The Experts below are selected from a list of 109407 Experts worldwide ranked by ideXlab platform
Miller Sa - One of the best experts on this subject based on the ideXlab platform.
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Investigation of Air–Liquid Interface Rings in Buffer Preparation Vessels: the Role of Slip Agents
Pda Journal of Pharmaceutical Science and Technology, 2016Co-Authors: Shi T, Ding W, Kessler Dw, De Mas N, Weaver Dg, Pathirana C, Martin Rd, Mackin Na, Casati M, Miller SaAbstract:Air–Liquid Interface rings were observed on the side walls of stainless steel buffer vessels after certain downstream buffer preparations. Those rings were resistant to regular cleaning-in-place procedures but could be removed by manual means. To investigate the root cause of this issue, multiple analytical techniques, including Liquid chromatography with tandem mass spectrometry detection (LC-MS/MS), high-resolution accurate mass Liquid chromatography with mass spectrometry, nuclear magnetic resonance, Fourier transform infrared spectroscopy, and scanning electron microscopy with energy-dispersive X-ray spectroscopy have been employed to characterize the chemical composition of air–Liquid Interface rings. The main component of air–Liquid Interface rings was determined to be slip agents, and the origin of the slip agents can be traced back to their presence on raw material packaging liners. Slip agents are commonly used in plastic industry as additives to reduce the coefficient of friction during the manufacturing process of thin films. To mitigate this air–Liquid Interface ring issue, an alternate liner with low slip agent was identified and implemented with minimal additional cost. We have also proactively tested the packaging liners of other raw materials currently used in our downstream buffer preparation to ensure slip agent levels are appropriate. LAY ABSTRACT: Air–Liquid Interface rings were observed on the side walls of stainless steel buffer vessels after certain downstream buffer preparations. To investigate the root cause of this issue, multiple analytical techniques have been employed to characterize the chemical composition of air–Liquid Interface rings. The main components of air–Liquid Interface rings were determined to be slip agents, which are common additives used in the manufacturing process of thin films. The origin of the slip agents can be traced back to their presence on certain raw material packaging liners. To mitigate this air–Liquid Interface ring issue, an alternate liner with low slip agent was identified and implemented.
Scott A Miller - One of the best experts on this subject based on the ideXlab platform.
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investigation of air Liquid Interface rings in buffer preparation vessels the role of slip agents
Pda Journal of Pharmaceutical Science and Technology, 2016Co-Authors: Wei Ding, Donald W Kessler, Douglas Weaver, Charles Pathirana, Russell D Martin, Nancy A Mackin, Michael Casati, Scott A MillerAbstract:Air–Liquid Interface rings were observed on the side walls of stainless steel buffer vessels after certain downstream buffer preparations. Those rings were resistant to regular cleaning-in-place procedures but could be removed by manual means. To investigate the root cause of this issue, multiple analytical techniques, including Liquid chromatography with tandem mass spectrometry detection (LC-MS/MS), high-resolution accurate mass Liquid chromatography with mass spectrometry, nuclear magnetic resonance, Fourier transform infrared spectroscopy, and scanning electron microscopy with energy-dispersive X-ray spectroscopy have been employed to characterize the chemical composition of air–Liquid Interface rings. The main component of air–Liquid Interface rings was determined to be slip agents, and the origin of the slip agents can be traced back to their presence on raw material packaging liners. Slip agents are commonly used in plastic industry as additives to reduce the coefficient of friction during the manufacturing process of thin films. To mitigate this air–Liquid Interface ring issue, an alternate liner with low slip agent was identified and implemented with minimal additional cost. We have also proactively tested the packaging liners of other raw materials currently used in our downstream buffer preparation to ensure slip agent levels are appropriate. LAY ABSTRACT: Air–Liquid Interface rings were observed on the side walls of stainless steel buffer vessels after certain downstream buffer preparations. To investigate the root cause of this issue, multiple analytical techniques have been employed to characterize the chemical composition of air–Liquid Interface rings. The main components of air–Liquid Interface rings were determined to be slip agents, which are common additives used in the manufacturing process of thin films. The origin of the slip agents can be traced back to their presence on certain raw material packaging liners. To mitigate this air–Liquid Interface ring issue, an alternate liner with low slip agent was identified and implemented.
