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Masayoshi Oikawa - One of the best experts on this subject based on the ideXlab platform.
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Plasma Volume status predicts prognosis in patients with acute heart failure syndromes
European heart journal. Acute cardiovascular care, 2018Co-Authors: Akiomi Yoshihisa, Satoshi Abe, Yu Sato, Shunsuke Watanabe, Tetsuro Yokokawa, Shunsuke Miura, Tomofumi Misaka, Takamasa Sato, Satoshi Suzuki, Masayoshi OikawaAbstract:Background:The intravascular compartment is known as the Plasma Volume, and the extravascular compartment represents fluid within the interstitial space. Plasma Volume expansion is a major symptom ...
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Plasma Volume status predicts prognosis in patients with acute heart failure syndromes.
European heart journal. Acute cardiovascular care, 2017Co-Authors: Akiomi Yoshihisa, Satoshi Abe, Yu Sato, Shunsuke Watanabe, Tetsuro Yokokawa, Shunsuke Miura, Tomofumi Misaka, Takamasa Sato, Satoshi Suzuki, Masayoshi OikawaAbstract:The intravascular compartment is known as the Plasma Volume, and the extravascular compartment represents fluid within the interstitial space. Plasma Volume expansion is a major symptom of heart failure. The aim of the current study was to investigate the impact of Plasma Volume status on the prognosis of acute heart failure syndromes. We analyzed 1115 patients with acute heart failure syndromes who were admitted to our hospital. These patients were divided into three groups based on their Plasma Volume status at admission: first tertile (Plasma Volume status <41.9%, n = 371), second tertile (41.9%⩽ Plasma Volume status <49.0%, n = 372), and third tertile (49.0%⩽ Plasma Volume status, n = 372). Plasma Volume status was defined as follows: actual Plasma Volume = (1 - hematocrit) × [ a + ( b × body weight)] ( a=1530 in males and a=864 in females, b=41.0 in males and b=47.9 in females); ideal Plasma Volume = c × body weight ( c=39 in males and c=40 in females); and Plasma Volume status = [(actual Plasma Volume - ideal Plasma Volume)/ideal Plasma Volume] × 100 (%). In the Kaplan-Meier analysis, all-cause mortality, cardiac mortality and cardiac events increased progressively from the first to third tertile ( p <0.001, respectively). In the Cox proportional hazard analysis, after adjusting for potential confounding factors, Plasma Volume status was an independent predictor of all-cause mortality (hazard ratio 1.429, p < 0.001), cardiac mortality (hazard ratio 1.416, p = 0.001) and cardiac events (hazard ratio 1.207, p = 0.004). Increased congestion is associated with increased morbidity and mortality in heart failure patients. Plasma Volume status, which represents intravascular compartment and congestion, can identify poor prognosis in patients with acute heart failure syndromes.
Ira M. Bernstein - One of the best experts on this subject based on the ideXlab platform.
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Platelet activation, sympathetic tone, and Plasma Volume in nulligravid women of reproductive age.
Obstetrics & Gynecology, 2004Co-Authors: Dana P Damron, Adrienne Schonberg, Robert E. Shapiro, Beth A Bouchard, Ira M. BernsteinAbstract:OBJECTIVE Preeclampsia is associated with increased platelet activation, increased sympathetic activity, and decreased Plasma Volume. We sought to estimate the relationship of Plasma Volume, sympathetic activity, or both to platelet activation in nonpregnant nulligravid women. METHODS We studied 37 healthy nulligravid subjects during the follicular phase of the menstrual cycle. After intravenous access was obtained, subjects rested in the supine position for 15 minutes. Blood was drawn without venous constriction for measurement of Plasma catecholamines (epinephrine and norepinephrine) and complete blood count. Antigenic markers of platelet activation, CD63 and CD61-CD14 (platelet-monocyte aggregates), were measured with flow cytometry. Plasma Volume was estimated in the supine position by using Evans blue dye and is expressed in milliliters and corrected for body mass index (BMI). We compared data from the lowest Plasma Volume/BMI quartile with the 2 middle quartiles combined and with the upper quartile. Data are expressed as mean +/- standard deviation. P
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Platelet activation, sympathetic tone, and Plasma Volume in nulligravid women of reproductive age.
