The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Jonathan Tobis - One of the best experts on this subject based on the ideXlab platform.
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Platypnea orthodeoxia syndrome an overlooked cause of hypoxemia
Jacc-cardiovascular Interventions, 2016Co-Authors: Jonathan Tobis, Islam AbudayyehAbstract:Platypnea-orthodeoxia syndrome (POS) is one of those onomatopoeic medical terms that is difficult to say but packs a lot of information into a short phrase. It describes a condition where patients are significantly hypoxemic and short of breath in the upright position but may have near-normal oxygen
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Platypnea-ORTHODEOXIA SYNDROME: A RARE CAUSE OF UNEXPLAINED HYPOXIA
Journal of the American College of Cardiology, 2016Co-Authors: Ninel Hovnanians, Mohammad K. Mojadidi, John Brandt, Jonathan TobisAbstract:Platypnea-orthodeoxia (POD) is a rare syndrome described by dyspnea and hypoxemia while upright that improves on recumbence. It is associated with an intracardiac shunt, pulmonary AVM, ventilation-perfusion mismatch or a combination of these. A 53-year-old woman was referred for unexplained hypoxia
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the effect of patent foramen ovale closure in patients with Platypnea orthodeoxia syndrome
Catheterization and Cardiovascular Interventions, 2015Co-Authors: Mohammad Khalid Mojadidi, Rubine Gevorgyan, Nabil Noureddin, Jonathan TobisAbstract:Author(s): Mojadidi, Mohammad Khalid; Gevorgyan, Rubine; Noureddin, Nabil; Tobis, Jonathan M | Abstract: Platypnea-orthodeoxia syndrome is a rare condition characterized by hypoxemia in the upright position that is improved in the supine position. Although several etiologies of Platypnea-orthodeoxia exist, it is frequently associated with right-to-left shunting of blood at the cardiac or pulmonary level, usually via a patent foramen ovale (PFO). The aim of this study was to evaluate the incidence of Platypnea-orthodeoxia syndrome in a select patient population with right-to-left shunting and to describe the outcomes after PFO closure.Patients with Platypnea-orthodeoxia were prospectively identified from a population of patients who had a PFO and were referred to UCLA from 2001 to 2012. Those patients who elected to have their PFO closed were assessed for the severity of their symptoms and interval SaO2 changes. The changes in SaO2 before and after closure were compared in the supine and upright position. Patients were classified depending on the result of PFO closure as having "improved SaO2 " or "no change."Of 683 patients with PFO-associated conditions, 17 (2.5%) had Platypnea-orthodeoxia and elected to close their PFO. The results in 11 of 17 patients (64.8%) were classified as having "improved SaO2 "; they experienced improvement or complete resolution of their dyspnea and hypoxemia (improved SaO2 from baseline 5.2 ± 4.7% when recumbent and 15.6 ± 3.0% when upright, P = 0.03 and P l 0.0001, respectively). Patients with no change after PFO closure predominantly had a pulmonary etiology for their hypoxia, with elevated mean pulmonary pressures measured before closure (51.4 ±16.8 mmHg, P = 0.06).PFO closure may resolve symptomatic postural dyspnea and hypoxemia and is an effective method for treating Platypnea-orthodeoxia, but is not effective when the primary etiology of the hypoxemia is due to a pulmonary cause.
