and Treatment of Cancer scoring system, only 3 patients had Grade 2 xerostomia. No greater toxicity was seen for the salivary glands. The change in the relative excretion rate was significantly greater, if the parotid glands received a mean dose of ≥26 Gy or ≥30 Gy. For the change in maximal uptake, a statistically significant difference was seen only for the parotid glands and a dose threshold of 30 Gy. For the end point of a reduction in the parotid excretion rate of >50% and 75%, the dose–response curves yielded a dose at 50% complication probability of 34.8 ± 3.6 and 40.8 ± 5.3 Gy, respectively. Conclusion Using IMRT, it is possible to protect the parotid glands and reduce the incidence and severity of xerostomia in patients. Doses
Laura J. Gray - One of the best experts on this subject based on the ideXlab platform.
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Reducing sitting at work: process evaluation of the SMArT Work (Stand More At Work) intervention
Trials, 2020Co-Authors: Stuart J. H. Biddle, Sophie E. O’connell, Melanie J. Davies, David Dunstan, Charlotte L. Edwardson, Dale W. Esliger, Laura J. Gray, Thomas Yates, Fehmidah MunirAbstract:Background Office-based workers accumulate high amounts of sitting time. Stand More At Work (SMArT Work) aimed to reduce occupational sitting time and a cluster randomised controlled trial demonstrated it was successful in achieving this aim. The purpose of this paper is to present the process evaluation of the SMArT Work intervention. Methods Questionnaire data were collected from intervention participants at 6 months ( n = 58) and 12 months ( n = 55). Questionnaires sought feedback on the different components of the intervention (education, height-adjustable desk, Darma cushion, behaviour feedback, progress chats (coaching) with research team, action Planning/Goal setting diary) and experiences of evaluation measures. Control participants ( n = 37) were asked via questionnaire at 12-month follow-up about the impact of the study on their behaviour and any lifestyle changes made during the study. Participants from both arms were invited to focus groups to gain a deeper understanding of their experiences on completion of 12-month follow-up. Results Focus group and questionnaire data showed a positive attitude towards the height-adjustable workstation with a high proportion of participants using it every day (62%). Most participants (92%) felt the education seminar increased their awareness of the health consequences of too much sitting and motivated them to change their behaviour. Receiving feedback on their sitting time and support from the research team also encouraged behaviour change. The Darma cushion and action Planning/Goal setting diary were seen to be less helpful for behaviour change. Benefits experienced included fewer aches and pains, improved cognitive functioning, increased productivity, more energy and positive feelings about general health. Conclusions Key elements of the programme identified as facilitating behaviour change were the educational seminar, the height-adjustable workstation, behavioural feedback and regular contact with research staff through regular progress chats. Trial registration ISRCTN: ISRCTN10967042 . Registered on 2 February 2015.
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a three arm cluster randomised controlled trial to test the effectiveness and cost effectiveness of the smart work life intervention for reducing daily sitting time in office workers study protocol
BMC Public Health, 2018Co-Authors: Charlotte L. Edwardson, Stuart J. H. Biddle, Melanie J. Davies, A M Clarkecornwell, Stacy A Clemes, David W Dunstan, Helen Eborall, M H Granat, Laura J. GrayAbstract:Office-based workers typically spend 70–85% of working hours, and a large proportion of leisure time, sitting. High levels of sitting have been linked to poor health. There is a need for fully powered randomised controlled trials (RCTs) with long-term follow-up to test the effectiveness of interventions to reduce sitting. This paper describes the methodology of a three-arm cluster RCT designed to determine the effectiveness and cost-effectiveness of the SMART Work & Life intervention, delivered with and without a height-adjustable desk, for reducing daily sitting. A three-arm cluster RCT of 33 clusters (660 council workers) will be conducted in three areas in England (Leicester; Manchester; Liverpool). Office groups (clusters) will be randomised to the SMART Work & Life intervention delivered with (group 1) or without (group 2) a height-adjustable desk or a control group (group 3). SMART Work & Life includes organisational (e.g., management buy-in, provision/support for standing meetings), environmental (e.g., relocating waste bins, printers), and group/individual (education, action Planning, Goal setting, addressing barriers, coaching, self-monitoring, social support) level behaviour change strategies, with strategies driven by workplace champions. Baseline, 3, 12 and 24 month measures will be taken. Primary outcome: Objectively measured daily sitting time (activPAL3). Secondary outcomes: objectively measured sitting, standing, stepping, prolonged sitting and moderate-to-vigorous physical activity time and number of steps at work and daily; objectively measured sleep (wrist accelerometry). Adiposity, blood pressure, fasting glucose, glycated haemoglobin, cholesterol (total, HDL, LDL) and triglycerides will be assessed from capillary blood samples. Questionnaires will examine dietary intake, fatigue, musculoskeletal issues, job performance and satisfaction, work engagement, occupational and general fatigue, stress, presenteeism, anxiety and depression and sickness absence (organisational records). Quality of life and resources used (e.g. GP visits, outpatient attendances) will also be assessed. We will conduct a full process evaluation and cost-effectiveness analysis. The results of this RCT will 1) help to understand how effective an important simple, yet relatively expensive environmental change is for reducing sitting, 2) provide evidence on changing behaviour across all waking hours, and 3) provide evidence for policy guidelines around population and workplace health and well-being. ISRCTN11618007 . Registered on 21 January 2018.