Robert A. W. Dryfe - One of the best experts on this subject based on the ideXlab platform.
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In situ XAFS Study of Palladium Electrodeposition at the Liquid/Liquid Interface
Electrochimica Acta, 2017Co-Authors: Samuel G. Booth, Sin-yuen Chang, Akihiro Uehara, Camille La Fontaine, Giannantonio Cibin, Sven L. M. Schroeder, Robert A. W. DryfeAbstract:We report the use of XAFS (X-ray absorption fine structure) as an in situ method to follow the electrochemically driven deposition of palladium nanoparticles at a Liquid/Liquid Interface. A novel glass/plastic hybrid electrochemical cell was used to enable control of the potential applied to the Liquid/Liquid Interface. In situ measurements indicate that the nucleation of metallic nanoparticles can be triggered through chronoamperometry or cyclic voltammetry. In contrast to spontaneous nucleation at the Liquid/Liquid Interface, whereby fluctuations in Pd oxidation state and concentration are observed, under a fixed interfacial potential the growth process occurs at a steady rate leading to a build-up of palladium at the Interface. Raman spectroscopy of the deposit suggests that the organic electrolyte binds directly to the surface of the deposited nanoparticles. It was found that the introduction of citric acid results in the formation of spherical nanoparticles at the Interface.
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Assembly of Nanoscale Objects at the Liquid/Liquid Interface
The Journal of Physical Chemistry C, 2015Co-Authors: Samuel G. Booth, Robert A. W. DryfeAbstract:The Liquid–Liquid Interface provides a molecularly sharp, defect-free focal plane for the assembly of solid materials. In this article we discuss the various materials which have been successfully assembled at the Liquid/Liquid Interface such as metallic nanoparticles, Janus particles, and carbon nanomaterials. Strategies to induce particle assembly include manipulation of surface chemistry, surface charge, and potential control. Liquid/Liquid assembly can be exploited to synthesize materials in situ and template preformed structures. We go on to discuss the difficulties encountered when attempting to fully understand the structure of assemblies present at the Liquid/Liquid Interface and the development of experimental techniques to elucidate information about the structure, stability, chemical composition, and reactivity of interfacial assemblies.
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Modifying the Liquid/Liquid Interface: pores, particles and deposition.
Physical chemistry chemical physics : PCCP, 2006Co-Authors: Robert A. W. DryfeAbstract:The modification of the Liquid/Liquid Interface with solid phases is discussed in this article. Modified Interfaces can be formed with molecular assemblies, but here attention is focussed on solid materials such as mesoscopic particles, or microporous and mesoporous membranes. Charge transfer across the modified Liquid/Liquid Interface is considered in particular. The most obvious consequence of the introduction of such modifying components is their effect on the transport to, and the transfer of material across, the Liquid/Liquid Interface, as measured voltammetrically for example. One particularly interesting reaction is interfacial metal deposition, which can also be studied under electrochemical control: the initial formation of metal nuclei at the Interface transforms it from the bare, pristine state to a modified state with very different reactivity. Deposition at Interfaces between Liquids is compared and contrasted with the cases of metal deposition in bulk solution and conventional heterogeneous deposition on conducting solid surfaces. Comparison is also made with work on the assembly of pre-formed micron and nanometre scale solids at the Liquid/Liquid Interface.
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Electrochemistry of cytochrome c at the Liquid-Liquid Interface
The Journal of Physical Chemistry B, 2002Co-Authors: Geoffrey C. Lillie, Stuart M. Holmes, Robert A. W. DryfeAbstract:The potential-controlled electron-transfer reaction between cytochrome c and 1,1‘-dimethylferrocene at a Liquid−Liquid Interface is reported. In this new approach to protein electrochemistry, the electron transfer process is apparently transport controlled, rather than adsorption limited. Furthermore, electron transfer at the Liquid−Liquid Interface more closely resembles the situation of the protein in vivo.
Wei Ding - One of the best experts on this subject based on the ideXlab platform.
