The Experts below are selected from a list of 249 Experts worldwide ranked by ideXlab platform
Isadore Kanfer - One of the best experts on this subject based on the ideXlab platform.
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Release of acyclovir from semi-solid dosage forms: A semi-automated procedure using a simple Plexiglass flow-through cell
International Journal of Pharmaceutics, 1995Co-Authors: S.c. Chattaraj, Isadore KanferAbstract:Abstract A simple Plexiglass flow-through cell (PFTC) was designed and utilized to monitor the release of acyclovir from two different semi-solid preparations. The influence of membrane type, flow rate and temperature was investigated. A small difference in temperature (32–37°C) had a significant effect on the release rate as did increasing flow rates from 2.9 to 10.0 ml/min. Cellulose acetate membranes showed a greater degree of release when compared with polytetrafluoroethylene and polyvinylidine difluoride membranes. The rank order of release of acyclovir between the two different semi-solid preparations remained the same irrespective of the membrane type, flow rate or temperature used during these studies. Data obtained from these experiments indicate that the Plexiglass flow-through cell is a simple, reproducible and reliable tool which can be readily applied to assess the pharmaceutical availability of drugs from semi-solid dosage forms.
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A simple diffusion cell to monitor drug release from semi-solid dosage forms
International Journal of Pharmaceutics, 1995Co-Authors: S.c. Chattaraj, J. Swarbrick, Isadore KanferAbstract:Abstract A simple Plexiglass cell was constructed and the in vitro release of acyclovir and diclofenac from semi-solid dosage forms was monitored using nylon and cellulose acetate membranes. The release of acyclovir was also monitored using Franz diffusion cells. Comparison of the data indicated that the rank order of release of acyclovir was the same using either the Plexiglass or the Franz cells. However, data from the Plexiglass cells indicated that better precision was obtained using this system as reflected by the much lower degree of variability between replicate experiments compared to the results obtained using the Franz cells. The results clearly indicate that the Plexiglass cells provide a simple, precise and reliable system to monitor in vitro drug release from semi-solid dosage forms and do not suffer from the problem of having to remove air bubbles at the membrane/liquid interface which often occurs when using the Franz cells.
S.c. Chattaraj - One of the best experts on this subject based on the ideXlab platform.
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Release of acyclovir from semi-solid dosage forms: A semi-automated procedure using a simple Plexiglass flow-through cell
International Journal of Pharmaceutics, 1995Co-Authors: S.c. Chattaraj, Isadore KanferAbstract:Abstract A simple Plexiglass flow-through cell (PFTC) was designed and utilized to monitor the release of acyclovir from two different semi-solid preparations. The influence of membrane type, flow rate and temperature was investigated. A small difference in temperature (32–37°C) had a significant effect on the release rate as did increasing flow rates from 2.9 to 10.0 ml/min. Cellulose acetate membranes showed a greater degree of release when compared with polytetrafluoroethylene and polyvinylidine difluoride membranes. The rank order of release of acyclovir between the two different semi-solid preparations remained the same irrespective of the membrane type, flow rate or temperature used during these studies. Data obtained from these experiments indicate that the Plexiglass flow-through cell is a simple, reproducible and reliable tool which can be readily applied to assess the pharmaceutical availability of drugs from semi-solid dosage forms.
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A simple diffusion cell to monitor drug release from semi-solid dosage forms
International Journal of Pharmaceutics, 1995Co-Authors: S.c. Chattaraj, J. Swarbrick, Isadore KanferAbstract:Abstract A simple Plexiglass cell was constructed and the in vitro release of acyclovir and diclofenac from semi-solid dosage forms was monitored using nylon and cellulose acetate membranes. The release of acyclovir was also monitored using Franz diffusion cells. Comparison of the data indicated that the rank order of release of acyclovir was the same using either the Plexiglass or the Franz cells. However, data from the Plexiglass cells indicated that better precision was obtained using this system as reflected by the much lower degree of variability between replicate experiments compared to the results obtained using the Franz cells. The results clearly indicate that the Plexiglass cells provide a simple, precise and reliable system to monitor in vitro drug release from semi-solid dosage forms and do not suffer from the problem of having to remove air bubbles at the membrane/liquid interface which often occurs when using the Franz cells.
T Mashhoodi - One of the best experts on this subject based on the ideXlab platform.
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Chronology of blood pressure changes in renal hypertension induced by solid Plexiglass clips in the rat.
Iranian Journal of Veterinary Research, 2007Co-Authors: Ali Akbar Nekooeian, T MashhoodiAbstract:Summary The objective of this study was to determine the chronology of changes in blood pressure in renal hypertension induced by solid Plexiglass clips in rats. Saw blades with the thickness of 0.21-0.22 mm were used to make clips sized 4 × 2 × 2 mm from a piece of 2-mm thick Plexiglass. Rats were subjected to sham- operation or left renal arterial clipping, and 1, 2, 3 and 4 weeks later blood pressure, and heart and kidneys weights were determined. Relative to those of sham-operated rats, mean blood pressure of left renal artery- clipped rats were significantly higher at week 1 through 4 after clipping. Left renal artery clipping was also associated with significant increases in heart and right kidney weights and significant decrease in left kidney weight. The findings suggest that clipping of left renal artery using solid Plexiglass clips resulted in changes in blood pressure, heart and left and right kidneys weights similar to reported changes in hypertension induced by silver clips.