Charlotte L. Edwardson - One of the best experts on this subject based on the ideXlab platform.
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Reducing sitting at work: process evaluation of the SMArT Work (Stand More At Work) intervention
Trials, 2020Co-Authors: Stuart J. H. Biddle, Sophie E. O’connell, Melanie J. Davies, David Dunstan, Charlotte L. Edwardson, Dale W. Esliger, Laura J. Gray, Thomas Yates, Fehmidah MunirAbstract:Background Office-based workers accumulate high amounts of sitting time. Stand More At Work (SMArT Work) aimed to reduce occupational sitting time and a cluster randomised controlled trial demonstrated it was successful in achieving this aim. The purpose of this paper is to present the process evaluation of the SMArT Work intervention. Methods Questionnaire data were collected from intervention participants at 6 months ( n = 58) and 12 months ( n = 55). Questionnaires sought feedback on the different components of the intervention (education, height-adjustable desk, Darma cushion, behaviour feedback, progress chats (coaching) with research team, action Planning/Goal setting diary) and experiences of evaluation measures. Control participants ( n = 37) were asked via questionnaire at 12-month follow-up about the impact of the study on their behaviour and any lifestyle changes made during the study. Participants from both arms were invited to focus groups to gain a deeper understanding of their experiences on completion of 12-month follow-up. Results Focus group and questionnaire data showed a positive attitude towards the height-adjustable workstation with a high proportion of participants using it every day (62%). Most participants (92%) felt the education seminar increased their awareness of the health consequences of too much sitting and motivated them to change their behaviour. Receiving feedback on their sitting time and support from the research team also encouraged behaviour change. The Darma cushion and action Planning/Goal setting diary were seen to be less helpful for behaviour change. Benefits experienced included fewer aches and pains, improved cognitive functioning, increased productivity, more energy and positive feelings about general health. Conclusions Key elements of the programme identified as facilitating behaviour change were the educational seminar, the height-adjustable workstation, behavioural feedback and regular contact with research staff through regular progress chats. Trial registration ISRCTN: ISRCTN10967042 . Registered on 2 February 2015.
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a three arm cluster randomised controlled trial to test the effectiveness and cost effectiveness of the smart work life intervention for reducing daily sitting time in office workers study protocol
BMC Public Health, 2018Co-Authors: Charlotte L. Edwardson, Stuart J. H. Biddle, Melanie J. Davies, A M Clarkecornwell, Stacy A Clemes, David W Dunstan, Helen Eborall, M H Granat, Laura J. GrayAbstract:Office-based workers typically spend 70–85% of working hours, and a large proportion of leisure time, sitting. High levels of sitting have been linked to poor health. There is a need for fully powered randomised controlled trials (RCTs) with long-term follow-up to test the effectiveness of interventions to reduce sitting. This paper describes the methodology of a three-arm cluster RCT designed to determine the effectiveness and cost-effectiveness of the SMART Work & Life intervention, delivered with and without a height-adjustable desk, for reducing daily sitting. A three-arm cluster RCT of 33 clusters (660 council workers) will be conducted in three areas in England (Leicester; Manchester; Liverpool). Office groups (clusters) will be randomised to the SMART Work & Life intervention delivered with (group 1) or without (group 2) a height-adjustable desk or a control group (group 3). SMART Work & Life includes organisational (e.g., management buy-in, provision/support for standing meetings), environmental (e.g., relocating waste bins, printers), and group/individual (education, action Planning, Goal setting, addressing barriers, coaching, self-monitoring, social support) level behaviour change strategies, with strategies driven by workplace champions. Baseline, 3, 12 and 24 month measures will be taken. Primary outcome: Objectively measured daily sitting time (activPAL3). Secondary outcomes: objectively measured sitting, standing, stepping, prolonged sitting and moderate-to-vigorous physical activity time and number of steps at work and daily; objectively measured sleep (wrist accelerometry). Adiposity, blood pressure, fasting glucose, glycated haemoglobin, cholesterol (total, HDL, LDL) and triglycerides will be assessed from capillary blood samples. Questionnaires will examine dietary intake, fatigue, musculoskeletal issues, job performance and satisfaction, work engagement, occupational and general fatigue, stress, presenteeism, anxiety and depression and sickness absence (organisational records). Quality of life and resources used (e.g. GP visits, outpatient attendances) will also be assessed. We will conduct a full process evaluation and cost-effectiveness analysis. The results of this RCT will 1) help to understand how effective an important simple, yet relatively expensive environmental change is for reducing sitting, 2) provide evidence on changing behaviour across all waking hours, and 3) provide evidence for policy guidelines around population and workplace health and well-being. ISRCTN11618007 . Registered on 21 January 2018.