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the effect of patent foramen ovale closure in patients with Platypnea orthodeoxia syndrome
Catheterization and Cardiovascular Interventions, 2015Co-Authors: Mohammad Khalid Mojadidi, Rubine Gevorgyan, Nabil Noureddin, Jonathan TobisAbstract:Author(s): Mojadidi, Mohammad Khalid; Gevorgyan, Rubine; Noureddin, Nabil; Tobis, Jonathan M | Abstract: BackgroundPlatypnea-orthodeoxia syndrome is a rare condition characterized by hypoxemia in the upright position that is improved in the supine position. Although several etiologies of Platypnea-orthodeoxia exist, it is frequently associated with right-to-left shunting of blood at the cardiac or pulmonary level, usually via a patent foramen ovale (PFO). The aim of this study was to evaluate the incidence of Platypnea-orthodeoxia syndrome in a select patient population with right-to-left shunting and to describe the outcomes after PFO closure.MethodsPatients with Platypnea-orthodeoxia were prospectively identified from a population of patients who had a PFO and were referred to UCLA from 2001 to 2012. Those patients who elected to have their PFO closed were assessed for the severity of their symptoms and interval SaO2 changes. The changes in SaO2 before and after closure were compared in the supine and upright position. Patients were classified depending on the result of PFO closure as having "improved SaO2 " or "no change."ResultsOf 683 patients with PFO-associated conditions, 17 (2.5%) had Platypnea-orthodeoxia and elected to close their PFO. The results in 11 of 17 patients (64.8%) were classified as having "improved SaO2 "; they experienced improvement or complete resolution of their dyspnea and hypoxemia (improved SaO2 from baseline 5.2 ± 4.7% when recumbent and 15.6 ± 3.0% when upright, P = 0.03 and P l 0.0001, respectively). Patients with no change after PFO closure predominantly had a pulmonary etiology for their hypoxia, with elevated mean pulmonary pressures measured before closure (51.4 ±16.8 mmHg, P = 0.06).ConclusionPFO closure may resolve symptomatic postural dyspnea and hypoxemia and is an effective method for treating Platypnea-orthodeoxia, but is not effective when the primary etiology of the hypoxemia is due to a pulmonary cause.
Yutaka Hatani - One of the best experts on this subject based on the ideXlab platform.
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a case of sudden onset of Platypnea orthodeoxia syndrome caused by traumatic tricuspid regurgitation with ruptured chordae tendineae after blunt chest trauma
Journal of the American College of Cardiology, 2019Co-Authors: Yutaka Hatani, Hidekazu Tanaka, Fumitaka Soga, Nao Shibata, Shun Yokota, Jun Mukai, Makiko Suto, Hiroki Takada, Kumiko Dokuni, Keiko HatazawaAbstract:Platypnea orthodeoxia syndrome (POS) is a disease which is characterized by hypoxemia and dyspnea in the upright position, but an oxygen saturation level is nearly normal in the supine position. It is a rare disorder which is usually associated with right-to-left shunt through a patent foramen ovale
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sudden onset of Platypnea orthodeoxia syndrome caused by traumatic tricuspid regurgitation with ruptured chordae tendineae after blunt chest trauma
Canadian Journal of Cardiology, 2018Co-Authors: Yutaka Hatani, Hidekazu Tanaka, Akane Kajiura, Daisuke Tsuda, Yoichiro Matsuoka, Hiroyuki Kawamori, Fumitaka Soga, Kensuke Matsumoto, Takeshi Inoue, Yutaka OkitaAbstract:Abstract An 86-year-old man was admitted our hospital because of sudden onset of dyspnea after blunt chest trauma. Because his oxygen saturation deteriorated from 92% in the supine position to 86% in the sitting position, Platypnea-orthodeoxia syndrome was suspected. Transesophageal echocardiography showed severe tricuspid regurgitation (TR) caused by anterior papillary muscle rupture. Furthermore, right-to-left shunt with TR through a patent foramen ovale (PFO) was observed. The diagnosis was therefore Platypnea-orthodeoxia syndrome with right-to-left shunt through PFO with shunting exacerbated by acute severe TR after blunt chest trauma. The patient underwent urgent tricuspid valve repair and PFO closure and has remained asymptomatic postoperatively.
Yutaka Okita - One of the best experts on this subject based on the ideXlab platform.
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sudden onset of Platypnea orthodeoxia syndrome caused by traumatic tricuspid regurgitation with ruptured chordae tendineae after blunt chest trauma
Canadian Journal of Cardiology, 2018Co-Authors: Yutaka Hatani, Hidekazu Tanaka, Akane Kajiura, Daisuke Tsuda, Yoichiro Matsuoka, Hiroyuki Kawamori, Fumitaka Soga, Kensuke Matsumoto, Takeshi Inoue, Yutaka OkitaAbstract:Abstract An 86-year-old man was admitted our hospital because of sudden onset of dyspnea after blunt chest trauma. Because his oxygen saturation deteriorated from 92% in the supine position to 86% in the sitting position, Platypnea-orthodeoxia syndrome was suspected. Transesophageal echocardiography showed severe tricuspid regurgitation (TR) caused by anterior papillary muscle rupture. Furthermore, right-to-left shunt with TR through a patent foramen ovale (PFO) was observed. The diagnosis was therefore Platypnea-orthodeoxia syndrome with right-to-left shunt through PFO with shunting exacerbated by acute severe TR after blunt chest trauma. The patient underwent urgent tricuspid valve repair and PFO closure and has remained asymptomatic postoperatively.