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Solid Plexiglass clips to induce reproducible renal hypertension in the rat
Indian Journal of Pharmacology, 2007Co-Authors: Ali Akbar Nekooeian, T MashhoodiAbstract:Objective: The objective of this study was to induce reproducible renal hypertension in rats using Plexiglass clips, and to compare it with that induced by silver clips. Materials and Methods: Saw blades (0.21-0.22 mm thick ) were used to make clips (4 x 2 x 2 mm) from a piece of 2-mm thick Plexiglass. Rats were subjected to sham-operation or placement of Plexiglass or silver clips around left renal artery, and 4 weeks later their mean blood pressure (MBP, mmHg), heart rate (HR, bpm), and heart weight (HW), left kidney weight (LKW), right kidney weight (RKW) and body weight (BW, g) were determined. The RKW, LKW and HW were calculated as a percentage of body weight. Results: Four weeks after sham-operation or placement of clips around renal artery, MBP, HW and RKW were significantly higher and LKW was significantly lower in left renal artery-clipped rats using Plexiglass or silver clips than sham-operated ones. There was also no significant differnce among the values of HR or BW from the 3 groups. Moreover, there was no significant difference among MBP, HR, LKW, RKW or BW from sham-operated or renal artery-clipped rats. Conclusion: The findings suggest that placement of solid Plexiglass clips around left renal artery resulted in hypertension comparable to that induced by silver clips.
Muthanna H Aldahhan - One of the best experts on this subject based on the ideXlab platform.
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study the effect of dense internals on the liquid velocity field and turbulent parameters in bubble column for fischer tropsch ft synthesis by using radioactive particle tracking rpt technique
Chemical Engineering Science, 2017Co-Authors: Mohammed Al K Mesfer, Abbas Jawad Sultan, Muthanna H AldahhanAbstract:Abstract In this study, the effects of the dense vertical internals on the liquid velocity field and turbulence parameters (Reynolds stresses, turbulent kinetic energy, and turbulent eddy diffusivities) are experimentally investigated for the first time by using advanced Radioactive Particle Tracking (RPT) technique. The experimental work was carried out in a Plexiglas bubble column with 5.5 in. (0.14 m) and a height of 72 in. (1.83 m) for the air-water system. In this work, thirty vertical Plexiglass internals of 0.5 in. (0.0127 m) outer diameter were used which covered ∼25% (typical for Fischer–Tropsch processes) of the total cross-sectional area of the column where they arranged as the triangular pitch of 0.84 in. (0.0214 m). The superficial gas velocities based on both total cross-sectional area and free cross-sectional area available for the flow were utilized (0.08, 0.2, and 0.45 m/s), which covered the transition and churn-turbulent flow regime to meet the industrial applications of FT synthesis. The experimental data show that the presence of the internals at a given superficial gas velocity causes an increase in the axial centerline liquid velocity and a sharp decrease in turbulence parameters while the increase in superficial gas velocity in the presence of internals causes an increase in axial centerline liquid velocity and turbulent parameters. The obtained data are reliable as a benchmark data for validation computational fluid dynamics (CFD) simulation, and models.
Ali Akbar Nekooeian - One of the best experts on this subject based on the ideXlab platform.
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Chronology of blood pressure changes in renal hypertension induced by solid Plexiglass clips in the rat.
Iranian Journal of Veterinary Research, 2007Co-Authors: Ali Akbar Nekooeian, T MashhoodiAbstract:Summary The objective of this study was to determine the chronology of changes in blood pressure in renal hypertension induced by solid Plexiglass clips in rats. Saw blades with the thickness of 0.21-0.22 mm were used to make clips sized 4 × 2 × 2 mm from a piece of 2-mm thick Plexiglass. Rats were subjected to sham- operation or left renal arterial clipping, and 1, 2, 3 and 4 weeks later blood pressure, and heart and kidneys weights were determined. Relative to those of sham-operated rats, mean blood pressure of left renal artery- clipped rats were significantly higher at week 1 through 4 after clipping. Left renal artery clipping was also associated with significant increases in heart and right kidney weights and significant decrease in left kidney weight. The findings suggest that clipping of left renal artery using solid Plexiglass clips resulted in changes in blood pressure, heart and left and right kidneys weights similar to reported changes in hypertension induced by silver clips.
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Solid Plexiglass clips to induce reproducible renal hypertension in the rat
Indian Journal of Pharmacology, 2007Co-Authors: Ali Akbar Nekooeian, T MashhoodiAbstract:Objective: The objective of this study was to induce reproducible renal hypertension in rats using Plexiglass clips, and to compare it with that induced by silver clips. Materials and Methods: Saw blades (0.21-0.22 mm thick ) were used to make clips (4 x 2 x 2 mm) from a piece of 2-mm thick Plexiglass. Rats were subjected to sham-operation or placement of Plexiglass or silver clips around left renal artery, and 4 weeks later their mean blood pressure (MBP, mmHg), heart rate (HR, bpm), and heart weight (HW), left kidney weight (LKW), right kidney weight (RKW) and body weight (BW, g) were determined. The RKW, LKW and HW were calculated as a percentage of body weight. Results: Four weeks after sham-operation or placement of clips around renal artery, MBP, HW and RKW were significantly higher and LKW was significantly lower in left renal artery-clipped rats using Plexiglass or silver clips than sham-operated ones. There was also no significant differnce among the values of HR or BW from the 3 groups. Moreover, there was no significant difference among MBP, HR, LKW, RKW or BW from sham-operated or renal artery-clipped rats. Conclusion: The findings suggest that placement of solid Plexiglass clips around left renal artery resulted in hypertension comparable to that induced by silver clips.