Marc W Munter - One of the best experts on this subject based on the ideXlab platform.
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evaluation of salivary gland function after treatment of head and neck tumors with intensity modulated radiotherapy by quantitative pertechnetate scintigraphy
International Journal of Radiation Oncology Biology Physics, 2004Co-Authors: Marc W Munter, Simone Hoffner, Volker Rudat, Christian P Karger, Christoph Thilmann, S Nill, Michael Wannenmacher, Jurgen DebusAbstract:Abstract Purpose To evaluate salivary gland function after inversely planned stereotactic intensity-modulated radiotherapy (IMRT) for tumors of the head-and-neck region using quantitative pertechnetate scintigraphy. Methods and materials Since January 2000, 18 patients undergoing IMRT for cancer of the head and neck underwent pre- and posttherapeutic scintigraphy to examine salivary gland function. The mean dose to the primary Planning target volume was 61.5 Gy (range 50.4–73.2), and the median follow-up was 23 months. In all cases, the parotid glands were directly adjacent to the Planning target volume. The treatment Planning Goal was for at least one parotid gland to receive a mean dose of Results Using IMRT, it was possible in 16 patients to reduce the dose for at least one parotid gland to ≤26 Gy. In 7 patients, protection of both parotid glands was possible. No recurrent disease adjacent to the protected parotid glands was observed. Using the Radiation Therapy Oncology Group/European Organization for the Research and Treatment of Cancer scoring system, only 3 patients had Grade 2 xerostomia. No greater toxicity was seen for the salivary glands. The change in the relative excretion rate was significantly greater, if the parotid glands received a mean dose of ≥26 Gy or ≥30 Gy. For the change in maximal uptake, a statistically significant difference was seen only for the parotid glands and a dose threshold of 30 Gy. For the end point of a reduction in the parotid excretion rate of >50% and 75%, the dose–response curves yielded a dose at 50% complication probability of 34.8 ± 3.6 and 40.8 ± 5.3 Gy, respectively. Conclusion Using IMRT, it is possible to protect the parotid glands and reduce the incidence and severity of xerostomia in patients. Doses
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evaluation of salivary gland function after treatment of head and neck tumors with intensity modulated radiotherapy by quantitative pertechnetate scintigraphy
International Journal of Radiation Oncology Biology Physics, 2004Co-Authors: Marc W Munter, Simone Hoffner, Volker Rudat, Christian P Karger, Christoph Thilmann, S Nill, Michael Wannenmacher, Holger Hof, Jurgen DebusAbstract:Abstract Purpose To evaluate salivary gland function after inversely planned stereotactic intensity-modulated radiotherapy (IMRT) for tumors of the head-and-neck region using quantitative pertechnetate scintigraphy. Methods and materials Since January 2000, 18 patients undergoing IMRT for cancer of the head and neck underwent pre- and posttherapeutic scintigraphy to examine salivary gland function. The mean dose to the primary Planning target volume was 61.5 Gy (range 50.4–73.2), and the median follow-up was 23 months. In all cases, the parotid glands were directly adjacent to the Planning target volume. The treatment Planning Goal was for at least one parotid gland to receive a mean dose of Results Using IMRT, it was possible in 16 patients to reduce the dose for at least one parotid gland to ≤26 Gy. In 7 patients, protection of both parotid glands was possible. No recurrent disease adjacent to the protected parotid glands was observed. Using the Radiation Therapy Oncology Group/European Organization for the Research and Treatment of Cancer scoring system, only 3 patients had Grade 2 xerostomia. No greater toxicity was seen for the salivary glands. The change in the relative excretion rate was significantly greater, if the parotid glands received a mean dose of ≥26 Gy or ≥30 Gy. For the change in maximal uptake, a statistically significant difference was seen only for the parotid glands and a dose threshold of 30 Gy. For the end point of a reduction in the parotid excretion rate of >50% and 75%, the dose–response curves yielded a dose at 50% complication probability of 34.8 ± 3.6 and 40.8 ± 5.3 Gy, respectively. Conclusion Using IMRT, it is possible to protect the parotid glands and reduce the incidence and severity of xerostomia in patients. Doses
Stuart J. H. Biddle - One of the best experts on this subject based on the ideXlab platform.