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investigation of air Liquid Interface rings in buffer preparation vessels the role of slip agents
Pda Journal of Pharmaceutical Science and Technology, 2016Co-Authors: Wei Ding, Donald W Kessler, Douglas Weaver, Charles Pathirana, Russell D Martin, Nancy A Mackin, Michael Casati, Scott A MillerAbstract:Air–Liquid Interface rings were observed on the side walls of stainless steel buffer vessels after certain downstream buffer preparations. Those rings were resistant to regular cleaning-in-place procedures but could be removed by manual means. To investigate the root cause of this issue, multiple analytical techniques, including Liquid chromatography with tandem mass spectrometry detection (LC-MS/MS), high-resolution accurate mass Liquid chromatography with mass spectrometry, nuclear magnetic resonance, Fourier transform infrared spectroscopy, and scanning electron microscopy with energy-dispersive X-ray spectroscopy have been employed to characterize the chemical composition of air–Liquid Interface rings. The main component of air–Liquid Interface rings was determined to be slip agents, and the origin of the slip agents can be traced back to their presence on raw material packaging liners. Slip agents are commonly used in plastic industry as additives to reduce the coefficient of friction during the manufacturing process of thin films. To mitigate this air–Liquid Interface ring issue, an alternate liner with low slip agent was identified and implemented with minimal additional cost. We have also proactively tested the packaging liners of other raw materials currently used in our downstream buffer preparation to ensure slip agent levels are appropriate. LAY ABSTRACT: Air–Liquid Interface rings were observed on the side walls of stainless steel buffer vessels after certain downstream buffer preparations. To investigate the root cause of this issue, multiple analytical techniques have been employed to characterize the chemical composition of air–Liquid Interface rings. The main components of air–Liquid Interface rings were determined to be slip agents, which are common additives used in the manufacturing process of thin films. The origin of the slip agents can be traced back to their presence on certain raw material packaging liners. To mitigate this air–Liquid Interface ring issue, an alternate liner with low slip agent was identified and implemented.
Shi T - One of the best experts on this subject based on the ideXlab platform.
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Investigation of Air–Liquid Interface Rings in Buffer Preparation Vessels: the Role of Slip Agents
Pda Journal of Pharmaceutical Science and Technology, 2016Co-Authors: Shi T, Ding W, Kessler Dw, De Mas N, Weaver Dg, Pathirana C, Martin Rd, Mackin Na, Casati M, Miller SaAbstract:Air–Liquid Interface rings were observed on the side walls of stainless steel buffer vessels after certain downstream buffer preparations. Those rings were resistant to regular cleaning-in-place procedures but could be removed by manual means. To investigate the root cause of this issue, multiple analytical techniques, including Liquid chromatography with tandem mass spectrometry detection (LC-MS/MS), high-resolution accurate mass Liquid chromatography with mass spectrometry, nuclear magnetic resonance, Fourier transform infrared spectroscopy, and scanning electron microscopy with energy-dispersive X-ray spectroscopy have been employed to characterize the chemical composition of air–Liquid Interface rings. The main component of air–Liquid Interface rings was determined to be slip agents, and the origin of the slip agents can be traced back to their presence on raw material packaging liners. Slip agents are commonly used in plastic industry as additives to reduce the coefficient of friction during the manufacturing process of thin films. To mitigate this air–Liquid Interface ring issue, an alternate liner with low slip agent was identified and implemented with minimal additional cost. We have also proactively tested the packaging liners of other raw materials currently used in our downstream buffer preparation to ensure slip agent levels are appropriate. LAY ABSTRACT: Air–Liquid Interface rings were observed on the side walls of stainless steel buffer vessels after certain downstream buffer preparations. To investigate the root cause of this issue, multiple analytical techniques have been employed to characterize the chemical composition of air–Liquid Interface rings. The main components of air–Liquid Interface rings were determined to be slip agents, which are common additives used in the manufacturing process of thin films. The origin of the slip agents can be traced back to their presence on certain raw material packaging liners. To mitigate this air–Liquid Interface ring issue, an alternate liner with low slip agent was identified and implemented.