Obstetrics and gynecology, 2004Co-Authors: Dana P Damron, Robert E. Shapiro, Beth A Bouchard, Adrienne L Schonberg, Ira M. BernsteinAbstract:Preeclampsia is associated with increased platelet activation, increased sympathetic activity, and decreased Plasma Volume. We sought to estimate the relationship of Plasma Volume, sympathetic activity, or both to platelet activation in nonpregnant nulligravid women. We studied 37 healthy nulligravid subjects during the follicular phase of the menstrual cycle. After intravenous access was obtained, subjects rested in the supine position for 15 minutes. Blood was drawn without venous constriction for measurement of Plasma catecholamines (epinephrine and norepinephrine) and complete blood count. Antigenic markers of platelet activation, CD63 and CD61-CD14 (platelet-monocyte aggregates), were measured with flow cytometry. Plasma Volume was estimated in the supine position by using Evans blue dye and is expressed in milliliters and corrected for body mass index (BMI). We compared data from the lowest Plasma Volume/BMI quartile with the 2 middle quartiles combined and with the upper quartile. Data are expressed as mean +/- standard deviation. P <.05 was considered significant. Subjects were aged 26.5 +/- 5.0 years, BMI was 24.0 +/- 3.0 kg/m(2), and Plasma Volume was 2,685 +/- 429 mL. We identified no significant relationship of platelet concentration to Plasma Volume/BMI between quartile groups (P =.944). However, there was a significant difference between quartiles for %CD63 expression (P =.013) and for CD61/CD14 expression (P =.018), with the lowest quartile demonstrating elevated platelet activation. We found evidence that enhanced platelet activation is associated with reduced Plasma Volume, but not with Plasma catecholamine concentrations. There was no association of platelet concentration with reduced Plasma Volume. We speculate that elements of the clinical syndrome of preeclampsia coexist as a subclinical phenotype before pregnancy.
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Relationship of Plasma Volume to sympathetic tone in nulliparous women.
American journal of obstetrics and gynecology, 2003Co-Authors: Ira M. Bernstein, Robert E. Shapiro, Amy I. Whitsel, Adrienne SchonbergAbstract:We sought to determine whether resting supine Plasma Volume is related to sympathetic tone in healthy young nulligravid normotensive women. Forty women were examined in the midfollicular phase. Alpha-adrenergic tone was estimated by an examination of the late phase II blood pressure response to the Valsalva maneuver. Resting heart rate was examined to evaluate the balance of sympathetic and parasympathetic input. Plasma catecholamines were measured during supine rest. Plasma Volume was estimated by Evans blue dilution. Plasma Volume corrected for body surface area was correlated inversely to late phase II blood pressure response to the Valsalva maneuver (r = -0.31, P <.05) and was correlated directly to the cardiac R-R interval (r = 0.41, P <.01). There was no relationship of Plasma Volume corrected for body surface area to mean arterial pressure (r = -0.13, P not significant). We found no significant relationship of Plasma epinephrine concentration (r = -0.05, P =.76) or Plasma norepinephrine (r = -0.09, P =.60) with Plasma Volume corrected for body surface area. We conclude that Plasma Volume is related inversely to both an estimate of alpha-adrenergic activation and heart rate. These findings are consistent with an adaptive physiologic response that is aimed at the maintenance of blood pressure in the face of reduced Plasma Volume.
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Angiotensinogen genotype and Plasma Volume in nulligravid women
Obstetrics and gynecology, 1998Co-Authors: Ira M. Bernstein, William F. Ziegler, William S. Stirewalt, John R. Brumsted, Kenneth WardAbstract:Objective: To determine if nonpregnant Plasma Volume is altered in women who are homozygous for the T 235 coding angiotensinogen allele, which predisposes women to an increased risk of preeclampsia. Methods: We measured Plasma Volume by Evans blue dilution and analyzed it as a function of angiotensinogen genotype in 15 nulligravid women during midfollicular phase of 26 menstrual cycles. Eleven women were evaluated during two cycles, and four women were evaluated in one cycle. Fourteen women were white, and one was Asian. No subjects had illnesses or were taking medication. The range of body mass index (BMI [kg/m2]) was 20.2–31.0. Plasma Volume (mL) was reported as Plasma Volume divided by BMI to control for variations in body sizes. Statistical analysis was performed by analysis of variance with post hoc testing using Fisher least significant difference test for multiple comparisons (P < .05 accepted for significance). Results: Angiotensinogen genotype analysis showed five women homozygous for M 235, three women homozygous for T 235, and seven women who were heterozygous (MT 235). T 235 homozygotes had significantly lower Plasma Volume divided by BMI compared with women who were homozygous for M 235 and women who were heterozygous for MT 235 (mean + standard deviation [SD] [71.2 + 8.8, 86.6 + 5.2, 95.8 + 15.6, respectively, P < .05]). There was a tendency toward higher Plasma Volume in heterozygote MT 235 compared with homozygote M 235 carriers, but it was not statistically significant. Conclusion: We conclude that the homozygous T 235 coding angiotensinogen genotype is associated with reduced Plasma Volume in nulligravid women during the follicular phase of the menstrual cycle compared with M 235 homozygotes and heterozygotes. This association of the T 235 coding genotype might contribute to fetal growth restriction in preeclampsia.