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Reducing sitting at work: process evaluation of the SMArT Work (Stand More At Work) intervention
Trials, 2020Co-Authors: Stuart J. H. Biddle, Sophie E. O’connell, Melanie J. Davies, David Dunstan, Charlotte L. Edwardson, Dale W. Esliger, Laura J. Gray, Thomas Yates, Fehmidah MunirAbstract:Background Office-based workers accumulate high amounts of sitting time. Stand More At Work (SMArT Work) aimed to reduce occupational sitting time and a cluster randomised controlled trial demonstrated it was successful in achieving this aim. The purpose of this paper is to present the process evaluation of the SMArT Work intervention. Methods Questionnaire data were collected from intervention participants at 6 months ( n = 58) and 12 months ( n = 55). Questionnaires sought feedback on the different components of the intervention (education, height-adjustable desk, Darma cushion, behaviour feedback, progress chats (coaching) with research team, action Planning/Goal setting diary) and experiences of evaluation measures. Control participants ( n = 37) were asked via questionnaire at 12-month follow-up about the impact of the study on their behaviour and any lifestyle changes made during the study. Participants from both arms were invited to focus groups to gain a deeper understanding of their experiences on completion of 12-month follow-up. Results Focus group and questionnaire data showed a positive attitude towards the height-adjustable workstation with a high proportion of participants using it every day (62%). Most participants (92%) felt the education seminar increased their awareness of the health consequences of too much sitting and motivated them to change their behaviour. Receiving feedback on their sitting time and support from the research team also encouraged behaviour change. The Darma cushion and action Planning/Goal setting diary were seen to be less helpful for behaviour change. Benefits experienced included fewer aches and pains, improved cognitive functioning, increased productivity, more energy and positive feelings about general health. Conclusions Key elements of the programme identified as facilitating behaviour change were the educational seminar, the height-adjustable workstation, behavioural feedback and regular contact with research staff through regular progress chats. Trial registration ISRCTN: ISRCTN10967042 . Registered on 2 February 2015.
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a three arm cluster randomised controlled trial to test the effectiveness and cost effectiveness of the smart work life intervention for reducing daily sitting time in office workers study protocol
BMC Public Health, 2018Co-Authors: Charlotte L. Edwardson, Stuart J. H. Biddle, Melanie J. Davies, A M Clarkecornwell, Stacy A Clemes, David W Dunstan, Helen Eborall, M H Granat, Laura J. GrayAbstract:Office-based workers typically spend 70–85% of working hours, and a large proportion of leisure time, sitting. High levels of sitting have been linked to poor health. There is a need for fully powered randomised controlled trials (RCTs) with long-term follow-up to test the effectiveness of interventions to reduce sitting. This paper describes the methodology of a three-arm cluster RCT designed to determine the effectiveness and cost-effectiveness of the SMART Work & Life intervention, delivered with and without a height-adjustable desk, for reducing daily sitting. A three-arm cluster RCT of 33 clusters (660 council workers) will be conducted in three areas in England (Leicester; Manchester; Liverpool). Office groups (clusters) will be randomised to the SMART Work & Life intervention delivered with (group 1) or without (group 2) a height-adjustable desk or a control group (group 3). SMART Work & Life includes organisational (e.g., management buy-in, provision/support for standing meetings), environmental (e.g., relocating waste bins, printers), and group/individual (education, action Planning, Goal setting, addressing barriers, coaching, self-monitoring, social support) level behaviour change strategies, with strategies driven by workplace champions. Baseline, 3, 12 and 24 month measures will be taken. Primary outcome: Objectively measured daily sitting time (activPAL3). Secondary outcomes: objectively measured sitting, standing, stepping, prolonged sitting and moderate-to-vigorous physical activity time and number of steps at work and daily; objectively measured sleep (wrist accelerometry). Adiposity, blood pressure, fasting glucose, glycated haemoglobin, cholesterol (total, HDL, LDL) and triglycerides will be assessed from capillary blood samples. Questionnaires will examine dietary intake, fatigue, musculoskeletal issues, job performance and satisfaction, work engagement, occupational and general fatigue, stress, presenteeism, anxiety and depression and sickness absence (organisational records). Quality of life and resources used (e.g. GP visits, outpatient attendances) will also be assessed. We will conduct a full process evaluation and cost-effectiveness analysis. The results of this RCT will 1) help to understand how effective an important simple, yet relatively expensive environmental change is for reducing sitting, 2) provide evidence on changing behaviour across all waking hours, and 3) provide evidence for policy guidelines around population and workplace health and well-being. ISRCTN11618007 . Registered on 21 January 2018.