Hidekazu Tanaka - One of the best experts on this subject based on the ideXlab platform.
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a case of sudden onset of Platypnea orthodeoxia syndrome caused by traumatic tricuspid regurgitation with ruptured chordae tendineae after blunt chest trauma
Journal of the American College of Cardiology, 2019Co-Authors: Yutaka Hatani, Hidekazu Tanaka, Fumitaka Soga, Nao Shibata, Shun Yokota, Jun Mukai, Makiko Suto, Hiroki Takada, Kumiko Dokuni, Keiko HatazawaAbstract:Platypnea orthodeoxia syndrome (POS) is a disease which is characterized by hypoxemia and dyspnea in the upright position, but an oxygen saturation level is nearly normal in the supine position. It is a rare disorder which is usually associated with right-to-left shunt through a patent foramen ovale
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sudden onset of Platypnea orthodeoxia syndrome caused by traumatic tricuspid regurgitation with ruptured chordae tendineae after blunt chest trauma
Canadian Journal of Cardiology, 2018Co-Authors: Yutaka Hatani, Hidekazu Tanaka, Akane Kajiura, Daisuke Tsuda, Yoichiro Matsuoka, Hiroyuki Kawamori, Fumitaka Soga, Kensuke Matsumoto, Takeshi Inoue, Yutaka OkitaAbstract:Abstract An 86-year-old man was admitted our hospital because of sudden onset of dyspnea after blunt chest trauma. Because his oxygen saturation deteriorated from 92% in the supine position to 86% in the sitting position, Platypnea-orthodeoxia syndrome was suspected. Transesophageal echocardiography showed severe tricuspid regurgitation (TR) caused by anterior papillary muscle rupture. Furthermore, right-to-left shunt with TR through a patent foramen ovale (PFO) was observed. The diagnosis was therefore Platypnea-orthodeoxia syndrome with right-to-left shunt through PFO with shunting exacerbated by acute severe TR after blunt chest trauma. The patient underwent urgent tricuspid valve repair and PFO closure and has remained asymptomatic postoperatively.
Fumitaka Soga - One of the best experts on this subject based on the ideXlab platform.
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a case of sudden onset of Platypnea orthodeoxia syndrome caused by traumatic tricuspid regurgitation with ruptured chordae tendineae after blunt chest trauma
Journal of the American College of Cardiology, 2019Co-Authors: Yutaka Hatani, Hidekazu Tanaka, Fumitaka Soga, Nao Shibata, Shun Yokota, Jun Mukai, Makiko Suto, Hiroki Takada, Kumiko Dokuni, Keiko HatazawaAbstract:Platypnea orthodeoxia syndrome (POS) is a disease which is characterized by hypoxemia and dyspnea in the upright position, but an oxygen saturation level is nearly normal in the supine position. It is a rare disorder which is usually associated with right-to-left shunt through a patent foramen ovale
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sudden onset of Platypnea orthodeoxia syndrome caused by traumatic tricuspid regurgitation with ruptured chordae tendineae after blunt chest trauma
Canadian Journal of Cardiology, 2018Co-Authors: Yutaka Hatani, Hidekazu Tanaka, Akane Kajiura, Daisuke Tsuda, Yoichiro Matsuoka, Hiroyuki Kawamori, Fumitaka Soga, Kensuke Matsumoto, Takeshi Inoue, Yutaka OkitaAbstract:Abstract An 86-year-old man was admitted our hospital because of sudden onset of dyspnea after blunt chest trauma. Because his oxygen saturation deteriorated from 92% in the supine position to 86% in the sitting position, Platypnea-orthodeoxia syndrome was suspected. Transesophageal echocardiography showed severe tricuspid regurgitation (TR) caused by anterior papillary muscle rupture. Furthermore, right-to-left shunt with TR through a patent foramen ovale (PFO) was observed. The diagnosis was therefore Platypnea-orthodeoxia syndrome with right-to-left shunt through PFO with shunting exacerbated by acute severe TR after blunt chest trauma. The patient underwent urgent tricuspid valve repair and PFO closure and has remained asymptomatic postoperatively.