Chun K. Kim - One of the best experts on this subject based on the ideXlab platform.
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Analysis of Red Cell Mass and Plasma Volume in Patients With Polycythemia
Archives of pathology & laboratory medicine, 2005Co-Authors: Mordechai Lorberboym, Naomi Rahimi-levene, Helena Lipszyc, Chun K. KimAbstract:Abstract Context.—Polycythemia describes an increased proportion of red blood cells in the peripheral blood. In absolute polycythemia, there is increased red cell mass (RCM) with normal Plasma Volume, in contrast with apparent polycythemia, in which there is increased or normal RCM and decreased Plasma Volume. In order to deliver the appropriate treatment it is necessary to differentiate between the two. Objective.—A retrospective analysis of RCM and Plasma Volume data are presented, with special attention to different methods of RCM interpretation. Design.—The measurements of RCM and Plasma Volume in 64 patients were compared with the venous and whole-body packed cell Volume, and the incidence of absolute and apparent polycythemia was determined for increasing hematocrit levels. Measurements of RCM and Plasma Volume were performed using chromium 51–labeled red cells and iodine 125–labeled albumin, respectively. The measured RCM of each patient was expressed as a percentage of the mean expected RCM and wa...
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Analysis of Red Cell Mass and Plasma Volume in Patients With Polycythemia
Archives of Pathology & Laboratory Medicine, 2005Co-Authors: Mordechai Lorberboym, Naomi Rahimi-levene, Helena Lipszyc, Chun K. KimAbstract:Abstract Context.—Polycythemia describes an increased proportion of red blood cells in the peripheral blood. In absolute polycythemia, there is increased red cell mass (RCM) with normal Plasma Volume, in contrast with apparent polycythemia, in which there is increased or normal RCM and decreased Plasma Volume. In order to deliver the appropriate treatment it is necessary to differentiate between the two. Objective.—A retrospective analysis of RCM and Plasma Volume data are presented, with special attention to different methods of RCM interpretation. Design.—The measurements of RCM and Plasma Volume in 64 patients were compared with the venous and whole-body packed cell Volume, and the incidence of absolute and apparent polycythemia was determined for increasing hematocrit levels. Measurements of RCM and Plasma Volume were performed using chromium 51–labeled red cells and iodine 125–labeled albumin, respectively. The measured RCM of each patient was expressed as a percentage of the mean expected RCM and was also defined as being within or outside the range of 2 SD of the mean. The results were also expressed in the traditional manner of mL/kg body weight. Results.—Twenty-one patients (13 women and 8 men) had absolute polycythemia. None of them had an increased Plasma Volume beyond 2 SD of the mean. When expressed according to the criteria of mL/kg body weight, 17 of the 21 patients had abnormally increased RCM, but 4 patients (19%) had a normal RCM value. Twenty-eight patients had apparent polycythemia. The remaining 15 patients had normal RCM and Plasma Volume. Conclusions.—The measurement of RCM and Plasma Volume is a simple and necessary procedure in the evaluation of polycythemia. In obese patients, the expression of RCM in mL/kg body weight lacks precision, considering that adipose tissue is hypovascular. The results of RCM are best described as being within or beyond 2 SD of the mean value.
Akiomi Yoshihisa - One of the best experts on this subject based on the ideXlab platform.
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Plasma Volume status predicts prognosis in patients with acute heart failure syndromes
European heart journal. Acute cardiovascular care, 2018Co-Authors: Akiomi Yoshihisa, Satoshi Abe, Yu Sato, Shunsuke Watanabe, Tetsuro Yokokawa, Shunsuke Miura, Tomofumi Misaka, Takamasa Sato, Satoshi Suzuki, Masayoshi OikawaAbstract:Background:The intravascular compartment is known as the Plasma Volume, and the extravascular compartment represents fluid within the interstitial space. Plasma Volume expansion is a major symptom ...
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Plasma Volume status predicts prognosis in patients with acute heart failure syndromes.
European heart journal. Acute cardiovascular care, 2017Co-Authors: Akiomi Yoshihisa, Satoshi Abe, Yu Sato, Shunsuke Watanabe, Tetsuro Yokokawa, Shunsuke Miura, Tomofumi Misaka, Takamasa Sato, Satoshi Suzuki, Masayoshi OikawaAbstract:The intravascular compartment is known as the Plasma Volume, and the extravascular compartment represents fluid within the interstitial space. Plasma Volume expansion is a major symptom of heart failure. The aim of the current study was to investigate the impact of Plasma Volume status on the prognosis of acute heart failure syndromes. We analyzed 1115 patients with acute heart failure syndromes who were admitted to our hospital. These patients were divided into three groups based on their Plasma Volume status at admission: first tertile (Plasma Volume status <41.9%, n = 371), second tertile (41.9%⩽ Plasma Volume status <49.0%, n = 372), and third tertile (49.0%⩽ Plasma Volume status, n = 372). Plasma Volume status was defined as follows: actual Plasma Volume = (1 - hematocrit) × [ a + ( b × body weight)] ( a=1530 in males and a=864 in females, b=41.0 in males and b=47.9 in females); ideal Plasma Volume = c × body weight ( c=39 in males and c=40 in females); and Plasma Volume status = [(actual Plasma Volume - ideal Plasma Volume)/ideal Plasma Volume] × 100 (%). In the Kaplan-Meier analysis, all-cause mortality, cardiac mortality and cardiac events increased progressively from the first to third tertile ( p <0.001, respectively). In the Cox proportional hazard analysis, after adjusting for potential confounding factors, Plasma Volume status was an independent predictor of all-cause mortality (hazard ratio 1.429, p < 0.001), cardiac mortality (hazard ratio 1.416, p = 0.001) and cardiac events (hazard ratio 1.207, p = 0.004). Increased congestion is associated with increased morbidity and mortality in heart failure patients. Plasma Volume status, which represents intravascular compartment and congestion, can identify poor prognosis in patients with acute heart failure syndromes.
Adrienne Schonberg - One of the best experts on this subject based on the ideXlab platform.
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Platelet activation, sympathetic tone, and Plasma Volume in nulligravid women of reproductive age.
Obstetrics & Gynecology, 2004Co-Authors: Dana P Damron, Adrienne Schonberg, Robert E. Shapiro, Beth A Bouchard, Ira M. BernsteinAbstract:OBJECTIVE Preeclampsia is associated with increased platelet activation, increased sympathetic activity, and decreased Plasma Volume. We sought to estimate the relationship of Plasma Volume, sympathetic activity, or both to platelet activation in nonpregnant nulligravid women. METHODS We studied 37 healthy nulligravid subjects during the follicular phase of the menstrual cycle. After intravenous access was obtained, subjects rested in the supine position for 15 minutes. Blood was drawn without venous constriction for measurement of Plasma catecholamines (epinephrine and norepinephrine) and complete blood count. Antigenic markers of platelet activation, CD63 and CD61-CD14 (platelet-monocyte aggregates), were measured with flow cytometry. Plasma Volume was estimated in the supine position by using Evans blue dye and is expressed in milliliters and corrected for body mass index (BMI). We compared data from the lowest Plasma Volume/BMI quartile with the 2 middle quartiles combined and with the upper quartile. Data are expressed as mean +/- standard deviation. P
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Relationship of Plasma Volume to sympathetic tone in nulliparous women.
American journal of obstetrics and gynecology, 2003Co-Authors: Ira M. Bernstein, Robert E. Shapiro, Amy I. Whitsel, Adrienne SchonbergAbstract:We sought to determine whether resting supine Plasma Volume is related to sympathetic tone in healthy young nulligravid normotensive women. Forty women were examined in the midfollicular phase. Alpha-adrenergic tone was estimated by an examination of the late phase II blood pressure response to the Valsalva maneuver. Resting heart rate was examined to evaluate the balance of sympathetic and parasympathetic input. Plasma catecholamines were measured during supine rest. Plasma Volume was estimated by Evans blue dilution. Plasma Volume corrected for body surface area was correlated inversely to late phase II blood pressure response to the Valsalva maneuver (r = -0.31, P <.05) and was correlated directly to the cardiac R-R interval (r = 0.41, P <.01). There was no relationship of Plasma Volume corrected for body surface area to mean arterial pressure (r = -0.13, P not significant). We found no significant relationship of Plasma epinephrine concentration (r = -0.05, P =.76) or Plasma norepinephrine (r = -0.09, P =.60) with Plasma Volume corrected for body surface area. We conclude that Plasma Volume is related inversely to both an estimate of alpha-adrenergic activation and heart rate. These findings are consistent with an adaptive physiologic response that is aimed at the maintenance of blood pressure in the face of reduced Plasma Volume.